Role of PERK-Mediated Endoplasmic Reticulum Stress in Ferroptosis Caused by Hexavalent Chromium in Chicken Hepatocytes
In conclusion, Cr(VI) can induce ferroptosis in chicken hepatocytes, and PERK plays an important role as a negative regulator.PMID:38183555 | DOI:10.1007/s12011-023-04046-8 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 6, 2024 Category: Biology Authors: Yukun Cui Pu Zhang Kaimin Song Changxi Qi Yongxia Liu Jianzhu Liu Source Type: research

Serum and Seminal Plasma Levels of Lead and Arsenic in Cigarette Smokers and Their Relation to the Semen Parameters
Biol Trace Elem Res. 2024 Jan 5. doi: 10.1007/s12011-023-04039-7. Online ahead of print.ABSTRACTMale infertility along with altered semen parameters have been related to smoking. Smoking-related elevations in serum and seminal lead (Pb) and arsenic (As) may play a role in mediating the toxic effects of smoking on seminogram. This research aims to determine whether smoking has any significant impact on Pb and As levels in the seminal plasma and serum, as well as on the various semen parameters, when compared to nonsmokers. In total, 80 adult males were included: 60 smokers and 20 age-matched nonsmokers. Based on the number ...
Source: Biological Trace Element Research - January 5, 2024 Category: Biology Authors: Azza Gaber Antar Farag Eman Abd-Elfatah Badr Alaa Osama Ali Kholif Mostafa Nabil Khalifa Mai Medhat Mohamed Ghanem Source Type: research

Upregulation of Intracellular Zinc Ion Level after Differentiation of the Neural Stem/Progenitor Cells In Vitro with the Changes in Gene Expression of Zinc Transporters
Biol Trace Elem Res. 2024 Jan 5. doi: 10.1007/s12011-023-04033-z. Online ahead of print.ABSTRACTWe measured the intracellular zinc ion concentration of murine fetal neural stem/progenitor cells (NSPCs) and that in the differentiated cells. The NSPCs cultured with 1.5 μM Zn2+ proliferated slightly faster than that in the zinc-deficient medium and the intracellular zinc concentration of the NSPCs and that of their differentiated cells (DCs) cultured with 1.5 μM Zn2+ was 1.34-fold and 2.00-fold higher than those in the zinc-deficient medium, respectively. The zinc transporter genes upregulated over the 3.5-fold change were ...
Source: Biological Trace Element Research - January 5, 2024 Category: Biology Authors: Hideki Mori Akari Goji Masayuki Hara Source Type: research

Serum and Seminal Plasma Levels of Lead and Arsenic in Cigarette Smokers and Their Relation to the Semen Parameters
Biol Trace Elem Res. 2024 Jan 5. doi: 10.1007/s12011-023-04039-7. Online ahead of print.ABSTRACTMale infertility along with altered semen parameters have been related to smoking. Smoking-related elevations in serum and seminal lead (Pb) and arsenic (As) may play a role in mediating the toxic effects of smoking on seminogram. This research aims to determine whether smoking has any significant impact on Pb and As levels in the seminal plasma and serum, as well as on the various semen parameters, when compared to nonsmokers. In total, 80 adult males were included: 60 smokers and 20 age-matched nonsmokers. Based on the number ...
Source: Biological Trace Element Research - January 5, 2024 Category: Biology Authors: Azza Gaber Antar Farag Eman Abd-Elfatah Badr Alaa Osama Ali Kholif Mostafa Nabil Khalifa Mai Medhat Mohamed Ghanem Source Type: research

Upregulation of Intracellular Zinc Ion Level after Differentiation of the Neural Stem/Progenitor Cells In Vitro with the Changes in Gene Expression of Zinc Transporters
Biol Trace Elem Res. 2024 Jan 5. doi: 10.1007/s12011-023-04033-z. Online ahead of print.ABSTRACTWe measured the intracellular zinc ion concentration of murine fetal neural stem/progenitor cells (NSPCs) and that in the differentiated cells. The NSPCs cultured with 1.5 μM Zn2+ proliferated slightly faster than that in the zinc-deficient medium and the intracellular zinc concentration of the NSPCs and that of their differentiated cells (DCs) cultured with 1.5 μM Zn2+ was 1.34-fold and 2.00-fold higher than those in the zinc-deficient medium, respectively. The zinc transporter genes upregulated over the 3.5-fold change were ...
Source: Biological Trace Element Research - January 5, 2024 Category: Biology Authors: Hideki Mori Akari Goji Masayuki Hara Source Type: research

