Examining the Influence of Zinc Oxide Nanoparticles and Bulk Zinc Oxide on Rat Brain Functions: a Comprehensive Neurobehavioral, Antioxidant, Gene Expression, and Histopathological Investigation
In conclusion, the studies emphasized the importance of further assessing various doses and forms of zinc oxide on brain health, highlighting the significance of dosage considerations when using nanomaterials.PMID:38190061 | DOI:10.1007/s12011-023-04043-x (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 8, 2024 Category: Biology Authors: Amira A Goma Alyaa R Salama Hossam G Tohamy Rashed R Rashed Mustafa Shukry Sara E El-Kazaz Source Type: research

Concentration of Heavy Metals in Traditional and Industrial Fruit Juices from Iran: Probabilistic Risk Assessment Study
Biol Trace Elem Res. 2024 Jan 8. doi: 10.1007/s12011-023-04049-5. Online ahead of print.ABSTRACTExposure to heavy metals can endanger the health of exposed people in the long term. The consumption of fruit juice is increasing; it is important to estimate the health risk of consumers due to heavy metals. The current study was carried out for the analysis of toxic metals (lead (Pb), arsenic (As), and cadmium (Cd)) and essential elements (copper (Cu) and zinc (Zn)) in 60 samples of traditional and industrial fruit juices (10 samples of different brands of apple, orange, grape, peach, mango, and pineapple) in Hamadan, West Ira...
Source: Biological Trace Element Research - January 8, 2024 Category: Biology Authors: Fereshteh Mehri Ali Heshmati Elaheh Talebi Ghane Trias Mahmudiono Yadolah Fakhri Source Type: research

Palliative Effect of Combined Application of Zinc and Selenium on Reproductive Injury Induced by Tripterygium Glycosides in Male Rats
Biol Trace Elem Res. 2024 Jan 8. doi: 10.1007/s12011-023-04054-8. Online ahead of print.ABSTRACTThe long-term use of tripterygium glycosides (TG) can lead to male reproductive damage. Research indicates that zinc and selenium exhibit a synergistic effect in the male reproductive system, with the combined preparation demonstrating superior therapeutic effects compared to individual preparations. The purpose of this study was to explore the specific mechanism by which zinc and selenium mitigate reproductive toxicity induced by TG in male rats. Rats were randomly assigned to three groups: control group (C group), model group ...
Source: Biological Trace Element Research - January 8, 2024 Category: Biology Authors: Junsheng Liu Xin Zuo Jiajie Bi Huanhuan Li Yuanjing Li Jing Ma Shusong Wang Source Type: research

Examining the Influence of Zinc Oxide Nanoparticles and Bulk Zinc Oxide on Rat Brain Functions: a Comprehensive Neurobehavioral, Antioxidant, Gene Expression, and Histopathological Investigation
In conclusion, the studies emphasized the importance of further assessing various doses and forms of zinc oxide on brain health, highlighting the significance of dosage considerations when using nanomaterials.PMID:38190061 | DOI:10.1007/s12011-023-04043-x (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 8, 2024 Category: Biology Authors: Amira A Goma Alyaa R Salama Hossam G Tohamy Rashed R Rashed Mustafa Shukry Sara E El-Kazaz Source Type: research

Role of PERK-Mediated Endoplasmic Reticulum Stress in Ferroptosis Caused by Hexavalent Chromium in Chicken Hepatocytes
In conclusion, Cr(VI) can induce ferroptosis in chicken hepatocytes, and PERK plays an important role as a negative regulator.PMID:38183555 | DOI:10.1007/s12011-023-04046-8 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 6, 2024 Category: Biology Authors: Yukun Cui Pu Zhang Kaimin Song Changxi Qi Yongxia Liu Jianzhu Liu Source Type: research

Serum and Seminal Plasma Levels of Lead and Arsenic in Cigarette Smokers and Their Relation to the Semen Parameters
Biol Trace Elem Res. 2024 Jan 5. doi: 10.1007/s12011-023-04039-7. Online ahead of print.ABSTRACTMale infertility along with altered semen parameters have been related to smoking. Smoking-related elevations in serum and seminal lead (Pb) and arsenic (As) may play a role in mediating the toxic effects of smoking on seminogram. This research aims to determine whether smoking has any significant impact on Pb and As levels in the seminal plasma and serum, as well as on the various semen parameters, when compared to nonsmokers. In total, 80 adult males were included: 60 smokers and 20 age-matched nonsmokers. Based on the number ...
Source: Biological Trace Element Research - January 5, 2024 Category: Biology Authors: Azza Gaber Antar Farag Eman Abd-Elfatah Badr Alaa Osama Ali Kholif Mostafa Nabil Khalifa Mai Medhat Mohamed Ghanem Source Type: research

