LINC00942 Alleviates NaAsO < sub > 2 < /sub > -induced Apoptosis by Promoting GSH Synthesis Through Targeting miR-214-5p
This study aimed to investigate the role of LINC00942 in arsenic-induced hepatotoxicity by regulating miR-214-5p. As the exposure dose of NaAsO2 gradually increases, cell viability, intracellular GSH content, ΔΨm, and the protein levels of GCLC and GCLM were reduced significantly. Apoptosis rate, ROS, and expression of apoptosis-related and NF-κB pathway proteins increased. The expression of LINC00942 was increased, while the expression of miR-214-5p was decreased. After suppressing LINC00942 levels, NaAsO2 exposure further decreased cell viability, intracellular GSH content, ΔΨm, GCLC protein, and miR-214-5p expressi...
Source: Biological Trace Element Research - April 5, 2024 Category: Biology Authors: Mingxiao Ma Jingyi Zhang Sheng Li Mengyao Zhang Weixin Chen Linzhi Li Shugang Li Source Type: research
Subchronic Exposure to Mixture of Cadmium, Copper, and Nickel Induces Neurobehavioral Deficits and Hippocampal Oxidative Stress of Wistar Rats
Biol Trace Elem Res. 2024 Apr 5. doi: 10.1007/s12011-024-04166-9. Online ahead of print.ABSTRACTThe present study was aimed at evaluating the influence of the subchronic exposure of cadmium (Cd), copper (Cu), and nickel (Ni) mixtures on affective behaviors, memory impairment, and oxidative stress (OS) in the hippocampus. Thirty male Wistar rats were divided into 5 equal groups. Group 1 (control) received a saline solution (NaCl 0.9%). Groups 2, 3, and 4 received Cd (0.25 mg/kg), Cu (0.5 mg/kg), and Ni (0.25 mg/kg), respectively, while group 5 received a Cd, Cu, and Ni mixture through intraperitoneal injections for 2 months...
Source: Biological Trace Element Research - April 5, 2024 Category: Biology Authors: Mouloud Lamtai Hajar Benmhammed Sofia Azirar Ayoub Rezqaoui Oussama Zghari Abdelghafour El Hamzaoui Mohamed Yassine El Brouzi Yassine Chahirou Samir Bikri Abdelhalem Mesfioui Aboubaker El Hessni Source Type: research
Activation of ERK/NF-kB Pathways Contributes to the Inflammatory Response in Epithelial Cells and Macrophages Following Manganese Exposure
Biol Trace Elem Res. 2024 Apr 6. doi: 10.1007/s12011-024-04154-z. Online ahead of print.ABSTRACTDifferent types of metals, including manganese (Mn), are constantly encountered in various environmental matrices due to natural and anthropogenic activities. They induce a sustained inflammatory response in various organs, which is considered to be an important priming event in the pathogenesis of several diseases. Mn-induced neuroinflammation and subsequent neurodegeneration are well recognized. However, emerging data suggest that occupationally and environmentally relevant levels may affect various organs, including the lungs...
Source: Biological Trace Element Research - April 5, 2024 Category: Biology Authors: Deepa Gandhi Sneha Bhandari Sangita Maity Santanu Kar Mahapatra Subbiah Rajasekaran Source Type: research
LINC00942 Alleviates NaAsO < sub > 2 < /sub > -induced Apoptosis by Promoting GSH Synthesis Through Targeting miR-214-5p
This study aimed to investigate the role of LINC00942 in arsenic-induced hepatotoxicity by regulating miR-214-5p. As the exposure dose of NaAsO2 gradually increases, cell viability, intracellular GSH content, ΔΨm, and the protein levels of GCLC and GCLM were reduced significantly. Apoptosis rate, ROS, and expression of apoptosis-related and NF-κB pathway proteins increased. The expression of LINC00942 was increased, while the expression of miR-214-5p was decreased. After suppressing LINC00942 levels, NaAsO2 exposure further decreased cell viability, intracellular GSH content, ΔΨm, GCLC protein, and miR-214-5p expressi...
Source: Biological Trace Element Research - April 5, 2024 Category: Biology Authors: Mingxiao Ma Jingyi Zhang Sheng Li Mengyao Zhang Weixin Chen Linzhi Li Shugang Li Source Type: research
Subchronic Exposure to Mixture of Cadmium, Copper, and Nickel Induces Neurobehavioral Deficits and Hippocampal Oxidative Stress of Wistar Rats
Biol Trace Elem Res. 2024 Apr 5. doi: 10.1007/s12011-024-04166-9. Online ahead of print.ABSTRACTThe present study was aimed at evaluating the influence of the subchronic exposure of cadmium (Cd), copper (Cu), and nickel (Ni) mixtures on affective behaviors, memory impairment, and oxidative stress (OS) in the hippocampus. Thirty male Wistar rats were divided into 5 equal groups. Group 1 (control) received a saline solution (NaCl 0.9%). Groups 2, 3, and 4 received Cd (0.25 mg/kg), Cu (0.5 mg/kg), and Ni (0.25 mg/kg), respectively, while group 5 received a Cd, Cu, and Ni mixture through intraperitoneal injections for 2 months...
