The Association Between Blood Mercury and Lipid Biomarkers in US Hypertensive Adults
CONCLUSIONS: Blood Hg exhibited a positive correlation with TC, LDL-C, and HDL-C in hypertensive adults in the USA. Nonetheless, no significant association was observed with TG.PMID:38368312 | DOI:10.1007/s12011-024-04103-w (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - February 17, 2024 Category: Biology Authors: Hang Zhao Jiecheng Peng Source Type: research

Grape Seed Proanthocyanidins Protect Pancreatic β Cells Against Ferroptosis via the Nrf2 Pathway in Type 2 Diabetes
This study explored the role of ferroptosis in pancreatic β cell damage and the protective effects of grape seed proanthocyanidin extract (GSPE). In T2DM model rats, the blood glucose, water intake, urine volume, HbA1c, and homeostasis model assessment-insulin resistance were significantly increased, while the body weight and the insulin level were significantly decreased, indicating the successful establishment of the T2DM model. MIN6 mouse insulinoma β cells were cultured in high glucose and sodium palmitate conditions to obtain a glycolipid damage model, which was administered with GSPE, ferrostatin-1 (Fer-1), or nucl...
Source: Biological Trace Element Research - February 17, 2024 Category: Biology Authors: Haiyan Li Haowei Zhang Tongling Wang Liyuan Zhang Hao Wang Heng Lu Ruirui Yang Yusong Ding Source Type: research

Boric Acid Affects the Expression of DNA Double-Strand Break Repair Factors in A549 Cells and A549 Cancer Stem Cells: An In Vitro Study
Biol Trace Elem Res. 2024 Feb 17. doi: 10.1007/s12011-024-04082-y. Online ahead of print.ABSTRACTDNA double-strand break (DSB) repair genes interact with tumor stemness- and resistance-associated processes in cancer stem cells (CSCs). Therefore, targeting DNA DSB genes in cancer treatment is important for the CSC phenotype. Although the anti-cancer effect of boric acid (BA) has been studied, its effect on DNA DSB is unclear. Moreover, no studies investigate BA's effects on DNA DSB of lung cancer stem cells (LC-SCs). To fill the gap, we aimed to assess the effects of BA on A549 cancer stem cells. CSCs were isolated from hum...
Source: Biological Trace Element Research - February 17, 2024 Category: Biology Authors: Tu ğba Semerci Sevimli Aynaz Ghorbani Bahar Demir Cevizlidere Burcug ül Altuğ Murat Sevimli Source Type: research

The Association Between Blood Mercury and Lipid Biomarkers in US Hypertensive Adults
CONCLUSIONS: Blood Hg exhibited a positive correlation with TC, LDL-C, and HDL-C in hypertensive adults in the USA. Nonetheless, no significant association was observed with TG.PMID:38368312 | DOI:10.1007/s12011-024-04103-w (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - February 17, 2024 Category: Biology Authors: Hang Zhao Jiecheng Peng Source Type: research

The Role of the Trace Element Selenium in Inflammatory Bowel Disease
Biol Trace Elem Res. 2024 Feb 16. doi: 10.1007/s12011-024-04074-y. Online ahead of print.ABSTRACTOne set of chronic gastrointestinal disorders called inflammatory bowel disease (IBD) is defined by persistent, non-specific inflammation. Abdominal pain, hematochezia, diarrhea, and other symptoms are among its clinical signs. Currently, managing and treating IBD remains a significant challenge. Patients with IBD frequently have deficits in trace elements. Selenium (Se) is one of the necessary trace elements for normal organismal function. It has several regulatory effects, including anti-oxidation, anti-inflammatory, and defe...
Source: Biological Trace Element Research - February 16, 2024 Category: Biology Authors: Ruifang Hu Jinliang Xiao Lijuan Fan Source Type: research

The Role of the Trace Element Selenium in Inflammatory Bowel Disease
Biol Trace Elem Res. 2024 Feb 16. doi: 10.1007/s12011-024-04074-y. Online ahead of print.ABSTRACTOne set of chronic gastrointestinal disorders called inflammatory bowel disease (IBD) is defined by persistent, non-specific inflammation. Abdominal pain, hematochezia, diarrhea, and other symptoms are among its clinical signs. Currently, managing and treating IBD remains a significant challenge. Patients with IBD frequently have deficits in trace elements. Selenium (Se) is one of the necessary trace elements for normal organismal function. It has several regulatory effects, including anti-oxidation, anti-inflammatory, and defe...
Source: Biological Trace Element Research - February 16, 2024 Category: Biology Authors: Ruifang Hu Jinliang Xiao Lijuan Fan Source Type: research

