Protective Effect of Selenoprotein X Against Oxidative Stress-Induced Cell Apoptosis in Human Hepatocyte (LO2) Cells via the p38 Pathway.
Abstract Oxidative stress, as mediated by ROS (reactive oxygen species), is a significant factor in initiating the cells damaged by affecting cellular macromolecules and impairing their biological functions; SelX, a selenoprotein also known as MsrB1 belonging to the methionine sulfoxide reductase (Msr) family, is the redox repairing enzyme and involved in redox-related functions. In order to more precisely analyze the relationship between oxidative stress, cell oxidative damage, and SelX, we stably overexpressed porcine Selx full-length cDNA in human normal hepatocyte (LO2) cells. Cell viability, cell apoptosis ra...
Source: Biological Trace Element Research - April 20, 2017 Category: Biology Authors: Tang JY, He AH, Jia G, Liu GM, Chen XL, Cai JY, Shang HY, Liao JQ, Zhao H Tags: Biol Trace Elem Res Source Type: research

Disparities of Selected Metal Levels in the Blood and Scalp Hair of Ischemia Heart Disease Patients and Healthy Subjects.
Abstract Imbalances in the concentrations of trace metals have become an increasingly recognized source of infirmity worldwide particularly in the development of ischemia heart disease (IHD). Present study is intended to analyze the concentrations of Ca, Cd, Co, Cr, Cu, Fe, K, Li, Mg, Mn, Na, Pb, Sr, and Zn in the blood and scalp hair of the patients and counterpart controls by flame atomic absorption spectrometry after wet-acid digestion. On the average, Cd, Co, Cr, Fe, K, Li, Mn, Na, and Pb revealed significantly elevated concentrations in the blood of the patients compared with the controls (p 
Source: Biological Trace Element Research - April 20, 2017 Category: Biology Authors: Ilyas A, Shah MH Tags: Biol Trace Elem Res Source Type: research

Effects of Nano-zinc on Biochemical Parameters in Cadmium-Exposed Rats.
Abstract Cadmium (Cd) is a toxic environmental and occupational pollutant with reported toxic effects on the kidneys, liver, lungs, bones, and the immunity system. Based on its physicochemical similarity to cadmium, zinc (Zn) shows protective effects against cadmium toxicity and cadmium accumulation in the body. Nano-zinc and nano-zinc oxide (ZnO), recently used in foods and pharmaceutical products, can release a great amount of Zn(2+) in their environment. This research was carried out to investigate the more potent properties of the metal zinc among sub-acute cadmium intoxicated rats. Seventy-five male Wistar ra...
Source: Biological Trace Element Research - April 17, 2017 Category: Biology Authors: Hejazy M, Koohi MK Tags: Biol Trace Elem Res Source Type: research

Attenuating Effect of Zinc and Vitamin E on the Intestinal Oxidative Stress Induced by Silver Nanoparticles in Broiler Chickens.
Abstract Silver nanoparticles (AgNPs) have been increasingly used as antimicrobial and disinfectant. However, intestinal model studies have shown that AgNPs induce oxidative stress. Hence, this study aims to investigate the effects of dietary supplemental zinc (Zn) and vitamin E (VE; α-tocopherol acetate) on attenuating AgNP-induced intestinal oxidative stress in broiler chickens. The chickens were divided into two groups as follows: (1) control group fed with a corn-soybean meal basal diet and (2) nano group, received drinking water containing 1000 mg/kg AgNPs. All the nano-exposed birds were divided i...
Source: Biological Trace Element Research - April 14, 2017 Category: Biology Authors: Song Z, Lv J, Sheikhahmadi A, Uerlings J, Everaert N Tags: Biol Trace Elem Res Source Type: research

Hypoglycemic and Hypolipidemic Effects of Leucine, Zinc, and Chromium, Alone and in Combination, in Rats with Type 2 Diabetes.
In conclusion, supplementation of diabetic rats with Leu was more effective in improving blood glucose and consequently decreasing glucose AUC than other nutritional supplements. Supplementary Zn and Cr only improved serum lipid profile. The combination of the nutritional supplements did not improve blood glucose level. Nevertheless, supplementation with Leu-Zn, Leu-Cr, Zn-Cr, and Leu-Zn-Cr led to an improved response in serum lipid profile over each supplement given alone. PMID: 28409409 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - April 13, 2017 Category: Biology Authors: Sadri H, Larki NN, Kolahian S Tags: Biol Trace Elem Res Source Type: research

Synergistic Cardioprotective Effects of Combined Chromium Picolinate and Atorvastatin Treatment in Triton X-100-Induced Hyperlipidemia in Rats: Impact on Some Biochemical Markers.
Abstract Hyperlipidemia is one of the major risk factors for atherosclerosis and ischemic heart disease. Chromium (Cr) mineral is playing a crucial role in glucose and lipid homeostasis. The aim of this study was to evaluate the protective effects of combined chromium picolinate (CrPic) and atorvastatin treatment against hyperlipidemia-induced cardiac injury. Seventy-five male albino rats were divided into five groups (15 rats each). Hyperlipidemia was induced by intraperitoneal injection of a single dose of Triton X-100 (300 mg/kg body weight (b.w) (group ІІ). Treatment of hyperlipidemic rats was induced b...
Source: Biological Trace Element Research - April 13, 2017 Category: Biology Authors: Shafik NM, Baalash A, Ebeid AM Tags: Biol Trace Elem Res Source Type: research

