Graphite Furnace Atomic Absorption Spectrometric Evaluation of Iron Excretion in Mouse Urine Caused by Whole-Body Gamma Irradiation.
Abstract A procedure for the determination of iron in mice urine using graphite furnace atomic absorption spectrometry was developed. The mice urinary samples contain many organic compounds in the matrix, whose concentrations are approximately 20%, and the value is 30-fold higher compared to those found in human urine. Moreover, only 0.2 mL or less of urine was obtained as a sample volume per urination event. It was difficult to decompose the organic materials in the samples by wet digestion using mineral acids and oxidising agents, because of the tiny volumes. In this experiment, raw urinary samples were pla...
Source: Biological Trace Element Research - November 30, 2018 Category: Biology Authors: Yoshiyama M, Okamoto Y, Izumi S, Iizuka D Tags: Biol Trace Elem Res Source Type: research

Prenatal and Early Postnatal Exposure to Total Mercury and Methylmercury from Low Maternal Fish Consumption.
Abstract The aim of this study was to investigate the influence of low fish consumption on prenatal and early postnatal exposure to mercury species. The samples of umbilical cord blood and maternal milk as well as interviewer-administered questionnaires were collected from 142 Slovak mother-child pairs. The mean total mercury (THg) concentrations in cord blood and milk were 0.949 μg/L and 0.376 μg/kg, respectively. The mean methylmercury (MeHg) concentration in cord blood was 0.504 μg/L. Fish eaters had significantly higher cord blood MeHg concentrations than non-fish eaters (p =&thi...
Source: Biological Trace Element Research - November 29, 2018 Category: Biology Authors: Ursinyova M, Masanova V, Uhnakova I, Murinova LP, Patayova H, Rausova K, Trnovec T, Stencl J, Gajdos M Tags: Biol Trace Elem Res Source Type: research

Ascorbic Acid Supplementation Prevents the Detrimental Effects of Prenatal and Postnatal Lead Exposure on the Purkinje Cell and Related Proteins in the Cerebellum of Developing Rats.
Abstract We investigated the effects of lead (Pb) and ascorbic acid co-administration on rat cerebellar development. Prior to mating, rats were randomly divided into control, Pb, and Pb plus ascorbic acid (PA) groups. Pregnant rats were administered Pb in drinking water (0.3% Pb acetate), and ascorbic acid (100 mg/kg) via oral intubation until the end of the experiment. Offspring were sacrificed at postnatal day 21, the age at which the morphology of the cerebellar cortex in developing pups is similar to that of the adult brain. In the cerebellum, Pb exposure significantly reduced Purkinje cells and ascorbic ...
Source: Biological Trace Element Research - November 28, 2018 Category: Biology Authors: Nam SM, Seo JS, Go TH, Nahm SS, Chang BJ Tags: Biol Trace Elem Res Source Type: research

Ethanol Exacerbates Manganese-Induced Neurobehavioral Deficits, Striatal Oxidative Stress, and Apoptosis Via Regulation of p53, Caspase-3, and Bax/Bcl-2 Ratio-Dependent Pathway.
This study investigated the effects of ethanol (EtOH) on manganese (Mn)-induced striatal toxicity in rat by evaluating the neurobehavioral changes, biochemical and molecular events in rats exposed to Mn alone at 30 mg/kg, or their combination with EtOH at 1.25- and 5-g/kg body weight for 35 consecutive days. Locomotive and exploratory profiles were assessed using a video tracking software (ANY-Maze software) during a 5-min trial in a novel environment. Subsequently, acetylcholinesterase (AChE) activity, oxidative stress markers, histological morphology, and expression of apoptotic proteins (p53 and Bax and caspase-3) ...
Source: Biological Trace Element Research - November 28, 2018 Category: Biology Authors: Nkpaa KW, Awogbindin IO, Amadi BA, Abolaji AO, Adedara IA, Wegwu MO, Farombi EO Tags: Biol Trace Elem Res Source Type: research

The Problematic Use of Dietary Reference Intakes to Assess Magnesium Status and Clinical Importance.
Abstract Determination of the public health concern about magnesium (Mg) in health and disease has been confounded by the lack of a practical measure of status. This has resulted in a lack of consistency in associating Mg deficiency with specific pathological conditions. Some attempts at associating Mg with a chronic disease have used the Dietary Reference Intakes (DRIs) as a status assessment measure. Use of current DRIs for Mg is problematic because recent evidence suggests that they should be updated and based on body weight. An evidence-based suggested Estimated Average Requirement (EAR) and Recommended D...
Source: Biological Trace Element Research - November 27, 2018 Category: Biology Authors: Nielsen FH Tags: Biol Trace Elem Res Source Type: research

The Study on Polymorphism of TrxR and Nrf2/HO-1 Signaling Pathway in Kaschin-Beck Disease.
Abstract Kaschin-Beck disease (KBD) is an endemic, chronic, and degenerative osteoarthropathy, which seriously impairs the quality of patients' life. We detected the expression of TrxR by ELISA and found that TrxR was lower in KBD than in normal control group significantly (P 
Source: Biological Trace Element Research - November 24, 2018 Category: Biology Authors: Li Y, Mo X, Xiong Y Tags: Biol Trace Elem Res Source Type: research

