Pharmacokinetics of Selenium in Healthy Piglets After Different Routes of Administration: Application of Pharmacokinetic Data to the Risk Assessment of Selenium.
Abstract Selenium (Se) is a trace element in the environment. Although it is a necessary trace element for human and animal health, excessive Se can also pollute the environment and show toxic effects on humans and animals. Since the safe dose range of Se is narrow, it is important to study the pharmacokinetics of Se in order to make better use of the biological effects of Se. In the present study, we investigated the pharmacokinetic process of sodium selenate in healthy piglet plasma after either intramuscular injection or oral administrations, and examined dynamic changes of antioxidant system in healthy piglets...
Source: Biological Trace Element Research - January 26, 2019 Category: Biology Authors: Xing H, Zheng S, Zhang Z, Zhu F, Xue H, Xu S Tags: Biol Trace Elem Res Source Type: research

Safety Assessment of the Trace Element Impurities Ni and Cr in Pharmaceutical Herbal Products for Teething from Polish Pharmacies.
Abstract Control of elemental impurities (EIs) in pharmaceutical herbal products is currently important but not a very popular topic in modern toxicological analysis. The occurrence and concentration of EIs in the pharmaceutical herbal products should be controlled and meet the standards of directive International Conference on Harmonisation's Q3D Guideline on Elemental Impurities. An interesting area of interest is measuring EIs including toxic and allergic metals in pharmaceutical herbal products for teething. The aim of this article was determination of Ni and Cr impurities in pharmaceutical herbal products for...
Source: Biological Trace Element Research - January 25, 2019 Category: Biology Authors: Jurowski K, Krośniak M, Fołta M, Tatar B, Cole M, Piekoszewski W Tags: Biol Trace Elem Res Source Type: research

Protective Effects of Salidroside on Lead Acetate-induced Oxidative Stress and Hepatotoxicity in Sprague-Dawley Rats.
In this study, we established an animal model to evaluate the protective effects of SDS on chronic lead exposure induced oxidative stress and hepatotoxicity. Forty healthy Sprague-Dawley (SD) rats were assigned to control group (control, animals were provided with distilled water, n = 10); lead acetate-exposed group (PbAc, animals received lead acetate solution of 500 ppm for 60 days, n = 10); low dosage of SDS-treated group (PbAc-SDS-L, lead acetate exposed animals were given intragastric SDS 150 mg/kg body weight for 60 days, n = 10); and high dosage of SDS-tr...
Source: Biological Trace Element Research - January 21, 2019 Category: Biology Authors: Chen C, Lin B, Qi S, He J, Zheng H Tags: Biol Trace Elem Res Source Type: research

Decreased Expression of CHST-12, CHST-13, and UST in the Proximal Interphalangeal Joint Cartilage of School-Age Children with Kashin-Beck Disease: an Endemic Osteoarthritis in China Caused by Selenium Deficiency.
The objective of this study is to investigate changes in the expression of enzymes involved in chondroitin sulfate (CS) sulfation in distal articular surface of proximal interphalangeal joint isolated from school-age children patients with Kashin-Beck disease (KBD), using normal children as controls. Articular cartilage samples were collected from four normal and four KBD children (7-12 years old), and these children were assigned to control and KBD groups. Hematoxylin and eosin (H&E), toluidine blue (TB), and immunohistochemical (IHC) stainings were utilized to evaluate changes in joint pathology and expression o...
Source: Biological Trace Element Research - January 19, 2019 Category: Biology Authors: Guo Y, Zhou Y, Yan S, Qu C, Wang L, Guo X, Han J Tags: Biol Trace Elem Res Source Type: research

Evaluation of Cadmium Levels in Dental Calculus of Male Oral SCC Patients with Betel-Quid Chewing in Hunan Province of China.
This study included 85 male oral squamous cell carcinoma (SCC) cases with betel-quid chewing and smoking as observation subjects (group A) and 67 healthy people with smoking but without betel-quid chewing as control subjects (group B) in Hunan province of Mainland China. Cd levels in calcified dental calculus samples from all participants were measured by inductively coupled plasma mass spectrometry (ICP-MS). The results of this study indicated that cadmium levels in dental calculus were significantly higher in male oral SCC patients with betel-quid chewing and smoking than that in healthy individuals without habit of bete...
Source: Biological Trace Element Research - January 19, 2019 Category: Biology Authors: Zhang B, Tan X, He X, Yang H, Wang Y, Zhang K Tags: Biol Trace Elem Res Source Type: research

Trace Elements Homeostatic Imbalance in Psoriasis: a Meta-Analysis.
Abstract Studies point out that trace elements take vital roles in immunological and inflammatory reactions, such as psoriasis, while the conclusions are controversial. The purpose of this study was to analyze the existing literatures and explore the relationship between the risk of psoriasis and four trace elements zinc (Zn), copper (Cu), iron (Fe), and selenium (Se). We identified 42 studies through the databases PubMed, Embase, Cochrane Library, Google Scholar, and Web of knowledge. After the meta-analysis, the serum zinc, iron, and selenium levels showed no remarkable difference between psoriasis and controls....
Source: Biological Trace Element Research - January 15, 2019 Category: Biology Authors: Chen W, Zhou X, Zhu W Tags: Biol Trace Elem Res Source Type: research

