Research Progress on the Toxic Antagonism of Selenium Against Mycotoxins.
This article reviews the current literature on the antagonistic effects of selenium on AFB1, T-2, DON, and OTA toxicity. PMID: 30267312 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - September 29, 2018 Category: Biology Authors: Ren Z, He H, Fan Y, Chen C, Zuo Z, Deng J Tags: Biol Trace Elem Res Source Type: research

Comparative Study of Different Maternal Zinc Resource Supplementation on Performance and Breast Muscle Development of their Offspring.
Abstract Maternal zinc supplementation has a pivotal role in enhancing breast muscle development of the offspring. What is poorly defined is the impact of supplemental zinc from different sources on the offspring. Broiler breeders at 24-week-old were randomly divided into three treatments with six replicates of 40 hens each and respectively fed for 8 weeks with supplemental 0-(group Zn/C), 100 mg/kg organic-(group Zn/O), and 100 mg/kg inorganic-(group Zn/I) zinc. The male offspring from each nutritional treatment were allocated into eight cages of 14 birds each, and a commercial diet supplemented wi...
Source: Biological Trace Element Research - September 29, 2018 Category: Biology Authors: Gao J, Nie W, Xing K, Guo Y Tags: Biol Trace Elem Res Source Type: research

Association Between Hypertension in Healthy Participants and Zinc and Copper Status: a Population-Based Study.
Abstract The prevalence of hypertension (HTN) is increasing globally. It has been shown that there is an association between micronutrient deficiency and HTN. In the current study, we aimed to assess the association between HTN with serum copper and zinc concentrations in a large representative Iranian population. The participants were enrolled into the Mashhad stroke and heart atherosclerotic disorders study (MASHAD study), a cohort study that was initiated in 2010. Anthropometric indices were assessed using standard procedures. Systolic (SBP) and diastolic (DBP) blood pressures were measured using a standard mer...
Source: Biological Trace Element Research - September 28, 2018 Category: Biology Authors: Darroudi S, Saberi-Karimian M, Tayefi M, Tayefi B, Khashyarmanesh Z, Fereydouni N, Haghighi HM, Mahmoudi AA, Kharazmi-Khorassani J, Gonoodi K, Esmaeili H, Mohammadpour AH, Ferns GA, Ghayour-Mobarhan M Tags: Biol Trace Elem Res Source Type: research

Small Molecule Modifiers of In Vitro Manganese Transport Alter Toxicity In Vivo.
Abstract Manganese (Mn) is essential for several species and daily requirements are commonly met by an adequate diet. Mn overload may cause motor and psychiatric disturbances and may arise from an impaired or not fully developed excretion system, transporter malfunction and/or exposure to excessive levels of Mn. Therefore, deciphering processes regulating neuronal Mn homeostasis is essential to understand the mechanisms of Mn neurotoxicity. In the present study, we selected two small molecules (with opposing effects on Mn transport) from a previous high throughput screen of 40,167 to test their effects on Mn toxic...
Source: Biological Trace Element Research - September 28, 2018 Category: Biology Authors: Peres TV, Horning KJ, Bornhorst J, Schwerdtle T, Bowman AB, Aschner M Tags: Biol Trace Elem Res Source Type: research

Correction to: Reduced Serum Selenium Concentration in Miscarriage Incidence of Indonesian Subjects.
Abstract The original version of this article unfortunately contained a mistake. The name of "Herlambang herlambang" is now corrected in the author group of this article. PMID: 30255338 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - September 26, 2018 Category: Biology Authors: Abdulah R, Herlambang H, Septiani L, Mutakin, Defi IR, Suradji EW, Puspitasari IM, Barliana MI, Yamazaki C, Nakazawa M, Koyama H Tags: Biol Trace Elem Res Source Type: research

Boron, Chromium, Manganese, and Nickel in Agricultural Animal Production.
Abstract This paper provides an overview of research that has been conducted with manganese (Mn), chromium (Cr), nickel (Ni), and boron (B) in poultry, swine, and ruminants. Manganese is an essential trace mineral that functions as an enzyme component and enzyme activator. A deficiency of Mn results in a variety of bone abnormalities, and Mn deficiency signs have been observed under practical conditions in poultry and cattle. Chromium can potentiate the action of insulin, but whether Cr is an essential trace mineral is controversial. Insulin sensitivity has been enhanced by Cr in cattle, swine, and broilers. Respo...
Source: Biological Trace Element Research - September 26, 2018 Category: Biology Authors: Spears JW Tags: Biol Trace Elem Res Source Type: research

Plasma Selenium and Cadmium Levels in Patients with Chronic Otitis Media in a Turkish Population and Their Relation to Inflammation Markers.
Abstract Chronic otitis media (COM) is a multifactorial process, for which a clear etiology has not yet been established. The aims of the present study were to evaluate selenium (Se) and cadmium (Cd) levels in patients with COM and to analyze the correlation between Se and Cd with inflammation markers. The study population consisted of 88 participants: 45 healthy controls (group 1) and 43 patients with COM (group 2). Demographic data, Se, Cd, C-reactive protein (CRP), and white blood cell count (WBC) levels were all recorded. Se and Cd measurements were performed in a graphite furnace atomic absorption spectrophot...
Source: Biological Trace Element Research - September 26, 2018 Category: Biology Authors: Arikan TA, Kelles M Tags: Biol Trace Elem Res Source Type: research

