Neuregulin-1 Compensates for Endothelial Nitric Oxide Synthase Deficiency
CONCLUSION: This study indicates that administration of endothelium-derived NRG1 can compensate for eNOS deficiency in the heart and kidneys.PMID:33989083 | DOI:10.1152/ajpheart.00914.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Hadis Shakeri Jente R A Boen Sofie De Moudt Jhana O Hendrickx Arthur J A Leloup Griet Jacobs Guido R Y De Meyer Gilles W De Keulenaer Pieter-Jan D F Guns Vincent F M Segers Source Type: research

Aerobic exercise training reduces cardiac function and coronary flow-induced vasodilation in mice lacking adiponectin
Am J Physiol Heart Circ Physiol. 2021 May 14. doi: 10.1152/ajpheart.00885.2020. Online ahead of print.ABSTRACTWe tested the hypothesis that adiponectin deficiency attenuates coronary microvascular and cardiac function and prevents exercise training-induced adaptations of the coronary microvasculature and the myocardium in adult mice. Adult wild-type (WT) or adiponectin knockout (adiponectin KO) mice underwent treadmill exercise training or remained sedentary for 8-10 weeks. Systolic and diastolic function were assessed before and after exercise training or cage confinement. Vasoreactivity of coronary resistance arteries wa...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Jacob T Caldwell Karissa M Dieseldorff Jones Hyerim Park Jose R Pinto Payal Ghosh Emily C Reid-Foley Brody Ulrich Michael D Delp Brad J Behnke Judy M Muller-Delp Source Type: research

Pericyte-specific deletion of Ninjurin-1 induces fragile vasa vasorum formation and enhances intimal hyperplasia of injured vasculature
In conclusion, deletion of Ninj1 in pericytes induces the immature vasa vasorum formation of injured vasculature and exacerbates adventitial inflammation and intimal hyperplasia. Thus, Ninj1 contributes to the vasa vasorum maturation in response to vascular injury, and to reduction of vascular remodeling.PMID:33961504 | DOI:10.1152/ajpheart.00931.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Kiwamu Horiuchi Kohei Kano Akiho Minoshima Taiki Hayasaka Atsushi Yamauchi Takamitsu Tatsukawa Risa Matsuo Yuri Yoshida Yui Tomita Maki Kabara Naoki Nakagawa Naofumi Takehara Naoyuki Hasebe Jun-Ichi Kawabe Source Type: research

Race-specific changes in endothelial inflammation and microRNA in response to an acute inflammatory stimulus
This study assessed racial differences in acute induced endothelial inflammation and related miRs. Cultured human umbilical vein endothelial cells (HUVECs) derived from AA and Caucasian Americans (CA) were exposed to the influenza vaccine to determine changes in inflammatory markers, endothelial nitric oxide synthase (eNOS), and miR expression/release. Endothelial function (flow-mediated dilation [FMD]), circulating IL-6, and circulating miR were also measured in young, healthy AA and CA individuals before and after receiving the influenza vaccine. There were no significant racial differences in any parameters at baseline....
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Ryan M Sapp Catalina A Chesney Catherine B Springer Matthew R Laskowski Daniel B Singer Lauren E Eagan Sara E Mascone William S Evans Steven J Prior James M Hagberg Sushant M Ranadive Source Type: research

Coronary Microvascular Adaptations Distal to Epicardial Artery Stenosis
Am J Physiol Heart Circ Physiol. 2021 May 7. doi: 10.1152/ajpheart.00992.2020. Online ahead of print.ABSTRACTUntil recently, epicardial coronary stenosis has been considered the primary outcome of coronary heart disease and clinical interventions have been dedicated primarily to identification and removal of flow-limiting stenoses. However, a growing body of literature indicates that both epicardial stenosis and microvascular dysfunction contribute to damaging myocardial ischemia. In this review, we discuss the co-existence of macro- and microvascular disease, and how the structure and function of the distal microcirculati...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Daphne Merkus Judy Muller-Delp Cristine L Heaps Source Type: research

Calcification Prevalence in Different Vascular Zones and Its Association With Demographics, Risk Factors, and Morphometry
Am J Physiol Heart Circ Physiol. 2021 May 7. doi: 10.1152/ajpheart.00040.2021. Online ahead of print.ABSTRACTVascular calcification is associated with a higher incidence of cardiovascular events, but its prevalence in different vascular zones and the influence of demographics, risk factors, and morphometry remain insufficiently understood. Computerized Tomography Angiography scans from 211 subjects 5-93 years old (mean age 47±24 years, 127M/84F) were used to build 3D vascular reconstructions and measure arterial diameters, tortuosity, and calcification volumes in six vascular zones spanning from the ascending thorac...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Majid Jadidi William Poulson Paul Aylward Jason MacTaggart Christian Sanderfer Blake Marmie Margarita Pipinos Alexey Kamenskiy Source Type: research

Spontaneous Extension Wave for In Vivo Assessment of Arterial Wall Anisotropy
Am J Physiol Heart Circ Physiol. 2021 May 7. doi: 10.1152/ajpheart.00756.2020. Online ahead of print.ABSTRACTAnother type of natural wave, traced from longitudinal wall motion and propagation along the artery, is unprecedentedly observed in our in vivo human carotid artery experiments. We coin it as extension wave (EW) and hypothesize that EW velocity (EWV) is associated with arterial longitudinal stiffness. The EW is thus assumed to complement the PW, whose velocity (PWV) is tracked from the radial wall displacement and linked to arterial circumferential stiffness through the Moens-Korteweg equation, as indicators for art...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Dan Ran Jinping Dong He Li Wei-Ning Lee Source Type: research