Serum and Seminal Plasma Levels of Lead and Arsenic in Cigarette Smokers and Their Relation to the Semen Parameters
Biol Trace Elem Res. 2024 Jan 5. doi: 10.1007/s12011-023-04039-7. Online ahead of print.ABSTRACTMale infertility along with altered semen parameters have been related to smoking. Smoking-related elevations in serum and seminal lead (Pb) and arsenic (As) may play a role in mediating the toxic effects of smoking on seminogram. This research aims to determine whether smoking has any significant impact on Pb and As levels in the seminal plasma and serum, as well as on the various semen parameters, when compared to nonsmokers. In total, 80 adult males were included: 60 smokers and 20 age-matched nonsmokers. Based on the number ...
Source: Biological Trace Element Research - January 5, 2024 Category: Biology Authors: Azza Gaber Antar Farag Eman Abd-Elfatah Badr Alaa Osama Ali Kholif Mostafa Nabil Khalifa Mai Medhat Mohamed Ghanem Source Type: research

Upregulation of Intracellular Zinc Ion Level after Differentiation of the Neural Stem/Progenitor Cells In Vitro with the Changes in Gene Expression of Zinc Transporters
Biol Trace Elem Res. 2024 Jan 5. doi: 10.1007/s12011-023-04033-z. Online ahead of print.ABSTRACTWe measured the intracellular zinc ion concentration of murine fetal neural stem/progenitor cells (NSPCs) and that in the differentiated cells. The NSPCs cultured with 1.5 μM Zn2+ proliferated slightly faster than that in the zinc-deficient medium and the intracellular zinc concentration of the NSPCs and that of their differentiated cells (DCs) cultured with 1.5 μM Zn2+ was 1.34-fold and 2.00-fold higher than those in the zinc-deficient medium, respectively. The zinc transporter genes upregulated over the 3.5-fold change were ...
Source: Biological Trace Element Research - January 5, 2024 Category: Biology Authors: Hideki Mori Akari Goji Masayuki Hara Source Type: research

Sodium Selenite Prevents Matrine-Induced Nephrotoxicity by Suppressing Ferroptosis via the GSH-GPX4 Antioxidant System
Biol Trace Elem Res. 2024 Jan 4. doi: 10.1007/s12011-023-04044-w. Online ahead of print.ABSTRACTMatrine (MT), an active ingredient derived from Sophor flavescens Ait, is used as a therapeutic agent to treat liver disease and cancer. However, the serious toxic effects of MT, including nephrotoxicity, have limited its clinical application. Here, we explored the involvement of ferroptosis in MT-induced kidney injury and evaluated the potential efficacy and underlying mechanism of sodium selenite (SS) in attenuating MT-induced nephrotoxicity. We found that MT not only disrupts renal structure in mice but also induces the death...
Source: Biological Trace Element Research - January 4, 2024 Category: Biology Authors: Xi Wang Zixiong Lin Ting Li Wenjing Zhu Hanxin Huang Jiayan Hu Jie Zhou Source Type: research

Ortho-silicic Acid Prevents Glucocorticoid-Induced Femoral Head Necrosis by Promoting Akt Phosphorylation to Inhibit Endoplasmic Reticulum Stress-Mediated Apoptosis and Enhance Angiogenesis and Osteogenesis
We examined the influence of ortho-silicic acid (OSA, Si(OH)4) on the apoptosis and proliferation of vascular endothelial cells after glucocorticoid induction. Additionally, we evaluated the expression of apoptosis-related genes such as cleaved-caspase-3, Bcl-2 and Bax. The impact of glucocorticoids and OSA on the function of vascular endothelial cells was evaluated through wound healing, transwell and angiogenesis assays. Osteogenic function was subsequently evaluated through alizarin red staining, alkaline phosphatase staining and expression levels of osteogenic genes like RUNX2 and ALP. Moreover, we investigated the pot...
Source: Biological Trace Element Research - January 4, 2024 Category: Biology Authors: Zhenqian Sun Jian Wang Zhongjie Ji Jinlong Ma Yunzhen Chen Guangjun Jiao Source Type: research

The Correlation Between Serum Copper and Non-alcoholic Fatty Liver Disease in American Adults: an Analysis Based on NHANES 2011 to 2016
Biol Trace Elem Res. 2024 Jan 3. doi: 10.1007/s12011-023-04029-9. Online ahead of print.ABSTRACTCopper functions as an essential micronutrient influencing diverse metabolic processes in mammals, encompassing oxidative stress responses, lipid metabolism, and participation in enzymatic reactions. However, the impact of serum copper on non-alcoholic fatty liver disease (NAFLD) remains controversial. Our aim was to explore the precise correlation between serum copper and NAFLD in a large-scale population-based study. A total of 1377 participants from the National Health and Nutrition Examination Survey (NHANES) 2011-2016 were ...
Source: Biological Trace Element Research - January 3, 2024 Category: Biology Authors: Lurao Li Yun Yi Xiawen Shu Jianghui Li Hui Kang Ying Chang Source Type: research

