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Allergen-Specific T Cells in IgE-Mediated Food Allergy
AbstractFood allergy is the major reason for severe anaphylaxis in childhood and adolescence. Currently, effective and safe treatments for food allergy are unavailable. Allergen-specific CD4+ T cells have a pivotal role in causing and maintaining the allergic response to food allergens. The purpose of this review is to provide an overview on the role of allergen-specific T cells in food allergy during allergic sensitization, natural tolerance development and allergen immunotherapy. Allergen-specific T cells in the context of food allergy are predominantly of a Th2 type with slightly different surface marker expression patt...
Source: Archivum Immunologiae et Therapiae Experimentalis - December 18, 2017 Category: Allergy & Immunology Source Type: research

Variation of Regulatory T Lymphocytes in the Peripheral Blood of Children with Allergic Rhinitis
In conclusion, the present study demonstrated that the percentages of CD8+Tregs and CD4+Tregs T cells were significantly decreased in children with AR. This suggests that decreased Treg cells might represent a defect in the compartment of T-cell population in children with AR. Further studies are warranted to fully appreciate the clinical relevance of Tregs in children with AR. (Source: Archivum Immunologiae et Therapiae Experimentalis)
Source: Archivum Immunologiae et Therapiae Experimentalis - December 18, 2017 Category: Allergy & Immunology Source Type: research

NK and NKT-Like Cells in Patients with Recurrent Furunculosis
AbstractTo analyze changes in the number and percentage of NK and NKT-like cells in relation to other immune cells as well as to examine associations between increased susceptibility to infections and NK and NKT-like status in patients with recurrent furunculosis (RF) and healthy controls. Thirty patients with RF and 20 healthy age- and sex-matched volunteers were recruited. Blood samples were examined. Lymphocyte count and cytometric analyses were conducted. For statistical analysis, the Student ’st test,F test, and Brown –Forsythe test were used for comparison between groups of variables. Associations were assessed w...
Source: Archivum Immunologiae et Therapiae Experimentalis - December 13, 2017 Category: Allergy & Immunology Source Type: research

Bindarit Attenuates Pain and Cancer-Related Inflammation by Influencing Myeloid Cells in a Model of Bone Cancer
AbstractC –C motif chemokine ligand 2 (CCL2) is a small cytokine that functions in inflammation and cancer development. Bindarit, a CCL2 inhibitor, is a small anti-inflammatory molecule proven safe by phase II trials in type 2 diabetic nephropathy patients. As cancer-related inflammation is a cause of pain, we investigated whether Bindarit suppresses cancer-related inflammation and pain. We established a bone-cancer mouse model by inoculating cancer cells. After applying Bindarit, we preformed pain sensitivity tests and checked cancer development by X-ray. Using flow cytometry and qRT-PCR assays, we a ssessed the effect ...
Source: Archivum Immunologiae et Therapiae Experimentalis - December 12, 2017 Category: Allergy & Immunology Source Type: research

Oxidative Stress in Kidney Diseases: The Cause or the Consequence?
AbstractExaggerated oxidative stress (OS) is usually considered as a disturbance in regular function of an organism. The excessive levels of OS mediators may lead to major damage within the organism ’s cells and tissues. Therefore, the OS-associated biomarkers may be considered as new diagnostic tools of various diseases. In nephrology, researchers are looking for alternative methods replacing the renal biopsy in patients with suspicion of chronic kidney disease (CKD). Currently, CKD is a fre quent health problem in world population, which can lead to progressive loss of kidney function and eventually to end-stage renal ...
Source: Archivum Immunologiae et Therapiae Experimentalis - December 6, 2017 Category: Allergy & Immunology Source Type: research