Pericyte-specific deletion of Ninjurin-1 induces fragile vasa vasorum formation and enhances intimal hyperplasia of injured vasculature
In conclusion, deletion of Ninj1 in pericytes induces the immature vasa vasorum formation of injured vasculature and exacerbates adventitial inflammation and intimal hyperplasia. Thus, Ninj1 contributes to the vasa vasorum maturation in response to vascular injury, and to reduction of vascular remodeling.PMID:33961504 | DOI:10.1152/ajpheart.00931.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Kiwamu Horiuchi Kohei Kano Akiho Minoshima Taiki Hayasaka Atsushi Yamauchi Takamitsu Tatsukawa Risa Matsuo Yuri Yoshida Yui Tomita Maki Kabara Naoki Nakagawa Naofumi Takehara Naoyuki Hasebe Jun-Ichi Kawabe Source Type: research

Race-specific changes in endothelial inflammation and microRNA in response to an acute inflammatory stimulus
This study assessed racial differences in acute induced endothelial inflammation and related miRs. Cultured human umbilical vein endothelial cells (HUVECs) derived from AA and Caucasian Americans (CA) were exposed to the influenza vaccine to determine changes in inflammatory markers, endothelial nitric oxide synthase (eNOS), and miR expression/release. Endothelial function (flow-mediated dilation [FMD]), circulating IL-6, and circulating miR were also measured in young, healthy AA and CA individuals before and after receiving the influenza vaccine. There were no significant racial differences in any parameters at baseline....
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Ryan M Sapp Catalina A Chesney Catherine B Springer Matthew R Laskowski Daniel B Singer Lauren E Eagan Sara E Mascone William S Evans Steven J Prior James M Hagberg Sushant M Ranadive Source Type: research

Coronary Microvascular Adaptations Distal to Epicardial Artery Stenosis
Am J Physiol Heart Circ Physiol. 2021 May 7. doi: 10.1152/ajpheart.00992.2020. Online ahead of print.ABSTRACTUntil recently, epicardial coronary stenosis has been considered the primary outcome of coronary heart disease and clinical interventions have been dedicated primarily to identification and removal of flow-limiting stenoses. However, a growing body of literature indicates that both epicardial stenosis and microvascular dysfunction contribute to damaging myocardial ischemia. In this review, we discuss the co-existence of macro- and microvascular disease, and how the structure and function of the distal microcirculati...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Daphne Merkus Judy Muller-Delp Cristine L Heaps Source Type: research

Calcification Prevalence in Different Vascular Zones and Its Association With Demographics, Risk Factors, and Morphometry
Am J Physiol Heart Circ Physiol. 2021 May 7. doi: 10.1152/ajpheart.00040.2021. Online ahead of print.ABSTRACTVascular calcification is associated with a higher incidence of cardiovascular events, but its prevalence in different vascular zones and the influence of demographics, risk factors, and morphometry remain insufficiently understood. Computerized Tomography Angiography scans from 211 subjects 5-93 years old (mean age 47±24 years, 127M/84F) were used to build 3D vascular reconstructions and measure arterial diameters, tortuosity, and calcification volumes in six vascular zones spanning from the ascending thorac...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Majid Jadidi William Poulson Paul Aylward Jason MacTaggart Christian Sanderfer Blake Marmie Margarita Pipinos Alexey Kamenskiy Source Type: research

Spontaneous Extension Wave for In Vivo Assessment of Arterial Wall Anisotropy
Am J Physiol Heart Circ Physiol. 2021 May 7. doi: 10.1152/ajpheart.00756.2020. Online ahead of print.ABSTRACTAnother type of natural wave, traced from longitudinal wall motion and propagation along the artery, is unprecedentedly observed in our in vivo human carotid artery experiments. We coin it as extension wave (EW) and hypothesize that EW velocity (EWV) is associated with arterial longitudinal stiffness. The EW is thus assumed to complement the PW, whose velocity (PWV) is tracked from the radial wall displacement and linked to arterial circumferential stiffness through the Moens-Korteweg equation, as indicators for art...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Dan Ran Jinping Dong He Li Wei-Ning Lee Source Type: research

Pericyte-specific deletion of Ninjurin-1 induces fragile vasa vasorum formation and enhances intimal hyperplasia of injured vasculature
In conclusion, deletion of Ninj1 in pericytes induces the immature vasa vasorum formation of injured vasculature and exacerbates adventitial inflammation and intimal hyperplasia. Thus, Ninj1 contributes to the vasa vasorum maturation in response to vascular injury, and to reduction of vascular remodeling.PMID:33961504 | DOI:10.1152/ajpheart.00931.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Kiwamu Horiuchi Kohei Kano Akiho Minoshima Taiki Hayasaka Atsushi Yamauchi Takamitsu Tatsukawa Risa Matsuo Yuri Yoshida Yui Tomita Maki Kabara Naoki Nakagawa Naofumi Takehara Naoyuki Hasebe Jun-Ichi Kawabe Source Type: research