The Impact of Trace Minerals on Bone Metabolism.
Abstract Bone is a metabolically active tissue that responds to alterations in dietary intake and nutritional status. It is ~ 35% protein, mostly collagen which provides an organic scaffolding for bone mineral. The mineral is the remaining ~ 65% of bone tissue and composed mostly of calcium and phosphate in a form that is structurally similar to mineral within the apatite group. The skeletal tissue is constantly undergoing turnover through resorption by osteoclasts coupled with formation by osteoblasts. In this regard, the overall bone balance is determined by the relative contribution of each of the...
Source: Biological Trace Element Research - November 23, 2018 Category: Biology Authors: Gaffney-Stomberg E Tags: Biol Trace Elem Res Source Type: research

Neural Differentiation of Mouse Neural Stem Cells as a Tool to Assess Developmental Neurotoxicity of Drinking Water in Taihu Lake.
In this study, we used neural stem cells (NSCs) as a toxicology tool to assess the potential developmental neurotoxicity of drinking water from Taihu Lake. We found that the condensed drinking water could inhibit the proliferation and differentiation of NSCs, especially the tap water. Inductively coupled plasma mass spectrometry and high-performance liquid chromatography analysis showed that nickel was detected in the tap water with a high concentration. Our study revealed that nickel could inhibit NSCs proliferation and differentiation, which is induced not only by the intracellular reactive oxygen species generation, but...
Source: Biological Trace Element Research - November 22, 2018 Category: Biology Authors: Zhou Y, Fu Y, Bai Z, Li P, Zhao B, Han Y, Xu T, Zhang N, Lin L, Cheng J, Zhang J, Zhang J Tags: Biol Trace Elem Res Source Type: research

Pharmacokinetics of Sodium Selenite Administered Orally in Blood and Tissues of Selenium-Deficient Ducklings.
Abstract Selenium (Se) is an essential trace element for humans and animals. Appropriate amount of Se in the body can prevent a variety of diseases. However, Se deficiency leads to pathological changes such as skeletal muscle necrosis and pancreatic atrophy in livestock and poultry. Se preparations are widely used in the prevention and treatment of Se-deficient disease, but there is no unified standard of medication, and the safe dose range of Se is narrow. Therefore, it is of great significance to study the pharmacokinetics of low-Se ducklings and to formulate drug administration schemes. In the present study, ei...
Source: Biological Trace Element Research - November 22, 2018 Category: Biology Authors: Zheng S, Xing H, Zhang Q, Xue H, Zhu F, Xu S Tags: Biol Trace Elem Res Source Type: research

Hair Trace Element Levels in Han and Indigenous Hualien Inhabitants in Taiwan.
The objective of the present study was to assess the impact of ethnicity on hair trace element content in Han and aboriginal inhabitants of Hualien in Taiwan. Fifty Han (female/male = 35/15) and 50 aboriginal (female/male = 40/10) Hualien inhabitants aged 40-60 years were involved in the present study. Anthropometric data and dietary patterns were recorded. Hair mineral, essential, and toxic trace element levels were assessed using inductively coupled plasma mass spectrometry at NexION 300D (PerkinElmer Inc., USA) equipped with ESI SC-2 DX4 autosampler (Elemental Scientific Inc., USA). No g...
Source: Biological Trace Element Research - November 21, 2018 Category: Biology Authors: Skalny AV, Mona W, Kao R, Skalnaya MG, Huang PT, Wu CC, Ajsuvakova OP, Skalnaya OA, Tinkov AA Tags: Biol Trace Elem Res Source Type: research

Associations of Internal-Migration Status with Maternal Exposure to Stress, Lead, and Selenium Deficiency Among Pregnant Women in Shanghai, China.
This study aims to explore the association of internal-migration status with maternal exposure to lead, low selenium, and stress among pregnant women. A total of 1931 pregnant women were investigated in 2010. The internal-migration status was grouped based on their hukou (registered residence) and length-of-residency in Shanghai. Maternal blood lead and serum selenium concentrations were assessed. Life event stress and emotional stress were evaluated using "Event-Stress-Scale-for-Pregnant-Women" and "Symptom-Checklist-90-R-Scale" (SCL-90-R), respectively. Logistic regression and general linear models we...
Source: Biological Trace Element Research - November 21, 2018 Category: Biology Authors: Jiang S, Yang B, Xu J, Liu Z, Yan C, Zhang J, Li S, Shen X Tags: Biol Trace Elem Res Source Type: research

The Protective Effect of α-Tocopherol on the Content of Selected Elements in the Calvaria for Exposed Hens to TCDD in the Early Embryonic Period.
The Protective Effect of α-Tocopherol on the Content of Selected Elements in the Calvaria for Exposed Hens to TCDD in the Early Embryonic Period. Biol Trace Elem Res. 2018 Nov 21;: Authors: Dobrzynski M, Kuropka P, Tarnowska M, Styczynska M, Dudek K, Leskow A, Targonska S, Wiglusz RJ Abstract This paper focuses on negative effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on element content in male chicken calvaria and α-tocopherol (vitamin E) ability to reduce its toxic potential on bone mineralization in offspring. In the experiment carried out once, a solution containing only DMSO, ...
Source: Biological Trace Element Research - November 21, 2018 Category: Biology Authors: Dobrzynski M, Kuropka P, Tarnowska M, Styczynska M, Dudek K, Leskow A, Targonska S, Wiglusz RJ Tags: Biol Trace Elem Res Source Type: research

Investigating the Essentiality and Requirements of Iron from the Ancient to the Present.
Abstract This review discusses the development of studies that evaluated the essentiality and requirements of iron from the ancient to the present. The therapeutic effects of iron compounds were recognized by the ancient Greeks and Romans. The earliest recognition of the essentiality of iron was stated by Paracelsus, a distinguished physician alchemist, in the sixteenth century. Iron was included in the earliest nutritional standard prepared for the Royal Army by E. A. Parkes, the first professor of hygiene. The League of Nations Health Organisation determined average iron requirements based on literature review. ...
Source: Biological Trace Element Research - November 21, 2018 Category: Biology Authors: Yokoi K Tags: Biol Trace Elem Res Source Type: research

