Mitigation of Acute Hepatotoxicity Induced by Cadmium Through Morin: Modulation of Oxidative and Pro-apoptotic Endoplasmic Reticulum Stress and Inflammatory Responses in Rats
This study demonstrated the dose-dependent antioxidant hepatoprotective effect of Morin against acute hepatic Cd intoxication. This effect is likely linked with the modulation of upstream p-GRP78/PERK/ATF6 pro-apoptotic oxidative/ER stress and the downstream JNK/BAX/caspase 12 apoptotic signaling pathways.PMID:38238535 | DOI:10.1007/s12011-024-04064-0 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 18, 2024 Category: Biology Authors: Emin Sengul Serkan Yildirim İrfan Cinar Samet Tekin Yusuf Dag Merve Bolat Melahat Gok Mohamad Warda Source Type: research

Chromium in the Diet of Dairy Calves: Benefits for Growth Performance, Feed Efficiency, Digestibility, and Health
In conclusion, the adding Cr to calf feed improves their health, indirectly favors growth performance, and increases protein digestibility.PMID:38231457 | DOI:10.1007/s12011-024-04063-1 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 17, 2024 Category: Biology Authors: Patr ícia Glombowsky Natan M Sold á Vitor L Molosse Guilherme L Deolindo Maiara M Sulzbach Nathieli B Bottari Maria Rosa C Schetinger Claiton A Zotti Gabriela Solivo Marcelo Vedovatto Aleksandro S da Silva Source Type: research

Effect of Aluminum Concentration in Water on Its Toxicity and Bioaccumulation in Zooplankton (Chaoborus and Chironomus) and Carp (Cyprinus carpio L.) Roe
Biol Trace Elem Res. 2024 Jan 17. doi: 10.1007/s12011-024-04062-2. Online ahead of print.ABSTRACTAn attempt to evaluate aluminum toxicity to living organisms was undertaken in the study. A laboratory experiment was conducted to determine aluminum bioaccumulation and toxicity in Chironomus and Chaoborus larvae and in Cyprinus carpio L. roe depending on aluminum concentration in water reflecting natural chemical composition. Water was examined for temperature, pH, electrical conductivity, dissolved oxygen, color, nitrate nitrogen, nitrite nitrogen, sulfates by spectrophotometric method; total hardness and chlorides by titrat...
Source: Biological Trace Element Research - January 17, 2024 Category: Biology Authors: Magdalena Senze Monika Kowalska-G óralska Katarzyna Czy ż Source Type: research

Genetic Determinants of Selenium Availability, Selenium-Response, and Risk of Polycystic Ovary Syndrome
Biol Trace Elem Res. 2024 Jan 16. doi: 10.1007/s12011-023-04052-w. Online ahead of print.ABSTRACTSelenium is a trace element and its deficiency has been associated with the risk of PCOS, a multifactorial syndrome that affects a large number of women worldwide. Several databases and literature were searched to find out genetic variants of the genes involved in selenium uptake, metabolism, and regulation which may be significantly associated with the risk of PCOS through Se-related pathways. Genes that require selenium for their biological actions to perform were also shortlisted. A total of eighteen significantly associated...
Source: Biological Trace Element Research - January 16, 2024 Category: Biology Authors: Priya Sharma Preeti Khetarpal Source Type: research

Effect of Zinc Supplementation on Lipid Profile and Body Composition in Patients with Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis
Biol Trace Elem Res. 2024 Jan 15. doi: 10.1007/s12011-024-04059-x. Online ahead of print.ABSTRACTThe aim of this systematic review and meta-analysis of randomized controlled trials (RCTs) is to investigate the overall effects of zinc supplementation on lipid profile and body composition such as body weight (BW), body mass index (BMI), triglycerides (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol (HDL-C) in patients with type 2 diabetes mellitus (T2DM). Scopus, Web of Science, PubMed, and Embase databases were searched from inception through October, 2023. ...
Source: Biological Trace Element Research - January 15, 2024 Category: Biology Authors: Mahsa Khajeh Shirin Hassanizadeh Fatemeh Pourteymour Fard Tabrizi Reza Hassanizadeh Mahdi Vajdi Gholamreza Askari Source Type: research