Effect of Aqueous Extract of Glycyrrhiza glabra on the Biochemical Changes Induced by Cadmium Chloride in Rats.
Abstract Twenty four rats were divided into four groups (6 rats/group): 1-control group; 2-licorice (Glycyrrhiza glabra) extract: rats administered with an oral dose of licorice (3 mg/ml/kg/day) using stomach tube for 4 weeks; 3-cadmium chloride group: rats administered with an oral dose of CdCl2 (10 mg/kg/day) using stomach tube for 4 weeks; and 4-licorice extract + CdCl2 group: rats administered orally with both licorice (3 mg/ml/kg/day) and CdCl2 (10 mg/kg/day) using stomach tube for 4 weeks. Administration of CdCl2 induced significant increase in thiobarbituric ...
Source: Biological Trace Element Research - September 24, 2018 Category: Biology Authors: Mohamed NE Tags: Biol Trace Elem Res Source Type: research

Evaluation of Nutritional and Mineral-Heavy Metal Contents of Horse Mackerel (Trachurus trachurus) in the Middle Black Sea in terms of Human Health.
This study suggests that horse mackerel is beneficial seafood for human health and nutrition. PMID: 30244434 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - September 22, 2018 Category: Biology Authors: Durmuş M Tags: Biol Trace Elem Res Source Type: research

Effects of Nickel Supplementation on Antioxidant Status, Immune Characteristics, and Energy and Lipid Metabolism in Growing Cattle.
This study was conducted to evaluate the effect of Ni supplementation on intake, growth performance, urease activity, antioxidant and immune status, and energy and lipid metabolism in growing cattle. Eighteen growing Hariana heifers were randomly allocated into three groups on body weight (125 ± 3.0 kg) and age basis (10 ± 2.0 months). Feeding regimen was similar in all the groups except that treatment groups were supplemented with 0.0 (Ni0.0), 1.5 (Ni1.5), and 3.0 (Ni3.0) mg of Ni/kg dry matter (DM) in three respective groups. DM intake (DMI), average daily gain (ADG), f...
Source: Biological Trace Element Research - September 20, 2018 Category: Biology Authors: Singh A, Kumar M, Kumar V, Roy D, Kushwaha R, Vaswani S, Kumar A Tags: Biol Trace Elem Res Source Type: research

Evaluation of Some Trace Elements and Vitamins in Major Depressive Disorder Patients: a Case-Control Study.
Abstract Major depressive disorder (MDD) is a common mental disorder worldwide; however, little is known about its etiology. It is well known that levels of certain trace elements are associated with the pathogenesis of some diseases. Accordingly, this study aims to evaluate the effect of trace elements and vitamins in the etiology of MDD. In this case-control study, sixty men patients with MDD and sixty, age and gender matched, control subjects were examined. Serum levels of Cu, Zn, Ni, Cr, Mn, Mg, and Al were determined by atomic absorption spectrometry as well as serum levels of vitamins E and A were determined...
Source: Biological Trace Element Research - September 20, 2018 Category: Biology Authors: Al-Fartusie FS, Al-Bairmani HK, Al-Garawi ZS, Yousif AH Tags: Biol Trace Elem Res Source Type: research

Effects of Different Selenium Sources on Laying Performance, Egg Selenium Concentration, and Antioxidant Capacity in Laying Hens.
This study aimed to compare the effects of NS, SS, and SY on productivity; selenium (Se) deposition in eggs; and antioxidant capacity in laying hens. A total of 288 30-week-old Brown Hy-line laying hens were randomly assigned into four dietary treatments, which included corn-soybean meal basal diet (Con) without Se sources and basal diets supplemented with 0.3 mg Se/kg as SS, SY, or NS, respectively. The results exhibited that Se-supplemented treatments achieved greater egg production, egg weight, and daily egg mass, also better feed conversion ratio than Con group (p 
Source: Biological Trace Element Research - September 19, 2018 Category: Biology Authors: Meng T, Liu YL, Xie CY, Zhang B, Huang YQ, Zhang YW, Yao Y, Huang R, Wu X Tags: Biol Trace Elem Res Source Type: research

Dietary Exposure Assessment of Potentially Toxic Trace Elements in Fruits and Vegetables Sold in Town of Kapan, Armenia.
Abstract Fruits and vegetables grown under the impact of Armenia's mining industry are widely sold in markets of adjacent towns. As the share of fruits and vegetables in Armenians' diet is significant, the present study aims to assess the dietary exposure of potentially toxic trace elements through the intake of fruits and vegetables sold in Kapan town, located in the biggest mining region of Armenia. The concentrations of Cu, Mo, Ni, Cr, Pb, Zn, Hg, As, and Cd in 15 types of fruits and vegetables were determined. Non-carcinogenic and carcinogenic risks were assessed. Although the estimated daily intakes of trace ...
Source: Biological Trace Element Research - September 19, 2018 Category: Biology Authors: Pipoyan D, Beglaryan M, Stepanyan S, Merendino N Tags: Biol Trace Elem Res Source Type: research