Race-specific changes in endothelial inflammation and microRNA in response to an acute inflammatory stimulus
This study assessed racial differences in acute induced endothelial inflammation and related miRs. Cultured human umbilical vein endothelial cells (HUVECs) derived from AA and Caucasian Americans (CA) were exposed to the influenza vaccine to determine changes in inflammatory markers, endothelial nitric oxide synthase (eNOS), and miR expression/release. Endothelial function (flow-mediated dilation [FMD]), circulating IL-6, and circulating miR were also measured in young, healthy AA and CA individuals before and after receiving the influenza vaccine. There were no significant racial differences in any parameters at baseline....
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Ryan M Sapp Catalina A Chesney Catherine B Springer Matthew R Laskowski Daniel B Singer Lauren E Eagan Sara E Mascone William S Evans Steven J Prior James M Hagberg Sushant M Ranadive Source Type: research

Coronary Microvascular Adaptations Distal to Epicardial Artery Stenosis
Am J Physiol Heart Circ Physiol. 2021 May 7. doi: 10.1152/ajpheart.00992.2020. Online ahead of print.ABSTRACTUntil recently, epicardial coronary stenosis has been considered the primary outcome of coronary heart disease and clinical interventions have been dedicated primarily to identification and removal of flow-limiting stenoses. However, a growing body of literature indicates that both epicardial stenosis and microvascular dysfunction contribute to damaging myocardial ischemia. In this review, we discuss the co-existence of macro- and microvascular disease, and how the structure and function of the distal microcirculati...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Daphne Merkus Judy Muller-Delp Cristine L Heaps Source Type: research

Calcification Prevalence in Different Vascular Zones and Its Association With Demographics, Risk Factors, and Morphometry
Am J Physiol Heart Circ Physiol. 2021 May 7. doi: 10.1152/ajpheart.00040.2021. Online ahead of print.ABSTRACTVascular calcification is associated with a higher incidence of cardiovascular events, but its prevalence in different vascular zones and the influence of demographics, risk factors, and morphometry remain insufficiently understood. Computerized Tomography Angiography scans from 211 subjects 5-93 years old (mean age 47±24 years, 127M/84F) were used to build 3D vascular reconstructions and measure arterial diameters, tortuosity, and calcification volumes in six vascular zones spanning from the ascending thorac...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Majid Jadidi William Poulson Paul Aylward Jason MacTaggart Christian Sanderfer Blake Marmie Margarita Pipinos Alexey Kamenskiy Source Type: research

Spontaneous Extension Wave for In Vivo Assessment of Arterial Wall Anisotropy
Am J Physiol Heart Circ Physiol. 2021 May 7. doi: 10.1152/ajpheart.00756.2020. Online ahead of print.ABSTRACTAnother type of natural wave, traced from longitudinal wall motion and propagation along the artery, is unprecedentedly observed in our in vivo human carotid artery experiments. We coin it as extension wave (EW) and hypothesize that EW velocity (EWV) is associated with arterial longitudinal stiffness. The EW is thus assumed to complement the PW, whose velocity (PWV) is tracked from the radial wall displacement and linked to arterial circumferential stiffness through the Moens-Korteweg equation, as indicators for art...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Dan Ran Jinping Dong He Li Wei-Ning Lee Source Type: research

Pericyte-specific deletion of Ninjurin-1 induces fragile vasa vasorum formation and enhances intimal hyperplasia of injured vasculature
In conclusion, deletion of Ninj1 in pericytes induces the immature vasa vasorum formation of injured vasculature and exacerbates adventitial inflammation and intimal hyperplasia. Thus, Ninj1 contributes to the vasa vasorum maturation in response to vascular injury, and to reduction of vascular remodeling.PMID:33961504 | DOI:10.1152/ajpheart.00931.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Kiwamu Horiuchi Kohei Kano Akiho Minoshima Taiki Hayasaka Atsushi Yamauchi Takamitsu Tatsukawa Risa Matsuo Yuri Yoshida Yui Tomita Maki Kabara Naoki Nakagawa Naofumi Takehara Naoyuki Hasebe Jun-Ichi Kawabe Source Type: research

Race-specific changes in endothelial inflammation and microRNA in response to an acute inflammatory stimulus
This study assessed racial differences in acute induced endothelial inflammation and related miRs. Cultured human umbilical vein endothelial cells (HUVECs) derived from AA and Caucasian Americans (CA) were exposed to the influenza vaccine to determine changes in inflammatory markers, endothelial nitric oxide synthase (eNOS), and miR expression/release. Endothelial function (flow-mediated dilation [FMD]), circulating IL-6, and circulating miR were also measured in young, healthy AA and CA individuals before and after receiving the influenza vaccine. There were no significant racial differences in any parameters at baseline....
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Ryan M Sapp Catalina A Chesney Catherine B Springer Matthew R Laskowski Daniel B Singer Lauren E Eagan Sara E Mascone William S Evans Steven J Prior James M Hagberg Sushant M Ranadive Source Type: research