Evaluation of the Content of Antimony, Arsenic, Bismuth, Selenium, Tellurium and Their Inorganic Forms in Commercially Baby Foods.
Abstract Baby foods, from the Spanish market and prepared from meat, fish, vegetables, cereals, legumes, and fruits, were analyzed to obtain the concentration of antimony (Sb), arsenic (As), bismuth (Bi), and tellurium (Te) as toxic elements and selenium (Se) as essential element. An analytical procedure was employed based on atomic fluorescence spectroscopy which allowed to obtain accurate data at low levels of concentration. Values of 14 commercial samples, expressed in nanograms per gram fresh weight, ranged for Sb 0.66-6.9, As 4.5-242, Te 1.35-2.94, Bi 2.18-4.79, and Se 5.4-109. Additionally, speciation studie...
Source: Biological Trace Element Research - April 11, 2017 Category: Biology Authors: Ruiz-de-Cenzano M, Rochina-Marco A, Cervera ML, de la Guardia M Tags: Biol Trace Elem Res Source Type: research

Do Dietary Habits Influence Trace Elements Release from Fixed Orthodontic Appliances?
The objective was to investigate the effect of dietary habits on the release of Cr and Ni ions from orthodontic appliances by hair mineral analysis. Patients (N = 47) underwent electronic questionnaire survey to investigate the effect of dietary habits on Cr and Ni levels in hair. The research was carried out on hair sampled at the beginning and in the 4th, 8th, and 12th months of the treatment. The content of Cr and Ni in the collected samples was determined by ICP-OES. The study showed that consumption of acidic dietary products may have the effect on increasing the release of Cr and Ni ions from orthodontic ap...
Source: Biological Trace Element Research - April 11, 2017 Category: Biology Authors: Wołowiec P, Chojnacka K, Loster BW, Mikulewicz M Tags: Biol Trace Elem Res Source Type: research

Iodinated TG in Thyroid Follicles Regulate TSH/TSHR Signaling for NIS Expression.
Abstract Our previous research has suggested that high degree of iodinated thyroglobulin (TG) may inhibit the expression and function of sodium iodide symporter (NIS), but the underlying mechanism remains unclear. In present study, we discuss a newly constructed follicle model in vitro, which was used to simulate the follicular structure of the thyroid and explore the regulatory roles of iodinated TG in the follicular lumen on NIS expression. The results showed that both NIS expression and PKA activity were increased in lowly iodinated TG group, while decreased NIS expression with increased PKC activity was found ...
Source: Biological Trace Element Research - April 10, 2017 Category: Biology Authors: Huang H, Shi Y, Liang B, Cai H, Cai Q Tags: Biol Trace Elem Res Source Type: research

Boric Acid Inhibition of Trichophyton rubrum Growth and Conidia Formation.
Abstract Trichophyton rubrum is a common human dermatophyte that is the causative agent of 80-93% of fungal infections of the skin and nails. While dermatophyte infections in healthy people are easily treatable with over-the-counter medications, such infections pose a higher risk for patients with compromised immune function and impaired regenerative potential. The efficacy of boric acid (BA) for the treatment of vaginal yeast infections prompted an investigation of the effect of BA on growth and morphology of T. rubrum. This is of particular interest since BA facilitates wound healing, raising the possibility tha...
Source: Biological Trace Element Research - April 8, 2017 Category: Biology Authors: Schmidt M Tags: Biol Trace Elem Res Source Type: research

Effects of Zinc and N-Acetylcysteine in Damage Caused by Lead Exposure in Young Rats.
This study investigated the toxicity of rats exposed to lead acetate (AcPb) during the second phase of brain development (8-12 days postnatal) in hematological and cerebral parameters. Moreover, the preventive effect of zinc chloride (ZnCl2) and N-acetylcysteine (NAC) was investigated. Pups were injected subcutaneously with saline (0.9% NaCl solution), ZnCl2 (27 mg/kg/day), NAC (5 mg/kg/day) or ZnCl2 plus NAC for 5 days (3rd-7th postnatal days), and with saline (0.9% NaCl solution) or AcPb (7 mg/kg/day) in the five subsequent days (8th-12th postnatal days). Animals were sacrificed 21 days afte...
Source: Biological Trace Element Research - April 7, 2017 Category: Biology Authors: Pedroso TF, Oliveira CS, Fonseca MM, Oliveira VA, Pereira ME Tags: Biol Trace Elem Res Source Type: research

Effect of Peroral Administration of Chromium on Insulin Signaling Pathway in Skeletal Muscle Tissue of Holstein Calves.
The objective of this study was to investigate the effects of peroral administration of chromium-enriched yeast on glucose tolerance in Holstein calves, assessed by insulin signaling pathway molecule determination and intravenous glucose tolerance test (IVGTT). Twenty-four Holstein calves, aged 1 month, were chosen for the study and divided into two groups: the PoCr group (n = 12) that perorally received 0.04 mg of Cr/kg of body mass daily, for 70 days, and the NCr group (n = 12) that received no chromium supplementation. Skeletal tissue samples from each calf were obtained on day 0 and d...
Source: Biological Trace Element Research - April 4, 2017 Category: Biology Authors: Jovanović L, Pantelić M, Prodanović R, Vujanac I, Đurić M, Tepavčević S, Vranješ-Đurić S, Korićanac G, Kirovski D Tags: Biol Trace Elem Res Source Type: research