Source: Biological Trace Element Research - April 5, 2024 Category: Biology Authors: Mouloud Lamtai Hajar Benmhammed Sofia Azirar Ayoub Rezqaoui Oussama Zghari Abdelghafour El Hamzaoui Mohamed Yassine El Brouzi Yassine Chahirou Samir Bikri Abdelhalem Mesfioui Aboubaker El Hessni Source Type: research
Activation of ERK/NF-kB Pathways Contributes to the Inflammatory Response in Epithelial Cells and Macrophages Following Manganese Exposure
Biol Trace Elem Res. 2024 Apr 6. doi: 10.1007/s12011-024-04154-z. Online ahead of print.ABSTRACTDifferent types of metals, including manganese (Mn), are constantly encountered in various environmental matrices due to natural and anthropogenic activities. They induce a sustained inflammatory response in various organs, which is considered to be an important priming event in the pathogenesis of several diseases. Mn-induced neuroinflammation and subsequent neurodegeneration are well recognized. However, emerging data suggest that occupationally and environmentally relevant levels may affect various organs, including the lungs...
Source: Biological Trace Element Research - April 5, 2024 Category: Biology Authors: Deepa Gandhi Sneha Bhandari Sangita Maity Santanu Kar Mahapatra Subbiah Rajasekaran Source Type: research
LINC00942 Alleviates NaAsO < sub > 2 < /sub > -induced Apoptosis by Promoting GSH Synthesis Through Targeting miR-214-5p
This study aimed to investigate the role of LINC00942 in arsenic-induced hepatotoxicity by regulating miR-214-5p. As the exposure dose of NaAsO2 gradually increases, cell viability, intracellular GSH content, ΔΨm, and the protein levels of GCLC and GCLM were reduced significantly. Apoptosis rate, ROS, and expression of apoptosis-related and NF-κB pathway proteins increased. The expression of LINC00942 was increased, while the expression of miR-214-5p was decreased. After suppressing LINC00942 levels, NaAsO2 exposure further decreased cell viability, intracellular GSH content, ΔΨm, GCLC protein, and miR-214-5p expressi...
Source: Biological Trace Element Research - April 5, 2024 Category: Biology Authors: Mingxiao Ma Jingyi Zhang Sheng Li Mengyao Zhang Weixin Chen Linzhi Li Shugang Li Source Type: research
Subchronic Exposure to Mixture of Cadmium, Copper, and Nickel Induces Neurobehavioral Deficits and Hippocampal Oxidative Stress of Wistar Rats
Biol Trace Elem Res. 2024 Apr 5. doi: 10.1007/s12011-024-04166-9. Online ahead of print.ABSTRACTThe present study was aimed at evaluating the influence of the subchronic exposure of cadmium (Cd), copper (Cu), and nickel (Ni) mixtures on affective behaviors, memory impairment, and oxidative stress (OS) in the hippocampus. Thirty male Wistar rats were divided into 5 equal groups. Group 1 (control) received a saline solution (NaCl 0.9%). Groups 2, 3, and 4 received Cd (0.25 mg/kg), Cu (0.5 mg/kg), and Ni (0.25 mg/kg), respectively, while group 5 received a Cd, Cu, and Ni mixture through intraperitoneal injections for 2 months...
Source: Biological Trace Element Research - April 5, 2024 Category: Biology Authors: Mouloud Lamtai Hajar Benmhammed Sofia Azirar Ayoub Rezqaoui Oussama Zghari Abdelghafour El Hamzaoui Mohamed Yassine El Brouzi Yassine Chahirou Samir Bikri Abdelhalem Mesfioui Aboubaker El Hessni Source Type: research
Activation of ERK/NF-kB Pathways Contributes to the Inflammatory Response in Epithelial Cells and Macrophages Following Manganese Exposure
Biol Trace Elem Res. 2024 Apr 6. doi: 10.1007/s12011-024-04154-z. Online ahead of print.ABSTRACTDifferent types of metals, including manganese (Mn), are constantly encountered in various environmental matrices due to natural and anthropogenic activities. They induce a sustained inflammatory response in various organs, which is considered to be an important priming event in the pathogenesis of several diseases. Mn-induced neuroinflammation and subsequent neurodegeneration are well recognized. However, emerging data suggest that occupationally and environmentally relevant levels may affect various organs, including the lungs...