Upregulation of Intracellular Zinc Ion Level after Differentiation of the Neural Stem/Progenitor Cells In Vitro with the Changes in Gene Expression of Zinc Transporters
Biol Trace Elem Res. 2024 Jan 5. doi: 10.1007/s12011-023-04033-z. Online ahead of print.ABSTRACTWe measured the intracellular zinc ion concentration of murine fetal neural stem/progenitor cells (NSPCs) and that in the differentiated cells. The NSPCs cultured with 1.5 μM Zn2+ proliferated slightly faster than that in the zinc-deficient medium and the intracellular zinc concentration of the NSPCs and that of their differentiated cells (DCs) cultured with 1.5 μM Zn2+ was 1.34-fold and 2.00-fold higher than those in the zinc-deficient medium, respectively. The zinc transporter genes upregulated over the 3.5-fold change were ...
Source: Biological Trace Element Research - January 5, 2024 Category: Biology Authors: Hideki Mori Akari Goji Masayuki Hara Source Type: research

Serum and Seminal Plasma Levels of Lead and Arsenic in Cigarette Smokers and Their Relation to the Semen Parameters
Biol Trace Elem Res. 2024 Jan 5. doi: 10.1007/s12011-023-04039-7. Online ahead of print.ABSTRACTMale infertility along with altered semen parameters have been related to smoking. Smoking-related elevations in serum and seminal lead (Pb) and arsenic (As) may play a role in mediating the toxic effects of smoking on seminogram. This research aims to determine whether smoking has any significant impact on Pb and As levels in the seminal plasma and serum, as well as on the various semen parameters, when compared to nonsmokers. In total, 80 adult males were included: 60 smokers and 20 age-matched nonsmokers. Based on the number ...
Source: Biological Trace Element Research - January 5, 2024 Category: Biology Authors: Azza Gaber Antar Farag Eman Abd-Elfatah Badr Alaa Osama Ali Kholif Mostafa Nabil Khalifa Mai Medhat Mohamed Ghanem Source Type: research

Upregulation of Intracellular Zinc Ion Level after Differentiation of the Neural Stem/Progenitor Cells In Vitro with the Changes in Gene Expression of Zinc Transporters
Biol Trace Elem Res. 2024 Jan 5. doi: 10.1007/s12011-023-04033-z. Online ahead of print.ABSTRACTWe measured the intracellular zinc ion concentration of murine fetal neural stem/progenitor cells (NSPCs) and that in the differentiated cells. The NSPCs cultured with 1.5 μM Zn2+ proliferated slightly faster than that in the zinc-deficient medium and the intracellular zinc concentration of the NSPCs and that of their differentiated cells (DCs) cultured with 1.5 μM Zn2+ was 1.34-fold and 2.00-fold higher than those in the zinc-deficient medium, respectively. The zinc transporter genes upregulated over the 3.5-fold change were ...
Source: Biological Trace Element Research - January 5, 2024 Category: Biology Authors: Hideki Mori Akari Goji Masayuki Hara Source Type: research

Serum and Seminal Plasma Levels of Lead and Arsenic in Cigarette Smokers and Their Relation to the Semen Parameters
Biol Trace Elem Res. 2024 Jan 5. doi: 10.1007/s12011-023-04039-7. Online ahead of print.ABSTRACTMale infertility along with altered semen parameters have been related to smoking. Smoking-related elevations in serum and seminal lead (Pb) and arsenic (As) may play a role in mediating the toxic effects of smoking on seminogram. This research aims to determine whether smoking has any significant impact on Pb and As levels in the seminal plasma and serum, as well as on the various semen parameters, when compared to nonsmokers. In total, 80 adult males were included: 60 smokers and 20 age-matched nonsmokers. Based on the number ...
Source: Biological Trace Element Research - January 5, 2024 Category: Biology Authors: Azza Gaber Antar Farag Eman Abd-Elfatah Badr Alaa Osama Ali Kholif Mostafa Nabil Khalifa Mai Medhat Mohamed Ghanem Source Type: research