Tracing Tellurium and Its Nanostructures in Biology.
Abstract Tellurium (Te) is a semimetal rare element in nature. Together with oxygen, sulfur (S), and selenium (Se), Te is considered a member of chalcogen group. Over recent decades, Te applications continued to emerge in different fields including metallurgy, glass industry, electronics, and applied chemical industries. Along these lines, Te has recently attracted research attention in various fields. Though Te exists in biologic organisms such as microbes, yeast, and human body, its importance and role and some of its potential implications have long been ignored. Some promising applications of Te using its inor...
Source: Biological Trace Element Research - April 4, 2017 Category: Biology Authors: Zare B, Nami M, Shahverdi AR Tags: Biol Trace Elem Res Source Type: research

Excess Manganese-Induced Apoptosis in Chicken Cerebrums and Embryonic Neurocytes.
Abstract There were many studies about the effect of excess manganese (Mn) on nervous system apoptosis; however, Mn-induced apoptosis in chicken cerebrums and embryonic neurocytes was unclear. The purpose of this study was to investigate the effect of excess Mn on chicken cerebrum and embryonic neurocyte apoptosis. Seven-day-old Hyline male chickens were fed either a commercial diet or three levels of manganese chloride (MnCl2)-added commercial diets containing 600-, 900-, and 1800-mg/kg-Mn diet, respectively. On the 30th, 60th, and 90th days, cerebrums were collected. Fertilized Hyline chicken eggs were hatched f...
Source: Biological Trace Element Research - March 30, 2017 Category: Biology Authors: Zhang K, Zhu Y, Wang X, Zhao X, Li S, Teng X Tags: Biol Trace Elem Res Source Type: research

Effects of Ag Nanoparticles on Growth and Fat Body Proteins in Silkworms (Bombyx mori).
n K Abstract Ag nanoparticles (AgNPs), a widely used non-antibiotic, antibacterial material, have shown toxic and other potentially harmful effects in mammals. However, the deleterious effects of AgNPs on insects are still unknown. Here, we studied the effects of AgNPs on the model invertebrate organism Bombyx mori. After feeding silkworm larvae different concentrations of AgNPs, we evaluated the changes of B. mori body weights, survival rates, and proteomic differences. The results showed that low concentrations (
Source: Biological Trace Element Research - March 30, 2017 Category: Biology Authors: Meng X, Abdlli N, Wang N, Lü P, Nie Z, Dong X, Lu S, Chen K Tags: Biol Trace Elem Res Source Type: research

Ameliorated Effects of (-)-Epigallocatechin Gallate Against Toxicity Induced by Vanadium in the Kidneys of Wistar Rats.
Abstract The aim of the study was to assess the protective effect of (-)-epigallocatechin gallate (EGCG), a flavonoid abundant in green tea, against ammonium metavanadate (AMV)-induced oxidative stress in male Wistar rats. Four groups of animals have been used, a control group and three test groups. In the first test group, AMV was intra-peritoneally (i.p) injected daily (5 mg/kg body weight for five consecutive days). The second test group of animals was also injected daily with EGCG (5 mg/kg body weight) during the same period. However, the third test group was i.p. injected with both AMV and EGCG (5&n...
Source: Biological Trace Element Research - March 29, 2017 Category: Biology Authors: Soussi A, Abdennabi R, Ghorbel F, Murat JC, El Feki AF Tags: Biol Trace Elem Res Source Type: research

Content of Minerals and Fatty Acids and Their Correlation with Phytochemical Compounds and Antioxidant Activity of Leguminous Seeds.
Abstract The aim of the study was to determine the mineral composition and fatty acid profile in the seeds of selected Fabaceae species and cultivars and to assess their correlations with phytochemicals and antioxidant activity. The Andean lupine was characterised by a particularly high level of Mg and K as well as Cu, Zn, and Fe (P 
Source: Biological Trace Element Research - March 29, 2017 Category: Biology Authors: Grela ER, Samolińska W, Kiczorowska B, Klebaniuk R, Kiczorowski P Tags: Biol Trace Elem Res Source Type: research

Effects of the Oral Administration of K2Cr2O7 and Na2SeO3 on Ca, Mg, Mn, Fe, Cu, and Zn Contents in the Heart, Liver, Spleen, and Kidney of Chickens.
In conclusion, the exposure of chickens to K2Cr2O7 induced changes in different trace elements, and Na2SeO3 supplementation could alleviate this condition. PMID: 28353138 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - March 28, 2017 Category: Biology Authors: Chen P, Zhu Y, Wan H, Wang Y, Hao P, Cheng Z, Liu Y, Liu J Tags: Biol Trace Elem Res Source Type: research

Bioaccumulation of Heavy Metals in Various Tissues of Some Fish Species and Green Tiger Shrimp (Penaeus semisulcatus) from İskenderun Bay, Turkey, and Risk Assessment for Human Health.
In this study, concentrations of heavy metals were determined by ICP-MS in the edible tissues of common sole (Solea solea Linnaeus, 1758), whiting (Merlangius merlangus Linnaeus, 1758), silver sillago (Sillago sihama Forsskål, 1775) and muscle-exoskeleton of green tiger shrimp (Penaeus semisulcatus De Haan, 1844), from the seas of İskenderun Bay, Eastern Mediterranean, Turkey, in January-February, 2016. The lowest and highest mean concentrations of Mn, Cr, Cd, Ni, Hg, As, Pb, and Co in fish and shrimp' muscles were found, respectively, as follows: 0.166-0.382, 0.134-0.336, 0.005-0.008, 0.091-0.140, 0.026-0.228, 1.74...
Source: Biological Trace Element Research - March 28, 2017 Category: Biology Authors: Kaya G, Turkoglu S Tags: Biol Trace Elem Res Source Type: research

