The Role of the Trace Element Selenium in Inflammatory Bowel Disease
Biol Trace Elem Res. 2024 Feb 16. doi: 10.1007/s12011-024-04074-y. Online ahead of print.ABSTRACTOne set of chronic gastrointestinal disorders called inflammatory bowel disease (IBD) is defined by persistent, non-specific inflammation. Abdominal pain, hematochezia, diarrhea, and other symptoms are among its clinical signs. Currently, managing and treating IBD remains a significant challenge. Patients with IBD frequently have deficits in trace elements. Selenium (Se) is one of the necessary trace elements for normal organismal function. It has several regulatory effects, including anti-oxidation, anti-inflammatory, and defe...
Source: Biological Trace Element Research - February 16, 2024 Category: Biology Authors: Ruifang Hu Jinliang Xiao Lijuan Fan Source Type: research
The Role of the Trace Element Selenium in Inflammatory Bowel Disease
Biol Trace Elem Res. 2024 Feb 16. doi: 10.1007/s12011-024-04074-y. Online ahead of print.ABSTRACTOne set of chronic gastrointestinal disorders called inflammatory bowel disease (IBD) is defined by persistent, non-specific inflammation. Abdominal pain, hematochezia, diarrhea, and other symptoms are among its clinical signs. Currently, managing and treating IBD remains a significant challenge. Patients with IBD frequently have deficits in trace elements. Selenium (Se) is one of the necessary trace elements for normal organismal function. It has several regulatory effects, including anti-oxidation, anti-inflammatory, and defe...
Source: Biological Trace Element Research - February 16, 2024 Category: Biology Authors: Ruifang Hu Jinliang Xiao Lijuan Fan Source Type: research
Anticarcinogenic Effects of Gold Nanoparticles and Metformin Against MCF-7 and A549 Cells
This study aims to investigate the effects of metformin and gold nanoparticles in MCF7 breast cancer and A549 lung cell lines. The effects of metformin and gold nanoparticles on MCF7 breast cancer and A549 lung cells were determined on cells grown in 24 h cell culture. MCF-7 and A549 cells were incubated for 24 h with the treatment of escalating molar concentrations of ifosfamide. The MTT assay was used to determine the cytotoxicity of metformin toward MCF7 and A549 cell lines. The expression of Bax, BCL2, PI3K, Akt3, mTOR, Hsp60, Hsp70, and TNF-α was measured by RT-PCR. Metformin and gold nanoparticles inhibited the prol...
Source: Biological Trace Element Research - February 15, 2024 Category: Biology Authors: Ali Ye şildağ Halime Topal K ızıloğlu Ebubekir Dirican Elif Erba ş Volkan Gelen Adem Kara Source Type: research
Anticarcinogenic Effects of Gold Nanoparticles and Metformin Against MCF-7 and A549 Cells
This study aims to investigate the effects of metformin and gold nanoparticles in MCF7 breast cancer and A549 lung cell lines. The effects of metformin and gold nanoparticles on MCF7 breast cancer and A549 lung cells were determined on cells grown in 24 h cell culture. MCF-7 and A549 cells were incubated for 24 h with the treatment of escalating molar concentrations of ifosfamide. The MTT assay was used to determine the cytotoxicity of metformin toward MCF7 and A549 cell lines. The expression of Bax, BCL2, PI3K, Akt3, mTOR, Hsp60, Hsp70, and TNF-α was measured by RT-PCR. Metformin and gold nanoparticles inhibited the prol...
Source: Biological Trace Element Research - February 15, 2024 Category: Biology Authors: Ali Ye şildağ Halime Topal K ızıloğlu Ebubekir Dirican Elif Erba ş Volkan Gelen Adem Kara Source Type: research
Thallium Toxicity and its Interference with Potassium Pathways Tested on Various Cell Lines
Biol Trace Elem Res. 2024 Feb 13. doi: 10.1007/s12011-024-04086-8. Online ahead of print.ABSTRACTThallium (Tl) is a highly toxic heavy metal whose mechanism of toxicity is still not completely understood. The aim of this study was to test Tl cytotoxicity on several cell lines of different tissue origin in order to clarify specific Tl toxicity to a particular organ. In addition, possible interference of Tl with cell potassium (K) transport was examined. Human keratinocytes (HaCaT), human hepatocellular carcinoma (HepG2), porcine kidney epithelial cells (PK15), human neuroblastoma (SH-SY5Y) and Chinese hamster lung fibroblas...
