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Correction to: Human Gyrovirus-Apoptin Interferes with the Cell Cycle and Induces G2/M Arrest Prior to Apoptosis
The authors would like to correct the following error. (Source: Archivum Immunologiae et Therapiae Experimentalis)
Source: Archivum Immunologiae et Therapiae Experimentalis - February 19, 2020 Category: Allergy & Immunology Source Type: research

Desloratadine Ameliorates Olfactory Disorder and Suppresses AMPA Receptor GluA1 Expression in Allergic Rhinitis Rat
AbstractAllergic rhinitis (AR) is an IgE-mediated inflammation which causes olfactory dysfunction. Antihistamines have been widely used to treat AR while few studies have investigated the effect of antihistamines on improving the sense of smell. In addition, the underlying mechanisms are not well elucidated. We established the ovalbumin (OVA)-induced allergic rhinitis rat model and administrated desloratadine to AR rats. The AR symptoms, serum level of OVA-specific IgE and IL-17, and expression of IL-4, IL-5 and IL-13 in nasal mucosa were measured. The olfactory dysfunction was monitored by buried food test and the express...
Source: Archivum Immunologiae et Therapiae Experimentalis - February 18, 2020 Category: Allergy & Immunology Source Type: research

Autotransplantation of the Adipose Tissue-Derived Mesenchymal Stromal Cells in Therapy of Venous Stasis Ulcers
AbstractAdipose tissue is a reliable source of mesenchymal stromal cells (MSC) for use in regenerative medicine. The aim of this pilot study was to describe the method, and assess the safety and the potential efficacy of transplantation of autologous adipose tissue-derived MSC for the treatment of chronic venous stasis ulcers. Study group consisted of 11 patients (mean age: 66.6  ± 9.5 years) with chronic venous stasis ulcers. Adipose tissue was harvested by tumescent-aspiration method. Stromal cells were separated using a dedicated closed system in a real-time bedside manner. The phenotype of cells was determined im...
Source: Archivum Immunologiae et Therapiae Experimentalis - February 13, 2020 Category: Allergy & Immunology Source Type: research

Can Interferon- γ Release Assays Be Useful for Monitoring the Response to Anti-tuberculosis Treatment?: A Systematic Review and Meta-analysis
AbstractThe number of studies which evaluated interferon-gamma release assays (IGRAs) results after anti-tuberculosis (TB) treatment has been rapidly increasing. The aim of this study was to investigate the potential use of IGRAs (QFT-GIT, T-SPOT.TB, QFT-Plus) in assessing the response to anti-TB treatment. We searched all studies in English language published from 1 October 2011 to 18 November 2018 in PubMed, Web of Science, and Scopus. Our search included the term “tuberculosis treatment AND interferon-γ release assay”. We included studies evaluating the performance of commercial IGRAs (including QFT-GIT, T-SPOT.TB ...
Source: Archivum Immunologiae et Therapiae Experimentalis - February 2, 2020 Category: Allergy & Immunology Source Type: research

Treatment with Lycopodium clavatum 200dH Intensifies Kidney and Liver Injury in Mice Infected with Toxoplasma gondii
In this study, physiological, histopathological, and immunological parameters were evaluated. TheL. clavatum 200dH intensified renal damage in mice infected withT. gondii from 7 dpi, causing severe and progressive alterations during this period, such as various degrees of inflammation, edema, atrophy, and tubular cystic dilation, degenerated tubules with intra-cytoplasmic vacuoles and coalescing spots, severe vascular lesions, glomerulonephritis, and peri-glomerular congestion. In the G72 animals, which receivedL. clavatum 200dH, more severe cortex damage was observed (91.66 –96.66%) as compared to the IC group (55–80%...
Source: Archivum Immunologiae et Therapiae Experimentalis - January 20, 2020 Category: Allergy & Immunology Source Type: research

Type III Interferons (Lambda Interferons) in Rheumatic Autoimmune Diseases
AbstractThe last 2  decades have witnessed the discovery and characterization of a new family of cytokines with immunological characteristics similar to those described for type I interferons, type III or lambda interferons. Unraveling the molecular mechanisms underlying each type of interferon has allowed us to unde rstand how some autoimmune diseases can be considered as interferonopathies. Under normal conditions, type III interferons play a key role in the defense against viruses by modulating the functioning of several types of innate and adaptive immune cells. These effects include upregulation of major hi stocompat...
Source: Archivum Immunologiae et Therapiae Experimentalis - January 8, 2020 Category: Allergy & Immunology Source Type: research

