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Hydroxychloroquine Therapy and Serum Immunoglobulin Levels in Women with IgG Subclass Deficiency and Systemic Lupus Erythematosus, Sj ögren Syndrome, and Rheumatoid Arthritis: A Retrospective Study
AbstractHydroxychloroquine (HCQ) therapy decreased immunoglobulin (Ig) levels in patients with Sj ögren syndrome (SS) and rheumatoid arthritis (RA) in previous studies. We found no report of Ig levels of women with IgG subclass deficiency (IgGSD) and systemic lupus erythematosus (SLE), SS, or RA treated with HCQ. We retrospectively evaluated IgG, IgG subclass, IgA, and IgM levels and other char acteristics of women at IgGSD diagnosis who did and did not take HCQ for SLE, SS, or RA. There were 132 women (48 subnormal IgG1 only, 49 combined subnormal IgG1/IgG3, and 35 subnormal IgG3 only). Mean age was 49 ± 13 years. ...
Source: Archivum Immunologiae et Therapiae Experimentalis - April 11, 2022 Category: Allergy & Immunology Source Type: research

Preliminary Results for Personalized Therapy in Pregnant Women with Polycystic Ovary Syndrome During the COVID-19 Pandemic
AbstractIncreased androgen level, hyperinsulinemia, diabetes, impaired fibrinolysis, obesity, hypertension, chronic inflammation, abnormal immune response to infections and hyperhomocysteinemia are the most common abnormalities related to polycystic ovary syndrome (PCOS) women and are the factors predisposing to the severe course of COVID-19. The SARS-Cov-2 infection during pregnancy is associated with an increased risk of complications (spontaneous abortion), similar to those in PCOS. The treatment of PCOS pregnant women with a history of fertility failures raises many doubts, especially during the COVID pandemic. However...
Source: Archivum Immunologiae et Therapiae Experimentalis - March 24, 2022 Category: Allergy & Immunology Source Type: research

Study of Plasma Anti-CD26 Autoantibody Levels in a Cohort of Treatment-Na ïve Early Arthritis Patients
AbstractIn rheumatoid arthritis (RA), the identification of biomarkers to adjust treatment intensity and to correctly diagnose the disease in early stages still constitutes a challenge and, as such, novel biomarkers are needed. We proposed that autoantibodies (aAbs) against CD26 (DPP4) might have both etiological importance and clinical value. Here, we perform a prospective study of the potential diagnostic power of Anti-CD26 aAbs through their quantification in plasmas from 106 treatment-na ïve early and undifferentiated AR. Clinical antibodies, Anti-CD26 aAbs, and other disease-related biomarkers were measured in plasma...
Source: Archivum Immunologiae et Therapiae Experimentalis - March 18, 2022 Category: Allergy & Immunology Source Type: research

New Treatment Options in Lupus Nephritis
AbstractThe aim of this study is to report major recent progresses in the treatment of lupus nephritis (LN). Results of controlled randomized trials are discussed in view of the unmet needs in the field. Current treatments of LN are not satisfactory, with a disappointing proportion of 20 –30% of patients achieving complete renal response within 6–12 months, and 5–20% developing end-stage kidney disease within ten years. Two drugs (belimumab and voclosporin) have been officially registered by the medical agencies as add on treatment of LN, a first-in-history success after deca des of use of non-registered drugs and t...
Source: Archivum Immunologiae et Therapiae Experimentalis - March 17, 2022 Category: Allergy & Immunology Source Type: research

CD5L Secreted by Macrophage on Atherosclerosis Progression Based on Lipid Metabolism Induced Inflammatory Damage
AbstractTo explore the molecular mechanism of exosomal protein CD5L secreted by macrophage to promote the progression of atherosclerosis. Twenty cases of patients with atherosclerosis (AS) and 20 cases of healthy subjects were collected. Morphological properties of exosomes were identified by transmission electron microscopy, and the marker proteins CD63 and CD81 of exosomes were measured by Western blot. The secretion of inflammatory factors in the blood supernatant were analyzed by ELISA. Atherosclerosis cell models were established by transwell and separated into three groups: first group was treated with exosome inhibi...
Source: Archivum Immunologiae et Therapiae Experimentalis - March 6, 2022 Category: Allergy & Immunology Source Type: research

Recombinant Human Lactoferrin Reduces Inflammation and Increases Fluoroquinolone Penetration to Primary Granulomas During Mycobacterial Infection of C57Bl/6 Mice
AbstractInfection withMycobacterium tuberculosis (Mtb) results in the primary formation of a densely packed inflammatory foci that limits entry of therapeutic agents into pulmonary sites where organisms reside. No current therapeutic regimens exist that modulate host immune responses to permit increased drug penetration to regions of pathological damage during tuberculosis disease. Lactoferrin is a natural iron-binding protein previously demonstrated to modulate inflammation and granuloma cohesiveness, while maintaining control of pathogenic burden. Studies were designed to examine recombinant human lactoferrin (rHLF) to m...
Source: Archivum Immunologiae et Therapiae Experimentalis - February 28, 2022 Category: Allergy & Immunology Source Type: research

Treat-to-Target in Lupus Nephritis. What is the Role of the Repeat Kidney Biopsy?
AbstractKidney involvement, termed lupus nephritis (LN), develops in 35 –60% of patients with systemic lupus erythematosus, often early during the disease course. When not treated promptly and efficiently, LN may lead to rapid and severe loss of kidney function, being the reason why it is considered one of the most severe lupus manifestations. Despite improved pharmac otherapy, 5–20% of LN patients develop end-stage kidney disease within ten years from the LN diagnosis. While the principal ground of LN therapy is prevention of renal function worsening, resembling a race against nephron loss, consensual agreement upon o...
Source: Archivum Immunologiae et Therapiae Experimentalis - February 11, 2022 Category: Allergy & Immunology Source Type: research

The Role of Gut Microbiota in Gastrointestinal Tract Cancers
AbstractDisturbances in gastrointestinal (GI) microbiota could play a significant role in the development of GI cancers, but the underlying mechanisms remain largely unclear. While some bacteria seem to facilitate carcinogenesis, others appear to be protective. So far only one bacterium (Helicobacter pylori) has been classified by the International Agency for Cancer Research as carcinogenic in humans but many other are the subject of intense research. Most studies on the role of microbiota in GI tract oncogenesis focus on pancreatic and colorectal cancers with the following three species:Helicobacter pylori, Escherichia co...
Source: Archivum Immunologiae et Therapiae Experimentalis - February 3, 2022 Category: Allergy & Immunology Source Type: research