The Thioredoxin-Like Family of Selenoproteins: Implications in Aging and Age-Related Degeneration.
Abstract The thioredoxin-like (Rdx) family proteins contain four selenoproteins (selenoprotein H, SELENOH; selenoprotein T, SELENOT; selenoprotein V, SELENOV; selenoprotein W, SELENOW) and a nonselenoprotein Rdx12. They share a CxxU or a CxxC (C, cysteine; x, any amino acid; U, selenocysteine) motif and a stretch of eGxFEI(V) sequence. From the evolutionary perspective, SELENOW and SELENOV are clustered together and SELENOH and SELENOT are in another branch. Selenoproteins in the Rdx family exhibit tissue- and organelle-specific distribution and are differentially influenced in response to selenium deficiency. Whi...
Source: Biological Trace Element Research - September 18, 2018 Category: Biology Authors: Zhang L, Zhu JH, Zhang X, Cheng WH Tags: Biol Trace Elem Res Source Type: research

Concentration of Micro- and Macro-Elements in Green and Roasted Coffee: Influence of Roasting Degree and Risk Assessment for the Consumers.
šák T, Král M, Kováčik A, Štefániková J Abstract The aim of the present study was to determine concentrations of 15 macro- and micro-elements in 10 commercially available plantation Arabica coffee brands. The elemental concentration was studied in 50 samples of green and roasted coffee beans of various roasting degrees and their infusions. There were four different roasting degrees: City + (C+), Full city (FC), Full city ++ (FC++), and Dark (D). The attention was given to the impact of the roasting process on the elemental composition. Statistically significant dif...
Source: Biological Trace Element Research - September 17, 2018 Category: Biology Authors: Árvay J, Šnirc M, Hauptvogl M, Bilčíková J, Bobková A, Demková L, Hudáček M, Hrstková M, Lošák T, Král M, Kováčik A, Štefániková J Tags: Biol Trace Elem Res Source Type: research

Carcinogenic and Non-carcinogenic Risk Assessment of Heavy Metals in Groundwater Wells in Neyshabur Plain, Iran.
This study aimed also to ascertain the potential consumers' health risk of heavy metal intake. Heavy metal concentrations were analyzed by inductively coupled plasma optical emission spectrometry. The highest and lowest average values in the analyzed water samples were observed for Fe (9.78 ± 5.61 μg/L) and As (1.30 ± 2.99 μg/L), respectively. These values were well below the limits recommended by the World Health Organization and the Iranian national standard. Heavy metal pollution index and heavy metal evaluation index were used to evaluate drinking water quality....
Source: Biological Trace Element Research - September 17, 2018 Category: Biology Authors: Saleh HN, Panahande M, Yousefi M, Asghari FB, Oliveri Conti G, Talaee E, Mohammadi AA Tags: Biol Trace Elem Res Source Type: research

Effect of Supplementation of Nano Zinc Oxide on Nutrient Retention, Organ and Serum Minerals Profile, and Hepatic Metallothionein Gene Expression in Wister Albino Rats.
Abstract A study was conducted to validate the effects of nano form of zinc (NZn) on nutrient digestibility, zinc retention, organ and serum zinc profile, and hepatic metallothionein gene expression in Wistar albino rats (WAR). Nano zinc (NZn) was synthesized through chemical method, by using 0.45 M zinc nitrate [Zn(NO3)2.6H2O] and 0.9 M sodium hydroxide (NaOH). The NZn particle in its oxide form was characterized by TEM-EDAX and XRD, and found to be in nano range (below 100 nm. Zinc was supplemented to the Wistar albino rats (WAR) through synthetic semi-purified diet either without Zn, or as inorganic z...
Source: Biological Trace Element Research - September 15, 2018 Category: Biology Authors: Swain PS, Rao SBN, Rajendran D, Pal D, Mondal S, Selvaraju S Tags: Biol Trace Elem Res Source Type: research

Factors Affecting Differential Methylation of DNA Promoters in Arsenic-Exposed Populations.
Abstract The exposure/biotransformation of inorganic arsenic (iAs) may perturb DNA methylation patterns and subsequently influence disease risk by altering the expression of key genes. Interindividual variation in patterns of DNA methylation can be explained by the influence of environmental, genetic, and stochastic factors. Here, we examined promoter DNA methylation levels with urinary arsenical concentrations and investigated the genetic and nongenetic determinants of DNA methylation in 105 samples collected from populations in Shanxi Province, China, with high levels of arsenic in drinking water. Arsenic concen...
Source: Biological Trace Element Research - September 15, 2018 Category: Biology Authors: Zhang Y, Li Y, Luo L, He Q, Gao Y, Feng H, Zhao L, Wei W, Fu S, Sun D Tags: Biol Trace Elem Res Source Type: research

Iodine Nutrition During Pregnancy: Past, Present, and Future.
Abstract Iodine is a trace element that is important for the synthesis of thyroid hormones. During pregnancy, iodine requirements are increased by approximately 50% because of physiological changes. Adequate iodine status in pregnancy is crucial for maternal health and fetal growth. The World Health Organization (WHO) recommends a daily intake of 250 μg iodine for pregnant women to maintain adequate iodine status. Severe iodine deficiency during pregnancy can result in a series of detrimental effects on maternal and fetal health including hypothyroidism, goiter, stillbirth, abortion, increased neonatal mor...
Source: Biological Trace Element Research - September 14, 2018 Category: Biology Authors: Zhao W, Li X, Xia X, Gao Z, Han C Tags: Biol Trace Elem Res Source Type: research