Increased Iron Availability Aggravates the Infection of Escherichia coli O157:H7 in Mice.
Abstract Iron plays an important role both in bacterial pathogenicity and in host defense mechanisms, which has frequently been underestimated. The primary purpose of this study was to investigate the influence of iron supplementation on the progression of bacterial infection. We used mice as an experimental model to supplement iron after Escherichia coli (E. coli) O157:H7 infection and found that iron supplementation exacerbated clinical symptoms of bacterial infection by increasing mortality and reducing body weight. Iron supplementation promoted the colonization of bacteria and enhanced inflammatory responses b...
Source: Biological Trace Element Research - November 19, 2018 Category: Biology Authors: Yu X, Gan Z, Wang Z, Tang X, Guo B, Du H Tags: Biol Trace Elem Res Source Type: research

Health Risks Associated with Heavy Metals in Imported Fish in a Coastal City in Colombia.
o-Negrete J Abstract Colombia is a fish exporter and consumer country because of its geographical location. Since 2012, imported fish have become a more economical option than domestic species due to free trade agreements. Concentrations of Pb, Cd, and Zn were evaluated in three imported and highly commercialized fish species in a city on the Caribbean coast of Colombia: Prochilodus lineatus, Prochilodus reticulatus, and Pangasianodon hypophthalmus, plus one brand of canned tuna and one brand of sardines. The canned species showed the highest values for Pb, Cd, and Zn; canned tuna (oil-packed) contained 0.189&thin...
Source: Biological Trace Element Research - November 17, 2018 Category: Biology Authors: Herrera-Herrera C, Fuentes-Gandara F, Zambrano-Arévalo A, Higuita FB, Hernández JP, Marrugo-Negrete J Tags: Biol Trace Elem Res Source Type: research

Oxidative Stress and Genomic Damage Induced In Vitro in Human Peripheral Blood by Two Preventive Treatments of Iron Deficiency Anemia.
Abstract Iron deficiency is the most prevalent nutritional deficiency and the main cause of anemia worldwide. Since children aged 6-24 months are among the most vulnerable groups at risk, daily supplementation with ferrous sulfate is recommended by the Argentine Society of Pediatrics as preventive treatment of anemia. However, a single weekly dose would have fewer adverse side effects and has been therefore proposed as an alternative treatment. Ferrous sulfate is known by its pro-oxidative properties, which may lead to increased oxidative stress as well as lipid, protein, and DNA damage. We analyzed the effec...
Source: Biological Trace Element Research - November 15, 2018 Category: Biology Authors: Gambaro RC, Seoane A, Padula G Tags: Biol Trace Elem Res Source Type: research

Stress Responses Against Rare Earth Ions Are Mediated by the JNK and p38 MAPK Pathways in Caenorhabditis elegans.
In this study, we found that both JNK- and p38-like MAPK pathways were involved in stress responses against RE. Unlike heavy metal responses, mutations in both the JNK and p38 pathways caused similar hypersensitivity to RE ions. Although the signaling pathways used for these stress responses were found to be similar, the degree of their respective contribution slightly differed between heavy metal and RE ions. PMID: 30443708 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - November 15, 2018 Category: Biology Authors: Wakabayashi T, Nakano Y Tags: Biol Trace Elem Res Source Type: research

Systematic Review of the Effects of Chromium(III) on Chickens.
Abstract Chromium supplementation has been proposed to have beneficial effects in farm animals, particularly when under stress. The last two decades, in particular, have seen an emphasis on examining the effects of supplemental chromium on a variety of variables in chicks and chickens. Thus, given the recent approval of a Cr(III) compound for use in chicken feed in the United States and the recent surge in papers on the use of Cr in chicken feed, the need for a systematic review of studies utilizing chickens is extremely urgent and timely. With the exception of studies on cold-stressed laying hens, the results of ...
Source: Biological Trace Element Research - November 14, 2018 Category: Biology Authors: White PE, Vincent JB Tags: Biol Trace Elem Res Source Type: research

The Combined Effects of Cr(III) Supplementation and Iron Deficiency on the Copper and Zinc Status in Wistar Rats.
Abstract The aim of the study was to assess the combined effects of chromium(III) supplementation and iron deficiency on the copper (Cu) and zinc (Zn) status in female rats. The Cr, Fe, Cu and Zn dietary and tissular levels were measured by Atomic Absorption Spectrometry (AAS) method. The data show that chromium(III) supplementation compensated for the negative effects of Fe deficiency on the Cu content but it deepened the effect on Zn levels in the female rats. Detailed data on the status of trace elements and their interactions in healthy subjects and patients with metabolic disorders (e.g. anaemia, diabetes mel...
Source: Biological Trace Element Research - November 14, 2018 Category: Biology Authors: Staniek H Tags: Biol Trace Elem Res Source Type: research

