Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Tolperisone hydrochloride improves motor functions in Parkinson's disease via MMP-9 inhibition and by downregulating p38 MAPK and ERK1/2 signaling cascade
This study explores the modulation of MMP-9 expression via the MAPK/ERK signaling cascade and its potential therapeutic implications in the context of PD-associated motor dysfunction. Here, tolperisone hydrochloride (TL), a muscle relaxant that blocks voltage-gated sodium and calcium channels, was used as a treatment to observe its effect on MAPK signaling and MMP-9 expression. Rotenone (RT) exposure in mice resulted in a significant reduction in substantia nigra and primary motor cortex neurons, which were further evidenced by impairments in motor function. When TL was administered, neuron count was restored (89.0 ± 4.78...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 21, 2024 Category: Drugs & Pharmacology Authors: Bushra Zaman Irona Mostafa Tazree Hassan Shamim Ahmed Nusrat Jahan Ikbal Esha Fowzia Afsana Chowdhury Tory Bosu Humayra Noor Chowdhury Anup Mallick Mm Shanjid Islam Ayesha Sharmin Kabir M Uddin Md Mainul Hossain Mahbubur Rahman Source Type: research

Maximakinin reversed H 2 O 2 induced oxidative damage in rat cardiac H9c2 cells through AMPK/Akt and AMPK/ERK1/2 signaling pathways
This study investigates the protective effect of MK on hydrogen peroxide (H2O2)-induced oxidative damage in rat cardiac H9c2 cells and explores its mechanism of action. A 3-(4,5-Dimethyl-2-Thiazolyl)-2,5-Diphenyl Tetrazolium Bromide (MTT) assay was selected to detect the effect of MK on H9c2 cell viability, while flow cytometry was used to investigate the influence of MK and H2O2 on intracellular reactive oxygen species (ROS) levels. Protein expression changes were detected by western blot. In addition, specific protein inhibitors were applied to confirm the induction of ROS-related signaling pathways by MK. MTT assay resu...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 21, 2024 Category: Drugs & Pharmacology Authors: Yang Yu Fan-Fan Su Cheng Xu Source Type: research

Artificial intelligence-driven drug repositioning uncovers efavirenz as a modulator of α-synuclein propagation: Implications in Parkinson's disease
This study opens new avenues for further investigation into the mechanisms underlying PD pathology and the exploration of additional drug candidates using advanced computational methodologies.PMID:38513596 | DOI:10.1016/j.biopha.2024.116442 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 21, 2024 Category: Drugs & Pharmacology Authors: Jae-Bong Kim Soo-Jeong Kim Minyoung So Dong-Kyu Kim Hye Rin Noh Beom Jin Kim Yu Ree Choi Doyoon Kim Heejung Koo Taeyong Kim Hyun Goo Woo Sang Myun Park Source Type: research

A new frontier in precision medicine: Exploring the role of extracellular vesicles in chronic obstructive pulmonary disease
Biomed Pharmacother. 2024 Mar 20;174:116443. doi: 10.1016/j.biopha.2024.116443. Online ahead of print.ABSTRACTChronic obstructive pulmonary disease (COPD) is a chronic inflammatory airway disease characterized by progressive respiratory difficulties. It has a high incidence and disability rate worldwide. However, currently there is still a lack of highly effective treatment methods for COPD, only symptom relief is possible. Therefore, there is an urgent need to explore new treatment options. Almost all cells can secrete extracellular vesicles (EVs), which participate in many physiological activities by transporting cargoes...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 21, 2024 Category: Drugs & Pharmacology Authors: Zixuan Gou Hongrun Yang Ruijia Wang Shihan Wang Qirui Chen Ziyu Liu Ying Zhang Source Type: research

Dexmedetomidine attenuates lipopolysaccharide-induced renal cell fibrotic phenotypic changes by inhibiting necroinflammation via activating α 2 -adrenoceptor: A combined randomised animal and in vitro study
CONCLUSIONS: Dex reduced EMT following LPS stimulation whilst simultaneously inhibiting pyroptosis and necroptosis via α2-AR activation in the renal tubular cells. The "anti-fibrotic" and cytoprotective properties and its clinical use of Dex need to be further studied.PMID:38513598 | DOI:10.1016/j.biopha.2024.116462 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 21, 2024 Category: Drugs & Pharmacology Authors: Qizhe Sun Priyanka Kamath Yibing Sun Min Liang Lingzhi Wu Enqiang Chang Qian Chen Azeem Alam Yi Liu Hailin Zhao Daqing Ma Source Type: research