Coronary Microvascular Adaptations Distal to Epicardial Artery Stenosis
Am J Physiol Heart Circ Physiol. 2021 May 7. doi: 10.1152/ajpheart.00992.2020. Online ahead of print.ABSTRACTUntil recently, epicardial coronary stenosis has been considered the primary outcome of coronary heart disease and clinical interventions have been dedicated primarily to identification and removal of flow-limiting stenoses. However, a growing body of literature indicates that both epicardial stenosis and microvascular dysfunction contribute to damaging myocardial ischemia. In this review, we discuss the co-existence of macro- and microvascular disease, and how the structure and function of the distal microcirculati...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Daphne Merkus Judy Muller-Delp Cristine L Heaps Source Type: research

Calcification Prevalence in Different Vascular Zones and Its Association With Demographics, Risk Factors, and Morphometry
Am J Physiol Heart Circ Physiol. 2021 May 7. doi: 10.1152/ajpheart.00040.2021. Online ahead of print.ABSTRACTVascular calcification is associated with a higher incidence of cardiovascular events, but its prevalence in different vascular zones and the influence of demographics, risk factors, and morphometry remain insufficiently understood. Computerized Tomography Angiography scans from 211 subjects 5-93 years old (mean age 47±24 years, 127M/84F) were used to build 3D vascular reconstructions and measure arterial diameters, tortuosity, and calcification volumes in six vascular zones spanning from the ascending thorac...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Majid Jadidi William Poulson Paul Aylward Jason MacTaggart Christian Sanderfer Blake Marmie Margarita Pipinos Alexey Kamenskiy Source Type: research

Spontaneous Extension Wave for In Vivo Assessment of Arterial Wall Anisotropy
Am J Physiol Heart Circ Physiol. 2021 May 7. doi: 10.1152/ajpheart.00756.2020. Online ahead of print.ABSTRACTAnother type of natural wave, traced from longitudinal wall motion and propagation along the artery, is unprecedentedly observed in our in vivo human carotid artery experiments. We coin it as extension wave (EW) and hypothesize that EW velocity (EWV) is associated with arterial longitudinal stiffness. The EW is thus assumed to complement the PW, whose velocity (PWV) is tracked from the radial wall displacement and linked to arterial circumferential stiffness through the Moens-Korteweg equation, as indicators for art...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Dan Ran Jinping Dong He Li Wei-Ning Lee Source Type: research

Pericyte-specific deletion of Ninjurin-1 induces fragile vasa vasorum formation and enhances intimal hyperplasia of injured vasculature
In conclusion, deletion of Ninj1 in pericytes induces the immature vasa vasorum formation of injured vasculature and exacerbates adventitial inflammation and intimal hyperplasia. Thus, Ninj1 contributes to the vasa vasorum maturation in response to vascular injury, and to reduction of vascular remodeling.PMID:33961504 | DOI:10.1152/ajpheart.00931.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Kiwamu Horiuchi Kohei Kano Akiho Minoshima Taiki Hayasaka Atsushi Yamauchi Takamitsu Tatsukawa Risa Matsuo Yuri Yoshida Yui Tomita Maki Kabara Naoki Nakagawa Naofumi Takehara Naoyuki Hasebe Jun-Ichi Kawabe Source Type: research

Race-specific changes in endothelial inflammation and microRNA in response to an acute inflammatory stimulus
This study assessed racial differences in acute induced endothelial inflammation and related miRs. Cultured human umbilical vein endothelial cells (HUVECs) derived from AA and Caucasian Americans (CA) were exposed to the influenza vaccine to determine changes in inflammatory markers, endothelial nitric oxide synthase (eNOS), and miR expression/release. Endothelial function (flow-mediated dilation [FMD]), circulating IL-6, and circulating miR were also measured in young, healthy AA and CA individuals before and after receiving the influenza vaccine. There were no significant racial differences in any parameters at baseline....
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Ryan M Sapp Catalina A Chesney Catherine B Springer Matthew R Laskowski Daniel B Singer Lauren E Eagan Sara E Mascone William S Evans Steven J Prior James M Hagberg Sushant M Ranadive Source Type: research

Coronary Microvascular Adaptations Distal to Epicardial Artery Stenosis
Am J Physiol Heart Circ Physiol. 2021 May 7. doi: 10.1152/ajpheart.00992.2020. Online ahead of print.ABSTRACTUntil recently, epicardial coronary stenosis has been considered the primary outcome of coronary heart disease and clinical interventions have been dedicated primarily to identification and removal of flow-limiting stenoses. However, a growing body of literature indicates that both epicardial stenosis and microvascular dysfunction contribute to damaging myocardial ischemia. In this review, we discuss the co-existence of macro- and microvascular disease, and how the structure and function of the distal microcirculati...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Daphne Merkus Judy Muller-Delp Cristine L Heaps Source Type: research

Calcification Prevalence in Different Vascular Zones and Its Association With Demographics, Risk Factors, and Morphometry
Am J Physiol Heart Circ Physiol. 2021 May 7. doi: 10.1152/ajpheart.00040.2021. Online ahead of print.ABSTRACTVascular calcification is associated with a higher incidence of cardiovascular events, but its prevalence in different vascular zones and the influence of demographics, risk factors, and morphometry remain insufficiently understood. Computerized Tomography Angiography scans from 211 subjects 5-93 years old (mean age 47±24 years, 127M/84F) were used to build 3D vascular reconstructions and measure arterial diameters, tortuosity, and calcification volumes in six vascular zones spanning from the ascending thorac...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Majid Jadidi William Poulson Paul Aylward Jason MacTaggart Christian Sanderfer Blake Marmie Margarita Pipinos Alexey Kamenskiy Source Type: research