Orthosilicic Acid Accelerates Bone Formation in Human Osteoblast-Like Cells Through the PI3K-Akt-mTOR Pathway.
In this study, we determined the possible osteogenesis-related mechanisms of orthosilicic acid at a molecular level. We detected the relevant pathway and osteogenic indicators by immunofluorescence (IF), Western blot, alkaline phosphatase (ALP) staining (using 5-bromo-4-chloro-3-indolyl phosphate/nitro blue tetrazolium [BCIP/NBT]), ALP enzyme labeling method, osteocalcin (OCN), and N-terminal propeptide of type 1 procollagen (P1NP) enzyme-linked immunosorbent assay (ELISA). We found that orthosilicic acid is capable of enhancing the expression of phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K), phospho-protein kinase...
Source: Biological Trace Element Research - November 12, 2018 Category: Biology Authors: Zhou H, Jiao G, Dong M, Chi H, Wang H, Wu W, Liu H, Ren S, Kong M, Li C, Zhang L, Chen Y Tags: Biol Trace Elem Res Source Type: research

Beneficial Effects of N-Acetyl-L-cysteine or Taurine Pre- or Post-treatments in the Heart, Spleen, Lung, and Testis of Hexavalent Chromium-Exposed Mice.
In this study, we probed the possible effects of N-acetyl-L-cysteine (NAC) and taurine pre- or post-treatments on Cr(VI)-induced changes in lipid peroxidation and nonprotein thiols (NPSH) in mice heart, lung, spleen, and testis tissues. The mice were randomly assigned to six groups, consisting of control, Cr(VI)-exposed (20 mg Cr/kg, intraperitoneal ,ip), NAC (200 mg/kg, ip) as pre-treatment and post-treatment, and taurine (1 g/kg, ip) pre-treatment and post-treatment groups. Lipid peroxidation and NPSH levels were determined and the results were compared with regard to tissue- and antioxidant-specific basis. Exp...
Source: Biological Trace Element Research - November 12, 2018 Category: Biology Authors: Boşgelmez Iİ, Güvendik G Tags: Biol Trace Elem Res Source Type: research

Effects of Dietary Organic, Inorganic, and Nanoparticulate Zinc on Rainbow Trout, Oncorhynchus mykiss Larvae.
Abstract The present study was conducted to investigate the effects of different dietary zinc sources on growth performance, survival, and body composition of larval rainbow trout, Oncorhynchus mykiss. A total of 3240 larvae with an average weight of 82.3 ± 11.6 mg were randomly divided into four groups by three replicates and were fed for 70 days. Organic zinc (Zn-proteinate, Bioplex Zn®), mineral zinc (ZnSO4), and nanoparticulate zinc (ZnO-NPs) were each added to the basal diet at 50-mg/kg diet. In all of the zinc-supplemented groups, final body weight (FBW) and weight gain (WG...
Source: Biological Trace Element Research - November 9, 2018 Category: Biology Authors: Shahpar Z, Johari SA Tags: Biol Trace Elem Res Source Type: research

Influence of Strontium on Vascular Endothelial Growth Factor and Fibroblast Growth Factor 2 Expression in Rat Chondrocytes Cultured In Vitro.
The objective of this study was to investigate the effects of different Sr concentrations on VEGF and FGF2 expressions in rat chondrocytes in vitro. Chondrocytes were isolated from Wistar rat articular by enzymatic digestion. As a Sr source, strontium chloride hexahydrate (SrCl2·6H2O) was added to the culture solution at final concentrations of 0, 0.5, 1.0, 2.0, 5.0, 20.0, and 100.0 μg/mL. After 72 h of continuous culture, mRNA abundance and protein expression levels of VEGF and FGF2 in the chondrocytes were determined by real-time polymerase chain reaction (real-time PCR) and Western blot, respectively...
Source: Biological Trace Element Research - November 9, 2018 Category: Biology Authors: Zhu X, Kong Y, Huang Y, Zhao B, Wang J Tags: Biol Trace Elem Res Source Type: research

Total Bioavailable Organic Selenium in Fishmeal-Based Diet Influences Growth and Physiology of Juvenile Cobia Rachycentron canadum (Linnaeus, 1766).
Abstract The study examined the effects of supplemental organic selenium (Se) extracted from selenoyeast on the growth performance, glutathione peroxidase (GPx) activity, biochemical status and liver histochemistry of juvenile cobia Rachycentron canadum. Six experimental diets were prepared supplemented with Se with total concentration of 1.52 (Se-1.52), 1.93 (Se-1.93), 2.29 (Se-2.29), 2.71 (Se-2.71) and 3.14 (Se-3.14) mg/kg of total Se in the diets and a fishmeal-based control diet without Se supplementation containing 1.15 (Se-1.15) mg/kg of Se was used as control. Experimental diets were fed to the fish of six ...
Source: Biological Trace Element Research - November 9, 2018 Category: Biology Authors: Pham HD, Siddik MAB, Fotedar R, Nguyen CM, Nahar A, Gupta SK Tags: Biol Trace Elem Res Source Type: research

GM1 Ameliorates Lead-Induced Cognitive Deficits and Brain Damage Through Activating the SIRT1/CREB/BDNF Pathway in the Developing Male Rat Hippocampus.
In conclusion, our study demonstrated that GM1 exerts a protective effect on lead-induced cognitive deficits via antioxidant activity, preventing apoptosis, and activating SIRT1/CREB/BDNF in the developing rat hippocampus, implying a novel potential assistant therapy for lead poisoning. PMID: 30414004 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - November 9, 2018 Category: Biology Authors: Chen F, Zhou CC, Yang Y, Liu JW, Yan CH Tags: Biol Trace Elem Res Source Type: research