Comparison of Copper Concentration Between Rejected Renal Grafts and Cancerous Kidneys.
ska E Abstract In the body, disorders in the composition and concentration of trace elements, including copper, can lead to the development of various alterations that may result in incorrect functioning of the kidneys. Data on the concentrations of copper in human kidneys are discussed; however, little is known about the concentration of trace elements within rejected renal grafts and kidneys with tumor lesions. The aim of our study was to compare the copper concentration between cancerous kidneys and rejected renal grafts with the division on renal cortex and renal medulla. Material consisted of kidneys from pat...
Source: Biological Trace Element Research - January 15, 2019 Category: Biology Authors: Wilk A, Wiszniewska B, Rzuchowska A, Romanowski M, Różański J, Słojewski M, Ciechanowski K, Kalisińska E Tags: Biol Trace Elem Res Source Type: research

Effects of Selenium Supplementation on Metabolic Status in Patients Undergoing for Coronary Artery Bypass Grafting (CABG) Surgery: a Randomized, Double-Blind, Placebo-Controlled Trial.
This study was carried out to evaluate the effects of selenium supplementation on glycemic control, lipid profiles, and biomarkers of inflammation and oxidative stress in patients undergoing for coronary artery bypass grafting (CABG) surgery. This randomized, double-blind, placebo-controlled trial was performed among 33 patients undergoing for CABG surgery, aged 40-85 years old. Subjects were randomly allocated into two groups to intake either 200 μg/day selenium supplements as selenium yeast (n = 17) or placebo (n = 16) for 4 weeks. Glycemic control, lipid profiles, and biomar...
Source: Biological Trace Element Research - January 14, 2019 Category: Biology Authors: Kamali A, Amirani E, Asemi Z Tags: Biol Trace Elem Res Source Type: research

Assessment of Gender Effects and Reference Values of Mane Hair Trace Element Content in English Thoroughbred Horses (North Caucasus, Russia) Using ICP-DRC-MS.
The objective of the present study was assessment of gender differences in hair trace element content in English Thoroughbred horses (North Caucasus, Russia) using ICP-DRC-MS and calculation of the reference values. Trace element content in mane hair of 190 stallions and 94 mares (3-7 years old) bred in North Caucasus (Russia) was assessed using inductively coupled plasma mass spectrometry. Mane hair Co, Cr, Mn, Li, Si, and Sr levels in mares exceeded those in stallions by 77%, 63%, 64%, 42%, 39%, and 64%, respectively. Hair Fe and Si content was nearly twofold higher in female horses as compared to the males. Only ha...
Source: Biological Trace Element Research - January 11, 2019 Category: Biology Authors: Kalashnikov VV, Zajcev AM, Atroshchenko MM, Miroshnikov SA, Zavyalov OA, Frolov AN, Skalny AV Tags: Biol Trace Elem Res Source Type: research

Zinc Deficiency and Arsenic Exposure Can Act Both Independently or Cooperatively to Affect Zinc Status, Oxidative Stress, and Inflammatory Response.
In this study, we tested the effect of arsenic exposure at environmentally relevant doses in combination with a physiologically relevant level of zinc deficiency (marginal zinc deficiency) on zinc status, oxidative damage, and inflammation. In cell culture, zinc-deficient THP-1 monocytes co-exposed with arsenic resulted in further reduction in intracellular zinc, as well as further increase in oxidative stress and inflammatory markers. In an animal study, zinc-deficient mice had further decrease in zinc status when co-exposed to arsenic. Zinc deficiency, but not arsenic exposure, resulted in an increase in baseline tr...
Source: Biological Trace Element Research - January 11, 2019 Category: Biology Authors: Wong CP, Dashner-Titus EJ, Alvarez SC, Chase TT, Hudson LG, Ho E Tags: Biol Trace Elem Res Source Type: research

Effects of Fungal Polysaccharide on Oxidative Damage and TLR4 Pathway to the Central Immune Organs in Cadmium Intoxication in Chickens.
Abstract Cadmium (Cd) can cause animal organism damage, but there have been few studies on the damage of cadmium to the immune organs of birds. Most fungal polysaccharide has antioxidant and immunomodulatory effects. The experimental study investigated the effects of fungal polysaccharide (Agaricus blazei Murill polysaccharide and Ganoderma luciduccharide) on the oxidative damage of central immune organs (thymus and bursa of Fabricius) and on the Toll-like receptor 4 (TLR4) pathway in cadmium-poisoned chickens. The results showed that Agaricus blazei polysaccharide and Ganoderma lucidum polysaccharide can reduce c...
Source: Biological Trace Element Research - January 10, 2019 Category: Biology Authors: Li R, Zhang L, Tang Z, Li T, Li G, Zhang R, Ge M Tags: Biol Trace Elem Res Source Type: research

A Review of Iodine Status of Women of Reproductive Age in the USA.
The objective of this scoping review was to summarize the studies that assessed iodine status of women of reproductive age in the USA. A systematic review of literature using the PRISMA Extension for Scoping Reviews (PRISMA-ScR) statement was conducted. PubMed, Medline, CINAHL, EMBASE, EBSCOHost, Cochrane, ERIC, Google Scholar, and Web of Science databases were searched, 1652 records were identified. One thousand six hundred forty-one records that did not satisfy the inclusion/exclusion criteria and quality review were excluded, and 11 peer-reviewed articles were determined to be eligible for this scoping review. Despite t...
Source: Biological Trace Element Research - January 7, 2019 Category: Biology Authors: Panth P, Guerin G, DiMarco NM Tags: Biol Trace Elem Res Source Type: research