Hemodialysis Water Parameters as Predisposing Factors for Anemia in Patients in Dialytic Treatment: Application of Mixed Regression Models.
The objective of this study was to assess hemodialysis water quality in a major tertiary hospital in Brazil and investigate the relationship between hemodialysis water quality and clinical intercurrences in hemodialysis patients. A prospective-observational cohort study for evaluation of water quality parameters and clinical intercurrences present by patients (n = 52) were performed from May 2014 to April 2015. Mixed linear regression models and binary regression models were fitted for water quality parameters and patients' clinical parameters. The increase in the levels of copper and nitrate in hemodialysis ...
Source: Biological Trace Element Research - September 14, 2018 Category: Biology Authors: Suzuki MN, Fregonesi BM, Machado CS, Zagui GS, Kusumota L, Suzuki AK, da Costa JAC, Llopart JS, Nadal M, Domingo JL, Segura-Muñoz S Tags: Biol Trace Elem Res Source Type: research

Biocompatibility Studies of Gadolinium Complexes with Iminodiacetic Acid Derivatives.
Abstract Apart from using as radiopharmaceuticals, iminodiacetic acid derivatives, after complexation with gadolinium, have been also tested as MRI CAs (magnetic resonance imaging contrast agents) since they show high affinity to hepatocytes and therefore provide high-resolution MRI of the liver. The purpose of this study was to evaluate the biocompatibility of four gadolinium complexes with iminodiacetic acid (IDA) derivatives differing in substituent in aromatic ring by estimating their influence on plasma hemostasis, integrity of erythrocyte membrane, and toxicity towards human umbilical vein endothelial cells ...
Source: Biological Trace Element Research - September 13, 2018 Category: Biology Authors: Markowicz-Piasecka M, Skupień A, Mikiciuk-Olasik E, Sikora J Tags: Biol Trace Elem Res Source Type: research

Effect of Fluoride on Small Intestine Morphology and Serum Cytokine Contents in Rats.
This study aimed to determine the effect of excessive fluoride (F) on the morphological characteristics of the small intestine and the contents of serum cytokines in rats. A total of 48 3-week-old healthy female Sprague-Dawley rats were randomly divided into four groups (n = 12). The control group was given deionized distilled water, while the F treatment groups were treated with water containing 25, 50, and 100 mg F-/L. After 70 days of treatment, the duodenum, the jejunum, and the ileum were collected to measure the developmental parameters and the distribution of intestinal glycoproteins, go...
Source: Biological Trace Element Research - September 13, 2018 Category: Biology Authors: Wang HW, Liu J, Zhao WP, Zhang ZH, Li SQ, Li SH, Zhu SQ, Zhou BH Tags: Biol Trace Elem Res Source Type: research

Association Between Exposure to Heavy Metals and Systemic Sclerosis: the Levels of Al, Cd, Hg, and Pb in Blood and Urine of Patients.
Abstract Systemic sclerosis (SSc) is a multisystem connective tissue disease; exogenous factors-including heavy metals-may have a role in the disease pathogenesis. In this context, a study on the quantification of Al, Cd, Hg, and Pb in blood and urine of 27 SSc patients and 30 controls was carried out. Main findings were that Al was significantly depleted in blood and increased in urine of SSc patients respect to controls; and Pb was found slightly increased in blood and significantly decreased in SSc group. In addition, higher Hg levels in urine were found in SSc subjects with the higher severity of the disease. ...
Source: Biological Trace Element Research - September 13, 2018 Category: Biology Authors: Forte G, Fadda C, Bocca B, Erre GL, Passiu G, Madeddu R Tags: Biol Trace Elem Res Source Type: research

Pre-analytical Factors Influence Accuracy of Urine Spot Iodine Assessment in Epidemiological Surveys.
PMID: 30209728 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - September 12, 2018 Category: Biology Authors: Ma ZF Tags: Biol Trace Elem Res Source Type: research

Hair Mineral and Trace Element Content in Children with Down's Syndrome.
The objective of the present study was to assess the level of minerals and trace elements in 40 children with Down's syndrome and 40 controls aged 1-2 years old. Hair mineral and trace element analysis was performed using inductively coupled plasma mass spectrometry. The obtained data demonstrate that hair levels of Mg, P, I, Cr, Si, Zn, and Pb in Down's syndrome patients exceeded the respective control values by 36, 36, 93, 57, 45, 28, and 54%, whereas hair mercury was more than twofold lower in children with Down's syndrome. The observed difference in the levels of trace elements was age-dependent. In particular, in...
Source: Biological Trace Element Research - September 12, 2018 Category: Biology Authors: Grabeklis AR, Skalny AV, Skalnaya AA, Zhegalova IV, Notova SV, Mazaletskaya AL, Skalnaya MG, Tinkov AA Tags: Biol Trace Elem Res Source Type: research

