Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.The isoproterenol-induced myocardial fibrosis: A biochemical and histological investigation
Biomed Pharmacother. 2024 Apr 1;174:116534. doi: 10.1016/j.biopha.2024.116534. Online ahead of print.ABSTRACTThe isoproterenol (ISO)-induced myocardial fibrosis is considered a reliable and repeatable experimental model characterized by a relatively low mortality rate. Although is well-known that ISO stimulates the β1 adrenergic receptors at the myocardial level, a high degree of heterogeneity emerges around the doses and duration of the treatment generating unclear results. Therefore, we propose to gain insights into the progression of ISO-induced myocardial fibrosis, in order to critically analyze and optimize the exper...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 2, 2024 Category: Drugs & Pharmacology Authors: Lorenzo Flori Giulia Lazzarini Jacopo Spezzini Andrea Pirone Vincenzo Calderone Lara Testai Vincenzo Miragliotta Source Type: research
Enhancing the therapeutic potential of isoliensinine for hypertension through PEG-PLGA nanoparticle delivery: A comprehensive in vivo and in vitro study
CONCLUSION: In this study, we successfully prepared PEG-PLGA@Isoliensinine by nano-precipitation, and we confirmed that PEG-PLGA@Isoliensinine surpasses free isoliensinine in its effectiveness for the treatment of hypertension, as demonstrated through both in vivo and in vitro experiments.SIGNIFICANCE: This study lays the foundation for isoliensinine's clinical use in hypertension treatment and vascular lesion protection, offering new insights for enhancing the bioavailability of traditional Chinese medicine components. Importantly, no toxicity was observed, affirming the successful implementation of this innovative drug d...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 2, 2024 Category: Drugs & Pharmacology Authors: Mengying Yao Ming Wu Meng Yuan Meizhu Wu Aling Shen Youqin Chen Dawei Lian Xiaolong Liu Jun Peng Source Type: research
Predicting potential therapeutic targets and small molecule drugs for early-stage lung adenocarcinoma
Biomed Pharmacother. 2024 Mar 30;174:116528. doi: 10.1016/j.biopha.2024.116528. Online ahead of print.ABSTRACTLung cancer is a leading cause of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) constituting the majority, and its main subtype being lung adenocarcinoma (LUAD). Despite substantial advances in LUAD diagnosis and treatment, early diagnostic biomarkers inadequately fulfill clinical requirements. Thus, we conducted bioinformatics analysis to identify potential biomarkers and corresponding therapeutic drugs for early-stage LUAD patients. Here we identified a total of 10 differentially exp...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 31, 2024 Category: Drugs & Pharmacology Authors: Yongxin Yu Lingchen Li Bangyu Luo Diangang Chen Chenrui Yin Chunli Jian Qiai You Jianmin Wang Ling Fang Dingqin Cai Jianguo Sun Source Type: research
Chrysin inhibits ferroptosis of cerebral ischemia/reperfusion injury via regulating HIF-1 α/CP loop
Biomed Pharmacother. 2024 Mar 30;174:116500. doi: 10.1016/j.biopha.2024.116500. Online ahead of print.ABSTRACTChrysin is a natural flavonoid with powerful neuroprotective capacity. Cerebral ischemia/reperfusion injury (CIRI) is associated with oxidative stress and ferroptosis. Hypoxia-inducible factor 1α (HIF-1α) and ceruloplasmin (CP) are the critical targets for oxidation reactions and iron transport. But the regulatory mechanism between them is still unclear. Transient middle cerebral artery occlusion (tMCAO) model in rats and oxygen and glucose deprivation/re-oxygenation (OGD/R) model in PC12 cells were applied. Path...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 31, 2024 Category: Drugs & Pharmacology Authors: Jinfeng Shang Jiakang Jiao Jingyi Wang Mingxue Yan Qiannan Li Lizha Shabuerjiang Guijinfeng Huang Qi Song Yinlian Wen Xiaolu Zhang Kai Wu Yiran Cui Xin Liu Source Type: research
Predicting potential therapeutic targets and small molecule drugs for early-stage lung adenocarcinoma
Biomed Pharmacother. 2024 Mar 30;174:116528. doi: 10.1016/j.biopha.2024.116528. Online ahead of print.ABSTRACTLung cancer is a leading cause of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) constituting the majority, and its main subtype being lung adenocarcinoma (LUAD). Despite substantial advances in LUAD diagnosis and treatment, early diagnostic biomarkers inadequately fulfill clinical requirements. Thus, we conducted bioinformatics analysis to identify potential biomarkers and corresponding therapeutic drugs for early-stage LUAD patients. Here we identified a total of 10 differentially exp...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 31, 2024 Category: Drugs & Pharmacology Authors: Yongxin Yu Lingchen Li Bangyu Luo Diangang Chen Chenrui Yin Chunli Jian Qiai You Jianmin Wang Ling Fang Dingqin Cai Jianguo Sun Source Type: research