Association Between Cortisol, Insulin Resistance and Zinc in Obesity: a Mini-Review.
Abstract Adipose tissue is considered an endocrine organ and its excess compromises the immune response and the metabolism of hormones and nutrients. Furthermore, visceral fat accumulation contributes to increased cortisol synthesis, which in turn induces metallothionein and Zip14 expression, which are proteins that contribute to reducing plasma zinc levels. Zinc plays a critical role in the secretion and signaling of insulin. Changes in the biochemical parameters of zinc, as observed in individuals who are obese, contribute to the manifestation of related disorders such as insulin resistance. Thus, the purpose of...
Source: Biological Trace Element Research - January 7, 2019 Category: Biology Authors: Morais JBS, Severo JS, Beserra JB, de Oiveira ARS, Cruz KJC, de Sousa Melo SR, do Nascimento GVR, de Macedo GFS, do Nascimento Marreiro D Tags: Biol Trace Elem Res Source Type: research

Cadmium and Lead Hazardous Impact Assessment of Pond Fish Species.
Abstract The current study aims to assess the concentration of cadmium (Cd) and lead (Pb) in five tissues of Cirrhinus mrigala, Labeo rohita, and Catla catla collected from fishponds of Jamshoro and Larkana, Sindh, Pakistan. Meanwhile, the levels of Cd and Pb in feeding materials, water, and sediments of fishponds of both areas were also studied. The daily intake and hazardous impact assessment of Cd and Pb by muscles of three fish species of fishponds of both areas were estimated. The concentration of Cd in tissues of C. mrigala and C. catla of Larkana were higher than that in tissues of same fish species of Jams...
Source: Biological Trace Element Research - January 5, 2019 Category: Biology Authors: Junejo SH, Baig JA, Kazi TG, Afridi HI Tags: Biol Trace Elem Res Source Type: research

Borax Alleviates Copper-Induced Renal Injury via Inhibiting the DNA Damage and Apoptosis in Rainbow Trout.
H, Atamanalp M Abstract The aim of this study was to determine the therapeutic potential of borax against copper in the kidney tissue of the rainbow trout fed with added borax (BX) (1.25, 2.5, and 5 mg/kg) and/or copper (Cu) (500,1000 mg/kg) contents. For this purpose, two treatment groups had designed, and glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) enzyme activities were determined. Besides, oxidative DNA damage (8-hydroxy-2'-deoxyguanosine, 8-OHdG), caspase-3, and malondialdehyde (MDA) levels were assessed in kidneys of all treatment groups. In molecular pathway, hsp7...
Source: Biological Trace Element Research - January 5, 2019 Category: Biology Authors: Alak G, Yeltekin AÇ, Uçar A, Parlak V, Türkez H, Atamanalp M Tags: Biol Trace Elem Res Source Type: research

Concentrations and Health Risk Assessment of Trace Elements in Cereals, Fruits, and Vegetables of Bangladesh.
This study was conducted to determine concentrations of five toxic trace elements (Cr, Ni, As, Cd, and Pb) in cereals, fruits, and vegetables of Bangladesh. The range of mass fractions (mg/kg) of Cr, Ni, As, Cd, and Pb in the foodstuffs was 0.090-2.5, 0.03-2.6, 0.13-1.7, 0.010-0.74, and 0.37-2.2, respectively. This study indicates that concentration of Cr, and Pb in fruits; As, Cd, and Pb in vegetables were higher than WHO/FAO maximum allowable concentration levels. The hazard index (HI) values for adults and children of the toxic elements in studied cereals, fruits and vegetables were higher than 1.0, suggesting non-carci...
Source: Biological Trace Element Research - January 5, 2019 Category: Biology Authors: Rahman M, Islam MA Tags: Biol Trace Elem Res Source Type: research

Copper and Zinc Nutritional Issues for Agricultural Animal Production.
Abstract Livestock have presented unique requirements and toxicity issues depending on the species for the various concentrations of Cu and Zn and their interactions with other nutrients especially Fe, Se, Mo, and S. Soil concentrations of these elements and their availability to crops influence the health of the crop and the amount found in vegetative tissues and seeds. Hence, many livestock issues are a result of the soils in the area where production is occurring (Loneragan et al. 1981). While water can provide minerals to animals, the amount consumed and availability are highly variable. Many discoveries about...
Source: Biological Trace Element Research - January 5, 2019 Category: Biology Authors: Hill GM, Shannon MC Tags: Biol Trace Elem Res Source Type: research

Mechanism Underlying the Protective Effect of Selenium on NO-Induced Oxidative Damage in Bovine Mammary Epithelial Cells.
Abstract This experiment was conducted to investigate the effects and mechanism of selenium (Se) on antioxidant and immune function of bovine mammary epithelial cells (BMEC) damaged by nitric oxide (NO). The third-generation BMEC was randomly divided into eight treatments with six replicates. The BMEC in the control group was cultured in the medium without Se and diethylenetriamine/NO (DETA/NO) for 30 h. For the DETA/NO group and Se protection group BMEC were exposed to different concentrations of Se (0, 10, 20, 50, 100, 150, and 200 nmol/L) for 24 h, followed by treatment with DETA/NO (1000 &m...
Source: Biological Trace Element Research - January 4, 2019 Category: Biology Authors: Guo Y, Guo X, Yan S, Zhang B, Shi B Tags: Biol Trace Elem Res Source Type: research

Use of 2-Hydrazinobenzothiazole-Modified Copolymer(s) as Potential Chelating Agent for Sensitive and Selective Determination of Low Levels of Mercury in Seafood by Ultrasound-Assisted Cloud-Point Extraction Combined with Spectrophotometry.
In this study, a new method was developed for the pre-concentration of trace mercury from seafood samples prior to analysis by spectrophotometry. The method is based on the complexation between 2-hydrazinobenzothiazole (2-HBT)-modified copolymer(s) and Hg(II) in the presence of an ionic surfactant, cetyltrimethylammonium bromide (CTAB), as sensitivity enhancer at pH 4.5 and the extraction of the complex into the surfactant-rich phase of polyethylene glycol tert-octylphenyl ether (Triton X-114) as the extractant. The variables affecting extraction efficiency were evaluated and optimized. Due to the observation that the...
Source: Biological Trace Element Research - January 3, 2019 Category: Biology Authors: Zengin HB, Gürkan R Tags: Biol Trace Elem Res Source Type: research