Protective Effect of Selenium on Aflatoxin B1-Induced Testicular Toxicity in Mice.
Abstract Aflatoxins have been considered as one of the major risk factors of male infertility, and aflatoxin B1 (AFB1) is the most highly toxic and prevalent member of the aflatoxins family. Selenium (Se), an essential nutritional trace mineral for normal testicular development and male fertility, has received extensive intensive on protective effects of male reproductive system due to its potential antioxidant and activating testosterone synthesis. To investigate the protective effect of Se on AFB1-induced testicular toxicity, the mice were orally administered with AFB1 (0.75 mg/kg) and Se (0.2 mg/kg or...
Source: Biological Trace Element Research - March 27, 2017 Category: Biology Authors: Cao Z, Shao B, Xu F, Liu Y, Li Y, Zhu Y Tags: Biol Trace Elem Res Source Type: research

Serum Hepcidin and Soluble Transferrin Receptor in the Assessment of Iron Metabolism in Children on a Vegetarian Diet.
Abstract The aim of this study was to assess the effect of vegetarian diet on iron metabolism parameters paying special attention to serum hepcidin and soluble transferrin receptor (sTfR) concentrations in 43 prepubertal children (age range 4.5-9.0 years) on vegetarian and in 46 children on omnivorous diets. There were no significant differences according to age, weight, height, and body mass index (BMI) between vegetarian and omnivorous children. Vegetarians had similar intake of iron and vitamin B12 and a significantly higher intake of vitamin C (p 
Source: Biological Trace Element Research - March 24, 2017 Category: Biology Authors: Ambroszkiewicz J, Klemarczyk W, Mazur J, Gajewska J, Rowicka G, Strucińska M, Chełchowska M Tags: Biol Trace Elem Res Source Type: research

Experimental Research Showing the Reduction of Naloxone-Place Aversion by Oral Zinc Administration in Rats.
Abstract Previous studies showed the attenuation of both morphine-dependence and morphine-place preference by zinc. Conditioned place preference and aversion are experimental models frequently used to test the reward-stimulating, respectively the aversive effects induced by different stimuli or substances. Addictive substances usually induce place preference (exhibit reward-stimulating properties), while their antagonists determine place-avoidance (aversion). The present study aimed to assess the effect determined by zinc sulphate oral administration (2 and 4 mg/kg/day, 14 days, prior to habituation) on ...
Source: Biological Trace Element Research - March 23, 2017 Category: Biology Authors: Ciubotariu D, Lupușoru RV, Luca E, Mititelu-Tarțău L, Lupușoru CE Tags: Biol Trace Elem Res Source Type: research

The Cytotoxicity and Genotoxicity of Particulate and Soluble Cobalt in Human Urothelial Cells.
Abstract Cobalt use is increasing particularly due to its use as one of the primary metals in cobalt-chromium-molybdenum (CoCrMo) metal-on-metal prosthetics. CoCrMo is a high-strength, wear-resistant alloy with reduced risk for prosthetic loosening and device fracture. More than 500,000 people receive hip implants each year in the USA which puts them at potential risk for exposure to metal ions and particles released by the prosthetic implants. Data show cobalt ions released from prosthetics reach the bloodstream and accumulate in the bladder. As patients with failed hip implants show increased urinary and blood c...
Source: Biological Trace Element Research - March 21, 2017 Category: Biology Authors: Speer RM, The T, Xie H, Liou L, Adam RM, Wise JP Tags: Biol Trace Elem Res Source Type: research

Dietary Intake of Minerals, Vitamins, and Trace Elements Among Geriatric Population in India.
Abstract The geriatric population is at a high risk of developing deficiencies of essential micronutrients such as minerals, vitamins, and trace elements and their related deficiency signs and symptoms. Scarce data is available on the dietary intake of essential micronutrients among geriatric subjects in India. Hence, to fill the gap in the existing knowledge, a community-based cross-sectional study was conducted during 2015-2016 in District Nainital, Uttarakhand State, India. A total of 255 geriatric subjects were enrolled from 30 clusters (villages) identified by using population proportionate to size sampling m...
Source: Biological Trace Element Research - March 20, 2017 Category: Biology Authors: Gupta A, Khenduja P, Pandey RM, Sati HC, Sofi NY, Kapil U Tags: Biol Trace Elem Res Source Type: research

A Preliminary Study about the Potential Effects of Heavy Metals on the Human Male Reproductive Parameters in HIV-Infected Population in China.
Abstract Due to the inconsistent effects of human immunodeficiency virus (HIV) on the human male reproduction in previous studies and the impacts of environmental exposures, such as heavy metals, on male reproduction receiving little attention in HIV-infected population, the aim of present study was to investigate whether heavy metals have potential effects on reproductive parameters in HIV-infected men. The current study assessed the associations between semen quality or serum hormone and concentration of the three heavy metal toxicants (lead (Pb), cadmium (Cd), and zinc (Zn)) in seminal, urine, and serum, and 50...
Source: Biological Trace Element Research - March 20, 2017 Category: Biology Authors: Li R, Zhao L, Li L, Hou Z, Zhang D, Wan L, Wei L, Yang Y, Lv J, Ma M, Zhu Y Tags: Biol Trace Elem Res Source Type: research

