Hydrogen sulfide dysfunction in metabolic syndrome-associated vascular complications involves cGMP regulation through soluble guanylyl cyclase persulfidation

In conclusion, our study demonstrates a pivotal role of reduced cGMP levels in impaired vasorelaxation in a murine model of MetS involving an impairment of both H2S and NO signaling. Exogenous H2S supplementation through Erucin represents a promising alternative in MetS therapy, targeting smooth muscle cells and supporting the importance of lifestyle and nutrition in managing MetS.PMID:38552439 | DOI:10.1016/j.biopha.2024.116466

Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 29, 2024 Category: Drugs & Pharmacology Authors: M Smimmo V Casale G M Casillo E Mitidieri R d'Emmanuele di Villa Bianca I Bello A Schettino R Montanaro V Brancaleone C Indolfi G Cirino A Di Lorenzo M Bucci E Panza V Vellecco Source Type: research