Upregulation of Intracellular Zinc Ion Level after Differentiation of the Neural Stem/Progenitor Cells In Vitro with the Changes in Gene Expression of Zinc Transporters
Biol Trace Elem Res. 2024 Jan 5. doi: 10.1007/s12011-023-04033-z. Online ahead of print.ABSTRACTWe measured the intracellular zinc ion concentration of murine fetal neural stem/progenitor cells (NSPCs) and that in the differentiated cells. The NSPCs cultured with 1.5 μM Zn2+ proliferated slightly faster than that in the zinc-deficient medium and the intracellular zinc concentration of the NSPCs and that of their differentiated cells (DCs) cultured with 1.5 μM Zn2+ was 1.34-fold and 2.00-fold higher than those in the zinc-deficient medium, respectively. The zinc transporter genes upregulated over the 3.5-fold change were ...
Source: Biological Trace Element Research - January 5, 2024 Category: Biology Authors: Hideki Mori Akari Goji Masayuki Hara Source Type: research

Sodium Selenite Prevents Matrine-Induced Nephrotoxicity by Suppressing Ferroptosis via the GSH-GPX4 Antioxidant System
Biol Trace Elem Res. 2024 Jan 4. doi: 10.1007/s12011-023-04044-w. Online ahead of print.ABSTRACTMatrine (MT), an active ingredient derived from Sophor flavescens Ait, is used as a therapeutic agent to treat liver disease and cancer. However, the serious toxic effects of MT, including nephrotoxicity, have limited its clinical application. Here, we explored the involvement of ferroptosis in MT-induced kidney injury and evaluated the potential efficacy and underlying mechanism of sodium selenite (SS) in attenuating MT-induced nephrotoxicity. We found that MT not only disrupts renal structure in mice but also induces the death...
Source: Biological Trace Element Research - January 4, 2024 Category: Biology Authors: Xi Wang Zixiong Lin Ting Li Wenjing Zhu Hanxin Huang Jiayan Hu Jie Zhou Source Type: research

Ortho-silicic Acid Prevents Glucocorticoid-Induced Femoral Head Necrosis by Promoting Akt Phosphorylation to Inhibit Endoplasmic Reticulum Stress-Mediated Apoptosis and Enhance Angiogenesis and Osteogenesis
We examined the influence of ortho-silicic acid (OSA, Si(OH)4) on the apoptosis and proliferation of vascular endothelial cells after glucocorticoid induction. Additionally, we evaluated the expression of apoptosis-related genes such as cleaved-caspase-3, Bcl-2 and Bax. The impact of glucocorticoids and OSA on the function of vascular endothelial cells was evaluated through wound healing, transwell and angiogenesis assays. Osteogenic function was subsequently evaluated through alizarin red staining, alkaline phosphatase staining and expression levels of osteogenic genes like RUNX2 and ALP. Moreover, we investigated the pot...
Source: Biological Trace Element Research - January 4, 2024 Category: Biology Authors: Zhenqian Sun Jian Wang Zhongjie Ji Jinlong Ma Yunzhen Chen Guangjun Jiao Source Type: research

The Correlation Between Serum Copper and Non-alcoholic Fatty Liver Disease in American Adults: an Analysis Based on NHANES 2011 to 2016
Biol Trace Elem Res. 2024 Jan 3. doi: 10.1007/s12011-023-04029-9. Online ahead of print.ABSTRACTCopper functions as an essential micronutrient influencing diverse metabolic processes in mammals, encompassing oxidative stress responses, lipid metabolism, and participation in enzymatic reactions. However, the impact of serum copper on non-alcoholic fatty liver disease (NAFLD) remains controversial. Our aim was to explore the precise correlation between serum copper and NAFLD in a large-scale population-based study. A total of 1377 participants from the National Health and Nutrition Examination Survey (NHANES) 2011-2016 were ...
Source: Biological Trace Element Research - January 3, 2024 Category: Biology Authors: Lurao Li Yun Yi Xiawen Shu Jianghui Li Hui Kang Ying Chang Source Type: research

Correction: Melatonin Attenuates Arsenic-Induced Neurotoxicity in Rats through the Regulation of miR-34a/miR-144 in Sirt1/Nrf2 Pathway
Biol Trace Elem Res. 2024 Jan 3. doi: 10.1007/s12011-023-04051-x. Online ahead of print.NO ABSTRACTPMID:38170428 | DOI:10.1007/s12011-023-04051-x (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 3, 2024 Category: Biology Authors: Nahid Najafi Samira Barangi Zahra Moosavi Seyed Hamid Aghaee-Bakhtiari Soghra Mehri Gholamreza Karimi Source Type: research