Selenium Content and/or T-2 Toxin Contamination of Cereals, Soil, and Children's Hair in Some Areas of Heilongjiang and Gansu Provinces, China.
Abstract It has been strongly suggested that selenium deficiency and T-2 contamination in cereals are responsible for the development of Kashin-Beck disease (KBD). In order to assess these risk factors of KBD in the internal and external environments, our team undertook a two-stage survey in some areas of Heilongjiang and Gansu Provinces, China. The selenium content in children's hair (293), cereal (192), and soil (46) samples were determined using the 2, 3-diamino-naphthalene fluorometric assay technique. The T-2 toxin contamination level in the cereal samples (704) was assayed using an ELISA kit. There were...
Source: Biological Trace Element Research - January 3, 2019 Category: Biology Authors: Sun L, Cui S, Deng Q, Liu H, Cao Y, Wang S, Yu J Tags: Biol Trace Elem Res Source Type: research

Selenium-Yeast Alleviated Inflammatory Damage Caused by Lead via Inhibiting Ras/ERK Pathway and Inflammatory Factors in Chicken Skeletal Muscles.
Abstract The aim of this study was to investigate the ameliorative effects of selenium-enriched yeast (Se-yeast) on the inflammatory damage induced by lead (Pb) in chicken skeletal muscles. A total of 108 1-day-old broiler chickens were randomly allocated into four groups (n = 27/group): the control group (C group), the Se-yeast-supplemented group (Se group), the lead-treated group (Pb group), and finally the Se- and Pb-combined group (Pb/Se group). The C group was fed with a basic diet comprising 0.049 mg/kg Se and 0.1 mg/kg Pb while the Se group was fed a Se-yeast diet containing 0.30&nbs...
Source: Biological Trace Element Research - January 2, 2019 Category: Biology Authors: Liu Z, Zhang F, Lu P, Zhao R, Zhang H, Song B, Li L, Wu Z, Wu R Tags: Biol Trace Elem Res Source Type: research

High Concentration of Sodium Metasilicate Impairs Autophagic Flux and Induces Apoptosis in Human Umbilical Vein Endothelial Cells.
This study aims to explore whether high level of sodium metasilicate can induce toxicity effect in human umbilical vein endothelial cells (HUVEC) and the role of autophagy and apoptosis in its toxic mechanism. HUVEC was treated with different level of high silicon and then investigated with respect to morphologic change, cell viability, immunofluorescence, the level of autophagy, and apoptosis-related protein. Moreover, bafilomycin A1 (Baf A1) was applied to detect whether autophagic flux is disrupted, and 3-methyladenine (3-MA, an autophagy inhibitor) was used to determine the relationship between autophagy and apoptosis....
Source: Biological Trace Element Research - January 2, 2019 Category: Biology Authors: Li Z, Liu S, Cao Y, Fu T, Jiang L, Zhang J Tags: Biol Trace Elem Res Source Type: research

Concentrations of Thirteen Trace Metals in Scales of Three Nototheniid Fishes from Antarctica (James Ross Island, Antarctic Peninsula).
In this study, we assessed concentrations of 13 trace metals in the scales of Notothenia coriiceps, Trematomus bernacchii and Gobionotothen gibberifrons caught off the coast of James Ross Island (Antarctic Peninsula). Overall, our results for scales broadly match those of previous studies using different fish and different organs, with most metals found at trace levels and manganese, aluminium, iron and zinc occurring at high levels in all species. This suggests that scales can serve as a useful, non-invasive bioindicator of long-term contamination in Antarctic fishes. High accumulation of manganese, aluminium, iron and zi...
Source: Biological Trace Element Research - January 2, 2019 Category: Biology Authors: Roche K, Kuta J, Sedláček I, Červenka R, Tomanová K, Jurajda P Tags: Biol Trace Elem Res Source Type: research

Nutritional Effects of Zinc on Metabolic Syndrome and Type 2 Diabetes: Mechanisms and Main Findings in Human Studies.
acute;rez A Abstract Zinc (Zn) plays crucial roles in mammalian metabolism. There is increasing interest about the potential beneficial effects of Zn on the prevention or treatment of non-communicable diseases. This review critically analyzes the information related to the role of Zn on the metabolic syndrome (MetS) as well as type 2 diabetes (T2D), and summarizes the biological basis of these potential effects of Zn. There are several mechanisms by which Zn may help to prevent the development or progression of MetS and T2D, respectively. Zn is involved in both insulin secretion and action in peripheral tissues. S...
Source: Biological Trace Element Research - January 2, 2019 Category: Biology Authors: Ruz M, Carrasco F, Rojas P, Basfi-Fer K, Hernández MC, Pérez A Tags: Biol Trace Elem Res Source Type: research

Nutraceutical Effect of Trace Elements as Additional Injectable Doses to Modulate Oxidant and Antioxidant Status, and Improves the Quality of Lamb Meat.
Abstract Our study aimed to evaluate whether zinc, copper, selenium, and manganese subcutaneous mineral application (trace elements) reduced mortality, improved performance, and modulated oxidant and antioxidant balance in lamb meat, thereby improving its quality. We divided the 110 newborn Lacaune lambs into two groups: non-treated (control), and treated (application of minerals) with three doses of 0.33 mL/kg of body weight mineral complex on days of life 1, 30, and 60. All animals were weighed on day of life 1, 30, 60, 90, and 150. At the end of the experiment, 12 animals were slaughtered for physical and ...
Source: Biological Trace Element Research - January 2, 2019 Category: Biology Authors: Cazarotto CJ, Boito JP, Glombowsky P, Baggio RA, Galli GM, Machado G, Bottari NB, Leal MLR, Kessler JD, Baldissera MD, da Silva AS Tags: Biol Trace Elem Res Source Type: research