Chrysin inhibits ferroptosis of cerebral ischemia/reperfusion injury via regulating HIF-1 α/CP loop
Biomed Pharmacother. 2024 Mar 30;174:116500. doi: 10.1016/j.biopha.2024.116500. Online ahead of print.ABSTRACTChrysin is a natural flavonoid with powerful neuroprotective capacity. Cerebral ischemia/reperfusion injury (CIRI) is associated with oxidative stress and ferroptosis. Hypoxia-inducible factor 1α (HIF-1α) and ceruloplasmin (CP) are the critical targets for oxidation reactions and iron transport. But the regulatory mechanism between them is still unclear. Transient middle cerebral artery occlusion (tMCAO) model in rats and oxygen and glucose deprivation/re-oxygenation (OGD/R) model in PC12 cells were applied. Path...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 31, 2024 Category: Drugs & Pharmacology Authors: Jinfeng Shang Jiakang Jiao Jingyi Wang Mingxue Yan Qiannan Li Lizha Shabuerjiang Guijinfeng Huang Qi Song Yinlian Wen Xiaolu Zhang Kai Wu Yiran Cui Xin Liu Source Type: research
Predicting potential therapeutic targets and small molecule drugs for early-stage lung adenocarcinoma
Biomed Pharmacother. 2024 Mar 30;174:116528. doi: 10.1016/j.biopha.2024.116528. Online ahead of print.ABSTRACTLung cancer is a leading cause of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) constituting the majority, and its main subtype being lung adenocarcinoma (LUAD). Despite substantial advances in LUAD diagnosis and treatment, early diagnostic biomarkers inadequately fulfill clinical requirements. Thus, we conducted bioinformatics analysis to identify potential biomarkers and corresponding therapeutic drugs for early-stage LUAD patients. Here we identified a total of 10 differentially exp...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 31, 2024 Category: Drugs & Pharmacology Authors: Yongxin Yu Lingchen Li Bangyu Luo Diangang Chen Chenrui Yin Chunli Jian Qiai You Jianmin Wang Ling Fang Dingqin Cai Jianguo Sun Source Type: research
Chrysin inhibits ferroptosis of cerebral ischemia/reperfusion injury via regulating HIF-1 α/CP loop
Biomed Pharmacother. 2024 Mar 30;174:116500. doi: 10.1016/j.biopha.2024.116500. Online ahead of print.ABSTRACTChrysin is a natural flavonoid with powerful neuroprotective capacity. Cerebral ischemia/reperfusion injury (CIRI) is associated with oxidative stress and ferroptosis. Hypoxia-inducible factor 1α (HIF-1α) and ceruloplasmin (CP) are the critical targets for oxidation reactions and iron transport. But the regulatory mechanism between them is still unclear. Transient middle cerebral artery occlusion (tMCAO) model in rats and oxygen and glucose deprivation/re-oxygenation (OGD/R) model in PC12 cells were applied. Path...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 31, 2024 Category: Drugs & Pharmacology Authors: Jinfeng Shang Jiakang Jiao Jingyi Wang Mingxue Yan Qiannan Li Lizha Shabuerjiang Guijinfeng Huang Qi Song Yinlian Wen Xiaolu Zhang Kai Wu Yiran Cui Xin Liu Source Type: research
Construction of aptamer-siRNA chimera and glutamine modified carboxymethyl- β-cyclodextrin nanoparticles for the combination therapy against lung squamous cell carcinoma
Biomed Pharmacother. 2024 Mar 29;174:116506. doi: 10.1016/j.biopha.2024.116506. Online ahead of print.ABSTRACTCombination therapy has become the most important treatment for advanced non-small cell lung cancer (NSCLC), which can significantly improve the prognosis of patients. However, poor targeting and adverse reactions limited its clinical application. Here, we constructed an AS1411 aptamer-programmed cell death ligand-1 (PD-L1) siRNA chimera/polyethylenimine/glutamine/β-cyclodextrin/doxorubicin (Chimera/ PEI/Gln/β-CD/DOX) nanoparticle for the combination therapy (chemotherapy combined with immunotherapy). Scanning el...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 30, 2024 Category: Drugs & Pharmacology Authors: Yanfei Hao Jintao Yang Dongxu Liu Hong Zhang Tongwen Ou Li Xiao Wen Chen Source Type: research
Lactoferrin as a therapeutic agent for attenuating hepatic stellate cell activation in thioacetamide-induced liver fibrosis