Spontaneous Extension Wave for In Vivo Assessment of Arterial Wall Anisotropy
Am J Physiol Heart Circ Physiol. 2021 May 7. doi: 10.1152/ajpheart.00756.2020. Online ahead of print.ABSTRACTAnother type of natural wave, traced from longitudinal wall motion and propagation along the artery, is unprecedentedly observed in our in vivo human carotid artery experiments. We coin it as extension wave (EW) and hypothesize that EW velocity (EWV) is associated with arterial longitudinal stiffness. The EW is thus assumed to complement the PW, whose velocity (PWV) is tracked from the radial wall displacement and linked to arterial circumferential stiffness through the Moens-Korteweg equation, as indicators for art...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Dan Ran Jinping Dong He Li Wei-Ning Lee Source Type: research

Pericyte-specific deletion of Ninjurin-1 induces fragile vasa vasorum formation and enhances intimal hyperplasia of injured vasculature
In conclusion, deletion of Ninj1 in pericytes induces the immature vasa vasorum formation of injured vasculature and exacerbates adventitial inflammation and intimal hyperplasia. Thus, Ninj1 contributes to the vasa vasorum maturation in response to vascular injury, and to reduction of vascular remodeling.PMID:33961504 | DOI:10.1152/ajpheart.00931.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Kiwamu Horiuchi Kohei Kano Akiho Minoshima Taiki Hayasaka Atsushi Yamauchi Takamitsu Tatsukawa Risa Matsuo Yuri Yoshida Yui Tomita Maki Kabara Naoki Nakagawa Naofumi Takehara Naoyuki Hasebe Jun-Ichi Kawabe Source Type: research

Race-specific changes in endothelial inflammation and microRNA in response to an acute inflammatory stimulus
This study assessed racial differences in acute induced endothelial inflammation and related miRs. Cultured human umbilical vein endothelial cells (HUVECs) derived from AA and Caucasian Americans (CA) were exposed to the influenza vaccine to determine changes in inflammatory markers, endothelial nitric oxide synthase (eNOS), and miR expression/release. Endothelial function (flow-mediated dilation [FMD]), circulating IL-6, and circulating miR were also measured in young, healthy AA and CA individuals before and after receiving the influenza vaccine. There were no significant racial differences in any parameters at baseline....
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Ryan M Sapp Catalina A Chesney Catherine B Springer Matthew R Laskowski Daniel B Singer Lauren E Eagan Sara E Mascone William S Evans Steven J Prior James M Hagberg Sushant M Ranadive Source Type: research

Coronary Microvascular Adaptations Distal to Epicardial Artery Stenosis
Am J Physiol Heart Circ Physiol. 2021 May 7. doi: 10.1152/ajpheart.00992.2020. Online ahead of print.ABSTRACTUntil recently, epicardial coronary stenosis has been considered the primary outcome of coronary heart disease and clinical interventions have been dedicated primarily to identification and removal of flow-limiting stenoses. However, a growing body of literature indicates that both epicardial stenosis and microvascular dysfunction contribute to damaging myocardial ischemia. In this review, we discuss the co-existence of macro- and microvascular disease, and how the structure and function of the distal microcirculati...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Daphne Merkus Judy Muller-Delp Cristine L Heaps Source Type: research

Calcification Prevalence in Different Vascular Zones and Its Association With Demographics, Risk Factors, and Morphometry
Am J Physiol Heart Circ Physiol. 2021 May 7. doi: 10.1152/ajpheart.00040.2021. Online ahead of print.ABSTRACTVascular calcification is associated with a higher incidence of cardiovascular events, but its prevalence in different vascular zones and the influence of demographics, risk factors, and morphometry remain insufficiently understood. Computerized Tomography Angiography scans from 211 subjects 5-93 years old (mean age 47±24 years, 127M/84F) were used to build 3D vascular reconstructions and measure arterial diameters, tortuosity, and calcification volumes in six vascular zones spanning from the ascending thorac...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Majid Jadidi William Poulson Paul Aylward Jason MacTaggart Christian Sanderfer Blake Marmie Margarita Pipinos Alexey Kamenskiy Source Type: research

Spontaneous Extension Wave for In Vivo Assessment of Arterial Wall Anisotropy
Am J Physiol Heart Circ Physiol. 2021 May 7. doi: 10.1152/ajpheart.00756.2020. Online ahead of print.ABSTRACTAnother type of natural wave, traced from longitudinal wall motion and propagation along the artery, is unprecedentedly observed in our in vivo human carotid artery experiments. We coin it as extension wave (EW) and hypothesize that EW velocity (EWV) is associated with arterial longitudinal stiffness. The EW is thus assumed to complement the PW, whose velocity (PWV) is tracked from the radial wall displacement and linked to arterial circumferential stiffness through the Moens-Korteweg equation, as indicators for art...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Dan Ran Jinping Dong He Li Wei-Ning Lee Source Type: research

