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Heterogeneous Mixture of Amniotic Cells is Likely a Better Source of Stem Cells than Adipose Tissue
AbstractStem cells are increasingly being used in the course of burn treatment. As several different types of stem cells are available for the purposes, it is important to chose the most efficient and the most practicable stem cell type. The aim of this study was to compare the potential of heterogeneous amnion cell mixture with the presently used standard therapy, the adipose tissue-derived stem cells. The placenta was collected during a Cesarean section procedure. Adipose tissue tissue-derived cells were isolated using the Cytori ’s Celution® System. Cells were tested for fulfillment of the minimum criteria for stem c...
Source: Archivum Immunologiae et Therapiae Experimentalis - April 15, 2019 Category: Allergy & Immunology Source Type: research

Significance and Role of Pattern Recognition Receptors in Malignancy
AbstractPattern recognition receptors (PRRs) are members of innate immunity, playing pivotal role in several immunological reactions. They are known to act as a bridge between innate and adaptive immunity. They are expressed on several normal cell types but have been shown with increasing frequency on/in tumor cells. Significance of this phenomenon is largely unknown, but it has been shown by several authors that they, predominantly Toll-like receptors (TLRs), act in the interest of tumor, by promotion of its growth and spreading. Preparation of artificial of TLRs ligands (agonists) paved the way to use them as a therapeut...
Source: Archivum Immunologiae et Therapiae Experimentalis - April 10, 2019 Category: Allergy & Immunology Source Type: research

Natural Killer and Natural Killer T Cells in Juvenile Systemic Lupus Erythematosus: Relation to Disease Activity and Progression
In conclusion, low frequency of NK and NKT and expansion of CD56bright NK cells are marked in juvenile SLE, particularly with activity. These changes have direct effect on renal impairment and growth failure, reflecting their potential influence on disease progression. (Source: Archivum Immunologiae et Therapiae Experimentalis)
Source: Archivum Immunologiae et Therapiae Experimentalis - April 3, 2019 Category: Allergy & Immunology Source Type: research

PD-L1 Ameliorates Murine Acute Graft-Versus-Host Disease by Suppressing Effector But Not Regulatory T Cells Function
In this study, we carried out studies in a murine aGVHD model to clarify the role of PD-L1 in aGVHD pathogenesis. We found that systemic overexpression of PD-L1 by hydrodynamic gene transfer (HGT) method in vivo ameliorates aGVHD-induced lethality in mice. Systemic overexpression of PD-L1 inhibits the donor T cells activation, effector memory status, as well as Th1 and Th17 cells responses in vivo. In addition, PD-L1 Ig treatment significantly suppressed T cells ’ proliferation, promoted T cells’ apoptosis, and reduced pro-inflammatory cytokines expression by effector T cells in vitro in the stimulation of anti-CD3/CD2...
Source: Archivum Immunologiae et Therapiae Experimentalis - March 28, 2019 Category: Allergy & Immunology Source Type: research

Theaflavin-3, 3 ′-Digallate Attenuates Rheumatoid Inflammation in Mice Through the Nuclear Factor-κB and MAPK Pathways
This study aimed to explore the attenuation of TFDG on RA. The collagen-induced arthritis (CIA) mouse model was established and administered with TFDG. The arthritis score and incidence was recorded to assess the ameli oration of TFDG on arthritis. Histopathological change of the mouse joint tissues was evaluated by haemotoxylin and eosin staining. The expression of pro-inflammatory mediators including interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and IL-6 was quantified by ELISA. The activation of nuclear factor (NF)-κB and mitogen-activated protein kinase (MAPK) signaling pathways in the synovium were determined...
Source: Archivum Immunologiae et Therapiae Experimentalis - March 13, 2019 Category: Allergy & Immunology Source Type: research

The Expression of the SLIT –ROBO Family in Adult Patients with Acute Myeloid Leukemia
ConclusionsThese data indicate that SLIT –ROBO family members play a role in the biology of AML. Low expression of SLIT in BM of AML patients may suggest its expression alterations in AML. Increased expression of ROBO1 and ROBO2 in AML patients suggests their participation in AML pathogenesis. (Source: Archivum Immunologiae et Therapiae Experimentalis)
Source: Archivum Immunologiae et Therapiae Experimentalis - February 28, 2019 Category: Allergy & Immunology Source Type: research

The Effect of Fucoidan, a Potential New, Natural, Anti-Neoplastic Agent on Uterine Sarcomas and Carcinosarcoma Cell Lines: ENITEC Collaborative Study
AbstractThe aim of the study was to assess the activity of fucoidan on the uterine sarcomas (MES-SA and ESS-1) and carcinosarcoma cell lines (SK-UT-1 and SK-UT-1B) and its toxicity on the human skin fibroblasts (HSF). Two uterine sarcomas and two carcinosarcoma cell lines were examined, as a control HSF were used. Cell viability was assessed with MTT test, apoptosis with caspase-3 activity and cell cycle by assessment of DNA synthesis. Fucoidan significantly decreases cell viability in SK-UT-1, SK-UT-1B, and ESS-1 cell lines, such effect was not observed in MES-SA. Fucoidan was not substantially affecting proliferation amo...
Source: Archivum Immunologiae et Therapiae Experimentalis - January 18, 2019 Category: Allergy & Immunology Source Type: research