The Role of Zinc on Liver Fibrosis by Modulating ZIP14 Expression Throughout Epigenetic Regulatory Mechanisms
Biol Trace Elem Res. 2024 Jan 15. doi: 10.1007/s12011-023-04057-5. Online ahead of print.ABSTRACTZinc plays a pivotal role in tissue regeneration and maintenance being as a central cofactor in a plethora of enzymatic activities. Hypozincemia is commonly seen with chronic liver disease and is associated with an increased risk of liver fibrosis development and hepatocellular carcinoma. Previously favorable effects of zinc supplementation on liver fibrosis have been shown. However, the underlying mechanism of this effect is not elucidated. Liver fibrosis was induced in mice by using CCl4 injection, followed by treatment with ...
Source: Biological Trace Element Research - January 14, 2024 Category: Biology Authors: Zeynep Busra Aksoy-Ozer Ceylan Verda Bitirim Belma Turan Kamil Can Akcali Source Type: research

Boric Acid and Borax Protect Human Lymphocytes from Oxidative Stress and Genotoxicity Induced by 3-Monochloropropane-1,2-diol
In conclusion, BA and BX are safe and non-genotoxic under the in vitro conditions and can alleviate cytotoxic, oxidative, and genetic damage induced by 3-MCPD in the human blood cells. Our findings suggest that dietary boron supplements may offer a novel strategy for mitigating hematotoxicity induced by xenobiotics, including 3-MCPD.PMID:38216793 | DOI:10.1007/s12011-024-04060-4 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 12, 2024 Category: Biology Authors: Hasan Turkez Ozlem Ozdemir Tozlu Mehmet Enes Arslan Cem Baba Muhammed Melik Saracoglu Edanur Y ıldız Abdulgani Tatar Adil Mardinoglu Source Type: research

Inflammation in Metal-Induced Neurological Disorders and Neurodegenerative Diseases
Biol Trace Elem Res. 2024 Jan 11. doi: 10.1007/s12011-023-04041-z. Online ahead of print.ABSTRACTEssential metals play critical roles in maintaining human health as they participate in various physiological activities. Nonetheless, both excessive accumulation and deficiency of these metals may result in neurotoxicity secondary to neuroinflammation and the activation of microglia and astrocytes. Activation of these cells can promote the release of pro-inflammatory cytokines. It is well known that neuroinflammation plays a critical role in metal-induced neurotoxicity as well as the development of neurological disorders, such...
Source: Biological Trace Element Research - January 11, 2024 Category: Biology Authors: Ruokun Wei Peiqi Wei Haiyan Yuan Xiang Yi Michael Aschner Yue-Ming Jiang Shao-Jun Li Source Type: research

Dietary Intake and Exposure Assessment of Trace Elements in Infants' Diets: A Case Study in Kuwait
This study confirms that infants are exposed to toxic trace elements via diet, warranting careful attention to diet choices both to limit this exposure and to avert potentially hazardous adverse health effects to the infants. However, based on the calculated hazard quotients (HQs) and margin of exposures (MOEs), consuming breast milk in addition to almost all different types of infant foods is considered safe and unlikely to contribute to infants' non-cancerous health hazards.PMID:38196052 | DOI:10.1007/s12011-023-04045-9 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 10, 2024 Category: Biology Authors: Karim N Jallad Source Type: research

The Association Between Dietary Magnesium Intake and Pulmonary Function: Recent Fndings from NHANES 2007-2012
This study suggested that dietary magnesium intake may improve pulmonary function.PMID:38196053 | DOI:10.1007/s12011-024-04061-3 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 10, 2024 Category: Biology Authors: Mo-Yao Tan Jian-Tao Wang Gao-Peng Wang Si-Xuan Zhu Xiang-Long Zhai Source Type: research