Role of Selenium from Different Sources in Prevention of Pulmonary Arterial Hypertension Syndrome in Broiler Chickens.
Abstract Pulmonary arterial hypertension (PAH) syndrome in broilers is associated with hypoxia, which prevails at high altitude. Oxidative stress is the pathogenic mechanism underlying PAH. Because selenium is key element in the structure of antioxidant enzymes, we evaluated pulmonary hypertensive responses in broiler chickens fed with diets supplemented with organic or nano-selenium. One hundred forty-four broilers (starting at 5 days old) were fed with (i) control group: birds received a standard diet; (ii) nano-selenium group: birds were fed with basal diet supplemented with nano-selenium at 0.3 mg/kg...
Source: Biological Trace Element Research - March 20, 2017 Category: Biology Authors: Zamani Moghaddam AK, Mehraei Hamzekolaei MH, Khajali F, Hassanpour H Tags: Biol Trace Elem Res Source Type: research

Serum Level of Zinc and Copper in Sudanese Women with Polycystic Ovarian Syndrome.
Abstract The study aimed to evaluate the serum level of zinc and copper in women with polycystic ovarian syndrome (PCOS). A case-control study was conducted at Saad Abualila infertility center (Khartoum, Sudan). The cases were women who had a PCOS based on Rotterdam criteria. The controls were infertile women with no evidence of PCOS. The socio-demographic characteristics and medical history data were gathered using questionnaires. Zinc and copper levels were measured using atomic absorption spectrophotometer. While there was no difference in zinc and copper levels between the two groups (50 women in each arm), me...
Source: Biological Trace Element Research - March 18, 2017 Category: Biology Authors: Sharif ME, Adam I, Ahmed MA, Rayis DA, Hamdan HZ Tags: Biol Trace Elem Res Source Type: research

The Reference Intervals of Hair Trace Element Content in Hereford Cows and Heifers (Bos taurus).
The objective of the present study was to assess hair trace element content in Hereford heifers and cows (Bos taurus) living in South Ural region and calculate the site-specific reference intervals. Hair trace element content in 150 cows and heifers farmed in the Southern Urals of Russia was assessed using inductively coupled plasma mass-spectrometry. Dietary trace element content corresponded to the adequate values as estimated by recommendations of USSR State Agriculture Committee and U.S. National Research Council. Comparative analysis demonstrated that heifers are characterized by significantly higher hair Se (3-fold),...
Source: Biological Trace Element Research - March 17, 2017 Category: Biology Authors: Miroshnikov SA, Zavyalov OA, Frolov AN, Bolodurina IP, Kalashnikov VV, Grabeklis AR, Tinkov AA, Skalny AV Tags: Biol Trace Elem Res Source Type: research

Alterations of Mg(2+) After Hemorrhagic Shock.
In conclusion, hemorrhagic shock induced an increase in both blood-free Mg(2+) and tMg, resulted from Mg(2+) efflux from metabolic damaged cell with acidosis and ATP depletion. PMID: 28315119 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - March 17, 2017 Category: Biology Authors: Lee MY, Yang DK, Kim SJ Tags: Biol Trace Elem Res Source Type: research

Macro- and Microelement Status in Animal and Human Hypertension: the Role of the ACE Gene I/D Polymorphism.
Abstract Genetic factors that predispose to hypertension may contribute to element disturbances observed in hypertensive patients. We tested the hypothesis that the deletion allele of the angiotensin-converting enzyme (ACE) gene is associated with element imbalances in hypertension. The concentrations of elements in genetically predisposed to hypertension rats (SHRs) and their controls (WKY rats) were also examined. ICP-MS was used for elemental analysis of human hair and animal fur. Genotyping was performed by PCR. We also measured micronuclei frequency and distribution of peripheral blood leukocytes in cell cycl...
Source: Biological Trace Element Research - March 16, 2017 Category: Biology Authors: Pavlyushchik O, Afonin V, Fatykhava S, Shabunya P, Sarokina V, Khapaliuk A Tags: Biol Trace Elem Res Source Type: research

A Rat Experimental Study of the Relationship Between Fluoride Exposure and Sensitive Biomarkers.
This study was aimed to establish the relationship between fluoride exposure and sensitive biomarkers. Ninety-six rats were randomly divided into six groups, with each group exposed to 0, 2, 4, 8, 16 and 32 mg NaF/(kg.bw), respectively. Correlation analysis of the exposure levels, the tissue distributions and the effects was done, and the possible mathematical relationship between the exposure and sensitive biomarkers is discussed. Our findings revealed that the level of serum fluoride can serve as one of the sensitive indicators to reflect the ex-exposure levels (in the present article, ex-exposure means the fluoride...
Source: Biological Trace Element Research - March 12, 2017 Category: Biology Authors: Zhou Z, Wang H, Zheng B, Han Z, Chen Y, Ma Y Tags: Biol Trace Elem Res Source Type: research