Gastrointestinal Absorption and Renal Excretion of Fluoride After Ingestion of a High-Fluoride Dentifrice.
This study aimed to evaluate the gastrointestinal absorption and renal excretion of fluoride after the ingestion of high-fluoride dentifrice. Twelve volunteers participated in this in vivo, crossover, and blinded study. In three experimental phases, the volunteers were randomly assigned to one of three treatment groups, who ingested either the following: distilled and deionized water (control), conventional dentifrice (1100 μg/g), or high-fluoride dentifrice (5000 μg/g). Both dentifrices contained fluoride in the form of NaF/SiO2. To determine the rate of fluoride absorption, non-stimulated saliva was colle...
Source: Biological Trace Element Research - September 11, 2018 Category: Biology Authors: Vale G, Simões N, Santana G, Mota B, Moura M Tags: Biol Trace Elem Res Source Type: research

The Hazards of a Ubiquitary Metalloid, Arsenic, Hiding in Infant Diets: Detection, Speciation, Exposure, and Risk Assessment.
This study confirms that infants are exposed to arsenic via diet since rice-based infant food products contained elevated levels of arsenic; consequently, warranting careful attention to diet choices both to limit this exposure and to avert potentially hazardous adverse health effects to the infants. PMID: 30203222 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - September 10, 2018 Category: Biology Authors: Jallad KN Tags: Biol Trace Elem Res Source Type: research

The Molecular Mechanisms of Protective Role of Se on the G0/G1 Phase Arrest Caused by AFB1 in Broiler's Thymocytes.
In conclusion, Se could relieve AFB1-induced G0/G1 phase arrest by p15 (or p16)-CyclinD1/Cdk6, ATM-p53-p21-CyclinE/Cdk2, p27-CyclinE/Cdk2 pathways. PMID: 30203223 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - September 10, 2018 Category: Biology Authors: Guan K, Li H, Zuo Z, Wang F, Hu P, Peng X, Fang J, Cui H, Shu G, Ouyang P Tags: Biol Trace Elem Res Source Type: research

Chlorogenic Acid Ameliorates Lead-Induced Renal Damage in Mice.
In this study, we aimed to investigate the protective efficacy and mechanism of CGA against Pb-induced nephrotoxicity in mice. The results showed that CGA inhibited Pb-induced bodyweight loss, reduced kidney coefficients, and alleviated renal function and structure. Exploration on the potential mechanism demonstrated that CGA suppressed Pb-induced inflammation in the kidney by regulating NF-κB pathway activation. Furthermore, CGA significantly increased Pb-induced reduction in the activity of SOD and GSH-Px, and reduced Pb-induced increase in the content of MDA. The expression of Bax and Bcl-2 associated with apoptos...
Source: Biological Trace Element Research - September 9, 2018 Category: Biology Authors: Zhang T, Chen S, Chen L, Zhang L, Meng F, Sha S, Ai C, Tai J Tags: Biol Trace Elem Res Source Type: research

Boric Acid Activation of eIF2 α and Nrf2 Is PERK Dependent: a Mechanism that Explains How Boron Prevents DNA Damage and Enhances Antioxidant Status.
Boric Acid Activation of eIF2α and Nrf2 Is PERK Dependent: a Mechanism that Explains How Boron Prevents DNA Damage and Enhances Antioxidant Status. Biol Trace Elem Res. 2018 Sep 08;: Authors: Yamada KE, Eckhert CD Abstract Boron is abundant in vegetables, nuts, legumes, and fruit and intake is associated with reduced risk of cancer and DNA damage and increased antioxidant status. Blood boric acid (BA) levels are approximately 10 μM BA in men at the mean US boron intake. Treatment of DU-145 human prostate cancer cells with 10 μM BA stimulates phosphorylation of elongation initiati...
Source: Biological Trace Element Research - September 8, 2018 Category: Biology Authors: Yamada KE, Eckhert CD Tags: Biol Trace Elem Res Source Type: research

Effect of Injectable Copper and Zinc Supplementation on Weight, Hematological Parameters, and Immune Response in Pre-weaning Beef Calves.
Abstract Copper (Cu) and zinc (Zn) deficiency may cause poor weight gain, hematological changes, and immune failure in extensive beef cattle breeding systems. Diagnosis of the deficiency is based on plasma Cu and Zn concentrations; however, there are discrepancies regarding data interpretation. Here, plasma Cu and Zn concentrations are discussed as risk markers. We evaluated the effect of parenteral Cu and Zn supplementation on their plasma concentrations, weight gain, hematological parameters, and antibody titers to bovine herpes virus 1 (BoHV-1). Pre-weaning calves (n = 40; 99 ±&thins...
Source: Biological Trace Element Research - September 8, 2018 Category: Biology Authors: Mattioli GA, Rosa DE, Turic E, Testa JA, Lizarraga RM, Fazzio LE Tags: Biol Trace Elem Res Source Type: research

Effect of an Acute Exercise Until Exhaustion on the Serum and Urinary Concentrations of Cobalt, Copper, and Manganese Among Well-Trained Athletes.
, Robles MC Abstract The current information about the effect of physical exercise on the body concentrations of several minerals is still limited, both in the acute (short-term) and adaptive (long-term) responses. So, this manuscript aims, on the one hand, to assess the possible differences on basal levels of cobalt (Co), copper (Cu), and manganese (Mn) concentrations in serum and urine between athletes and sedentary participants and, on the other hand, to evaluate the effect of an acute progressive physical exercise until voluntary exhaustion on the serum and urinary concentrations of Co, Cu, and Mn. Two groups ...
Source: Biological Trace Element Research - September 7, 2018 Category: Biology Authors: Muñoz D, Maynar M, Barrientos G, Siquier-Coll J, Bartolomé I, Grijota FJ, Robles MC Tags: Biol Trace Elem Res Source Type: research