Anticarcinogenic Effects of Gold Nanoparticles and Metformin Against MCF-7 and A549 Cells
This study aims to investigate the effects of metformin and gold nanoparticles in MCF7 breast cancer and A549 lung cell lines. The effects of metformin and gold nanoparticles on MCF7 breast cancer and A549 lung cells were determined on cells grown in 24 h cell culture. MCF-7 and A549 cells were incubated for 24 h with the treatment of escalating molar concentrations of ifosfamide. The MTT assay was used to determine the cytotoxicity of metformin toward MCF7 and A549 cell lines. The expression of Bax, BCL2, PI3K, Akt3, mTOR, Hsp60, Hsp70, and TNF-α was measured by RT-PCR. Metformin and gold nanoparticles inhibited the prol...
Source: Biological Trace Element Research - February 15, 2024 Category: Biology Authors: Ali Ye şildağ Halime Topal K ızıloğlu Ebubekir Dirican Elif Erba ş Volkan Gelen Adem Kara Source Type: research

Anticarcinogenic Effects of Gold Nanoparticles and Metformin Against MCF-7 and A549 Cells
This study aims to investigate the effects of metformin and gold nanoparticles in MCF7 breast cancer and A549 lung cell lines. The effects of metformin and gold nanoparticles on MCF7 breast cancer and A549 lung cells were determined on cells grown in 24 h cell culture. MCF-7 and A549 cells were incubated for 24 h with the treatment of escalating molar concentrations of ifosfamide. The MTT assay was used to determine the cytotoxicity of metformin toward MCF7 and A549 cell lines. The expression of Bax, BCL2, PI3K, Akt3, mTOR, Hsp60, Hsp70, and TNF-α was measured by RT-PCR. Metformin and gold nanoparticles inhibited the prol...
Source: Biological Trace Element Research - February 15, 2024 Category: Biology Authors: Ali Ye şildağ Halime Topal K ızıloğlu Ebubekir Dirican Elif Erba ş Volkan Gelen Adem Kara Source Type: research

Thallium Toxicity and its Interference with Potassium Pathways Tested on Various Cell Lines
Biol Trace Elem Res. 2024 Feb 13. doi: 10.1007/s12011-024-04086-8. Online ahead of print.ABSTRACTThallium (Tl) is a highly toxic heavy metal whose mechanism of toxicity is still not completely understood. The aim of this study was to test Tl cytotoxicity on several cell lines of different tissue origin in order to clarify specific Tl toxicity to a particular organ. In addition, possible interference of Tl with cell potassium (K) transport was examined. Human keratinocytes (HaCaT), human hepatocellular carcinoma (HepG2), porcine kidney epithelial cells (PK15), human neuroblastoma (SH-SY5Y) and Chinese hamster lung fibroblas...
Source: Biological Trace Element Research - February 13, 2024 Category: Biology Authors: Ana Marija Marjanovi ć Čermak Stipe Musta ć Petra Cvjetko Ivan Pavi čić Domagoj Kifer Erim Be šić Ana-Marija Domijan Source Type: research

Therapeutic Potential of Green Synthesized Silver Nanoparticles for Promoting Wound-Healing Process in Diabetic Mice
In this study, silver nanoparticles (AgNPs) were synthesized using a green method involving cucumber pulp extract. The synthesis was confirmed using techniques including ultraviolet-visible spectrophotometry (UV-Vis), Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy dispersive X-ray (EDX). To evaluate wound-healing properties, mouse models were utilized with wounds induced by excision on the dorsal surface. An ointment containing silver nanoparticles was applied to assess its healing potential. Additionally, antibacterial and antioxidant activities wer...
Source: Biological Trace Element Research - February 13, 2024 Category: Biology Authors: Riffat Iqbal Amna Asghar Arslan Habib Shaista Ali Sadaf Zahra Muhammad Imran Hussain Ahmad Bilal Ahsan Yulai Liang Source Type: research