Fibroblast Growth Factor 23 (FGF23) Induces Ventricular Arrhythmias and Prolongs QTc Interval in Mice in an FGF Receptor 4-Dependent Manner
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00798.2020. Online ahead of print.ABSTRACTFibroblast growth factor 23 (FGF23) is a phosphate regulating protein hormone released by osteocytes. FGF23 becomes markedly elevated in chronic kidney disease (CKD), for which the leading cause of death is cardiovascular disease, particularly sudden cardiac death. Previously, we found that FGF23 increases intracellular Ca2+ in cardiomyocytes and alters contractility in mouse ventricles ex vivo via FGF-receptor 4 (FGFR4). In the present study, we demonstrate that FGF23 induces cardiac arrhythmias and prolongs QTc i...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Jonah M Graves Julian A Vallejo Chelsea S Hamill Derek Wang Rohan Ahuja Shaan Patel Christian Faul Michael J Wacker Source Type: research

Deficiency of Ataxia-Telangiectasia Mutated Kinase Modulates Functional and Biochemical Parameters of the Heart in Response to Western-type Diet
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00990.2020. Online ahead of print.ABSTRACTAtaxia telangiectasia mutated kinase (ATM) deficiency exacerbates heart dysfunction late after myocardial infarction. Here, we hypothesized that ATM deficiency modulates Western-type diet (WD)-induced cardiac remodeling with an emphasis on functional and biochemical parameters of the heart. Weight gain was assessed in male wild-type (WT) and ATM heterozygous knockout (hKO) mice on weekly basis, while cardiac functional and biochemical parameters were measured 14 weeks post-WD. hKO-WD mice exhibited rapid body weigh...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Mary C Wingard Suman Dalal Paige L Shook Rachel Myers Barbara A Connelly Douglas P Thewke Mahipal Singh Krishna Singh Source Type: research

Male and Female High Fat Fed Dahl SS rats are largely protected from vascular dysfunctions: PVAT contributions reveal sex differences
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00131.2021. Online ahead of print.ABSTRACTVascular dysfunctions are observed in arteries from hypertensive subjects. The establishment of the Dahl SS male and female rat model to develop a reproducible hypertension with high fat (HF) diet feeding from weaning allows addressing the question of whether HF-diet associated hypertension results in vascular dysfunction similar to that of essential hypertension in both sexes. We hypothesized that dysfunction of three distinct vascular layers -- endothelial, smooth muscle and perivascular adipose tissue (PVAT) -- ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Stephanie W Watts Emma S Darios G Andres Contreras Hannah Garver Gregory D Fink Source Type: research

Barth Syndrome-Related Cardiomyopathy is Associated with a Reduction in Myocardial Glucose Oxidation
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00873.2020. Online ahead of print.ABSTRACTHeart failure presents as the leading cause of infant mortality in individuals with Barth syndrome (BTHS), a rare genetic disorder due to mutations in the tafazzin (TAZ) gene affecting mitochondrial structure and function. Investigations into the perturbed bioenergetics in the BTHS heart remain limited. Hence, our objective was to identify the potential alterations in myocardial energy metabolism and molecular underpinnings that may contribute to the early cardiomyopathy and heart failure development in BTHS. Cardi...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Amanda A Greenwell Keshav Gopal Tariq Altamimi Christina T Saed Faqi Wang Seyed Amirhossein Tabatabaei-Dakhili Kim L Ho Liyan Zhang Farah Eaton Jennifer L Kruger Rami Al Batran Gary D Lopaschuk Gavin Y Oudit John R Ussher Source Type: research

Fibroblast Growth Factor 23 (FGF23) Induces Ventricular Arrhythmias and Prolongs QTc Interval in Mice in an FGF Receptor 4-Dependent Manner
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00798.2020. Online ahead of print.ABSTRACTFibroblast growth factor 23 (FGF23) is a phosphate regulating protein hormone released by osteocytes. FGF23 becomes markedly elevated in chronic kidney disease (CKD), for which the leading cause of death is cardiovascular disease, particularly sudden cardiac death. Previously, we found that FGF23 increases intracellular Ca2+ in cardiomyocytes and alters contractility in mouse ventricles ex vivo via FGF-receptor 4 (FGFR4). In the present study, we demonstrate that FGF23 induces cardiac arrhythmias and prolongs QTc i...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Jonah M Graves Julian A Vallejo Chelsea S Hamill Derek Wang Rohan Ahuja Shaan Patel Christian Faul Michael J Wacker Source Type: research

Deficiency of Ataxia-Telangiectasia Mutated Kinase Modulates Functional and Biochemical Parameters of the Heart in Response to Western-type Diet
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00990.2020. Online ahead of print.ABSTRACTAtaxia telangiectasia mutated kinase (ATM) deficiency exacerbates heart dysfunction late after myocardial infarction. Here, we hypothesized that ATM deficiency modulates Western-type diet (WD)-induced cardiac remodeling with an emphasis on functional and biochemical parameters of the heart. Weight gain was assessed in male wild-type (WT) and ATM heterozygous knockout (hKO) mice on weekly basis, while cardiac functional and biochemical parameters were measured 14 weeks post-WD. hKO-WD mice exhibited rapid body weigh...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Mary C Wingard Suman Dalal Paige L Shook Rachel Myers Barbara A Connelly Douglas P Thewke Mahipal Singh Krishna Singh Source Type: research