Detection of Trace Elements Se, Cu, and Zn Levels in Biological Samples of Drug Abusers: Halani Sindh, Pakistan
Biol Trace Elem Res. 2024 Jan 9. doi: 10.1007/s12011-023-04056-6. Online ahead of print.ABSTRACTIllicit drug use has become a global issue, posing significant health, socioeconomic, and cultural risks. The study examined essential trace metals: selenium, zinc, and copper in blood concentrations, as well as in serum and scalp hair samples, from 240 male drug-abuse subjects/patients aged 18-45, categorized into three age groups. The study compared 45 healthy subjects of the same age group using an acid digestion method supported by a microwave oven during sample preparation. The technique of atomic absorption spectrometry wa...
Source: Biological Trace Element Research - January 10, 2024 Category: Biology Authors: Sajjad Ali Chang Aamna Balouch Waheed Ali Nahyoon Aamir Ali Raja Source Type: research

Analysis of Isotretinoin-Induced Alterations in the Levels of Plasma Trace Elements: Investigation of the Relationship Between Magnesium, Phosphorus, Potassium, Zinc, and Treatment-Related Side Effects
Biol Trace Elem Res. 2024 Jan 10. doi: 10.1007/s12011-023-04053-9. Online ahead of print.ABSTRACTIsotretinoin is an effective treatment against acne vulgaris, but it also causes many side effects during and after the treatment. The relationship between the changes in the levels of plasma trace elements of patients with AV after 3 months of isotretinoin treatment and the side effects was investigated in the study. Plasma samples of 35 patients were collected before and after isotretinoin treatment. Samples were analyzed by Inductively Coupled Plasma-Mass Spectrometer. After treatment, the levels of phosphorus, magnesium, an...
Source: Biological Trace Element Research - January 10, 2024 Category: Biology Authors: Tugrul Cagri Akman Mustafa Yazici Alptug Atila Cuma Mertoglu Source Type: research

Silver Nanoparticles Loaded with Oleuropein Reduce Doxorubicin-Induced Testicular Damage by Regulating Endoplasmic Reticulum Stress, and Apoptosis
Biol Trace Elem Res. 2024 Jan 10. doi: 10.1007/s12011-024-04058-y. Online ahead of print.ABSTRACTDoxorubicin (DOX) is the most used chemotherapeutic agent for treating solid tumors. DOX treatment may lead to testicular damage using oxidative stress, resulting in infertility. These adverse effects may be prevented by the activation of antioxidant systems. Oleuropein (OLE) is a powerful flavonoid with several ameliorative effects, including antioxidative, antiproliferative, and anti-inflammatory. It would be more efficient and applicable in treating chronic human diseases if its poor bioavailability improves with a nano-deli...
Source: Biological Trace Element Research - January 10, 2024 Category: Biology Authors: Elif Erba ş Volkan Gelen H ülya Kara Semin Gedikli Ali Ye şildağ Se çkin Özkanlar Serkan Ali Akarsu Source Type: research

Differential Modulatory Effects of Methylmercury (MeHg) on Ahr-regulated Genes in Extrahepatic Tissues of C57BL/6 Mice
In conclusion, this study reveals intricate interplay between MeHg and TCDD on AHR-regulated CYP1 enzymes, with interesting inhibitory effects observed that might be significant for procarcinogen metabolism. Varied responses across tissues highlight the potential implications for environmental health.PMID:38197905 | DOI:10.1007/s12011-023-04050-y (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 10, 2024 Category: Biology Authors: Mohammed A Alqahtani Mahmoud A El-Ghiaty Sara R El-Mahrouk Ayman O S El-Kadi Source Type: research

Selenomethionine, a Trace Element, Increases Osteoblastic Activity of hFOB 1.19 Cells (an In Vitro Study)
Biol Trace Elem Res. 2024 Jan 11. doi: 10.1007/s12011-023-04055-7. Online ahead of print.ABSTRACTOsteoporosis and resulting fractures affect a significant group of people in the world. It has been shown in many studies that selenium has positive effects on bone metabolism. Based on this information, the aim of this study is to investigate whether bone differentiation will start in a shorter time by applying selenomethionine (SeMet) to hFOB cells.First, hFOB 1.19 cells were cultured. Safe doses of SeMet were determined by MTT and LDH tests. Ossification levels were determined by alizarin red staining and measurement of alka...
Source: Biological Trace Element Research - January 10, 2024 Category: Biology Authors: Erhan Sahin Mahmoud Arafat Ayse Tansu Koparal Source Type: research