Relationships Between Element Contents in Polish Children's and Adolescents' Hair.
The objective of the study is to determine the contents of calcium (Ca), magnesium (Mg), zinc (Zn), copper (Cu), iron (Fe), lead (Pb), and cadmium (Cd) in girls' and boys' hair in five age groups (within 1-19-year range) corresponding to successive human ontogenesis phases as well as to evaluate the relationships between these elements. Quantitative analysis has been carried out using atomic absorption spectrometry (AAS). Experimental results were analyzed using classic and principal component (PCA) statistical analyses. In particular, differences between contents of particularly Ca, Mg, and Zn in girls' and boys' hair wer...
Source: Biological Trace Element Research - March 10, 2017 Category: Biology Authors: Długaszek M, Skrzeczanowski W Tags: Biol Trace Elem Res Source Type: research

Trace Element Levels in Scalp Hair of School Children in Shigatse, Tibet, an Endemic Area for Kaschin-Beck Disease (KBD).
This study aimed to assess some essential trace elements (Se, Mo, Mn, Zn, Fe, Cu, Co, and Sr) in children using scalp hair as a biomarker, and 157 samples from school children aged 8-14 years old were collected from both KBD and non-KBD areas in Shigatse, Tibet. Se and Mo were measured by inductive coupled plasma mass spectrometry, and the other elements were determined by inductive coupled plasma optical emission spectrometry. Compared with the non-KBD areas, Se, Mo, Mn, Fe, Zn, Co, and Sr levels of children in KBD areas were found to be significantly different (P 
Source: Biological Trace Element Research - March 10, 2017 Category: Biology Authors: Guo Y, Li H, Yang L, Li Y, Wei B, Wang W, Gong H, Guo M, Nima C, Zhao S, Wang J Tags: Biol Trace Elem Res Source Type: research

The Effects of Agaricus blazei Murill Polysaccharides on Cadmium-Induced Apoptosis and the TLR4 Signaling Pathway of Peripheral Blood Lymphocytes in Chicken.
In this study, we investigated the effects of Agaricus blazei Murill polysaccharides (ABP) on cadmium (Cd)-induced apoptosis and the TLR4 signaling pathway of chicken peripheral blood lymphocytes (PBLs). Seven-day-old healthy chickens were randomly divided into four groups, and each group contained 20 males. The cadmium-supplemented diet group (Cd group) was fed daily with full feed that contained 140 mg cadmium chloride (CdCl2)/kg and 0.2 mL saline. The A. blazei Murill polysaccharide diet group (ABP group) was fed daily with full feed with 0.2 mL ABP solution (30 mg/mL) by oral gavage. The cadmium-sup...
Source: Biological Trace Element Research - March 10, 2017 Category: Biology Authors: Liu W, Ge M, Hu X, Lv A, Ma D, Huang X, Zhang R Tags: Biol Trace Elem Res Source Type: research

The Effects of Supplementary Cr3 (Chromium(III) Propionate Complex) on the Mineral Status in Healthy Female Rats.
In conclusion, high dietary doses of Cr3 (10 and 100 mg Cr· kg(-1) b.m.) given for 4 weeks affected the mineral status of Fe, Zn, Cu and Ca in the tissues of healthy female Wistar rats. PMID: 28281224 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - March 10, 2017 Category: Biology Authors: Staniek H, Krejpcio Z Tags: Biol Trace Elem Res Source Type: research

The Concentration of Vanadium in Pathologically Altered Human Kidneys.
ska E Abstract Vanadium has a unique and beneficial effect on both humans and animal organisms; however, excessive amount of the above-mentioned metal can cause many alterations in tissues and organs, including the kidneys. The aim of the study was to determine the concentration of vanadium (V) in the kidneys removed from patients due to lesions of various etiologies, including the rejection of the transplanted kidneys. Additionally, we determined the influence of selected biological and environmental factors on the V concentration. The study material consisted of the kidneys with tumor lesions (n = 27) ...
Source: Biological Trace Element Research - March 9, 2017 Category: Biology Authors: Wilk A, Wiszniewska B, Szypulska-Koziarska D, Kaczmarek P, Romanowski M, Różański J, Słojewski M, Ciechanowski K, Marchelek-Myśliwiec M, Kalisińska E Tags: Biol Trace Elem Res Source Type: research

Gene Silencing of Selenoprotein K Induces Inflammatory Response and Activates Heat Shock Proteins Expression in Chicken Myoblasts.
Abstract In the present study, specific small interfering RNA (siRNA) for selenoprotein K (Selk) gene was designed and transfected into chicken myoblasts. Then, the expressions of inflammatory factors (including induced nitric oxide synthase [iNOS], nuclear factor-kappa B [NF-κB], heme-oxygenase-1 [HO-1], cyclooxygenase-2 [COX-2], and prostaglandin E synthase [PTGEs]), inflammation-related cytokines (including interleukin [IL]-1β, IL-6, IL-7, IL-8, IL-17, and interferon [IFN]-γ), and heat shock proteins (HSPs) (including HSP27, HSP40, HSP60, HSP70, and HSP90) were examined at 24 and 72 h afte...
Source: Biological Trace Element Research - March 9, 2017 Category: Biology Authors: Fan R, Yao H, Cao C, Zhao X, Khalid A, Zhao J, Zhang Z, Xu S Tags: Biol Trace Elem Res Source Type: research