Assessment of Human Health Risk of Toxic Elements Due to Cinnamon Ingestion in the Diet.
This study aimed to investigate the elemental concentration profile in cinnamon powder products available in the Portuguese market and to assess the cumulative non-carcinogenic risk to human health due to the exposure to mixtures of such elements through the inclusion of 6 g of cinnamon in diet. Concentrations of Cu, Zn, Fe, Al, Cl, Mn, and Sr were determined by wavelength dispersive X-ray fluorescence spectroscopy in different lots of eight branded and one bulk cinnamon powder products. Linear mixed models have revealed significant differences in concentrations of Zn, Fe, Al, and Cl between brands. In particular, bul...
Source: Biological Trace Element Research - September 6, 2018 Category: Biology Authors: L Gonçalves L, Fernandes T, Bernardo MA, A Brito J Tags: Biol Trace Elem Res Source Type: research

Comparative Safety and Pharmacokinetic Evaluation of Three Oral Selenium Compounds in Cancer Patients.
Abstract Selenium (Se) compounds have demonstrated anticancer properties in both preclinical and clinical studies, with particular promise in combination therapy where the optimal form and dose of selenium has yet to be established. In a phase I randomised double-blinded study, the safety, tolerability and pharmacokinetic (PK) profiles of sodium selenite (SS), Se-methylselenocysteine (MSC) and seleno-l-methionine (SLM) were compared in patients with chronic lymphocytic leukaemia and a cohort of patients with solid malignancies. Twenty-four patients received 400 μg of elemental Se as either SS, MSC or SLM f...
Source: Biological Trace Element Research - September 5, 2018 Category: Biology Authors: Evans SO, Jacobson GM, Goodman HJB, Bird S, Jameson MB Tags: Biol Trace Elem Res Source Type: research

Effects of Nutritional Deficiency of Boron on the Bones of the Appendicular Skeleton of Mice.
Abstract Scientific evidence has shown the nutritional importance of boron (B) in the remodeling and repair of cancellous bone tissue. However, the effects of the nutritional deficiency of B on the cortical bone tissue of the appendicular skeleton have not yet been described. Thus, a study was performed to histomorphometrically evaluate the density of osteocyte lacunae of cortical bone of mouse femora under conditions of nutritional deficiency of B and to analyze the effects of the deficiency on the biomechanical properties of mouse tibiae. Weaning, 21-day-old male Swiss mice were assigned to the following two gro...
Source: Biological Trace Element Research - September 4, 2018 Category: Biology Authors: Gorustovich AA, Nielsen FH Tags: Biol Trace Elem Res Source Type: research

Correction to: Investigation and Comparison of In Vitro Genotoxic Potency of PM10 Collected in Rural and Urban Sites at Tehran in Different Metrological Conditions and Different Seasons.
Abstract The original version of this article unfortunately contained a mistake. Figure 6 caption should be "The light microscopic image (a) and transmission electron microscopic image (b) of A549 cell after 24 h of exposure to PM10 (150 μg/ml). PMID: 30182353 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - September 4, 2018 Category: Biology Authors: Ghanbarian M, Nicknam MH, Mesdaghinia A, Yunesian M, Hassanvand MS, Soleimanifar N, Rezaei S, Atafar Z, Ghanbarian M, Faraji M, Ghozikali MG, Naddafi K Tags: Biol Trace Elem Res Source Type: research

Biochemical CuSO4 Toxicity in Drosophila melanogaster Depends on Sex and Developmental Stage of Exposure.
Abstract Copper is a transition metal that exists in different chemical forms (e.g., Cu2+,Cu+, and Cu0) and at high concentrations it is toxic. Here, we investigated the Cu2+-induced toxicity in Drosophila melanogaster, evaluating the survival, locomotion, and the activity of acetylcholinesterase (AChE) and glutathione S-transferase (GST) enzymes. Flies were exposed to Cu2+(0.1-1 mmol CuSO4/kg of diet or approximately 0.1-1 mM Cu2+) and allowed to mate during 24 h. GST and AChE enzymes were evaluated in the larvae and in the head and the body (thorax + abdomen) of the adult male and females flies. T...
Source: Biological Trace Element Research - September 3, 2018 Category: Biology Authors: Halmenschelager PT, da Rocha JBT Tags: Biol Trace Elem Res Source Type: research

Response to Letter to the Editor: "Comment on "Serum Hepcidin and Soluble Transferrin Receptor in the Assessment of Iron Metabolism in Children on a Vegetarian Diet"".
Response to Letter to the Editor: "Comment on "Serum Hepcidin and Soluble Transferrin Receptor in the Assessment of Iron Metabolism in Children on a Vegetarian Diet"". Biol Trace Elem Res. 2018 Sep 03;: Authors: Ambroszkiewicz J, Klemarczyk W, Mazur J, Gajewska J, Rowicka G, Strucińska M, Chełchowska M PMID: 30178146 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - September 3, 2018 Category: Biology Authors: Ambroszkiewicz J, Klemarczyk W, Mazur J, Gajewska J, Rowicka G, Strucińska M, Chełchowska M Tags: Biol Trace Elem Res Source Type: research