Plasma Levels of Magnesium, Calcium, Calcium to Magnesium Ratio, and Associations with Metabolic Syndrome and Cardiometabolic Risk Factors
Biol Trace Elem Res. 2024 Feb 12. doi: 10.1007/s12011-024-04088-6. Online ahead of print.ABSTRACTMagnesium and calcium are elements that have been associated with cardiometabolic risk factors related to metabolic syndrome (MetS). However, there are gaps in the knowledge regarding the impact of the calcium to magnesium (Ca/Mg) ratio in plasma. Thus, we aim to evaluate the associations between magnesium and calcium levels in plasma, and the Ca/Mg ratio in plasma with MetS components and other cardiometabolic risk factors. This cross-sectional study was carried out with 112 adults and older people, distributed into groups wit...
Source: Biological Trace Element Research - February 12, 2024 Category: Biology Authors: Melissa Nunes Moia Severina Carla Vieira Cunha Lima Francisca Leide da Silva Nunes Salom ão Israel Monteiro Lourenço Queiroz Dirce Maria Lobo Marchioni Lucia F átima Campos Pedrosa Fernando Barbosa Cl élia de Oliveira Lyra Karine Cavalcanti Maur ício Source Type: research

Effects of Boric acid as Maternal Feed Additives on the Development and Sex Ratio of Mouse pups
In this study, we administered boric acid (BA), which has positive effects on reproduction, in conjunction with feed supplementation to serve as a model for experimental animal development and breeding. The pregnancy performance, offspring development, and biochemical effects of mice given feed supplemented with BA at concentrations of 0 (control group), 250, and 500 ppm (BA groups) were investigated. A total of 18 female Balb-C mice were utilized for pregnancy. The mice were given the BA-supplemented feed during a period encompassing three weeks of pregnancy and three weeks of lactation. The numbers and weights of offspri...
Source: Biological Trace Element Research - February 11, 2024 Category: Biology Authors: M B Aykal M N Gecin I Sogut F Kar A C Taskin Source Type: research

Correction: The Impact of the High-Fructose Corn Syrup on Cardiac Damage via SIRT1/PGC1- α Pathway: Potential Ameliorative Effect of Selenium
Biol Trace Elem Res. 2024 Feb 12. doi: 10.1007/s12011-024-04100-z. Online ahead of print.NO ABSTRACTPMID:38342846 | DOI:10.1007/s12011-024-04100-z (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - February 11, 2024 Category: Biology Authors: İlter İlhan Halil Asc ı Halil İbrahim Buyukbayram Orhan Berk Imeci Mehmet Abdulkadir Sevuk Zeki Erol Fatih Aksoy Adem Milletsever Source Type: research

Antagonistic Effects, Sources, and Distribution of Selenium and Toxic Metals in Fish from Selenium-Rich and High Cadmium Areas, Dashan Region, China
In this study, 120 fish samples (14 species), 24 sediment samples, and 24 water samples were collected to investigate the antagonistic effects, sources, and health risks of TMs and Se in fish from a typical selenium-rich and high cadmium region. Zn and Se in fish from the Gongxin River were higher than in the background, which might be attributed to the different feeding habits of different fish species. The apparent antagonism between Se and Cu, Pb, and Cd was explored, and the results showed that 30%, 75%, and 100% of the Se/Cu, Se/Pb, and Se/Cd ratios were greater than one, indicating that Cu, Pb, and Cd in fish might b...
Source: Biological Trace Element Research - February 9, 2024 Category: Biology Authors: Bing Zhao Duozhi Tu Bowen Kong Ting Yue Shoubiao Zhou Shuai Liu Xiaoguo Wu Source Type: research

Measurement of Iron in Flour and Commonly-Used Breads Baked in Isfahan, Iran: A Risk Assessment Study with Monte Carlo Simulation
Biol Trace Elem Res. 2024 Feb 9. doi: 10.1007/s12011-023-04047-7. Online ahead of print.ABSTRACTFortification of highly-consumed foods such as bread is an easy and cheap strategy to combat the iron deficiency anemia. However, there have sometimes been some side effects such as iron overload and digestive problems. Accordingly, this study aimed to examine the amount of iron as well as its non-carcinogenic risks in commonly-used types of Iranian flour and breads (Barbary, Lavash, and Tafton) in Isfahan, Iran. Iron concentration of 100 samples of flour and breads were measured by Inductively Coupled Plasma Optical Emission Sp...
Source: Biological Trace Element Research - February 9, 2024 Category: Biology Authors: Zahra Esfandiari Roya Abdei Soleimani Raziyeh Eshaghi Fateme Saffari Samani Mohammad Kazerooni Arghavan Madani Sara Mohamadi Source Type: research