Source: Biological Trace Element Research - February 13, 2024 Category: Biology Authors: Ana Marija Marjanovi ć Čermak Stipe Musta ć Petra Cvjetko Ivan Pavi čić Domagoj Kifer Erim Be šić Ana-Marija Domijan Source Type: research
Therapeutic Potential of Green Synthesized Silver Nanoparticles for Promoting Wound-Healing Process in Diabetic Mice
In this study, silver nanoparticles (AgNPs) were synthesized using a green method involving cucumber pulp extract. The synthesis was confirmed using techniques including ultraviolet-visible spectrophotometry (UV-Vis), Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy dispersive X-ray (EDX). To evaluate wound-healing properties, mouse models were utilized with wounds induced by excision on the dorsal surface. An ointment containing silver nanoparticles was applied to assess its healing potential. Additionally, antibacterial and antioxidant activities wer...
Source: Biological Trace Element Research - February 13, 2024 Category: Biology Authors: Riffat Iqbal Amna Asghar Arslan Habib Shaista Ali Sadaf Zahra Muhammad Imran Hussain Ahmad Bilal Ahsan Yulai Liang Source Type: research
Plasma Levels of Magnesium, Calcium, Calcium to Magnesium Ratio, and Associations with Metabolic Syndrome and Cardiometabolic Risk Factors
Biol Trace Elem Res. 2024 Feb 12. doi: 10.1007/s12011-024-04088-6. Online ahead of print.ABSTRACTMagnesium and calcium are elements that have been associated with cardiometabolic risk factors related to metabolic syndrome (MetS). However, there are gaps in the knowledge regarding the impact of the calcium to magnesium (Ca/Mg) ratio in plasma. Thus, we aim to evaluate the associations between magnesium and calcium levels in plasma, and the Ca/Mg ratio in plasma with MetS components and other cardiometabolic risk factors. This cross-sectional study was carried out with 112 adults and older people, distributed into groups wit...
Source: Biological Trace Element Research - February 12, 2024 Category: Biology Authors: Melissa Nunes Moia Severina Carla Vieira Cunha Lima Francisca Leide da Silva Nunes Salom ão Israel Monteiro Lourenço Queiroz Dirce Maria Lobo Marchioni Lucia F átima Campos Pedrosa Fernando Barbosa Cl élia de Oliveira Lyra Karine Cavalcanti Maur ício Source Type: research
Effects of Boric acid as Maternal Feed Additives on the Development and Sex Ratio of Mouse pups
In this study, we administered boric acid (BA), which has positive effects on reproduction, in conjunction with feed supplementation to serve as a model for experimental animal development and breeding. The pregnancy performance, offspring development, and biochemical effects of mice given feed supplemented with BA at concentrations of 0 (control group), 250, and 500 ppm (BA groups) were investigated. A total of 18 female Balb-C mice were utilized for pregnancy. The mice were given the BA-supplemented feed during a period encompassing three weeks of pregnancy and three weeks of lactation. The numbers and weights of offspri...
Source: Biological Trace Element Research - February 11, 2024 Category: Biology Authors: M B Aykal M N Gecin I Sogut F Kar A C Taskin Source Type: research
Correction: The Impact of the High-Fructose Corn Syrup on Cardiac Damage via SIRT1/PGC1- α Pathway: Potential Ameliorative Effect of Selenium
Biol Trace Elem Res. 2024 Feb 12. doi: 10.1007/s12011-024-04100-z. Online ahead of print.NO ABSTRACTPMID:38342846 | DOI:10.1007/s12011-024-04100-z (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - February 11, 2024 Category: Biology Authors: İlter İlhan Halil Asc ı Halil İbrahim Buyukbayram Orhan Berk Imeci Mehmet Abdulkadir Sevuk Zeki Erol Fatih Aksoy Adem Milletsever Source Type: research
Antagonistic Effects, Sources, and Distribution of Selenium and Toxic Metals in Fish from Selenium-Rich and High Cadmium Areas, Dashan Region, China
In this study, 120 fish samples (14 species), 24 sediment samples, and 24 water samples were collected to investigate the antagonistic effects, sources, and health risks of TMs and Se in fish from a typical selenium-rich and high cadmium region. Zn and Se in fish from the Gongxin River were higher than in the background, which might be attributed to the different feeding habits of different fish species. The apparent antagonism between Se and Cu, Pb, and Cd was explored, and the results showed that 30%, 75%, and 100% of the Se/Cu, Se/Pb, and Se/Cd ratios were greater than one, indicating that Cu, Pb, and Cd in fish might b...