Evaluation of Whole Blood Trace Element Levels in Chinese Children with Autism Spectrum Disorder.
The objective of the present study was to investigate whole blood levels of trace elements including zinc (Zn), copper (Cu), iron (Fe), and magnesium (Mg) in Chinese children with ASD. In total, 113 children diagnosed with ASD and 141 age-matched and gender-matched neurotypical children, divided into two gender and age groups of preschool age (2-5 years old) and school (6-10 years old) age, were examined. The quantitative analyses of whole blood trace element contents were performed by using flame atomic absorption spectroscopy. In the present study, the children with ASD generally had lower whole blood levels of...
Source: Biological Trace Element Research - January 2, 2019 Category: Biology Authors: Wu LL, Mao SS, Lin X, Yang RW, Zhu ZW Tags: Biol Trace Elem Res Source Type: research

Trace Elements Associated with Systemic Lupus Erythematosus and Insulin Resistance.
os MJ Abstract Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease of multifactorial origin. Studies have shown that trace elements such as zinc and copper may help maintain optimum function of the immune system and metabolism, while toxic metals such as lead may increase systemic autoimmunity. The current study aimed to assess the relationship between serum concentration of lithium (Li), vanadium (V), copper (Cu), zinc (Zn), molybdenum (Mo), cadmium (Cd), and lead (Pb) and SLE diagnosis, disease activity measured by SLE disease activity index (SLEDAI) and insulin resistance (IR). This ...
Source: Biological Trace Element Research - January 2, 2019 Category: Biology Authors: Pedro EM, da Rosa Franchi Santos LF, Scavuzzi BM, Iriyoda TMV, Peixe TS, Lozovoy MAB, Reiche EMV, Dichi I, Simão ANC, Santos MJ Tags: Biol Trace Elem Res Source Type: research

Relationship Between Dietary Intake and Urinary Excretion of Silicon in Free-Living Korean Adult Men and Women.
Abstract Previous studies have reported that silicon (Si) has a positive effect on bone health, immune response, and cognitive health. However, basic and important studies on evaluating dietary intake and urinary excretion of Si are limited. The aim of this study was to evaluate dietary Si intake and urinary excretion according to gender and age in healthy and free-living Korean adults and to investigate the relationship between them with gender. In this cross-sectional study, anthropometric measurements, dietary assessment using a food record, and a 24-h urine collection were conducted in 80 healthy Korean adults...
Source: Biological Trace Element Research - January 2, 2019 Category: Biology Authors: Kim YY, Kim MH, Choi MK Tags: Biol Trace Elem Res Source Type: research

Role of Oxidative Stress in Lithium-Induced Nephropathy.
Abstract Long-term lithium treatment was associated with chronic kidney disease and renal failure although the underlying pathogenic mechanisms are not certainty known. The aim of this study was to evaluate changes in oxidative stress measures as well as renal functional and structural alterations associated with chronic use of lithium in rats. Forty Wistar male rats were randomized into four groups: control groups fed ad libitum powered standard diet for 1 and 3 months and experimental groups fed ad libitum the same diet supplemented with 60 mmol/kg diet for 1 and 3 months. Histopathological change...
Source: Biological Trace Element Research - January 2, 2019 Category: Biology Authors: Ossani GP, Uceda AM, Acosta JM, Lago NR, Repetto MG, Martino DJ, Toblli JE Tags: Biol Trace Elem Res Source Type: research

The Inverted U-Curve Association of Fluoride and Osteoclast Formation in Mice.
Abstract The effect of fluoride on osteoclasts is still controversial. In the past, researchers thought that the effects of fluoride on osteoclast and osteoblast formation occurred in a dose-dependent pattern. However, our previous in vitro study showed fluoride elicited a notably different effect on osteoclast formation. To further verify the relationship between fluoride and osteoclast formation in vivo, 60 male C57BL/6 mice were randomly divided into three groups: two treatment groups consuming water supplemented with 50 and 100 mg/L of fluoride, and a third control group with nonsupplemented water. Ion se...
Source: Biological Trace Element Research - January 2, 2019 Category: Biology Authors: Yao Y, Ma Y, Zhong N, Pei J Tags: Biol Trace Elem Res Source Type: research

Is the Concentration of Cadmium, Lead, Mercury, and Selenium Related to Preterm Birth?
In this study, between November 2017 and April 2018, preterm delivery mothers and term delivery mothers were compared in Çorum, Turkey. All deliveries were performed with cesarean sections and there were 30 mothers in the control group and 20 in the study group. The maternal blood, maternal urine, umbilical cord blood, and heavy metal levels in the amnion fluid in both groups were studied. Graphite furnace atomic absorption spectrometry was used to determine the blood concentration of Cd, Pb, Hg, and Se. We found lower levels of selenium in blood and urine of preterm delivery mothers and umbilical cord and amnion fl...
Source: Biological Trace Element Research - January 2, 2019 Category: Biology Authors: Yıldırım E, Derici MK, Demir E, Apaydın H, Koçak Ö, Kan Ö, Görkem Ü Tags: Biol Trace Elem Res Source Type: research

