The Role of Zinc on Liver Fibrosis by Modulating ZIP14 Expression Throughout Epigenetic Regulatory Mechanisms
Biol Trace Elem Res. 2024 Jan 15. doi: 10.1007/s12011-023-04057-5. Online ahead of print.ABSTRACTZinc plays a pivotal role in tissue regeneration and maintenance being as a central cofactor in a plethora of enzymatic activities. Hypozincemia is commonly seen with chronic liver disease and is associated with an increased risk of liver fibrosis development and hepatocellular carcinoma. Previously favorable effects of zinc supplementation on liver fibrosis have been shown. However, the underlying mechanism of this effect is not elucidated. Liver fibrosis was induced in mice by using CCl4 injection, followed by treatment with ...
Source: Biological Trace Element Research - January 14, 2024 Category: Biology Authors: Zeynep Busra Aksoy-Ozer Ceylan Verda Bitirim Belma Turan Kamil Can Akcali Source Type: research
Boric Acid and Borax Protect Human Lymphocytes from Oxidative Stress and Genotoxicity Induced by 3-Monochloropropane-1,2-diol
In conclusion, BA and BX are safe and non-genotoxic under the in vitro conditions and can alleviate cytotoxic, oxidative, and genetic damage induced by 3-MCPD in the human blood cells. Our findings suggest that dietary boron supplements may offer a novel strategy for mitigating hematotoxicity induced by xenobiotics, including 3-MCPD.PMID:38216793 | DOI:10.1007/s12011-024-04060-4 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 12, 2024 Category: Biology Authors: Hasan Turkez Ozlem Ozdemir Tozlu Mehmet Enes Arslan Cem Baba Muhammed Melik Saracoglu Edanur Y ıldız Abdulgani Tatar Adil Mardinoglu Source Type: research
Inflammation in Metal-Induced Neurological Disorders and Neurodegenerative Diseases
Biol Trace Elem Res. 2024 Jan 11. doi: 10.1007/s12011-023-04041-z. Online ahead of print.ABSTRACTEssential metals play critical roles in maintaining human health as they participate in various physiological activities. Nonetheless, both excessive accumulation and deficiency of these metals may result in neurotoxicity secondary to neuroinflammation and the activation of microglia and astrocytes. Activation of these cells can promote the release of pro-inflammatory cytokines. It is well known that neuroinflammation plays a critical role in metal-induced neurotoxicity as well as the development of neurological disorders, such...
Source: Biological Trace Element Research - January 11, 2024 Category: Biology Authors: Ruokun Wei Peiqi Wei Haiyan Yuan Xiang Yi Michael Aschner Yue-Ming Jiang Shao-Jun Li Source Type: research
Dietary Intake and Exposure Assessment of Trace Elements in Infants' Diets: A Case Study in Kuwait
This study confirms that infants are exposed to toxic trace elements via diet, warranting careful attention to diet choices both to limit this exposure and to avert potentially hazardous adverse health effects to the infants. However, based on the calculated hazard quotients (HQs) and margin of exposures (MOEs), consuming breast milk in addition to almost all different types of infant foods is considered safe and unlikely to contribute to infants' non-cancerous health hazards.PMID:38196052 | DOI:10.1007/s12011-023-04045-9 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 10, 2024 Category: Biology Authors: Karim N Jallad Source Type: research
The Association Between Dietary Magnesium Intake and Pulmonary Function: Recent Fndings from NHANES 2007-2012
This study suggested that dietary magnesium intake may improve pulmonary function.PMID:38196053 | DOI:10.1007/s12011-024-04061-3 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 10, 2024 Category: Biology Authors: Mo-Yao Tan Jian-Tao Wang Gao-Peng Wang Si-Xuan Zhu Xiang-Long Zhai Source Type: research
Detection of Trace Elements Se, Cu, and Zn Levels in Biological Samples of Drug Abusers: Halani Sindh, Pakistan
Biol Trace Elem Res. 2024 Jan 9. doi: 10.1007/s12011-023-04056-6. Online ahead of print.ABSTRACTIllicit drug use has become a global issue, posing significant health, socioeconomic, and cultural risks. The study examined essential trace metals: selenium, zinc, and copper in blood concentrations, as well as in serum and scalp hair samples, from 240 male drug-abuse subjects/patients aged 18-45, categorized into three age groups. The study compared 45 healthy subjects of the same age group using an acid digestion method supported by a microwave oven during sample preparation. The technique of atomic absorption spectrometry wa...
