NGF increases Connexin-43 expression and function in pulmonary arterial smooth muscle cells to induce pulmonary artery hyperreactivity

CONCLUSIONS: Modulation of Cx43 by NGF in pulmonary arterial smooth muscle cells contributes to NGF-induced alterations of pulmonary artery reactivity. Since NGF and its TrkA receptor play a role in vivo in Cx43 increased expression in PH induced by chronic hypoxia, these NGF/Cx43-dependent mechanisms may therefore play a significant role in human PH pathophysiology.PMID:38599061 | DOI:10.1016/j.biopha.2024.116552

Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 10, 2024 Category: Drugs & Pharmacology Authors: Guillaume Cardouat Matthieu Douard Cl ément Bouchet Lukas Roubenne Zuzana Kmecov á Pauline Esteves Fabien Brette Christophe Guignabert Ly Tu Marilyne Campagnac Paul Robillard Florence Coste Fr édéric Delcambre Matthieu Thumerel Hugues Begueret Arnaud Source Type: research