Effect of Epigallo-Catechin-3-Gallate on Lipid Metabolism Related Gene Expression and Yolk Fatty Acid Profiles of Laying Hens Exposed to Vanadium.
Abstract As the understanding of the pathways involved in such effect are quite limited, we investigated the gene pathways that modulate lipid metabolism in layers and the fatty acid profiles of the yolk of layers that were challenged with dietary vanadium (V) and supplemented with epigallo-catechin-3-gallate (EGCG). For this purpose, a total of 120 hens were divided into four groups which were fed the following experimental diets for a period of 8 weeks: control (basal diet), V10 (control + 10 mg/kg V), EGCG130 (V10 + 130 mg/kg EGCG), and EGCG217 (V10 + 217 mg/kg EGCG). Blood total cholesterol...
Source: Biological Trace Element Research - November 7, 2018 Category: Biology Authors: Qiu LY, Wang JP, Pietro C, Zhang KY, Ding XM, Bai SP, Zeng QF, Peng HW Tags: Biol Trace Elem Res Source Type: research

Expression Profiles of Selenium-Related Genes in Human Chondrocytes Exposed to T-2 Toxin and Deoxynivalenol.
Abstract The combination of excess mycotoxin exposure and selenium deficiency has been widely considered as a cause of Kashin-Beck disease (KBD). The present study aimed to investigate the expression profiles of selenium-related genes in human chondrocytes after exposure to T-2 toxin and deoxynivalenol (DON) and to preliminarily identify the potential biological functions of the identified genes. Gene expression profiling was performed on human chondrocytes treated with 0.01 μg/ml T-2 toxin and 1.0 μg/ml DON by using Affymetrix Human Gene Arrays. The 1660 selenium-related genes were derived from th...
Source: Biological Trace Element Research - November 7, 2018 Category: Biology Authors: Yang L, Zhang J, Li X, Xu C, Wang X, Guo X Tags: Biol Trace Elem Res Source Type: research

The Protection of Selenium Against Cadmium-Induced Mitochondrial Damage via the Cytochrome P450 in the Livers of Chicken.
Abstract Cadmium (Cd) is a heavy metal in natural environment and has extreme toxicity. Selenium (Se) has protective effect against heavy metal-induced injury or oxidative stress. Cytochrome P450 (CYP450) enzymes are a family of hemoproteins primarily responsible for detoxification functions. In order to investigate whether CYP450 is related to the damage of livers caused by Cd exposure, we chose forty-eight 28-day-old healthy Hailan cocks for four groups: control group, Se group, Cd group, and Se + Cd group. After 90-day treatment, euthanized for experiment. Based on an established subchronic Cd poi...
Source: Biological Trace Element Research - November 3, 2018 Category: Biology Authors: Cong Y, Chi Q, Teng X, Li S Tags: Biol Trace Elem Res Source Type: research

Effects of Selenium Yeast in Combination with Boron on Muscle Growth and Muscle Quality in Broilers.
Abstract The effect of selenium yeast in combination with boron on both growth and quality of the muscle in broilers was investigated. A total of 600 one-day-old Arbor Acres broilers were randomly divided into five groups with 120 broilers per group (6 replicates per group). The control group received a basal diet, and experimental groups I-IV received the same basal diet supplemented with 0.3 mg/kg selenium yeast and different doses of boron (0, 5, 10, and 15 mg/kg, respectively). The experiment was conducted for 42 days. Breast and thigh muscles were harvested and muscle quality were examined on d...
Source: Biological Trace Element Research - November 3, 2018 Category: Biology Authors: Jin E, Hu Q, Ren M, Jin G, Liang L, Li S Tags: Biol Trace Elem Res Source Type: research

Role of Pigment Epithelium-Derived Factor in Arsenic-Induced Vascular Endothelial Dysfunction in a Rat Model.
Abstract Water-borne arsenicosis is caused by the consumption of excess levels of inorganic arsenic from drinking water and is a worldwide public health issue. Arsenic exposure has recently attracted extensive attention due to its damage to the cardiovascular system. Vascular endothelial dysfunction (VED) is recognized as an important cause of cardiovascular diseases. Pigment epithelium-derived factor (PEDF) plays an important role in maintaining endothelial function, and our previous studies suggested that PEDF may have role in arsenic-induced damage. In the present study, we established subchronic arsenic exposu...
Source: Biological Trace Element Research - November 3, 2018 Category: Biology Authors: Guo X, Fu X, Liu X, Wang J, Li Z, Gao L, Li Y, Zhang W Tags: Biol Trace Elem Res Source Type: research

Dietary Zinc-Amino Acid Complex Does Not Affect Markers of Mammary Epithelial Integrity or Heat Stability of Milk in Mid-Lactating Cows.
This study provided no evidence that supplemental Zn above the established requirements can improve blood-milk epithelial barrier or heat stability of milk in healthy mid-lactation dairy cows. PMID: 30382478 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - October 31, 2018 Category: Biology Authors: Shaffer JE, Mamedova LK, DeFrain JM, Pandalaneni K, Amamcharla JK, Takiya CS, Bradford BJ Tags: Biol Trace Elem Res Source Type: research

Is There Any Relevance Between Serum Heavy Metal Concentration and BBB Leakage in Multiple Sclerosis Patients?
Abstract Sharp increase in multiple sclerosis (MS) incidence rate has been observed in Iranian people. In addition, it has been suggested that increased S100B level may be useful as an indicative factor of blood-brain barrier disruption. The propose of this study was to measuring blood arsenic, lead, and cadmium concentration and serum S100B concentration in a group of healthy and multiple sclerosis patients in Tehran as the most polluted city in Iran. All subjects were interviewed regarding age, medical history, possible chemical exposure, acute or chronic diseases, smoking, and dietary habits. Blood heavy metal ...
Source: Biological Trace Element Research - October 27, 2018 Category: Biology Authors: Paknejad B, Shirkhanloo H, Aliomrani M Tags: Biol Trace Elem Res Source Type: research