Source: Biological Trace Element Research - January 10, 2024 Category: Biology Authors: Sajjad Ali Chang Aamna Balouch Waheed Ali Nahyoon Aamir Ali Raja Source Type: research
Analysis of Isotretinoin-Induced Alterations in the Levels of Plasma Trace Elements: Investigation of the Relationship Between Magnesium, Phosphorus, Potassium, Zinc, and Treatment-Related Side Effects
Biol Trace Elem Res. 2024 Jan 10. doi: 10.1007/s12011-023-04053-9. Online ahead of print.ABSTRACTIsotretinoin is an effective treatment against acne vulgaris, but it also causes many side effects during and after the treatment. The relationship between the changes in the levels of plasma trace elements of patients with AV after 3 months of isotretinoin treatment and the side effects was investigated in the study. Plasma samples of 35 patients were collected before and after isotretinoin treatment. Samples were analyzed by Inductively Coupled Plasma-Mass Spectrometer. After treatment, the levels of phosphorus, magnesium, an...
Source: Biological Trace Element Research - January 10, 2024 Category: Biology Authors: Tugrul Cagri Akman Mustafa Yazici Alptug Atila Cuma Mertoglu Source Type: research
Silver Nanoparticles Loaded with Oleuropein Reduce Doxorubicin-Induced Testicular Damage by Regulating Endoplasmic Reticulum Stress, and Apoptosis
Biol Trace Elem Res. 2024 Jan 10. doi: 10.1007/s12011-024-04058-y. Online ahead of print.ABSTRACTDoxorubicin (DOX) is the most used chemotherapeutic agent for treating solid tumors. DOX treatment may lead to testicular damage using oxidative stress, resulting in infertility. These adverse effects may be prevented by the activation of antioxidant systems. Oleuropein (OLE) is a powerful flavonoid with several ameliorative effects, including antioxidative, antiproliferative, and anti-inflammatory. It would be more efficient and applicable in treating chronic human diseases if its poor bioavailability improves with a nano-deli...
Source: Biological Trace Element Research - January 10, 2024 Category: Biology Authors: Elif Erba ş Volkan Gelen H ülya Kara Semin Gedikli Ali Ye şildağ Se çkin Özkanlar Serkan Ali Akarsu Source Type: research
Differential Modulatory Effects of Methylmercury (MeHg) on Ahr-regulated Genes in Extrahepatic Tissues of C57BL/6 Mice
In conclusion, this study reveals intricate interplay between MeHg and TCDD on AHR-regulated CYP1 enzymes, with interesting inhibitory effects observed that might be significant for procarcinogen metabolism. Varied responses across tissues highlight the potential implications for environmental health.PMID:38197905 | DOI:10.1007/s12011-023-04050-y (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 10, 2024 Category: Biology Authors: Mohammed A Alqahtani Mahmoud A El-Ghiaty Sara R El-Mahrouk Ayman O S El-Kadi Source Type: research
Selenomethionine, a Trace Element, Increases Osteoblastic Activity of hFOB 1.19 Cells (an In Vitro Study)
Biol Trace Elem Res. 2024 Jan 11. doi: 10.1007/s12011-023-04055-7. Online ahead of print.ABSTRACTOsteoporosis and resulting fractures affect a significant group of people in the world. It has been shown in many studies that selenium has positive effects on bone metabolism. Based on this information, the aim of this study is to investigate whether bone differentiation will start in a shorter time by applying selenomethionine (SeMet) to hFOB cells.First, hFOB 1.19 cells were cultured. Safe doses of SeMet were determined by MTT and LDH tests. Ossification levels were determined by alizarin red staining and measurement of alka...