Male and Female High Fat Fed Dahl SS rats are largely protected from vascular dysfunctions: PVAT contributions reveal sex differences
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00131.2021. Online ahead of print.ABSTRACTVascular dysfunctions are observed in arteries from hypertensive subjects. The establishment of the Dahl SS male and female rat model to develop a reproducible hypertension with high fat (HF) diet feeding from weaning allows addressing the question of whether HF-diet associated hypertension results in vascular dysfunction similar to that of essential hypertension in both sexes. We hypothesized that dysfunction of three distinct vascular layers -- endothelial, smooth muscle and perivascular adipose tissue (PVAT) -- ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Stephanie W Watts Emma S Darios G Andres Contreras Hannah Garver Gregory D Fink Source Type: research

Barth Syndrome-Related Cardiomyopathy is Associated with a Reduction in Myocardial Glucose Oxidation
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00873.2020. Online ahead of print.ABSTRACTHeart failure presents as the leading cause of infant mortality in individuals with Barth syndrome (BTHS), a rare genetic disorder due to mutations in the tafazzin (TAZ) gene affecting mitochondrial structure and function. Investigations into the perturbed bioenergetics in the BTHS heart remain limited. Hence, our objective was to identify the potential alterations in myocardial energy metabolism and molecular underpinnings that may contribute to the early cardiomyopathy and heart failure development in BTHS. Cardi...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Amanda A Greenwell Keshav Gopal Tariq Altamimi Christina T Saed Faqi Wang Seyed Amirhossein Tabatabaei-Dakhili Kim L Ho Liyan Zhang Farah Eaton Jennifer L Kruger Rami Al Batran Gary D Lopaschuk Gavin Y Oudit John R Ussher Source Type: research

Fibroblast Growth Factor 23 (FGF23) Induces Ventricular Arrhythmias and Prolongs QTc Interval in Mice in an FGF Receptor 4-Dependent Manner
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00798.2020. Online ahead of print.ABSTRACTFibroblast growth factor 23 (FGF23) is a phosphate regulating protein hormone released by osteocytes. FGF23 becomes markedly elevated in chronic kidney disease (CKD), for which the leading cause of death is cardiovascular disease, particularly sudden cardiac death. Previously, we found that FGF23 increases intracellular Ca2+ in cardiomyocytes and alters contractility in mouse ventricles ex vivo via FGF-receptor 4 (FGFR4). In the present study, we demonstrate that FGF23 induces cardiac arrhythmias and prolongs QTc i...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Jonah M Graves Julian A Vallejo Chelsea S Hamill Derek Wang Rohan Ahuja Shaan Patel Christian Faul Michael J Wacker Source Type: research

Deficiency of Ataxia-Telangiectasia Mutated Kinase Modulates Functional and Biochemical Parameters of the Heart in Response to Western-type Diet
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00990.2020. Online ahead of print.ABSTRACTAtaxia telangiectasia mutated kinase (ATM) deficiency exacerbates heart dysfunction late after myocardial infarction. Here, we hypothesized that ATM deficiency modulates Western-type diet (WD)-induced cardiac remodeling with an emphasis on functional and biochemical parameters of the heart. Weight gain was assessed in male wild-type (WT) and ATM heterozygous knockout (hKO) mice on weekly basis, while cardiac functional and biochemical parameters were measured 14 weeks post-WD. hKO-WD mice exhibited rapid body weigh...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Mary C Wingard Suman Dalal Paige L Shook Rachel Myers Barbara A Connelly Douglas P Thewke Mahipal Singh Krishna Singh Source Type: research

Male and Female High Fat Fed Dahl SS rats are largely protected from vascular dysfunctions: PVAT contributions reveal sex differences
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00131.2021. Online ahead of print.ABSTRACTVascular dysfunctions are observed in arteries from hypertensive subjects. The establishment of the Dahl SS male and female rat model to develop a reproducible hypertension with high fat (HF) diet feeding from weaning allows addressing the question of whether HF-diet associated hypertension results in vascular dysfunction similar to that of essential hypertension in both sexes. We hypothesized that dysfunction of three distinct vascular layers -- endothelial, smooth muscle and perivascular adipose tissue (PVAT) -- ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Stephanie W Watts Emma S Darios G Andres Contreras Hannah Garver Gregory D Fink Source Type: research

Barth Syndrome-Related Cardiomyopathy is Associated with a Reduction in Myocardial Glucose Oxidation
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00873.2020. Online ahead of print.ABSTRACTHeart failure presents as the leading cause of infant mortality in individuals with Barth syndrome (BTHS), a rare genetic disorder due to mutations in the tafazzin (TAZ) gene affecting mitochondrial structure and function. Investigations into the perturbed bioenergetics in the BTHS heart remain limited. Hence, our objective was to identify the potential alterations in myocardial energy metabolism and molecular underpinnings that may contribute to the early cardiomyopathy and heart failure development in BTHS. Cardi...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Amanda A Greenwell Keshav Gopal Tariq Altamimi Christina T Saed Faqi Wang Seyed Amirhossein Tabatabaei-Dakhili Kim L Ho Liyan Zhang Farah Eaton Jennifer L Kruger Rami Al Batran Gary D Lopaschuk Gavin Y Oudit John R Ussher Source Type: research