In this study, we investigated LF's mechanisms in thioacetamide (TAA)-induced liver fibrosis in rats and TGF-β1-treated HSC-T6 cells. Using ultrasonic imaging, H&E, Masson's, and Sirius Red staining, we demonstrated LF's ability to improve liver tissue damage and fibrosis induced by TAA. LF reduced the levels of ALT, AST, and hydroxyproline in TAA-treated liver tissues, while increasing catalase levels. Additionally, LF treatment decreased mRNA expression of inflammatory factors such as Il-1β and Icam-1, as well as fibrogenic factors including α-Sma, Collagen I, and Ctgf in TAA-treated liver tissues. Furthermore, LF...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 30, 2024 Category: Drugs & Pharmacology Authors: Tzu-Yu Pu Kai-Cheng Chuang Min-Che Tung Chih-Ching Yen Yu-Hsuan Chen Abdulkadir Cidem Chu-Hsun Ko Wei Chen Chuan-Mu Chen Source Type: research
TMF inhibits extracellular matrix degradation by regulating the C/EBP β/ADAMTS5 signaling pathway in osteoarthritis
In this study, we found that aggrecan expression was down-regulated, and ADAMTS5 expression was up-regulated. Knockdown of C/EBPβ could up-regulate aggrecan expression and down-regulate ADAMTS5 expression in IL-1β-treated C28/I2 cells. TMF could compromise the effects of C/EBPβ on OA chondrocytes by activating the Sirt1/FOXO3a signaling. Conclusively, TMF exhibited protective activity against ECM degradation by mediating the Sirt1/FOXO3a/C/EBPβ pathway in OA chondrocytes.PMID:38554527 | DOI:10.1016/j.biopha.2024.116501 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 30, 2024 Category: Drugs & Pharmacology Authors: Zeyu Wang Weimei Shi Longhuo Wu Yaosheng Xiao Miaofei Wang Sainan Zhang Zhixi Chen Guoqiang Yin Xunlu Xie Shengrong Bi Shiwei Liu Weihao Kong Jianguo Zhou Source Type: research
Direct exposure to CpG and specific antigens mitigate airway allergy through modulating dendritic cell properties
CONCLUSIONS: Direct exposure to CpG.DME induces DC1s and pDCs in the airway tissues. DC1s in synergy with pDCs induce type 1 regulatory T cells. The CpG.DME therapy is effective in suppressing allergic responses in mice with airway allergy.PMID:38554528 | DOI:10.1016/j.biopha.2024.116510 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 30, 2024 Category: Drugs & Pharmacology Authors: Aizhi Zhang Lihua Mo Xiaoxue Chen Ping Tang Yu Liu Wenkai Zhang Cheng Zhang Cailing Wang Huanping Zhang Pingchang Yang Source Type: research
Corrigendum to " β-Asarone suppresses Wnt/β-catenin signaling to reduce viability, inhibit migration/invasion/adhesion and induce mitochondria-related apoptosis in lung cancer cells" [Biomed. Pharmacother. 106 (2018) 821-830]
Biomed Pharmacother. 2024 Mar 29:116499. doi: 10.1016/j.biopha.2024.116499. Online ahead of print.NO ABSTRACTPMID:38555193 | DOI:10.1016/j.biopha.2024.116499 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 30, 2024 Category: Drugs & Pharmacology Authors: Tao-Li Wang Chen-Sheng Ouyang Li-Zhu Lin Source Type: research
Hydrogen sulfide dysfunction in metabolic syndrome-associated vascular complications involves cGMP regulation through soluble guanylyl cyclase persulfidation
In conclusion, our study demonstrates a pivotal role of reduced cGMP levels in impaired vasorelaxation in a murine model of MetS involving an impairment of both H2S and NO signaling. Exogenous H2S supplementation through Erucin represents a promising alternative in MetS therapy, targeting smooth muscle cells and supporting the importance of lifestyle and nutrition in managing MetS.PMID:38552439 | DOI:10.1016/j.biopha.2024.116466 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 29, 2024 Category: Drugs & Pharmacology Authors: M Smimmo V Casale G M Casillo E Mitidieri R d'Emmanuele di Villa Bianca I Bello A Schettino R Montanaro V Brancaleone C Indolfi G Cirino A Di Lorenzo M Bucci E Panza V Vellecco Source Type: research
Investigation of prunetrin induced G2/M cell cycle arrest and apoptosis via Akt/mTOR/MAPK pathways in hepatocellular carcinoma cells
Biomed Pharmacother. 2024 Mar 28;174:116483. doi: 10.1016/j.biopha.2024.116483. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) stands as a leading cause of mortality, and despite recent advancements in the overall survival rates, the prognosis remains dismal. Prunetin 4-O-glucoside (Prunetrin or PUR), an active compound derived from Prunus sp., was explored for its impact on HepG2 and Huh7 cells. The cytotoxicity assessment revealed a notable reduction in cell viability in both cell lines, while exhibiting non-toxicity towards HaCaT cells. Colony formation studies underscored PUR's inhibitory effect on cell p...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 29, 2024 Category: Drugs & Pharmacology Authors: Abuyaseer Abusaliya Pritam Bhagwan Bhosale Hun Hwan Kim Min Yeong Park Se Hyo Jeong Sijoon Lee Gon Sup Kim Source Type: research