The Variable Regulatory Effect of Arsenic on Nrf2 Signaling Pathway in Mouse: a Systematic Review and Meta-analysis.
Abstract Arsenic is known to cause oxidative damage. Nuclear factor E2-relate factor-2 (Nrf2) can resist this toxicity. Scholars demonstrated that Nrf2 pathway was activated by arsenic. In contrast, other articles established arsenic-induced inhibition of Nrf2 pathway. To resolve the contradiction and elucidate the mechanism of Nrf2 induced by arsenic, 39 publications involving mouse models were identified through exhaustive database retrieval and were analyzed. The pooled results suggested that arsenic obviously elevated transcription and translation levels of Nrf2 and its downstream genes, NAD(P)H dehydrogenase ...
Source: Biological Trace Element Research - October 25, 2018 Category: Biology Authors: Wang C, Niu Q, Ma R, Song G, Hu Y, Xu S, Li Y, Wang H, Li S, Ding Y Tags: Biol Trace Elem Res Source Type: research

Taurine Treatment Provides Neuroprotection in a Mouse Model of Manganism.
Abstract Manganese (Mn) is a trace element involved in many physiological processes. However, excessive Mn exposure leads to neurological complications. Although no precise mechanism(s) has been found for Mn-induced neurotoxicity, oxidative stress and mitochondrial injury seem to play a relevant role in this complication. On the other hand, there is no protective strategy against Mn neurotoxicity so far. Taurine is an amino acid with significant neuroprotective properties. The current study was designed to evaluate the effect of taurine supplementation and its potential mechanism(s) of action in a mouse model of m...
Source: Biological Trace Element Research - October 24, 2018 Category: Biology Authors: Ommati MM, Heidari R, Ghanbarinejad V, Abdoli N, Niknahad H Tags: Biol Trace Elem Res Source Type: research

Investigating the Bioaccessibility and Bioavailability of Cadmium in a Cooked Rice Food Matrix by Using an 11-Day Rapid Caco-2/HT-29 Co-culture Cell Model Combined with an In Vitro Digestion Model.
Abstract Investigating the bioaccessibility and bioavailability of Cd based on real contaminated cooked rice matrixes helps establish an accurate risk assessment method and effectively reduce the digestion and absorption of Cd. An 11-day in vitro rapid Caco-2/HT-29 co-culture cell model was used to establish and evaluate the simulation of the absorption and transport of Cd in the small intestine with a 70:30 Caco-2/HT-29 co-culture ratio and 1.0 mmol L-1 butyric acid as a differentiation inducer. The bioaccessibility and bioavailability of Cd in cooked rice were studied using the cell model combined with...
Source: Biological Trace Element Research - October 24, 2018 Category: Biology Authors: Lv Q, He Q, Wu Y, Chen X, Ning Y, Chen Y Tags: Biol Trace Elem Res Source Type: research

Vanadium in Biological Action: Chemical, Pharmacological Aspects, and Metabolic Implications in Diabetes Mellitus.
nzález-Vergara E Abstract Vanadium compounds have been primarily investigated as potential therapeutic agents for the treatment of various major health issues, including cancer, atherosclerosis, and diabetes. The translation of vanadium-based compounds into clinical trials and ultimately into disease treatments remains hampered by the absence of a basic pharmacological and metabolic comprehension of such compounds. In this review, we examine the development of vanadium-containing compounds in biological systems regarding the role of the physiological environment, dosage, intracellular interactions, metaboli...
Source: Biological Trace Element Research - October 22, 2018 Category: Biology Authors: Treviño S, Díaz A, Sánchez-Lara E, Sanchez-Gaytan BL, Perez-Aguilar JM, González-Vergara E Tags: Biol Trace Elem Res Source Type: research

The Fructoborates: Part of a Family of Naturally Occurring Sugar-Borate Complexes-Biochemistry, Physiology, and Impact on Human Health: a Review.
Abstract Sugar-borates (SBs) are mono- or di-sugar-borate esters (SBEs) comprised of one or two monosaccharide molecules linked to a boron (B) atom. SBEs occur naturally in commonly consumed herbs, vegetables, fruits, seeds, and nuts and, other than greatly varying levels of B found in local drinking water, are the primary natural dietary sources of B-containing molecules in humans. To date, the most studied SBE is calcium fructoborate (CaFB). CaFB represents an important example of how organic B-containing molecules are significantly distinct from their inorganic counterparts. During these past two decades, CaFB ...
Source: Biological Trace Element Research - October 20, 2018 Category: Biology Authors: Hunter JM, Nemzer BV, Rangavajla N, Biţă A, Rogoveanu OC, Neamţu J, Scorei IR, Bejenaru LE, Rău G, Bejenaru C, Mogoşanu GD Tags: Biol Trace Elem Res Source Type: research

Simultaneous Functionalization and Reduction of Magnetic Graphene Oxide by L-Histidine and its Application for Magnetic Separation/Preconcentration of Antioxidant Trace Elements.
Abstract In the present study, for the first time, the magnetic graphene oxide was simultaneously functionalized and reduced with the aim of imidazole-based L-histidine amino acid (rGO/Fe3O4-histidine). The prepared nanocomposite was characterized by field emission scanning electron microscopy, energy dispersive X-ray spectroscopy, Raman spectroscopy, and vibrating sample magnetometer. The synthesized rGO/Fe3O4-histidine nanosheets were implied for solid phase extraction of ultra-trace amounts of Zn2+, Cu2+, and Mn2+ from biological samples prior to ICP-OES determination. The calibration curves were linear in the ...
Source: Biological Trace Element Research - October 20, 2018 Category: Biology Authors: Amiri M, Shabani AMH, Dadfarnia S, Sadjadi S Tags: Biol Trace Elem Res Source Type: research

