Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

S1PR3 agonism and S1P lyase inhibition rescue mice in the severe state of experimental sepsis
Biomed Pharmacother. 2024 Apr 9;174:116575. doi: 10.1016/j.biopha.2024.116575. Online ahead of print.ABSTRACTSepsis is characterized as life-threatening organ dysfunction caused by a dysregulated host response to an infection. Despite numerous clinical trials that addressed this syndrome, there is still no causative treatment available to dampen its severity. Curtailing the infection at an early stage with anti-infectives is the only effective treatment regime besides intensive care. In search for additional treatment options, we recently discovered the inhibition of the sphingosine 1-phosphate (S1P) lyase and subsequent a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 10, 2024 Category: Drugs & Pharmacology Authors: Anke C Ziegler Raphael S Haider Carsten Hoffmann Markus H Gr äler Source Type: research

NGF increases Connexin-43 expression and function in pulmonary arterial smooth muscle cells to induce pulmonary artery hyperreactivity
CONCLUSIONS: Modulation of Cx43 by NGF in pulmonary arterial smooth muscle cells contributes to NGF-induced alterations of pulmonary artery reactivity. Since NGF and its TrkA receptor play a role in vivo in Cx43 increased expression in PH induced by chronic hypoxia, these NGF/Cx43-dependent mechanisms may therefore play a significant role in human PH pathophysiology.PMID:38599061 | DOI:10.1016/j.biopha.2024.116552 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 10, 2024 Category: Drugs & Pharmacology Authors: Guillaume Cardouat Matthieu Douard Cl ément Bouchet Lukas Roubenne Zuzana Kmecov á Pauline Esteves Fabien Brette Christophe Guignabert Ly Tu Marilyne Campagnac Paul Robillard Florence Coste Fr édéric Delcambre Matthieu Thumerel Hugues Begueret Arnaud Source Type: research

Effect of adalimumab as an anti-inflammatory agent on gene expression of retinal pigment epithelial cells
In conclusion, despite its safety, the 2x concentration of ADA was the only dose that did not ignite the expression of any of the studied inflammatory and fibrogenesis genes. This dosage, which is roughly equal to 2 mg intravitreal dose in a clinical setting, might be referred to as a reference starting point for future in-vivo studies in ocular conditions.PMID:38599062 | DOI:10.1016/j.biopha.2024.116568 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 10, 2024 Category: Drugs & Pharmacology Authors: M Hossein Nowroozzadeh Mojtaba Yousefi Mostafa Abuali Fatemeh Sanie-Jahromi Source Type: research

Roles and mechanisms of copper homeostasis and cuproptosis in osteoarticular diseases
Biomed Pharmacother. 2024 Apr 9;174:116570. doi: 10.1016/j.biopha.2024.116570. Online ahead of print.ABSTRACTCopper is an essential trace element in the human body that is extensively distributed throughout various tissues. The appropriate level of copper is crucial to maintaining the life activities of the human body, and the excess and deficiency of copper can lead to various diseases. The copper levels in the human body are regulated by copper homeostasis, which maintains appropriate levels of copper in tissues and cells by controlling its absorption, transport, and storage. Cuproptosis is a distinct form of cell death ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 10, 2024 Category: Drugs & Pharmacology Authors: Juanjuan Han Jiayi Luo Cuijing Wang Leonid Kapilevich Xin-An Zhang Source Type: research

Chinese medicinal formula Fu Xin decoction against chronic heart failure by inhibiting the NLRP3/caspase-1/GSDMD pyroptotic pathway
CONCLUSION: FXD exhibits a cardioprotective effect, improving CHF and alleviating pyroptosis by inhibiting the NLRP3/caspase-1/GSDMD pathway.PMID:38599064 | DOI:10.1016/j.biopha.2024.116548 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 10, 2024 Category: Drugs & Pharmacology Authors: Lei Zhang Yan Li Cun-Dong Fan Yong-Hao Jiang Li-Song Sheng Xu-Yu Song Yu-Xing Lin Yi-Tao Xue Rong Sun Source Type: research