HER2-Positive Breast Cancer Immunotherapy: A Focus on Vaccine Development
AbstractClinical progress in the field of HER2-positive breast cancer therapy has been dramatically improved by understanding of the immune regulatory mechanisms of tumor microenvironment. Passive immunotherapy utilizing recombinant monoclonal antibodies (mAbs), particularly trastuzumab and pertuzumab has proved to be an effective strategy in HER2-positive breast cancer treatment. However, resistance to mAb therapy and relapse of disease are still considered important challenges in clinical practice. There are increasing reports on the induction of cellular and humoral immune responses in HER2-positive breast cancer patien...
Source: Archivum Immunologiae et Therapiae Experimentalis - January 8, 2020 Category: Allergy & Immunology Source Type: research

Modulatory Effect of the Euro-Lupus Low-Dose Intravenous Cyclophosphamide Regimen on Circulating Immune Cells in Systemic Lupus Erythematosus
AbstractA Euro-Lupus regimen of low-dose intravenous cyclophosphamide (CFA) is commonly used to treat severe organ manifestations of systemic lupus erythematosus (SLE), particularly lupus nephritis (LN). There are no data on the distributions and dynamics of immune cell populations in patients with various treatment outcomes. The circulating immune cells of 11 female SLE patients were assessed before and after Euro-Lupus regimen (cumulative dose of 3000  mg CFA) by flow cytometry together with those of 16 healthy women. A subanalysis was performed in LN patients who achieved complete remission(CR;n  =  3), partial rem...
Source: Archivum Immunologiae et Therapiae Experimentalis - October 15, 2019 Category: Allergy & Immunology Source Type: research

Gut Microbiota in Neurological Disorders
AbstractThe incidence of neurological disorders such as multiple sclerosis (MS), Alzheimer ’s disease (AD) and Parkinson’s disease (PD) is increasing throughout the world, but their pathogenesis remains unclear and successful treatment remains elusive. Bidirectional communications between the central nervous system and gut microbiota may play some role in the pathogenesis of the above disorders. Up to a thousand bacterial species reside in human intestine; they colonize the gut shortly after birth and remain for life. Numerous studies point to the role of microbiota composition in the development, course and treatment ...
Source: Archivum Immunologiae et Therapiae Experimentalis - September 30, 2019 Category: Allergy & Immunology Source Type: research

Retinoids as an Immunity-modulator in Dermatology Disorders
AbstractThe skin is the largest epithelial surface protecting the body from invading microbes. Vitamin A plays vital roles in the host defence of the skin, including promoting epithelial cell integrity, proliferation, and differentiation and even mediating immune responses. Furthermore, vitamin A derivatives, retinoid drugs, are widely used to treat skin diseases, such as acne and psoriasis. However, the immunoregulatory mechanisms of retinoids in dermatology have not been systematically described. In this paper, we discuss the immunological functions of retinoids during disease treatment, especially in skin disorders caus...
Source: Archivum Immunologiae et Therapiae Experimentalis - September 23, 2019 Category: Allergy & Immunology Source Type: research

Peripheral Blood B and T Cell Profiles in Children with Active Juvenile Idiopathic Arthritis
In conclusion; JIA patients have an alteration in both B and T lymphocytes with the predisposition of memory cells which may have a role in sustaining the JIA disease activity. (Source: Archivum Immunologiae et Therapiae Experimentalis)
Source: Archivum Immunologiae et Therapiae Experimentalis - September 17, 2019 Category: Allergy & Immunology Source Type: research

Professor W łodzimierz Ptak (1928–2019)
(Source: Archivum Immunologiae et Therapiae Experimentalis)
Source: Archivum Immunologiae et Therapiae Experimentalis - September 12, 2019 Category: Allergy & Immunology Source Type: research

Correction to: Significance and Role of Pattern Recognition Receptors in Malignancy
The authors would like to correct the following error. (Source: Archivum Immunologiae et Therapiae Experimentalis)
Source: Archivum Immunologiae et Therapiae Experimentalis - August 30, 2019 Category: Allergy & Immunology Source Type: research

90th Birthday of Prof. Czes ław Radzikowski
(Source: Archivum Immunologiae et Therapiae Experimentalis)
Source: Archivum Immunologiae et Therapiae Experimentalis - August 29, 2019 Category: Allergy & Immunology Source Type: research

Clinical and Immunological Features of 78 Adult Patients with Primary Selective IgG Subclass Deficiencies
AbstractThe purpose of this study is to describe both clinical and immunological features in large cohort of adult patients with IgG subclass deficiency, and response to immunoglobulin therapy. This is a retrospective study of data obtained from electronic medical records and paper charts of 78 patients with IgG subclass deficiency seen and followed at our immunology clinics from 2010 to 2016. Both isolated selective IgG subclass deficiency as well as combined (two) subclass deficiencies were observed. IgG3 subclass deficiency, isolated and in combination with other IgG subclass deficiency, is the most frequent of IgG subc...
Source: Archivum Immunologiae et Therapiae Experimentalis - July 29, 2019 Category: Allergy & Immunology Source Type: research