Effects of Excess Dietary Fluoride on Serum Biochemical Indices, Egg Quality, and Concentrations of Fluoride in Soft Organs, Eggs, and Serum of Laying Hens.
This study was conducted to investigate the effects of excess dietary fluoride (F) on serum biochemical indices, egg quality, and concentrations of F in soft tissues, eggs, and serum of laying hens. Commercial laying hens (n = 576, 51 weeks of age) were randomly allotted to 6 treatments with 6 replicates of 16 birds. The basal diets contained fluorine inclusions at a level of 16 mg/kg, and graded sodium fluoride was added to the basal diet to achieve fluorine inclusions, respectively, at a level of 200, 400, 600, 800, and 1000 mg/kg in the experimental diets. Dietary F levels at 600, 800, and 1000&...
Source: Biological Trace Element Research - March 9, 2017 Category: Biology Authors: Miao L, Li L, Qi M, Zhou M, Zhang N, Zou X Tags: Biol Trace Elem Res Source Type: research

Dihydroartemisinin Sensitizes Human Lung Adenocarcinoma A549 Cells to Arsenic Trioxide via Apoptosis.
In this study, we have explored a possibility of combination of dihydroartemisinin (DHA) and ATO treatments to reduce ATO resistance of lung cancer cells. We determined the combinatory effects of DHA and ATO on cytotoxicity of human lung adenocarcinoma (A549) cells. We showed that co-exposure to DHA and ATO of A549 cells synergistically increased the cytotoxicity and apoptotic cell death in the cells. We found that the synergistic effect of DHA and ATO in promoting apoptosis mainly resulted from increased cellular level of reactive oxygen species (ROS) and DNA damage. ATO alone only exerted moderate growth inhibitory effec...
Source: Biological Trace Element Research - March 6, 2017 Category: Biology Authors: Chen H, Gu S, Dai H, Li X, Zhang Z Tags: Biol Trace Elem Res Source Type: research

Evidence of Zinc in Affording Protection Against X-Ray-Induced Brain Injury in Rats.
Abstract In the present world, X-rays have been regarded as one of the most efficient tools in medicine, industry and research. On the contrary, extensive human exposure to these rays is responsible for causing detrimental effects on physiological system. The aim of the present study was to investigate the role of zinc (Zn), if any, in mitigating the adverse effects induced by fractionated X-irradiation on rat brain. Female Sprague-Dawley rats weighing 170-200 g were divided into four different groups viz.: (a) normal control, (b) X-irradiated (21Gy), (c) zinc treated (227 mg/L in drinking water) and (d)...
Source: Biological Trace Element Research - March 6, 2017 Category: Biology Authors: Sharma P, Singla N, Dhawan DK Tags: Biol Trace Elem Res Source Type: research

ATP5J and ATP5H Proactive Expression Correlates with Cardiomyocyte Mitochondrial Dysfunction Induced by Fluoride.
Abstract To investigate the effect of excessive fluoride on the mitochondrial function of cardiomyocytes, 20 healthy male mice were randomly divided into 2 groups of 10, as follows: control group (animals were provided with distilled water) and fluoride group (animals were provided with 150 mg/L F(-) drinking water). Ultrastructure and pathological morphological changes of myocardial tissue were observed under the transmission electron and light microscopes, respectively. The content of hydrolysis ATP enzyme was observed by ATP enzyme staining. The expression levels of ATP5J and ATP5H were measured by Western...
Source: Biological Trace Element Research - March 6, 2017 Category: Biology Authors: Wang HW, Zhao WP, Liu J, Tan PP, Tian WS, Zhou BH Tags: Biol Trace Elem Res Source Type: research

Involvement of Zn Depletion in Cd-Induced Toxicity on Prenatal Bone Formation in Rat.
This study explored the potential toxicity of Cd on the Zn bone depletion in prenatal bone formation. Female rats received either tap water, Cd, Zn, or Cd + Zn in their drinking water during gestation, and some markers of bone formation were studied in their fetuses removed at the 20th day of pregnancy (GD20). Cd exposure induced maternal hypozincemia and Zn depletion in the femur of the fetuses. A striking inhibition of bone formation in fetuses, expressed by decreases in femur length, width, and area, by the shortening of diaphysis, and by a decrease in length and area of distal and proximal proliferative zones, was obse...
Source: Biological Trace Element Research - March 6, 2017 Category: Biology Authors: Boughammoura S, Chemek M, Mimouna SB, Banni M, Messaoudi I Tags: Biol Trace Elem Res Source Type: research

Effects of Selenium Nanoparticles on Reproductive Performance of Male Sprague-Dawley Rats at Supranutritional and Nonlethal Levels.
Abstract This research investigated the influence of selenium nanoparticles (SeNPs) on the reproductive performance of male Sprague-Dawley (SD) rats. A suspension of SeNPs was consecutively administered by oral gavage for 2 weeks at supranutritional (0.2, 0.4, or 0.8 mg Se/kg bw) and nonlethal (2.0, 4.0, or 8.0 mg Se/kg bw) levels to male SD rats. The normal control (NC) rats were exposed to physiological saline alone. Biochemical parameters, sperm motility, gene expression of GPx1 and GPx4, and histopathological evaluation of male spermary were measured in this work. The supranutritional doses could promote ...
Source: Biological Trace Element Research - March 6, 2017 Category: Biology Authors: Liu L, He Y, Xiao Z, Tao W, Zhu J, Wang B, Liu Z, Wang M Tags: Biol Trace Elem Res Source Type: research

