Sodium Selenite Prevents Matrine-Induced Nephrotoxicity by Suppressing Ferroptosis via the GSH-GPX4 Antioxidant System
Biol Trace Elem Res. 2024 Jan 4. doi: 10.1007/s12011-023-04044-w. Online ahead of print.ABSTRACTMatrine (MT), an active ingredient derived from Sophor flavescens Ait, is used as a therapeutic agent to treat liver disease and cancer. However, the serious toxic effects of MT, including nephrotoxicity, have limited its clinical application. Here, we explored the involvement of ferroptosis in MT-induced kidney injury and evaluated the potential efficacy and underlying mechanism of sodium selenite (SS) in attenuating MT-induced nephrotoxicity. We found that MT not only disrupts renal structure in mice but also induces the death...
Source: Biological Trace Element Research - January 4, 2024 Category: Biology Authors: Xi Wang Zixiong Lin Ting Li Wenjing Zhu Hanxin Huang Jiayan Hu Jie Zhou Source Type: research

Ortho-silicic Acid Prevents Glucocorticoid-Induced Femoral Head Necrosis by Promoting Akt Phosphorylation to Inhibit Endoplasmic Reticulum Stress-Mediated Apoptosis and Enhance Angiogenesis and Osteogenesis
We examined the influence of ortho-silicic acid (OSA, Si(OH)4) on the apoptosis and proliferation of vascular endothelial cells after glucocorticoid induction. Additionally, we evaluated the expression of apoptosis-related genes such as cleaved-caspase-3, Bcl-2 and Bax. The impact of glucocorticoids and OSA on the function of vascular endothelial cells was evaluated through wound healing, transwell and angiogenesis assays. Osteogenic function was subsequently evaluated through alizarin red staining, alkaline phosphatase staining and expression levels of osteogenic genes like RUNX2 and ALP. Moreover, we investigated the pot...
Source: Biological Trace Element Research - January 4, 2024 Category: Biology Authors: Zhenqian Sun Jian Wang Zhongjie Ji Jinlong Ma Yunzhen Chen Guangjun Jiao Source Type: research

The Correlation Between Serum Copper and Non-alcoholic Fatty Liver Disease in American Adults: an Analysis Based on NHANES 2011 to 2016
Biol Trace Elem Res. 2024 Jan 3. doi: 10.1007/s12011-023-04029-9. Online ahead of print.ABSTRACTCopper functions as an essential micronutrient influencing diverse metabolic processes in mammals, encompassing oxidative stress responses, lipid metabolism, and participation in enzymatic reactions. However, the impact of serum copper on non-alcoholic fatty liver disease (NAFLD) remains controversial. Our aim was to explore the precise correlation between serum copper and NAFLD in a large-scale population-based study. A total of 1377 participants from the National Health and Nutrition Examination Survey (NHANES) 2011-2016 were ...
Source: Biological Trace Element Research - January 3, 2024 Category: Biology Authors: Lurao Li Yun Yi Xiawen Shu Jianghui Li Hui Kang Ying Chang Source Type: research

Correction: Melatonin Attenuates Arsenic-Induced Neurotoxicity in Rats through the Regulation of miR-34a/miR-144 in Sirt1/Nrf2 Pathway
Biol Trace Elem Res. 2024 Jan 3. doi: 10.1007/s12011-023-04051-x. Online ahead of print.NO ABSTRACTPMID:38170428 | DOI:10.1007/s12011-023-04051-x (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 3, 2024 Category: Biology Authors: Nahid Najafi Samira Barangi Zahra Moosavi Seyed Hamid Aghaee-Bakhtiari Soghra Mehri Gholamreza Karimi Source Type: research

A Meta-Analysis of the Prevalence of Children Goiter in High Water Iodine Areas of China
Biol Trace Elem Res. 2024 Jan 3. doi: 10.1007/s12011-023-04035-x. Online ahead of print.ABSTRACTAlthough there are now a large number of studies confirming that high iodine levels can cause goiter, there is controversy and a lack of quantitative data. A systematic search of PubMed, Web of Science, China National Knowledge Infrastructure, Wanfang Database, and China Biomedical Database for literature on high iodine and goiter in children was performed with a time limit from January 2013 to October 2023. After screening the literature based on the inclusion criteria, extracting the literature data, and evaluating the risk of...
Source: Biological Trace Element Research - January 3, 2024 Category: Biology Authors: Zhilei Xing Siyu Liu Peisen Ding Xiaomeng Yu Jiahui Song Huajun Sun Yushan Cui Hongliang Liu Source Type: research