Fibroblast Growth Factor 23 (FGF23) Induces Ventricular Arrhythmias and Prolongs QTc Interval in Mice in an FGF Receptor 4-Dependent Manner
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00798.2020. Online ahead of print.ABSTRACTFibroblast growth factor 23 (FGF23) is a phosphate regulating protein hormone released by osteocytes. FGF23 becomes markedly elevated in chronic kidney disease (CKD), for which the leading cause of death is cardiovascular disease, particularly sudden cardiac death. Previously, we found that FGF23 increases intracellular Ca2+ in cardiomyocytes and alters contractility in mouse ventricles ex vivo via FGF-receptor 4 (FGFR4). In the present study, we demonstrate that FGF23 induces cardiac arrhythmias and prolongs QTc i...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Jonah M Graves Julian A Vallejo Chelsea S Hamill Derek Wang Rohan Ahuja Shaan Patel Christian Faul Michael J Wacker Source Type: research

Deficiency of Ataxia-Telangiectasia Mutated Kinase Modulates Functional and Biochemical Parameters of the Heart in Response to Western-type Diet
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00990.2020. Online ahead of print.ABSTRACTAtaxia telangiectasia mutated kinase (ATM) deficiency exacerbates heart dysfunction late after myocardial infarction. Here, we hypothesized that ATM deficiency modulates Western-type diet (WD)-induced cardiac remodeling with an emphasis on functional and biochemical parameters of the heart. Weight gain was assessed in male wild-type (WT) and ATM heterozygous knockout (hKO) mice on weekly basis, while cardiac functional and biochemical parameters were measured 14 weeks post-WD. hKO-WD mice exhibited rapid body weigh...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Mary C Wingard Suman Dalal Paige L Shook Rachel Myers Barbara A Connelly Douglas P Thewke Mahipal Singh Krishna Singh Source Type: research

Male and Female High Fat Fed Dahl SS rats are largely protected from vascular dysfunctions: PVAT contributions reveal sex differences
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00131.2021. Online ahead of print.ABSTRACTVascular dysfunctions are observed in arteries from hypertensive subjects. The establishment of the Dahl SS male and female rat model to develop a reproducible hypertension with high fat (HF) diet feeding from weaning allows addressing the question of whether HF-diet associated hypertension results in vascular dysfunction similar to that of essential hypertension in both sexes. We hypothesized that dysfunction of three distinct vascular layers -- endothelial, smooth muscle and perivascular adipose tissue (PVAT) -- ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Stephanie W Watts Emma S Darios G Andres Contreras Hannah Garver Gregory D Fink Source Type: research

Barth Syndrome-Related Cardiomyopathy is Associated with a Reduction in Myocardial Glucose Oxidation
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00873.2020. Online ahead of print.ABSTRACTHeart failure presents as the leading cause of infant mortality in individuals with Barth syndrome (BTHS), a rare genetic disorder due to mutations in the tafazzin (TAZ) gene affecting mitochondrial structure and function. Investigations into the perturbed bioenergetics in the BTHS heart remain limited. Hence, our objective was to identify the potential alterations in myocardial energy metabolism and molecular underpinnings that may contribute to the early cardiomyopathy and heart failure development in BTHS. Cardi...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Amanda A Greenwell Keshav Gopal Tariq Altamimi Christina T Saed Faqi Wang Seyed Amirhossein Tabatabaei-Dakhili Kim L Ho Liyan Zhang Farah Eaton Jennifer L Kruger Rami Al Batran Gary D Lopaschuk Gavin Y Oudit John R Ussher Source Type: research

Fibroblast Growth Factor 23 (FGF23) Induces Ventricular Arrhythmias and Prolongs QTc Interval in Mice in an FGF Receptor 4-Dependent Manner
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00798.2020. Online ahead of print.ABSTRACTFibroblast growth factor 23 (FGF23) is a phosphate regulating protein hormone released by osteocytes. FGF23 becomes markedly elevated in chronic kidney disease (CKD), for which the leading cause of death is cardiovascular disease, particularly sudden cardiac death. Previously, we found that FGF23 increases intracellular Ca2+ in cardiomyocytes and alters contractility in mouse ventricles ex vivo via FGF-receptor 4 (FGFR4). In the present study, we demonstrate that FGF23 induces cardiac arrhythmias and prolongs QTc i...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Jonah M Graves Julian A Vallejo Chelsea S Hamill Derek Wang Rohan Ahuja Shaan Patel Christian Faul Michael J Wacker Source Type: research

Deficiency of Ataxia-Telangiectasia Mutated Kinase Modulates Functional and Biochemical Parameters of the Heart in Response to Western-type Diet
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00990.2020. Online ahead of print.ABSTRACTAtaxia telangiectasia mutated kinase (ATM) deficiency exacerbates heart dysfunction late after myocardial infarction. Here, we hypothesized that ATM deficiency modulates Western-type diet (WD)-induced cardiac remodeling with an emphasis on functional and biochemical parameters of the heart. Weight gain was assessed in male wild-type (WT) and ATM heterozygous knockout (hKO) mice on weekly basis, while cardiac functional and biochemical parameters were measured 14 weeks post-WD. hKO-WD mice exhibited rapid body weigh...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Mary C Wingard Suman Dalal Paige L Shook Rachel Myers Barbara A Connelly Douglas P Thewke Mahipal Singh Krishna Singh Source Type: research