Source: Biological Trace Element Research - April 5, 2024 Category: Biology Authors: Deepa Gandhi Sneha Bhandari Sangita Maity Santanu Kar Mahapatra Subbiah Rajasekaran Source Type: research
Correction to: Anticarcinogenic Effects of Gold Nanoparticles and Metformin Against MCF-7 and A549 Cells
Biol Trace Elem Res. 2024 Apr 4. doi: 10.1007/s12011-024-04155-y. Online ahead of print.NO ABSTRACTPMID:38573475 | DOI:10.1007/s12011-024-04155-y (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - April 4, 2024 Category: Biology Authors: Ali Ye şildağ Halime Topal K ızıloğlu Ebubekir Dirican Elif Erba ş Volkan Gelen Adem Kara Source Type: research
Correction to: Anticarcinogenic Effects of Gold Nanoparticles and Metformin Against MCF-7 and A549 Cells
Biol Trace Elem Res. 2024 Apr 4. doi: 10.1007/s12011-024-04155-y. Online ahead of print.NO ABSTRACTPMID:38573475 | DOI:10.1007/s12011-024-04155-y (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - April 4, 2024 Category: Biology Authors: Ali Ye şildağ Halime Topal K ızıloğlu Ebubekir Dirican Elif Erba ş Volkan Gelen Adem Kara Source Type: research
Blood Lead Levels and Their Association with Iron Deficiency and Anemia in Children
In conclusion, blood lead levels ≥ 5 µg/dL were significantly associated with ID and anemia in children aged 1-6 years.PMID:38568334 | DOI:10.1007/s12011-024-04163-y (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - April 3, 2024 Category: Biology Authors: Liliana Disalvo Ana Varea Natalia Matamoros Marisa Sala Mar ía V Fasano Horacio F Gonz ález Source Type: research
Toxicity of REEs, Th, and U: A Biodisponibility, Cytotoxicity, and Bioaccumulation Assessment in Marine Sediment
Biol Trace Elem Res. 2024 Apr 3. doi: 10.1007/s12011-024-04160-1. Online ahead of print.ABSTRACTIn this work, bioaccessibility tests for rare earth elements (REEs), Th, and U in marine sediment were carried out, in addition to complementary tests for cytotoxicity and bioaccumulation for the elements La, Ce, Eu, and Gd. The evaluation of human health risk through dermal absorption and oral ingestion was performed using the hazard quotient (HQ). According to the gastric digestion simulation (SBET), it was observed that the elements Ce and Nd exhibited higher absorption capacities in the human body (> 2 µg g-1). La and Sc...
Source: Biological Trace Element Research - April 3, 2024 Category: Biology Authors: Suellen Ger ônimo Cordeiro Ana Cl áudia H Pereira Denise Coutinho Endringer Luana Santos Moreira Maria Tereza W D Carneiro Jefferson Rodrigues de Souza Geisamanda Pedrini Brand ão Source Type: research
Investigation of accumulation of element contents in some wild and cultivated dried fruits
In this study, the moisture and biogenic element quantities of most wild and cultivated edible dried fruits were investigated. Macroelements found in highest amounts in fruits were K, P, Ca, and Mg. While K quantities of the fruits are recorded between 5212.77 ("white myrtle") and 25550.60 mg/kg ("black nightshade"), P amounts of the fruits were characterized to be between 949.08 (black myrtle) and 4420.75 mg/kg ("black nightshade"). Ca and Mg amounts of the fruits were assessed to be between 359.83 (plum) and 4330.89 mg/kg ("yellow hawthorn") to 214.98 (plum) and 1852.04 mg/kg ("black nightshade"), respectively. Fe and B ...
Source: Biological Trace Element Research - April 3, 2024 Category: Biology Authors: Fahad AlJuhaimi Duygu Ak çay Kulluk Isam Ali Mohamed Ahmed Mehmet Musa Özcan Emad Karrar Source Type: research
Protective Effect of Selenium-enriched Peptide from Cardamine violifolia on Ethanol-induced L-02 Hepatocyte Injury
In this study, we investigated the protective effect of selenium (Se)-enriched peptide isolated from Cardamine violifolia (SPE) against ethanol-induced liver injury. Cell proliferation assays show that different concentrations of SPE protect human embryonic liver L-02 cells against ethanol-induced injury in a dose-dependent manner. Treatment with 12 μmol/L Se increases the cell survival rate (82.44%) and reduces the release of alanine aminotransferase, aspartate transaminase, lactate dehydrogenase, and apoptosis rate. SPE treatment with 12 μmol/L Se effectively reduces the concentration of intracellular reactive oxygen s...
Source: Biological Trace Element Research - March 28, 2024 Category: Biology Authors: Rongrui Ling Chaodong Du Yue Li Shan Wang Xin Cong Dejian Huang Shangwei Chen Song Zhu Source Type: research