Effects of Sodium Selenite, L-Selenomethionine, and Selenium Nanoparticles During Late Pregnancy on Selenium, Zinc, Copper, and Iron Concentrations in Khalkhali Goats and Their Kids.
The objective of this study was to evaluate the effect of organic, inorganic, and selenium nanoparticle supplements at the final stage of pregnancy on selenium, zinc, copper, and iron concentrations of goats and placental, colostrum, and milk transfer of these trace minerals from goats to their kids. Forty pregnant Khalkhali goats (30 ± 5 kg) were randomly allocated to four treatments including (1) no supplement (control), 0.6 mg Se head-1 day-1 of selenomethionine (SM), 0.6 mg Se head-1 day-1 of selenium nanoparticles (SN), and 0.6 mg Se head...
Source: Biological Trace Element Research - January 2, 2019 Category: Biology Authors: Kachuee R, Abdi-Benemar H, Mansoori Y, Sánchez-Aparicio P, Seifdavati J, Elghandour MMMY, Guillén RJ, Salem AZM Tags: Biol Trace Elem Res Source Type: research

The Effects of Magnesium and Vitamin E Co-Supplementation on Hormonal Status and Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome.
This study was designed to determine the effects of magnesium and vitamin E co-supplementation on hormonal status and biomarkers of inflammation and oxidative stress in women with PCOS. This randomized, double-blind, placebo-controlled trial was conducted among 60 women with PCOS, aged 18-40 years old. Participants were randomly divided into two groups to take 250 mg/day magnesium plus 400 mg/day vitamin E supplements or placebo (n = 30 each group) for 12 weeks. Fasting blood samples were taken at baseline and after the 12-week intervention to quantify related variables. Magnesium and vita...
Source: Biological Trace Element Research - December 18, 2018 Category: Biology Authors: Shokrpour M, Asemi Z Tags: Biol Trace Elem Res Source Type: research

Vitamin C Attenuates Sodium Fluoride-Induced Mitochondrial Oxidative Stress and Apoptosis via Sirt1-SOD2 Pathway in F9 Cells.
Abstract Increasing evidence has suggested an important role played by reactive oxygen species (ROS) in the pathogenesis of fluorosis. Accumulating evidence demonstrates that vitamin C administration ameliorate sodium fluoride (NaF)-induced oxidative stress. However, the potentially beneficial effects of vitamin C against NaF-induced cytotoxicity and the underlying molecular mechanisms of this protection are not fully understood. Here, we found that NaF stimulated cytotoxicity, increased mitochondrial reactive oxygen species (mROS) production, and induced apoptosis in F9 embryonic carcinoma cells. Consistent with ...
Source: Biological Trace Element Research - December 18, 2018 Category: Biology Authors: Peng W, Xu S, Zhang J, Zhang Y Tags: Biol Trace Elem Res Source Type: research

Evaluation of Possible Human Health Risk of Heavy Metals from the Consumption of Two Marine Fish Species Tenualosa ilisha and Dorosoma cepedianum.
Abstract In order to study the effects of contaminants on human health, fish is considered as a powerful model among all available species for risk-benefit assessments. Tenualosa ilisha and Dorosoma cepedianum are two fish species of great economic importance as they are found in undeveloped, developing and developed countries. Concentrations of heavy metals lead (Pb), cadmium (Cd), chromium (Cr), arsenic (As) and mercury (Hg) were determined using validated and accredited test methods in order to assess the potential human health risk from the dietary intake of these two selected fish species. The estimated daily...
Source: Biological Trace Element Research - December 18, 2018 Category: Biology Authors: Atique Ullah AKM, Akter M, Musarrat M, Quraishi SB Tags: Biol Trace Elem Res Source Type: research

Salivary Nickel and Chromium Levels in Orthodontic Patients with and Without Periodontitis: a Preliminary Historical Cohort Study.
Abstract Many periodontal patients may need orthodontic treatment. Alterations in oral environment particularly the reduction of pH in periodontal patients could affect metal ion release from orthodontic appliances. However, there is no study on metal ion release in periodontal patients. The aim of this preliminary study was to comparatively evaluate, for the first time, salivary levels of nickel and chromium in periodontal patients (versus healthy controls) under orthodontic treatment for 2 months. In this in vivo study, 40 subjects were evaluated. Patient selection and standardization of orthodontic treatme...
Source: Biological Trace Element Research - December 15, 2018 Category: Biology Authors: Amini F, Asadi E, Hakimpour D, Rakhshan A Tags: Biol Trace Elem Res Source Type: research

Effects of Selenium-Enriched Yeast Improved Aflatoxin B1-Induced Changes in Growth Performance, Antioxidation Capacity, IL-2 and IFN- γ Contents, and Gene Expression in Mice.
Effects of Selenium-Enriched Yeast Improved Aflatoxin B1-Induced Changes in Growth Performance, Antioxidation Capacity, IL-2 and IFN-γ Contents, and Gene Expression in Mice. Biol Trace Elem Res. 2018 Dec 15;: Authors: Liu L, Chen F, Qin S, Ma J, Li L, Jin T, Zhao R Abstract Sixty Kunming mice were randomly assigned into three groups. Mice in a control group were fed a basal diet, while mice in AFB1 group and AFB1-Se group were fed the basal diet supplemented with 250 μg/kg AFB1 or the basal diet supplemented with 250 μg/kg AFB1 and 0.2 mg/kg selenium as selenium-enriched yea...
Source: Biological Trace Element Research - December 15, 2018 Category: Biology Authors: Liu L, Chen F, Qin S, Ma J, Li L, Jin T, Zhao R Tags: Biol Trace Elem Res Source Type: research