Effect of Iron Supplementation on Growth Performance, Hematological Parameters, Nutrient Utilization, Organ Development, and Fe-Containing Enzyme Activity in Pekin Ducks.
Abstract The current study was conducted with a mathematical model to investigate the appropriate iron supplementation by analyzing growth performance, hematological parameters, nutrient utilization, organ development, and Fe-containing enzyme activity in Pekin ducks. A total of 1120 ducks (1-day-old; 50.62 ± 0.20 g) were randomly allotted to seven groups with eight replicates of 20 ducks per replicate. Ducks were fed either a low-iron diet or basal diets supplemented with 0, 30, 60, 90, 120, and 150 mg Fe/kg from iron sulfate, respectively. The results showed that iron deficiency de...
Source: Biological Trace Element Research - September 3, 2018 Category: Biology Authors: Xie D, Wen M, Wu B, Zhang Z, Zhao H, Liu G, Chen X, Tian G, Cai J, Jia G Tags: Biol Trace Elem Res Source Type: research

Brain Selenium in Alzheimer's Disease (BRAIN SEAD Study): a Systematic Review and Meta-Analysis.
Abstract Oxidative stress has been found to be implicated in the development of Alzheimer's disease (AD). In this meta-analytic review, we compared tissue levels between AD and non-AD brains of selenium, an important biological trace element well known for its vital role in the brain function. We included 14 studies with 40 observations on selenium concentrations in AD and control brains. The effect size as standardized mean difference (SMD) was generated using review manager 5.3. Random-effects meta-analysis indicated a decrease (SMD = - 0.42) in brain tissue selenium levels in AD as compared...
Source: Biological Trace Element Research - August 31, 2018 Category: Biology Authors: Varikasuvu SR, Prasad V S, Kothapalli J, Manne M Tags: Biol Trace Elem Res Source Type: research

Dietary Intakes of Calcium, Iron, Magnesium, and Potassium Elements and the Risk of Colorectal Cancer: a Meta-Analysis.
Abstract The purpose of this study was to analyze the existing studies and to investigate the relationship between the risk of colorectal cancer (CRC) and intakes of four individual dietary elements calcium (Ca), iron (Fe), magnesium (Mg), and potassium (K). All relevant articles in both Chinese and English were searched and collected from PubMed, Web of Science, and Chinese National Knowledge Infrastructure databases up to December 17, 2017. There were 29 eligible literatures selected for further meta-analysis, including 14 cohort studies and 15 case-control studies. The meta-analysis of cohort studies indicated ...
Source: Biological Trace Element Research - August 31, 2018 Category: Biology Authors: Meng Y, Sun J, Yu J, Wang C, Su J Tags: Biol Trace Elem Res Source Type: research

Effect of 4-Phenylbutyric Acid and Tauroursodeoxycholic Acid on Magnesium and Calcium Metabolism in Streptozocin-Induced Type 1 Diabetic Mice.
This study established and characterized a mouse model of type 1 diabetes (T1D) and investigated the effect of PBA and TUDCA on Mg2+ and Ca2+ metabolism in these mice. T1D was established in Friend virus B-type mice using multiple low doses of streptozotocin. Mice were administered chaperones. Mg2+and Ca2+ levels in tissues and serum were detected using acid digestion and ICP-MS. At 2 weeks and 2 months after chaperone administration was initiated, Mg2+ levels in the heart, liver, kidney, and serum and Ca2+ levels in spleen and serum of T1D mice were significantly decreased compared with controls; Ca2+ levels in ...
Source: Biological Trace Element Research - August 31, 2018 Category: Biology Authors: Zhou Q, Guo W, Jia Y, Xu J Tags: Biol Trace Elem Res Source Type: research

Serum Cesium, Rhenium, and Rubidium in Rheumatoid Arthritis Patients.
Abstract A considerable attention has been focused on the possible association between ultra-trace elements (UTEs) status and pathogenesis of many diseases including rheumatoid arthritis (RA). UTEs have important roles in numerous metabolic processes. Serum Cs, Rb, and Re levels in RA are not studied previously. The correlation of serum Cs, Rb, and Re levels with the well-known serological parameters, anticyclic citrullinated protein antibody (ACPA), C-reactive protein (CRP), ESR, and rheumatoid factor (RF) is also not studied previously. The present study aimed to measure the level and the correlation between ser...
Source: Biological Trace Element Research - August 31, 2018 Category: Biology Authors: Al-Hakeim HK, Moustafa SR, Jasem KM Tags: Biol Trace Elem Res Source Type: research

A Spatial Ecology Study of Keshan Disease and Hair Selenium.
Abstract Few spatial ecological studies on hair selenium (Se) and Keshan disease (KD) have been reported. To investigate the relationships of hair Se with KD and economic indicators and to visualize the evidence for KD precise prevention. An ecological study design was employed. The levels of hair Se of 636 adult men (≥ 18 years old) living in rural, general cities and developed cities in 15 KD endemic provinces and 11 KD non-endemic provinces in mainland China were measured using hydride generation atomic fluorescence spectrometry. Spatial description and spatial analysis of hair Se were conducted....
Source: Biological Trace Element Research - August 31, 2018 Category: Biology Authors: Zhang X, Wang T, Li S, Ye C, Hou J, Li Q, Liang H, Zhou H, Guo Z, Han X, Wang Z, Wu H, Gao X, Xu C, Zhen R, Chen X, Duan Y, Wang Y, Han S Tags: Biol Trace Elem Res Source Type: research