Source: Biological Trace Element Research - January 10, 2024 Category: Biology Authors: Erhan Sahin Mahmoud Arafat Ayse Tansu Koparal Source Type: research
Palliative Effect of Combined Application of Zinc and Selenium on Reproductive Injury Induced by Tripterygium Glycosides in Male Rats
Biol Trace Elem Res. 2024 Jan 8. doi: 10.1007/s12011-023-04054-8. Online ahead of print.ABSTRACTThe long-term use of tripterygium glycosides (TG) can lead to male reproductive damage. Research indicates that zinc and selenium exhibit a synergistic effect in the male reproductive system, with the combined preparation demonstrating superior therapeutic effects compared to individual preparations. The purpose of this study was to explore the specific mechanism by which zinc and selenium mitigate reproductive toxicity induced by TG in male rats. Rats were randomly assigned to three groups: control group (C group), model group ...
Source: Biological Trace Element Research - January 8, 2024 Category: Biology Authors: Junsheng Liu Xin Zuo Jiajie Bi Huanhuan Li Yuanjing Li Jing Ma Shusong Wang Source Type: research
Examining the Influence of Zinc Oxide Nanoparticles and Bulk Zinc Oxide on Rat Brain Functions: a Comprehensive Neurobehavioral, Antioxidant, Gene Expression, and Histopathological Investigation
In conclusion, the studies emphasized the importance of further assessing various doses and forms of zinc oxide on brain health, highlighting the significance of dosage considerations when using nanomaterials.PMID:38190061 | DOI:10.1007/s12011-023-04043-x (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 8, 2024 Category: Biology Authors: Amira A Goma Alyaa R Salama Hossam G Tohamy Rashed R Rashed Mustafa Shukry Sara E El-Kazaz Source Type: research
Concentration of Heavy Metals in Traditional and Industrial Fruit Juices from Iran: Probabilistic Risk Assessment Study
Biol Trace Elem Res. 2024 Jan 8. doi: 10.1007/s12011-023-04049-5. Online ahead of print.ABSTRACTExposure to heavy metals can endanger the health of exposed people in the long term. The consumption of fruit juice is increasing; it is important to estimate the health risk of consumers due to heavy metals. The current study was carried out for the analysis of toxic metals (lead (Pb), arsenic (As), and cadmium (Cd)) and essential elements (copper (Cu) and zinc (Zn)) in 60 samples of traditional and industrial fruit juices (10 samples of different brands of apple, orange, grape, peach, mango, and pineapple) in Hamadan, West Ira...
Source: Biological Trace Element Research - January 8, 2024 Category: Biology Authors: Fereshteh Mehri Ali Heshmati Elaheh Talebi Ghane Trias Mahmudiono Yadolah Fakhri Source Type: research
Palliative Effect of Combined Application of Zinc and Selenium on Reproductive Injury Induced by Tripterygium Glycosides in Male Rats
Biol Trace Elem Res. 2024 Jan 8. doi: 10.1007/s12011-023-04054-8. Online ahead of print.ABSTRACTThe long-term use of tripterygium glycosides (TG) can lead to male reproductive damage. Research indicates that zinc and selenium exhibit a synergistic effect in the male reproductive system, with the combined preparation demonstrating superior therapeutic effects compared to individual preparations. The purpose of this study was to explore the specific mechanism by which zinc and selenium mitigate reproductive toxicity induced by TG in male rats. Rats were randomly assigned to three groups: control group (C group), model group ...
Source: Biological Trace Element Research - January 8, 2024 Category: Biology Authors: Junsheng Liu Xin Zuo Jiajie Bi Huanhuan Li Yuanjing Li Jing Ma Shusong Wang Source Type: research
Examining the Influence of Zinc Oxide Nanoparticles and Bulk Zinc Oxide on Rat Brain Functions: a Comprehensive Neurobehavioral, Antioxidant, Gene Expression, and Histopathological Investigation
In conclusion, the studies emphasized the importance of further assessing various doses and forms of zinc oxide on brain health, highlighting the significance of dosage considerations when using nanomaterials.PMID:38190061 | DOI:10.1007/s12011-023-04043-x (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 8, 2024 Category: Biology Authors: Amira A Goma Alyaa R Salama Hossam G Tohamy Rashed R Rashed Mustafa Shukry Sara E El-Kazaz Source Type: research