The Correlation Between Serum Copper and Non-alcoholic Fatty Liver Disease in American Adults: an Analysis Based on NHANES 2011 to 2016
Biol Trace Elem Res. 2024 Jan 3. doi: 10.1007/s12011-023-04029-9. Online ahead of print.ABSTRACTCopper functions as an essential micronutrient influencing diverse metabolic processes in mammals, encompassing oxidative stress responses, lipid metabolism, and participation in enzymatic reactions. However, the impact of serum copper on non-alcoholic fatty liver disease (NAFLD) remains controversial. Our aim was to explore the precise correlation between serum copper and NAFLD in a large-scale population-based study. A total of 1377 participants from the National Health and Nutrition Examination Survey (NHANES) 2011-2016 were ...
Source: Biological Trace Element Research - January 3, 2024 Category: Biology Authors: Lurao Li Yun Yi Xiawen Shu Jianghui Li Hui Kang Ying Chang Source Type: research

Correction: Melatonin Attenuates Arsenic-Induced Neurotoxicity in Rats through the Regulation of miR-34a/miR-144 in Sirt1/Nrf2 Pathway
Biol Trace Elem Res. 2024 Jan 3. doi: 10.1007/s12011-023-04051-x. Online ahead of print.NO ABSTRACTPMID:38170428 | DOI:10.1007/s12011-023-04051-x (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 3, 2024 Category: Biology Authors: Nahid Najafi Samira Barangi Zahra Moosavi Seyed Hamid Aghaee-Bakhtiari Soghra Mehri Gholamreza Karimi Source Type: research

Selenium Deficiency Can Promote the Expression of VEGF and Inflammatory Factors in Cartilage Differentiation and Mediates Cartilage Injury
Biol Trace Elem Res. 2023 Dec 30. doi: 10.1007/s12011-023-04003-5. Online ahead of print.ABSTRACTSelenium plays a crucial role as a micronutrient, primarily exerting its biological functions through selenoproteins. It has been established that selenium deficiency adversely impacts cartilage development, leading to alterations in chondrocyte function. In regions with low selenium intake, endemic osteochondrosis has been documented, characterized by compromised growth plate and articular cartilage formation. Vascular endothelial growth factor (VEGF) stands out as a pivotal angiogenic factor, with elevated levels contributing...
Source: Biological Trace Element Research - December 30, 2023 Category: Biology Authors: Xiang Meng Xiumei Meng Zeju He Ye Yuan Yong Fan Li Yin Yu Tong Zheping Hong Senbo Zhu Qiong Zhang Qing Bi Source Type: research

Exploring the Complex Interplay of Trace Elements and Their Association with the Risk of Development of Pre-eclampsia in Pregnancy: a Case-Control
This study examines the intricate relationship between trace elements (magnesium, copper, zinc, calcium, phosphorus, and iron) and the severity of pre-eclampsia. The study involves a total of 150 participants, categorized into three distinct groups: 50 individuals with mild pre-eclampsia, 50 with severe pre-eclampsia, and 50 healthy pregnant controls. Specifically, out of the 100 pre-eclampsia cases, 5 were identified as early-onset and 95 as late-onset. Participants were recruited from a tertiary care hospital based on stringent inclusion and exclusion criteria. All the trace elements were quantitatively measured by direc...
Source: Biological Trace Element Research - December 30, 2023 Category: Biology Authors: Kusuma Kumari Pyla Vasundhara Devi Ilaka Poornima Penmetsa Pvsn Kiran Kumar Surya Prabha Yerramilli Source Type: research

Selenium Deficiency Can Promote the Expression of VEGF and Inflammatory Factors in Cartilage Differentiation and Mediates Cartilage Injury
Biol Trace Elem Res. 2023 Dec 30. doi: 10.1007/s12011-023-04003-5. Online ahead of print.ABSTRACTSelenium plays a crucial role as a micronutrient, primarily exerting its biological functions through selenoproteins. It has been established that selenium deficiency adversely impacts cartilage development, leading to alterations in chondrocyte function. In regions with low selenium intake, endemic osteochondrosis has been documented, characterized by compromised growth plate and articular cartilage formation. Vascular endothelial growth factor (VEGF) stands out as a pivotal angiogenic factor, with elevated levels contributing...
Source: Biological Trace Element Research - December 30, 2023 Category: Biology Authors: Xiang Meng Xiumei Meng Zeju He Ye Yuan Yong Fan Li Yin Yu Tong Zheping Hong Senbo Zhu Qiong Zhang Qing Bi Source Type: research