Concentration of Zinc, Copper, Iron, Calcium, and Magnesium in the Serum, Tissues, and Urine of Streptozotocin-Induced Mild Diabetic Rat Model.
, Clapés S Abstract The present study aimed to investigate, in the streptozotocin-induced mild diabetic rat model, the zinc (Zn), copper (Cu), iron (Fe), calcium (Ca), and magnesium (Mg) concentration in serum, liver, and kidney tissues, and urine samples from adult Wistar rats treated neonatally with streptozotocin (STZ). Diabetes was induced by subcutaneous administration of streptozotocin (100 mg/Kg) in female Wistar rats of 2 days old (STZ, n = 10). Control group (CG, n = 10) received only sodium-citrate buffer. The mineral concentrations were measured by atomic absorption ...
Source: Biological Trace Element Research - March 3, 2017 Category: Biology Authors: Gómez T, Bequer L, Mollineda A, Molina JL, Álvarez A, Lavastida M, Clapés S Tags: Biol Trace Elem Res Source Type: research

Analysis of the Interactions Between Thioredoxin and 20 Selenoproteins in Chicken.
Abstract Thioredoxin (Trx) is a small molecular protein with complicated functions in a number of processes, including inflammation, apoptosis, embryogenesis, cardiovascular disease, and redox regulation. Some selenoproteins, such as glutathione peroxidase (Gpx), iodothyronine deiodinase (Dio), and thioredoxin reductase (TR), are involved in redox regulation. However, whether there are interactions between Trx and selenoproteins is still not known. In the present paper, we used a Modeller, Hex 8.0.0, and the KFC2 Server to predict the interactions between Trx and selenoproteins. We used the Modeller to predict the...
Source: Biological Trace Element Research - March 2, 2017 Category: Biology Authors: Liu Q, Yang J, Cai J, Luan Y, Sattar H, Liu M, Xu S, Zhang Z Tags: Biol Trace Elem Res Source Type: research

Serum Selenium Levels and Cervical Cancer: Systematic Review and Meta-Analysis.
In conclusion, high serum selenium levels were associated with cervical cancer, and selenium exposure might be a protective factor for cervical cancer. PMID: 28255860 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - March 2, 2017 Category: Biology Authors: He D, Wang Z, Huang C, Fang X, Chen D Tags: Biol Trace Elem Res Source Type: research

Hair Zinc and Severity of Symptoms Are Increased in Children with Attention Deficit and Hyperactivity Disorder: a Hair Multi-Element Profile Study.
In this study, we have compared multi-element hair profiles between healthy and ADHD Thai children. In addition, the correlations between bioelements and ADHD symptoms according to Diagnostic and Statistical Manual of Mental Disorders, 5th edition, diagnostic criteria were identified. A case-control study was conducted in 111 Thai children (45 newly diagnosed ADHD and 66 matched healthy), aged 3-7 years, living in Bangkok and suburban areas. Levels of 39 bioelements in hair were measured by ICP-MS. Among the analyzed bioelements, Cu/Zn and P/Zn ratios in ADHD children were significantly lower than those in healthy chi...
Source: Biological Trace Element Research - March 1, 2017 Category: Biology Authors: Tippairote T, Temviriyanukul P, Benjapong W, Trachootham D Tags: Biol Trace Elem Res Source Type: research

Erratum to: Stimulated and Unstimulated Saliva Levels of Calcium and Magnesium in Giardiasis.
PMID: 28243850 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - February 27, 2017 Category: Biology Authors: Shaddel M, Mirzaii-Dizgah I, Sharifi-Sarasiabi K, Kamali Z, Dastgheib M Tags: Biol Trace Elem Res Source Type: research

Inactivation of Kupffer Cells by Selenizing Astragalus Polysaccharides Prevents CCl4-Induced Hepatocellular Necrosis in the Male Wistar Rat.
Abstract Selenizing astragalus polysaccharides-3 (sAPS3) was prepared by nitric acid-sodium selenite method. The effects of sAPS3 on carbon tetrachloride (CCl4) induced hepatocellular necrosis, and its underlying mechanisms were studied in male Wistar rats. Hepatic damage was induced by intraperitoneal injection of CCl4 twice a week, for 3 weeks. Meanwhile, the rats in addition to CCl4 were also exposed to sodium selenite (SS), astragalus polysaccharides (APS), SS + APS or sAPS3, in parallel by oral gavage once a day for 3 weeks. At the end of 3 weeks, blood and liver tissue were taken. Serum was co...
Source: Biological Trace Element Research - February 27, 2017 Category: Biology Authors: Hamid M, Liu D, Abdulrahim Y, Khan A, Qian G, Huang K Tags: Biol Trace Elem Res Source Type: research

Effects of Copper on Hemocyte Apoptosis, ROS Production, and Gene Expression in White Shrimp Litopenaeus vannamei.
Abstract Copper, a common chemical contaminant in aquatic environment, is known to be toxic to aquatic life at high concentrations. In the present study, we evaluated the apoptotic cell ratio and ROS production in hemocytes of the white shrimp Litopenaeus vannamei exposed to 1 or 5 mg L(-1) Cu for 0, 3, 6, 12, 24, and 48 h. The expression changes of antioxidant biomarker genes, i.e., copper-zinc superoxide dismutase (Cu-Zn SOD) and catalase (CAT), apoptosis-related genes, i.e., caspase-3 and inhibitor of apoptosis protein (IAP), and a specific biomarker gene of heavy metal pollution, i.e., metalloth...
Source: Biological Trace Element Research - February 25, 2017 Category: Biology Authors: Guo H, Li K, Wang W, Wang C, Shen Y Tags: Biol Trace Elem Res Source Type: research