Source: Biological Trace Element Research - February 9, 2024 Category: Biology Authors: Bing Zhao Duozhi Tu Bowen Kong Ting Yue Shoubiao Zhou Shuai Liu Xiaoguo Wu Source Type: research
Measurement of Iron in Flour and Commonly-Used Breads Baked in Isfahan, Iran: A Risk Assessment Study with Monte Carlo Simulation
Biol Trace Elem Res. 2024 Feb 9. doi: 10.1007/s12011-023-04047-7. Online ahead of print.ABSTRACTFortification of highly-consumed foods such as bread is an easy and cheap strategy to combat the iron deficiency anemia. However, there have sometimes been some side effects such as iron overload and digestive problems. Accordingly, this study aimed to examine the amount of iron as well as its non-carcinogenic risks in commonly-used types of Iranian flour and breads (Barbary, Lavash, and Tafton) in Isfahan, Iran. Iron concentration of 100 samples of flour and breads were measured by Inductively Coupled Plasma Optical Emission Sp...
Source: Biological Trace Element Research - February 9, 2024 Category: Biology Authors: Zahra Esfandiari Roya Abdei Soleimani Raziyeh Eshaghi Fateme Saffari Samani Mohammad Kazerooni Arghavan Madani Sara Mohamadi Source Type: research
Impact of Trace Mineral Source and Phytase Supplementation on Prececal Phytate Degradation and Mineral Digestibility, Bone Mineralization, and Tissue Gene Expression in Broiler Chickens
In conclusion, the tested TMS had minor effects on endogenous phytate degradation in the digestive tract of broiler chickens. However, in phytase-supplemented diets, the choice of TMS was not relevant to phytate degradation under the conditions of this study.PMID:38329568 | DOI:10.1007/s12011-024-04076-w (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - February 8, 2024 Category: Biology Authors: Hanna Philippi Vera Sommerfeld Alessandra Monteiro Markus Rodehutscord Oluyinka A Olukosi Source Type: research
Zinc Transporter ZnT1 mRNA Expression Is Negatively Associated with Leptin Serum Concentrations but Is not Associated with Insulin Resistance or Inflammatory Markers in Visceral Adipose Tissue
Biol Trace Elem Res. 2024 Feb 6. doi: 10.1007/s12011-024-04089-5. Online ahead of print.ABSTRACTThe aim of this study was to evaluate the relationship between biomarkers of chronic inflammation, insulin resistance, and zinc transporter ZnT1 expression in human visceral adipose tissue. Visceral adipose tissue obtained from 47 adults undergoing laparoscopic surgery for cholecystectomy was used to analyze ZnT1 mRNA expression by RT-qPCR. ZnT1 mRNA levels were compared between subjects with normal weight, overweight, and obesity. A significantly lower ZnT1 expression was observed in overweight and obesity compared with normal-...
Source: Biological Trace Element Research - February 6, 2024 Category: Biology Authors: Ana Karen Torres-Arreola Olga P Garc ía Paulina Estrella-Ibarra Francisco Campos-Maldonado Mariela Camacho-Barron Mar ía Del Carmen Aburto-Fernández Ricardo Mart ín Lerma-Alvarado Adriana Jheny Rodriguez-M éndez Juan Carlos Sol ís-Sáinz Pablo Garc Source Type: research
Biochemical Markers of Zinc Nutrition
Biol Trace Elem Res. 2024 Feb 6. doi: 10.1007/s12011-024-04091-x. Online ahead of print.ABSTRACTZinc is an important trace element involved in the biochemical and physiological functions of the organism and is essential in the human body. It has been reported that 17.3% of people around the world are at risk of many diseases due to zinc deficiency, which has already affected people's healthy lives. Currently, mild zinc deficiency is difficult to diagnose early due to the lack of typical clinical manifestations, so finding zinc biomarkers is crucial for people's health. The present article reviews the main representative zi...
Source: Biological Trace Element Research - February 6, 2024 Category: Biology Authors: Xinying Wang Menghui Zhang Jing Ma Yanqing Tie Shusong Wang Source Type: research
Evaluation of the Concentration of Selected Elements in the Serum of Patients with Degenerative Stenosis of the Lumbosacral Spine
Biol Trace Elem Res. 2024 Feb 7. doi: 10.1007/s12011-024-04083-x. Online ahead of print.ABSTRACTIn humans, 23 elements have been shown to have biological activity. The purpose of this study was to evaluate the concentrations of iron (Fe), zinc (Zn), sodium (Na), potassium (K), magnesium (Mg), phosphorus (P), and calcium (Ca) in the serum of patients diagnosed with lumbar degenerative stenosis when compared to the concentrations of those elements in the serum of healthy volunteers. The study group consisted of 60 patients who were diagnosed with degenerative stenosis of the lumbosacral spine and who qualified for hemilamine...
Source: Biological Trace Element Research - February 6, 2024 Category: Biology Authors: Dawid Soba ński Rafa ł Staszkiewicz Micha ł Filipowicz Mateusz Holi ński Maciej J ędrocha Marek Migda ł Beniamin Oskar Grabarek Source Type: research