Exploring the Complex Interplay of Trace Elements and Their Association with the Risk of Development of Pre-eclampsia in Pregnancy: a Case-Control
This study examines the intricate relationship between trace elements (magnesium, copper, zinc, calcium, phosphorus, and iron) and the severity of pre-eclampsia. The study involves a total of 150 participants, categorized into three distinct groups: 50 individuals with mild pre-eclampsia, 50 with severe pre-eclampsia, and 50 healthy pregnant controls. Specifically, out of the 100 pre-eclampsia cases, 5 were identified as early-onset and 95 as late-onset. Participants were recruited from a tertiary care hospital based on stringent inclusion and exclusion criteria. All the trace elements were quantitatively measured by direc...
Source: Biological Trace Element Research - December 30, 2023 Category: Biology Authors: Kusuma Kumari Pyla Vasundhara Devi Ilaka Poornima Penmetsa Pvsn Kiran Kumar Surya Prabha Yerramilli Source Type: research

Sex-Specific Associations of Five Serum Essential Metal Elements with Thyroid Nodules in Euthyroid Adults: a Cross ‑sectional Study
In conclusion, our study suggests that gender is an important factor when studying the association between serum metals and thyroid nodules. The imbalance of selected metal elements (calcium, copper, zinc, and magnesium) may relate to thyroid nodules and their malignant tendency, and future prospective studies are needed to further confirm the associations.PMID:38157093 | DOI:10.1007/s12011-023-04024-0 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - December 29, 2023 Category: Biology Authors: Qintao Ma Ying Li Genfeng Yu Siyang Liu Yuqi Jiang Hualin Duan Dongmei Wang Yajun He Xingying Chen Nanfang Yao Xu Lin Heng Wan Jie Shen Source Type: research

Correction: Cobalt Uptake by Food Plants and Accumulation in Municipal Solid Waste Materials Compost-amended Soil: Public Health Implications
Biol Trace Elem Res. 2023 Dec 29. doi: 10.1007/s12011-023-04040-0. Online ahead of print.NO ABSTRACTPMID:38157094 | DOI:10.1007/s12011-023-04040-0 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - December 29, 2023 Category: Biology Authors: Zafar Iqbal Khan Asma Ashfaq Kafeel Ahmad Aima Iram Batool Mehwish Aslam Tasneem Ahmad Naunain Mehmood Ijaz Rasool Noorka Abdel-Rhman Z Gaafar Mohamed S Elshikh Syed Sikandar Habib Riaz Khan Ilker Ugulu Source Type: research

Association Between the Serum Copper Levels and Environmental Tobacco Exposure on the Risk of Overweight and Obesity in Children: a Study Based on the National Health and Nutrition Examination Survey
This study was to assess the individual effects of serum copper levels and environmental tobacco exposure and their joint effects on the risk of overweight and obesity among children and adolescents of 6 to 19 year olds. We analyzed cross-sectional data from 1849 children and adolescents participating in the National Health and Nutrition Examination Survey (NHANES) collected between 2011 and 2016. Environmental tobacco exposure was determined by cotinine levels. The serum copper level was divided into < median group and ≥ median groups according to the median of 109.81 µg/dL. The outcome was overweight/obese in child...
Source: Biological Trace Element Research - December 29, 2023 Category: Biology Authors: Yujun Luo Linzhu Zhang Yanting Lu Xiaohong Lin Zelin Weng Youjia Xu Source Type: research

Quercetin Supplementation Alleviates Cadmium Induced Genotoxicity-Mediated Apoptosis in Caprine Testicular Cells
Biol Trace Elem Res. 2023 Dec 30. doi: 10.1007/s12011-023-04038-8. Online ahead of print.ABSTRACTBeing a common environmental pollutant, cadmium causes detrimental health effects, including testicular injury. Herein, we document the ameliorative potential of quercetin, a potent antioxidant, against cadmium-induced geno-cytotoxicity and steroidogenic toxicity in goat testicular tissue. Cadmium induced different comet types (Type 0 - Type 4), indicating the varying degree of DNA-damage in testicular cells. The quantitative analysis at 50 and 100 µM cadmium concentration revealed the DNA damage with per cent tail DNA as 75.7...
Source: Biological Trace Element Research - December 29, 2023 Category: Biology Authors: Harish Panchal Jitender Kumar Bhardwaj Source Type: research