Microwave-Assisted Digestion Procedures Using Diluted Oxidant Mixture for Elemental Analysis of Crustaceans by MIP OES.
Abstract The aim of this study was to evaluate three digestion procedures using a diluted oxidant mixture of nitric acid, hydrogen peroxide, and water for determination of Cu, Fe, K, Mg, Mn, and Zn in shrimp and crab samples from Northern Brazil by microwave-induced plasma optical emission spectrometry. The efficiency of the digestion procedure was evaluated by comparing the residual carbon content, residual acidity, and elemental concentrations obtained in the samples. Digestion procedure 2 (4 mL HNO3 + 4 mL H2O2 + 4 mL H2O) was chosen due the adequate residual carbon co...
Source: Biological Trace Element Research - December 14, 2018 Category: Biology Authors: Lemos MS, Cruz AS, Fernandes Dantas KG Tags: Biol Trace Elem Res Source Type: research

Serum and Urinary Selenium Status in Patients with the Pre-diabetes and Diabetes in Northeast China.
This study investigated serum and urinary Se levels in patients with impaired fasting glucose (IFG), impaired glucose tolerance (IGT), type 1 diabetes (T1D), and type 2 diabetes (T2D) in Northeast Chinese populations. From January 2010 to October 2011, patients with IFG (n = 12), IGT (n = 15), T1D (n = 25), T2D (n = 137), and healthy controls (n = 50) were enrolled in the First Hospital of Jilin University. Se was detected using inductively coupled plasma spectrometer. The serum Se level was dramatically lower in patients with T1D and was significantly h...
Source: Biological Trace Element Research - December 14, 2018 Category: Biology Authors: Zhou Q, Guo W, Jia Y, Xu J Tags: Biol Trace Elem Res Source Type: research

Selenium-Mercury Balance in Commercial Fish Species from the Turkish Waters.
Abstract The interactions between selenium (Se) and mercury (Hg) were assessed in order to interpret public health risk, associated with dietary mercury exposure due to fish consumption. For this purpose, the mass and molar concentrations of Se and Hg were determined in the edible tissues of six species of fish, collected from the commercial fishing grounds of Turkey. The Se/Hg molar ratios and selenium health benefit values (Se-HBVs) were also calculated. The main fish species exported from Turkey to Europe were studied to determine the risks or benefits for human health. The mean Hg levels (μg g-1, wet w...
Source: Biological Trace Element Research - December 14, 2018 Category: Biology Authors: Ulusoy Ş, Mol S, Karakulak FS, Kahraman AE Tags: Biol Trace Elem Res Source Type: research

Tissue Concentrations of Zinc, Iron, Copper, and Magnesium During the Phases of Full Thickness Wound Healing in a Rodent Model.
In conclusion, zinc, iron, and copper, even though differing in their total mass within the wound, exhibited concentration curve transitions at day 3. Interestingly, this time point correlates with the maximum proliferating keratinocyte rate during the proliferation phase. PMID: 30552609 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - December 14, 2018 Category: Biology Authors: Coger V, Million N, Rehbock C, Sures B, Nachev M, Barcikowski S, Wistuba N, Strauß S, Vogt PM Tags: Biol Trace Elem Res Source Type: research

A New Insight on Activation of Human Endogenous Retroviruses (HERVs) in Malignant Melanoma upon Exposure to CuSO4.
Abstract Human endogenous retroviruses (HERVs) are semi-conserved subtypes of long-terminal repeats containing retrotransposons that constitute approximately 8% of the genome. Under pathological conditions, the expression of HERVs is also affected by epigenetic modifications. The extent to which the activation of human endogenous retroviruses can be influenced upon exposure to copper remains to be evaluated. Thus, the present study was designed to evaluate the effects of CuSO4 administration on the transcriptional activity of three HERV families (H, K, and W) in human malignant melanoma cells. For this purpose, fo...
Source: Biological Trace Element Research - December 11, 2018 Category: Biology Authors: Karimi A, Sheervalilou R, Kahroba H Tags: Biol Trace Elem Res Source Type: research

Abnormal Iodine Nutrition-Induced ER Stress Upregulates MCP-1 Expression Through P38/MAPK Signaling Pathway in Thyroid Cells.
Abstract Iodine is an important chemical for thyroid hormone synthesis. The association between iodine nutrition status and the risk of disease present U-shaped curve, as either low or high iodine nutrition status will increase the risk of thyroid diseases. Endoplasmic reticulum stress (ER stress), which can induce over expressions of inflammation factors, like monocyte chemo-attractant protein-1 (MCP-1), is related to the pathogenesis of thyroid disease. However, the correlations among iodine, MCP-1 and ER stress are not entirely clear during the pathogenesis of thyroid diseases. Present study aims to investigate...
Source: Biological Trace Element Research - December 11, 2018 Category: Biology Authors: Chen X, Huang H, Liang B, Zhou J Tags: Biol Trace Elem Res Source Type: research

Determination of Heavy Metal Concentrations and Their Potential Sources in Selected Plants: Xanthium strumarium L. (Asteraceae), Ficus exasperata Vahl (Moraceae), Persicaria attenuata (R.Br) Sojak (Polygonaceae), and Kanahia laniflora (Forssk.) R.Br. (Asclepiadaceae) from Awash River Basin, Ethiopia.
The objective of this study was to determine the concentrations, potential sources and evaluate the risks of heavy metals in selected plants from Awash River Basin, Ethiopia. A total of 57 samples were analyzed from four different plant species. Microwave-assisted digestion was applied to digest the samples and the concentration of nine elements namely: Al, Cr, Ni, Cu, Zn, As, Cd, Hg, and Pb were analyzed using Inductively Coupled Plasma-Mass Spectrometry (ICP- MS) (Thermos X SERIES2). The obtained data were analyzed using Statistical Package for Social Sciences (SPSS IBM version 20). The recorded mean concentration of hea...
Source: Biological Trace Element Research - December 8, 2018 Category: Biology Authors: Tadesse AW, Gereslassie T, Yan X, Wang J Tags: Biol Trace Elem Res Source Type: research