Deciphering mitochondrial dysfunction: Pathophysiological mechanisms in vascular cognitive impairment
Biomed Pharmacother. 2024 Apr 9;174:116428. doi: 10.1016/j.biopha.2024.116428. Online ahead of print.ABSTRACTVascular cognitive impairment (VCI) encompasses a range of cognitive deficits arising from vascular pathology. The pathophysiological mechanisms underlying VCI remain incompletely understood; however, chronic cerebral hypoperfusion (CCH) is widely acknowledged as a principal pathological contributor. Mitochondria, crucial for cellular energy production and intracellular signaling, can lead to numerous neurological impairments when dysfunctional. Recent evidence indicates that mitochondrial dysfunction-marked by oxid...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 10, 2024 Category: Drugs & Pharmacology Authors: Yuyao He Tiantian He Hongpei Li Wei Chen Biying Zhong Yue Wu Runming Chen Yuli Hu Huaping Ma Bin Wu Wenyue Hu Zhenyun Han Source Type: research

Co-administration of "L-Lysine, Vitamin C, and Zinc" increased the antioxidant activity, decreased insulin resistance, and improved lipid profile in streptozotocin-induced diabetic rats
CONCLUSIONS: The results of this study indicated that co-administration of Lys, a chemical chaperone, with two antioxidants (VC and Zn) potentiates its antidiabetic effects and prevent diabetic complications in rat model of diabetes.PMID:38599057 | DOI:10.1016/j.biopha.2024.116525 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 10, 2024 Category: Drugs & Pharmacology Authors: Mostafa Yousefian Saeid Abedimanesh Amirhossein Yadegar Manouchehr Nakhjavani S Zahra Bathaie Source Type: research

In vivo effects of a selected thiourea derivative 1-(2-chlorobenzoyl)-3-(2,3-dichlorophenyl) against nociception, inflammation and gastric ulcerogenicity: Biochemical, histopathological and in silico approaches
In conclusion, these findings suggest that our test compound exhibits potent antinociceptive, anti-inflammatory properties and is devoid of ulcerogenic effects.PMID:38599058 | DOI:10.1016/j.biopha.2024.116544 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 10, 2024 Category: Drugs & Pharmacology Authors: Gowhar Ali Farrah Deeba Umer Rashid Aman Ullah Hammad Ullah Inayat Ali Khan Syed Ishtiaq Khan Amin Badshah Muhammad Arif Khan Muhammad Ayaz Maria Daglia Source Type: research

Vitamin B < sub > 6 < /sub > alleviates chronic sleep deprivation-induced hippocampal ferroptosis through CBS/GSH/GPX4 pathway
Biomed Pharmacother. 2024 Apr 9;174:116547. doi: 10.1016/j.biopha.2024.116547. Online ahead of print.ABSTRACTSeveral studies have found that sleep deprivation (SD) can lead to neuronal ferroptosis and affect hippocampal function. However, there are currently no effective interventions. Vitamin B6 is a co-factor for key enzymes in the transsulfuration pathway which is critical for maintaining cell growth in the presence of cysteine deprivation. The results showed that SD inhibited cystine-glutamate antiporter light chain subunit xCT protein expression and caused cysteine deficiency, which reduced the synthesis of the glutat...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 10, 2024 Category: Drugs & Pharmacology Authors: Man Yuan Feng Wang Tieqiang Sun Xiangyu Bian Yuxian Zhang Changjiang Guo Lixia Yu Zhanxin Yao Source Type: research

Characterization of the structure, anti-inflammatory activity and molecular docking of a neutral polysaccharide separated from American ginseng berries
CONCLUSION: Our study indicated the potential efficacy of AGBP-A as a safe and valid natural anti-inflammatory component.PMID:38593700 | DOI:10.1016/j.biopha.2024.116521 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 9, 2024 Category: Drugs & Pharmacology Authors: Qixiang Feng Huijiao Yan Yu Feng Li Cui Hidayat Hussain Jeong Hill Park Sung Won Kwon Lei Xie Yan Zhao Zhihao Zhang Jinfan Li Daijie Wang Source Type: research