Correction: Melatonin Attenuates Arsenic-Induced Neurotoxicity in Rats through the Regulation of miR-34a/miR-144 in Sirt1/Nrf2 Pathway
Biol Trace Elem Res. 2024 Jan 3. doi: 10.1007/s12011-023-04051-x. Online ahead of print.NO ABSTRACTPMID:38170428 | DOI:10.1007/s12011-023-04051-x (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 3, 2024 Category: Biology Authors: Nahid Najafi Samira Barangi Zahra Moosavi Seyed Hamid Aghaee-Bakhtiari Soghra Mehri Gholamreza Karimi Source Type: research

A Meta-Analysis of the Prevalence of Children Goiter in High Water Iodine Areas of China
Biol Trace Elem Res. 2024 Jan 3. doi: 10.1007/s12011-023-04035-x. Online ahead of print.ABSTRACTAlthough there are now a large number of studies confirming that high iodine levels can cause goiter, there is controversy and a lack of quantitative data. A systematic search of PubMed, Web of Science, China National Knowledge Infrastructure, Wanfang Database, and China Biomedical Database for literature on high iodine and goiter in children was performed with a time limit from January 2013 to October 2023. After screening the literature based on the inclusion criteria, extracting the literature data, and evaluating the risk of...
Source: Biological Trace Element Research - January 3, 2024 Category: Biology Authors: Zhilei Xing Siyu Liu Peisen Ding Xiaomeng Yu Jiahui Song Huajun Sun Yushan Cui Hongliang Liu Source Type: research

The Correlation Between Serum Copper and Non-alcoholic Fatty Liver Disease in American Adults: an Analysis Based on NHANES 2011 to 2016
Biol Trace Elem Res. 2024 Jan 3. doi: 10.1007/s12011-023-04029-9. Online ahead of print.ABSTRACTCopper functions as an essential micronutrient influencing diverse metabolic processes in mammals, encompassing oxidative stress responses, lipid metabolism, and participation in enzymatic reactions. However, the impact of serum copper on non-alcoholic fatty liver disease (NAFLD) remains controversial. Our aim was to explore the precise correlation between serum copper and NAFLD in a large-scale population-based study. A total of 1377 participants from the National Health and Nutrition Examination Survey (NHANES) 2011-2016 were ...
Source: Biological Trace Element Research - January 3, 2024 Category: Biology Authors: Lurao Li Yun Yi Xiawen Shu Jianghui Li Hui Kang Ying Chang Source Type: research

Correction: Melatonin Attenuates Arsenic-Induced Neurotoxicity in Rats through the Regulation of miR-34a/miR-144 in Sirt1/Nrf2 Pathway
Biol Trace Elem Res. 2024 Jan 3. doi: 10.1007/s12011-023-04051-x. Online ahead of print.NO ABSTRACTPMID:38170428 | DOI:10.1007/s12011-023-04051-x (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 3, 2024 Category: Biology Authors: Nahid Najafi Samira Barangi Zahra Moosavi Seyed Hamid Aghaee-Bakhtiari Soghra Mehri Gholamreza Karimi Source Type: research

Selenium Deficiency Can Promote the Expression of VEGF and Inflammatory Factors in Cartilage Differentiation and Mediates Cartilage Injury
Biol Trace Elem Res. 2023 Dec 30. doi: 10.1007/s12011-023-04003-5. Online ahead of print.ABSTRACTSelenium plays a crucial role as a micronutrient, primarily exerting its biological functions through selenoproteins. It has been established that selenium deficiency adversely impacts cartilage development, leading to alterations in chondrocyte function. In regions with low selenium intake, endemic osteochondrosis has been documented, characterized by compromised growth plate and articular cartilage formation. Vascular endothelial growth factor (VEGF) stands out as a pivotal angiogenic factor, with elevated levels contributing...
Source: Biological Trace Element Research - December 30, 2023 Category: Biology Authors: Xiang Meng Xiumei Meng Zeju He Ye Yuan Yong Fan Li Yin Yu Tong Zheping Hong Senbo Zhu Qiong Zhang Qing Bi Source Type: research