Effects of Dietary Zinc on Carcass Traits, Meat Quality, Antioxidant Status, and Tissue Zinc Accumulation of Pekin Ducks.
This study investigated the effects of dietary zinc on carcass traits, meat quality, antioxidant capacity, and tissue zinc accumulation of Pekin ducks. A total of 768 1-day-old Pekin ducks were randomly allocated to six dietary treatments and penned in groups of 16 with 8 pens per treatment. Ducks were fed a basal corn-soybean meal diet supplemented with graded levels of zinc sulfate (0, 15, 30, 60, 120, 240 mg zinc/kg) for 35 days. The slaughter weight, carcass weight, eviscerated weight, and breast and leg muscle weight of Pekin ducks were increased with increasing dietary zinc levels (P 
Source: Biological Trace Element Research - October 20, 2018 Category: Biology Authors: Wen M, Wu B, Zhao H, Liu G, Chen X, Tian G, Cai J, Jia G Tags: Biol Trace Elem Res Source Type: research

Effect of Duration of Exposure to Fluoride and Type of Diet on Lipid Parameters and De Novo Lipogenesis.
Abstract The effect of duration of chronic treatment with fluoride (F, 50 mg/L as NaF) on the lipid profile, lipid droplets and triglycerides (TG) in liver was evaluated in mice with nonalcoholic fatty liver disease (NAFLD) previously induced by hyperlipidic diet and in animals fed normocaloric diet. In addition, the effect of F administered for a short period (20 days) was evaluated on de novo lipogenesis, by nuclear magnetic resonance. GRP78, Apo-E, and sterol regulatory element-binding protein (SREBP) were quantified by Western blotting. Our data indicate that F interferes in lipid metabolism and lipi...
Source: Biological Trace Element Research - October 16, 2018 Category: Biology Authors: Dionizio A, Pereira HABS, Araujo TT, Sabino-Arias IT, Fernandes MS, Oliveira KA, Raymundo FS, Cestari TM, Nogueira FN, Carvalho RA, Buzalaf MAR Tags: Biol Trace Elem Res Source Type: research

Morning (First) Urine Copper Concentration: a New Approach for the Diagnosis of Wilson's Disease.
Abstract Twenty-four-hour (h) urinary copper content is considered as the most suitable tool for the diagnosis of Wilson's disease (WD); however, it is less accurate, time-consuming, and non-economical. Consequently, in the present study, an alternative method through measuring the morning (first) urine copper (Cu) concentration is proposed for the diagnosis of WD, which is more accurate, precise, faster, and cheaper. For this purpose, a sensitive, accurate, and precise analytical method was developed and validated in regard to Commission Decision 657/2002/EC, Council Directive 333/2007/EC, ISO/IEC 17025:2005, and...
Source: Biological Trace Element Research - October 15, 2018 Category: Biology Authors: Ullah AKMA, Maksud MA, Khan SR, Quraishi SB Tags: Biol Trace Elem Res Source Type: research

Effect on Serum Parameters and Immune Responses of Carassius auratus gibelio Exposed to Dietary Lead and Bacillus subtilis.
Abstract Lead (Pb), a heavy metal and an environmental stressor, may affect many physiological processes, including the serum index and the immune response. The aim of this study was to explore the toxic effects of Pb on the serum index and the immune response of Carassius auratus gibelio (C. gibelio) fed 0, 120, or 240 mg/kg Pb, and 109 cfu/g Bacillus subtilis (B. subtilis). After 15 and 30 days of dietary exposure, the serum indices and the immune responses of the fish were assessed. Dietary Pb exposure significantly affected various components of the serum index, including calcium, magnesium, glu...
Source: Biological Trace Element Research - October 15, 2018 Category: Biology Authors: Cai Y, Yin Y, Wang L, Leng D, Ge C, Abdallah A, Li Y Tags: Biol Trace Elem Res Source Type: research

Diagnostic Value of Energy Dispersive Hand-Held X-ray Fluorescence Spectrometry in Determining Trace Element Concentrations in Ovine Liver.
The objective of this study was to compare ovine hepatic copper (Cu), iron (Fe), manganese (Mn), molybdenum (Mo), selenium (Se) and zinc (Zn) concentrations as obtained with the hand-held XRF spectrometer to those of a reference laboratory using inductively coupled plasma mass spectrometry (ICP-MS). Thirty ovine livers were obtained from an abattoir; prepared as wet blended and oven-dried samples and analysed. Bayesian correlation was used to assess the correspondence between results from the XRF and ICP-MS analyses. The oven-dried preparation procedure for XRF provided the best correlation with the ICP-MS data. The correl...
Source: Biological Trace Element Research - October 13, 2018 Category: Biology Authors: van Loggerenberg DE, Laver PN, Myburgh JG, Botha CJ Tags: Biol Trace Elem Res Source Type: research

Role of PI3K-Akt and MAPK Signaling in Uranyl Nitrate-Induced Nephrotoxicity.
Abstract Uranium is a heavy metal of considerable environmental and occupational concern. It is well-known that the kidney is the major target organ of uranium exposure. Elucidating the mechanistic basis of uranium interactions is essential for monitoring the health risk. In the present study, we investigated the cellular mechanisms involved in uranyl nitrate-induced nephrotoxicity. Male Swiss albino mice were administrated with a single intraperitoneal dose of 2 and 4 mg/kg of uranyl nitrate at different time points 1, 3, 5, 7, 14, and 28 days. Uranyl nitrate intoxication-induced apoptosis in the kidney...
Source: Biological Trace Element Research - October 10, 2018 Category: Biology Authors: P SV, P D R, A B A Tags: Biol Trace Elem Res Source Type: research