Correction to: Building the Prestige of Archivum Immunologiae et Therapiae Experimentalis : From a Little Known to an Internationally Recognized Journal
According to JCR data, updated in October 2018 by Clarivate Analytics. (Source: Archivum Immunologiae et Therapiae Experimentalis)
Source: Archivum Immunologiae et Therapiae Experimentalis - December 7, 2018 Category: Allergy & Immunology Source Type: research

Modulation of the Immune System in Chronic Hepatitis C and During Antiviral Interferon-Free Therapy
AbstractThe treatment of patients with chronic hepatitis C virus (HCV) infection has changed tremendously over the past 2  years, with an increasing variety of all-oral direct-acting antiviral (DAA) treatment regimens available for different HCV genotypes and distinct clinical settings. These treatments have significantly improved safety in patients with advanced liver disease compared with interferon (IFN)-based regi mens. HCV modifies the human immune system to escape immunosurveillance via several mechanisms. One of the basic mechanisms of HCV is the ability to “switch” the immune response by reducing the activity ...
Source: Archivum Immunologiae et Therapiae Experimentalis - November 15, 2018 Category: Allergy & Immunology Source Type: research

Roles of Myeloid-Derived Suppressor Cells in Cancer Metastasis: Immunosuppression and Beyond
AbstractMetastasis is the direst face of cancer, and it is not a feature solely dependent on cancer cells; however, a complex interaction between cancer cells and host causes this process. Investigating the mechanisms of metastasis can lead to its control. Myeloid-derived suppressor cells (MDSCs) are key components of tumor microenvironment that favor cancer progression. These cells result from altered myelopoiesis in response to the presence of tumor. The most recognized function of MDSCs is suppressing anti-tumor immune responses. Strikingly, these cells are among important players in cancer dissemination and metastasis....
Source: Archivum Immunologiae et Therapiae Experimentalis - November 2, 2018 Category: Allergy & Immunology Source Type: research

Characterization of Regulatory T Cells in Preterm and Term Infants
AbstractOur study aimed to study regulatory T cells (Tregs) and their expression of CD45RA, HLA-DR, and CD39 in preterm and full-term infants. In an observational study, we used a three-color flow cytometry for determination of Tregs and their expression of CD45RA, HLA-DR, and CD39 in preterm and full-term infants. The percentages of CD4+CD25+highFoxp3+, CD39+ Tregs, HLA-DR+ Tregs and the expression of Foxp3+ in CD4+CD25+highFoxp3 Tregs cells were significantly lower in neonates when compared to healthy adult controls. The levels of na ïve resting Tregs (CD45RA+Tregs) were significantly higher in neonates than controls. T...
Source: Archivum Immunologiae et Therapiae Experimentalis - October 29, 2018 Category: Allergy & Immunology Source Type: research

Building the Prestige of Archivum Immunologiae et Therapiae Experimentalis : From a Little Known to an Internationally Recognized Journal
AbstractArchivum Immunologiae et Therapiae Experimentalis (AITE) was founded in 1953 by Ludwik Hirszfeld, a world famous Polish physician and scientist in the field of microbiology and immunology. Initially, AITE was published in Polish, but within a few years, it changed to English to increase the range and number of international readers. In its over 65  year history, AITE has had several Editors and a number of Publishers. In the period 1977–1991, AITE was listed in the system of scientific information Current Contents/Life Sciences, but for several years, its impact on the international readership of the Journal was...
Source: Archivum Immunologiae et Therapiae Experimentalis - October 16, 2018 Category: Allergy & Immunology Source Type: research

Human Microbiome: Composition and Role in Inflammatory Skin Diseases
AbstractThis review focuses on recent evidences about human microbiome composition and functions, exploring the potential implication of its impairment in some diffuse and invalidating inflammatory skin diseases, such as atopic dermatitis, psoriasis, hidradenitis suppurativa and acne. We analysed current scientific literature, focusing on the current evidences about gut and skin microbiome composition and the complex dialogue between microbes and the host. Finally, we examined the consequences of this dialogue for health and skin diseases. This review highlights how human microbes interact with different anatomic niches mo...
Source: Archivum Immunologiae et Therapiae Experimentalis - October 9, 2018 Category: Allergy & Immunology Source Type: research

Interleukin-22 and Its Correlation with Disease Activity in Plaque Psoriasis
In conclusion, IL-22 may collaborate with other soluble factors and cells together forming inflammatory circuits that otherwise exist as constitutive or inducible pathways in normal skin and become pathologically amplificated in psoriasis. Targeting IL-22 may be promising as a pot ential therapeutic for plaque psoriasis. (Source: Archivum Immunologiae et Therapiae Experimentalis)
Source: Archivum Immunologiae et Therapiae Experimentalis - October 5, 2018 Category: Allergy & Immunology Source Type: research

Analysis of Polymorphisms in the Mediator Complex Subunit 13-like ( Med13L ) Gene in the Context of Immune Function and Development of Experimental Arthritis
AbstractThe Mediator complex subunit 13-like (MED13L) protein is part of the multi-protein mediator complex and plays an important role in gene transcription. Polymorphisms in theMED13L gene have been linked to congenital heart anomalies and intellectual disabilities. Despite recent evidence of indirect links of MED13L to cytokine release and inflammation, impact of genetic variations inMED13L on immune cells remains unexplored. The B10.RIII and RIIIS/J mouse strains vary in susceptibility to induced experimental autoimmune disease models. From sequencing data of the two mouse strains, we identified six polymorphisms in th...
Source: Archivum Immunologiae et Therapiae Experimentalis - October 1, 2018 Category: Allergy & Immunology Source Type: research