Association Among Sources Exposure of Cadmium in the Adult Non-smoking General Population of Tehran.
This study tried to evaluate one of these models' validity which is developed to predict urinary cadmium from dietary. Afterwards, the predicted urinary compared with the measured urinary cadmium. The correlation coefficient between dietary and blood cadmium equaled 0.66 which was statically significant, but the correlation between dietary and urinary cadmium was minimal and not statically significant (p > 0.05). An inverse and negative correlation was found between serum ferritin and blood cadmium. The mean predicted urinary cadmium calculated by the model was 2.5-fold higher than the measured value in th...
Source: Biological Trace Element Research - December 7, 2018 Category: Biology Authors: Ghoochani M, Dehghani MH, Rastkari N, Nodehi RN, Yunesian M, Mesdaghinia A, Houshiarrad A, Saraei M Tags: Biol Trace Elem Res Source Type: research

Iron-Related Factors in Early Pregnancy and Subsequent Risk of Gestational Diabetes Mellitus: the Ma'anshan Birth Cohort (MABC) Study.
In conclusion, the three iron-related factors are all related to GDM risk on some level. PMID: 30515713 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - December 5, 2018 Category: Biology Authors: Zhu B, Liang C, Xia X, Huang K, Yan S, Hao J, Zhu P, Gao H, Tao F Tags: Biol Trace Elem Res Source Type: research

Metvan, bis(4,7-Dimethyl-1,10-phenanthroline)sulfatooxidovanadium(IV): DFT and Spectroscopic Study-Antitumor Action on Human Bone and Colorectal Cancer Cell Lines.
S, Baran EJ Abstract The complex bis(4,7-dimethyl-1,10-phenantroline)sulfatooxidovanadium(IV), commonly known as Metvan, was prepared using a known synthetic procedure. Its optimized molecular structure was obtained by DFT calculations, as it was impossible to grow single crystals adequate for a crystallographic study. The complex was also characterized by a detailed analysis of its infrared spectrum, supported by the theoretical calculations, and also by some data derived from its Raman spectrum. In addition, cytotoxicity studies were performed using human osteosarcoma (MG-63) and human colorectal adenocarcinoma ...
Source: Biological Trace Element Research - December 5, 2018 Category: Biology Authors: León IE, Ruiz MC, Franca CA, Parajón-Costa BS, Baran EJ Tags: Biol Trace Elem Res Source Type: research

Effect of Long-term Administration of Oral Magnesium Sulfate and Insulin to Reduce Streptozotocin-Induced Hyperglycemia in Rats: the Role of Akt2 and IRS1 Gene Expressions.
Abstract The effects of long-term oral administration of magnesium sulfate and insulin on hyperglycemia were investigated using Akt2 and IRS1 gene expression methods in streptozotocin-induced diabetic rats. Fifty rats were randomly divided into five experimental groups: 1, non-diabetic control (NDC); 2, Mg2+-treated non-diabetic control (Mg-NDC); 3, chronic diabetic (CD); 4, Mg2+-treated chronic diabetic (Mg-CD); and 5, insulin-treated chronic diabetic (Ins-CD). Streptozotocin was used to induce diabetes. The Mg-CD and Mg-NDC groups received 10 g/l of MgSO4 added to drinking water. The Ins-CD group received 2...
Source: Biological Trace Element Research - December 5, 2018 Category: Biology Authors: Kamran M, Kharazmi F, Malekzadeh K, Talebi A, Khosravi F, Soltani N Tags: Biol Trace Elem Res Source Type: research

Influence of Dietary Copper Methionine Concentrations on Growth Performance, Digestibility of Nutrients, Serum Lipid Profiles, and Immune Defenses in Broilers.
Abstract A 42-day experiment was conducted to evaluate the influence of dietary copper (Cu) concentrations on growth performance, nutrient digestibility, and serum parameters in broilers aged from 1 to 42 days. Five hundred forty 1-day-old broilers were randomly assigned into 1 of the following 6 dietary treatments: (1) control (basal diet without supplemental Cu), (2) 15 mg/kg supplemental Cu (Cu15), (3) 30 mg/kg supplemental Cu (Cu30), (4) 60 mg/kg supplemental Cu (Cu60), (5) 120 mg/kg supplemental Cu (Cu120), and (6) 240 mg/kg supplemental Cu (Cu240), Cu as copper methionine. A 4-d...
Source: Biological Trace Element Research - December 4, 2018 Category: Biology Authors: Wu X, Dai S, Hua J, Hu H, Wang S, Wen A Tags: Biol Trace Elem Res Source Type: research

Graphite Furnace Atomic Absorption Spectrometric Evaluation of Iron Excretion in Mouse Urine Caused by Whole-Body Gamma Irradiation.
Abstract A procedure for the determination of iron in mice urine using graphite furnace atomic absorption spectrometry was developed. The mice urinary samples contain many organic compounds in the matrix, whose concentrations are approximately 20%, and the value is 30-fold higher compared to those found in human urine. Moreover, only 0.2 mL or less of urine was obtained as a sample volume per urination event. It was difficult to decompose the organic materials in the samples by wet digestion using mineral acids and oxidising agents, because of the tiny volumes. In this experiment, raw urinary samples were pla...
Source: Biological Trace Element Research - November 30, 2018 Category: Biology Authors: Yoshiyama M, Okamoto Y, Izumi S, Iizuka D Tags: Biol Trace Elem Res Source Type: research