Spatial Variation of Human Selenium in Ethiopia.
Abstract Selenium is an important nutrient for humans and livestock. Soil selenium concentration in the world is highly variable; deficiency and toxicity occur in populations living short distance apart. Knowledge of Se concentrations in humans and the environments, especially because the range for toxicity and deficiency is narrow, is important for effective intervention. Dietary data and serum samples were collected from children (n = 555) 69-78 months old from rural villages of the Amhara Region, Ethiopia. In addition, information on the socio-demography of households was collected. Serum Se ...
Source: Biological Trace Element Research - August 30, 2018 Category: Biology Authors: Gashu D, Marquis GS, Bougma K, Stoecker BJ Tags: Biol Trace Elem Res Source Type: research

Protective Role of Selenium Against Hemolytic Anemia Is Mediated Through Redox Modulation.
In conclusion, dietary Se supplementation protected the RBCs against hemolysis by mitigating ROS-mediated oxidative stress. PMID: 30151563 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - August 27, 2018 Category: Biology Authors: Kaur R, Ghanghas P, Rastogi P, Kaushal N Tags: Biol Trace Elem Res Source Type: research

Sodium Arsenite Injection Induces Ovarian Oxidative Stress and Affects Steroidogenesis in Rats.
Abstract Oxidative stress is involved in the regulation of mammalian reproduction. The present study was conducted to detect the sodium arsenite-induced oxidative stress and alterations in the structure and steroidogenesis in rat ovary. Twenty female adult rats were injected i.p. with sodium arsenite (8 mg/kg BW, T) or 0.9% saline (C) for 16 days. The oxidative stress indexes and morphology of the liver, kidney, and ovary were detected using commercial kits and HE staining, respectively. The serum progesterone and estradiol were detected by RIA, and the ovarian steroidogenic gene expressions were detecte...
Source: Biological Trace Element Research - August 27, 2018 Category: Biology Authors: Yu H, Kuang M, Wang Y, Rodeni S, Wei Q, Wang W, Mao D Tags: Biol Trace Elem Res Source Type: research

Heavy Metal Levels and Mineral Nutrient Status of Natural Walnut (Juglans regia L.) Populations in Kyrgyzstan: Nutritional Values of Kernels.
In this study, mineral nutrient and heavy metal (Al, Ca, Cd, Cu, Fe, K, Mg, Mn, Na, Ni, Pb, and Zn) contents of the walnut kernels and their co-located soil samples collected from the four different zones of natural walnut forests (Sary-Chelek, Arslanbap, and Kara-Alma in Jalal-Abad Region and Kara-Shoro in Osh Region) in Kyrgyzstan were investigated. The highest concentrations for all elements determined in the soil samples were observed in the Sary-Chelek zone whereas the Arslanbap zone was found to be having the lowest concentrations except Fe and Zn. The highest concentrations in the kernels of walnut samples were...
Source: Biological Trace Element Research - August 27, 2018 Category: Biology Authors: Ozyigit II, Uras ME, Yalcin IE, Severoglu Z, Demir G, Borkoev B, Salieva K, Yucel S, Erturk U, Solak AO Tags: Biol Trace Elem Res Source Type: research

Reference Range and Sociodemographic Characteristics of TSH among Reproductive Age Women in Rural China.
Abstract Appropriate reference range of thyroid-stimulating hormone (TSH) is important to interpreting the results of thyroid functional tests. However, the reference range and sociodemographic characteristics of TSH based on large-scale studies are yet to be declared in rural China. To clarify reference range and sociodemographic characteristics of TSH in reproductive age of women from rural China. A nationwide population-based study was conducted as The National Free Preconception Health Examination Project (NFPHEP). Nearly 400,000 (n = 392,659) of Chinese rural women aged 15-55 years were ran...
Source: Biological Trace Element Research - August 25, 2018 Category: Biology Authors: Su Q, Zhang S, Hu M, Wang Q, Liu N, Shen H, Zhang Y, Zhang M Tags: Biol Trace Elem Res Source Type: research

Assessment of 12 Metals and Metalloids in Blood of General Populations Living in Wuhan of China by ICP-MS.
Abstract Assessment of trace element levels in general population from the specific area is of importance for nutritional and occupational monitoring. In the current study, baseline blood levels of 12 toxic and/or essential metals and metalloids, including arsenic (As), cadmium (Cd), lead (Pb), mercury (Hg), chromium (Cr), thallium (Tl), manganese (Mn), copper (Cu), Zinc (Zn), calcium (Ca), iron (Fe), and magnesium (Mg), in general populations (n = 477) of Wuhan in central China were investigated by using inductively coupled plasma mass spectrometry (ICP-MS). The geometric means for As, Cd, Pb, Hg, C...
Source: Biological Trace Element Research - August 23, 2018 Category: Biology Authors: Zeng HL, Li H, Lu J, Guan Q, Cheng L Tags: Biol Trace Elem Res Source Type: research