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Molecular insights into experimental models and therapeutics for cholestasis
Biomed Pharmacother. 2024 Apr 13;174:116594. doi: 10.1016/j.biopha.2024.116594. Online ahead of print.ABSTRACTCholestatic liver disease (CLD) is a range of conditions caused by the accumulation of bile acids (BAs) or disruptions in bile flow, which can harm the liver and bile ducts. To investigate its pathogenesis and treatment, it is essential to establish and assess experimental models of cholestasis, which have significant clinical value. However, owing to the complex pathogenesis of cholestasis, a single modelling method can merely reflect one or a few pathological mechanisms, and each method has its adaptability and l...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 14, 2024 Category: Drugs & Pharmacology Authors: Wenwen Zhang Hefei Wu Shiman Luo Xiaohua Lu Xiyue Tan Li Wen Xiao Ma Thomas Efferth Source Type: research

Role of epigenetics in the regulation of skin aging and geroprotective intervention: A new sight
Biomed Pharmacother. 2024 Apr 13;174:116592. doi: 10.1016/j.biopha.2024.116592. Online ahead of print.ABSTRACTMultiple epigenetic factors play a regulatory role in maintaining the homeostasis of cutaneous components and are implicated in the aging process of the skin. They have been associated with the activation of the senescence program, which is the primary contributor to age-related decline in the skin. Senescent species drive a series of interconnected processes that impact the immediate surroundings, leading to structural changes, diminished functionality, and heightened vulnerability to infections. Geroprotective me...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 14, 2024 Category: Drugs & Pharmacology Authors: Lisa Dal Pozzo Zhe Xu Shan Lin Jida Wang Ying Wang Ogbe Susan Enechojo Joseph Kofi Abankwah Yanfei Peng Xiaoqian Chu Huifang Zhou Yuhong Bian Source Type: research

Xanthohumol, a prenylated chalcone, regulates lipid metabolism by modulating the LXR α/RXR-ANGPTL3-LPL axis in hepatic cell lines and high-fat diet-fed zebrafish models
Biomed Pharmacother. 2024 Apr 13;174:116598. doi: 10.1016/j.biopha.2024.116598. Online ahead of print.ABSTRACTAngiopoietin-like 3 (ANGPTL3) acts as an inhibitor of lipoprotein lipase (LPL), impeding the breakdown of triglyceride-rich lipoproteins (TGRLs) in circulation. Targeting ANGPTL3 is considered a novel strategy for improving dyslipidemia and atherosclerotic cardiovascular diseases (ASCVD). Hops (Humulus lupulus L.) contain several bioactive prenylflavonoids, including xanthohumol (Xan), isoxanthohumol (Isoxan), 6-prenylnaringenin (6-PN), and 8-prenylnaringenin (8-PN), with the potential to manage lipid metabolism. T...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 14, 2024 Category: Drugs & Pharmacology Authors: Wan-Yun Gao Pei-Yi Chen Hao-Jen Hsu Je-Wen Liou Chia-Ling Wu Ming-Jiuan Wu Jui-Hung Yen Source Type: research

The effect of calpain inhibitor-I on copper oxide nanoparticle-induced damage and cerebral ischemia-reperfusion in a rat model
This study aimed to investigate the effects of the calpain inhibitor N-Acetyl-Leu-Leu-norleucinal (ALLN) on neuroapoptotic cell damage caused by Copper Oxide Nanoparticles (CuO-NP) and exacerbation of damage through brain ischemia/reperfusion (I/R) in a rat model. Male Wistar Albino rats (n=80) were divided into eight groups: Control, I/R, CuO-NP, CuO-NP+I/R, I/R+ALLN, CuO-NP+ALLN, CuO-NP+I/R+ALLN, and DMSO. Biochemical markers (MBP, S100B, NEFL, NSE, BCL-2, Cyt-C, Calpain, TNF-α, Caspase-3, MDA, and CAT) were measured in serum and brain tissue samples. Histological examinations (H&E staining), DNA fragmentation analy...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 14, 2024 Category: Drugs & Pharmacology Authors: Hadi Karimkhani Paria Shojaolsadati T ürkan Yiğitbaşı Bircan Kolbas ı Neslin Emekli Source Type: research

Elucidating cuproptosis in metabolic dysfunction-associated steatotic liver disease
Biomed Pharmacother. 2024 Apr 13;174:116585. doi: 10.1016/j.biopha.2024.116585. Online ahead of print.ABSTRACTEmerging research into metabolic dysfunction-associated steatotic liver disease (MASLD) up until January 2024 has highlighted the critical role of cuproptosis, a unique cell death mechanism triggered by copper overload, in the disease's development. This connection offers new insights into MASLD's complex pathogenesis, pointing to copper accumulation as a key factor that disrupts lipid metabolism and insulin sensitivity. The identification of cuproptosis as a significant contributor to MASLD underscores the potenti...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 14, 2024 Category: Drugs & Pharmacology Authors: Yamei Li Ping Qi Si-Yuan Song Yiping Wang Hailian Wang Peng Cao Yu'e Liu Yi Wang Source Type: research