Effect of Exogenous Zinc on MsrB1 Expression and Protein Oxidation in Human Lens Epithelial Cells.
This study was designed to investigate the levels of methionine sulfoxide reductase B1 (MsrB1) mRNA and oxidized proteins in human lens epithelial (hLE) cells after treatment with exogenous zinc. The role of exogenous zinc in regulation of MsrB1 gene expression and protein oxidation in hLE cells was studied by MTT assay, oxidized protein measurement kit, and real-time PCR. The results showed that hLE cell viability was significantly decreased by MsrB1 gene knockdown or peroxynitrite (ONOO-) treatment, while it was significantly increased after treatment with exogenous zinc (P 
Source: Biological Trace Element Research - October 10, 2018 Category: Biology Authors: Jia Y, Dai J, Zhang L, Xia H Tags: Biol Trace Elem Res Source Type: research

Melatonin Ameliorates Neuropharmacological and Neurobiochemical Alterations Induced by Subchronic Exposure to Arsenic in Wistar Rats.
Abstract An experimental study was conducted in Wistar rats to characterize the arsenic ("As")-induced alterations in neurobiochemistry in brain and its impact on neuropharmacological activities with or without the melatonin (MLT) as an antioxidant given exogenously. Male Wistar rats were randomly divided in to four groups of six each. Group I served as untreated control, while group II received As [sodium (meta) arsenite; NaAsO2] at 10 mg/kg bw (p.o.) for a period of 56 days. Experimental rats in group III received treatment similar to group II but in addition received MLT at 10 mg/kg bw ...
Source: Biological Trace Element Research - October 10, 2018 Category: Biology Authors: Durappanavar PN, Nadoor P, Waghe P, Pavithra BH, Jayaramu GM Tags: Biol Trace Elem Res Source Type: research

Enhancement in Iron Absorption on Intake of Chemometrically Optimized Ratio of Probiotic Strain Lactobacillus plantarum 299v with Iron Supplement Pearl Millet.
Abstract This research article aims to establish the intake ratio of probiotic Lactobacillus plantarum 299v with iron supplement pearl millet by central composite design of response surface methodology so as to enhance iron absorption. In anemic rat models, the food intake pattern, body weight, hemoglobin content, and hematocrit values were found to be significantly increased on treatment with pearl millet:probiotic; however, incorporation of probiotics at lower dose (0.5 g) was significantly (p 
Source: Biological Trace Element Research - October 7, 2018 Category: Biology Authors: Adiki SK, Perla CK, Saha G, Katakam P, Theendra V Tags: Biol Trace Elem Res Source Type: research

Combination of Soy Protein, Amylopectin, and Chromium Stimulates Muscle Protein Synthesis by Regulation of Ubiquitin-Proteasome Proteolysis Pathway after Exercise.
Abstract The present study was undertaken to investigate the effect of the combination of soy protein, amylopectin, and chromium (SAC) on muscle protein synthesis and signal transduction pathways involved in protein synthesis (mTOR pathways, IGF-1, and AktSer473) and proteolysis (FOXO1Ser256; MURF1, MAFbx) after exercise. Thirty-five Wistar rats were randomly divided into five groups: (1) control (C); (2) exercise (E); (3) exercise + soy protein (3.1 g/kg/day) (E + S); (4) exercise + soy protein + chromium (E + S + Cr); (5) ex...
Source: Biological Trace Element Research - October 6, 2018 Category: Biology Authors: Kayri V, Orhan C, Tuzcu M, Deeh Defo PB, Telceken H, Irmak M, Sahin N, Tastan H, Komorowski JR, Sahin K Tags: Biol Trace Elem Res Source Type: research

Semen Uranium Concentrations in Depleted Uranium Exposed Gulf War Veterans: Correlations with Other Body Fluid Matrices.
We report here uranium seminal fluid results and the high correlation of uranium concentrations across several body fluid matrices in a cohort of military veterans exposed to depleted uranium in combat events during the Iraqi Gulf War. These results inform the risk communication conversation for exposed populations and broaden the public health assessments from various exposure scenarios. PMID: 30293130 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - October 6, 2018 Category: Biology Authors: McDiarmid MA, Gucer P, Centeno JA, Todorov T, Squibb KS Tags: Biol Trace Elem Res Source Type: research

Toxic Metals and Trace Elements in Artisanal Honeys from the Canary Islands.
The objective of this study was to determine the content of 20 metals (Al, B, Ba, Ca, Cd, Co, Cr, Cu, Fe, K, Li, Mg, Mn, Mo, Na, Ni, Pb, Sr, V, and Zn) in different samples of artisanal honey from the Canary Islands (Spain) in order to evaluate the dietary intake derived from the consumption of these honeys. A total of 161 samples of different types of Canary honey were analyzed by ICP-OES (inductively coupled plasma-optical emission spectrometry). K (825 mg/kg) was the macroelement found in highest concentration, while B (4.25 mg/kg) was the trace element with the highest mean concentration. Al (3.33 mg/kg)...
Source: Biological Trace Element Research - October 5, 2018 Category: Biology Authors: Díaz S, Paz S, Rubio C, Gutiérrez ÁJ, González-Weller D, Revert C, Bentabol A, Hardisson A Tags: Biol Trace Elem Res Source Type: research