The use of a selective, nontoxic dual-acting peptide for breast cancer patients with brain metastasis
In conclusion, we have designed a dual-acting peptide capable of brain penetration and TNBC cell elimination, thus expanding the drug arsenal to fight this BC subtype and its BM.PMID:38613996 | DOI:10.1016/j.biopha.2024.116573 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 13, 2024 Category: Drugs & Pharmacology Authors: Marco Cavaco Clara P érez-Peinado Javier Valle Ruben D M Silva Lurdes Gano Jo ão D G Correia David Andreu Miguel A R B Castanho Vera Neves Source Type: research

Tumor extrachromosomal DNA: Biogenesis and recent advances in the field
This article examines the latest advancements in this area and discusses the potential clinical applications of ecDNA.PMID:38613997 | DOI:10.1016/j.biopha.2024.116588 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 13, 2024 Category: Drugs & Pharmacology Authors: Haomin Wu Shiqi Liu Di Wu Haonan Zhou Gang Wu Source Type: research

Therapeutic vulnerabilities in triple negative breast cancer: Stem-like traits explored within molecular classification
Biomed Pharmacother. 2024 Apr 12;174:116584. doi: 10.1016/j.biopha.2024.116584. Online ahead of print.ABSTRACTTriple Negative Breast Cancer (TNBC) is the most aggressive type of breast cancer (BC). Despite advances in the clinical management of TNBC, recurrence-related mortality remains a challenge. The stem-like phenotype of TNBC plays a significant role in the persistence of minimal disease residue after therapy. Individuals exhibiting stem-like characteristics are particularly prone to inducing malignant relapse accompanied by strong resistance. Therefore, stem-like traits have been broadly proposed as therapeutic vulne...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 13, 2024 Category: Drugs & Pharmacology Authors: Peng Huang Xi Zhang Jyothi S Prabhu Vijay Pandey Source Type: research

Research status and challenges of plant-derived exosome-like nanoparticles
Biomed Pharmacother. 2024 Apr 11;174:116543. doi: 10.1016/j.biopha.2024.116543. Online ahead of print.ABSTRACTIn recent years, there has been an increasing number of related studies on exosomes. Most studies have focused on exosomes derived from mammals, confirming the important role that exosomes play in cell communication. Plants, as a natural ingredient, plant-derived exosomes have been confirmed to have similar structures and functions to mammalian-derived exosomes. Plant-derived exosome-like nanoparticles (PELNs) are lipid bilayer membrane nanovesicles containing bioactive constituents such as miRNA, mRNA, protein, an...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 12, 2024 Category: Drugs & Pharmacology Authors: Chunmei Bai Jianrong Liu Xumin Zhang Yang Li Qin Qin Haixia Song Caixia Yuan Ziwei Huang Source Type: research

Response to antifibrotic therapy and decrease of circulating BAG3 protein levels in systemic sclerosis patients with reduced forced vital capacity
Biomed Pharmacother. 2024 Apr 11;174:116578. doi: 10.1016/j.biopha.2024.116578. Online ahead of print.NO ABSTRACTPMID:38608524 | DOI:10.1016/j.biopha.2024.116578 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 12, 2024 Category: Drugs & Pharmacology Authors: Margot De Marco Anna Basile Anna Lisa Cammarota Claudia Iannone Antonia Falco Liberato Marzullo Alessandra Rosati Roberto Caporali Maria Caterina Turco Nicoletta Del Papa Source Type: research

Resolvin D2 prevents vascular remodeling, hypercontractility and endothelial dysfunction in obese hypertensive mice through modulation of vascular and proinflammatory factors
Biomed Pharmacother. 2024 Apr 11;174:116564. doi: 10.1016/j.biopha.2024.116564. Online ahead of print.ABSTRACTDuring resolution of inflammation, specialized proresolving mediators (SPMs), including resolvins, are produced to restore tissue homeostasis. We hypothesized that there might be a dysregulation of SPMs pathways in pathological vascular remodeling and that resolvin D2 (RvD2) might prevent vascular remodeling and contractile and endothelial dysfunction in a model of obesity and hypertension. In aortic samples of patients with or without abdominal aortic aneurysms (AAA), we evaluated gene expression of enzymes involv...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 12, 2024 Category: Drugs & Pharmacology Authors: Raquel Rodrigues-Diez Constanza Ballesteros-Martinez Rosa Mar ía Moreno-Carriles Francisco Nistal Luc ía S Díaz Del Campo Victoria Cachofeiro Jesmond Dalli Ana B Garc ía-Redondo Juan M Redondo Mercedes Salaices Ana M Briones Source Type: research

Mechanical stress induced mitochondrial dysfunction in cardiovascular diseases: Novel mechanisms and therapeutic targets
Biomed Pharmacother. 2024 Apr 10;174:116545. doi: 10.1016/j.biopha.2024.116545. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Others and our studies have shown that mechanical stresses (forces) including shear stress and cyclic stretch, occur in various pathological conditions, play significant roles in the development and progression of CVDs. Mitochondria regulate the physiological processes of cardiac and vascular cells mainly through adenosine triphosphate (ATP) production, calcium flux and redox control while promote cell death through electron transport comp...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 11, 2024 Category: Drugs & Pharmacology Authors: He Ren Weiyi Hu Tao Jiang Qingping Yao Yingxin Qi Kai Huang Source Type: research