American Journal of Physiology. Heart and Circulatory Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Vascular adaptation to exercise: A systematic review and audit of female representation
Am J Physiol Heart Circ Physiol. 2024 Feb 23. doi: 10.1152/ajpheart.00788.2023. Online ahead of print.ABSTRACTBiological sex is a salient factor in exercise-induced vascular adaptation. While a male bias is apparent in the literature, the methodological quality of available studies in females is not yet known. This systematic review with narrative synthesis aimed to assess available evidence of exercise interventions on endothelial function, measured using flow-mediated dilation, in otherwise healthy individuals and athletes. A standardized audit framework was applied to quantify the representation of female participants. ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 23, 2024 Category: Physiology Authors: Sarah L Thompson Carly Brade Sarah R Henley-Martin Louise H Naylor Angela L Spence Source Type: research

Cerebral sympatholysis: experiments on < em > in vivo < /em > cerebrovascular regulation and < em > ex vivo < /em > cerebral vasomotor control
This study tested the hypothesis that application or removal of a cognitive task during a cold pressor test (CPT) would attenuate and restore decreases in cerebrovascular conductance (CVC), respectively. Middle cerebral artery blood velocity (transcranial Doppler) and mean arterial pressure (finger photoplethysmography) were examined in healthy adults (n=16; 8 F and 8 M) who completed a control CPT, followed by a CPT coupled with a cognitive task administered either A) 30 s after the onset of the CPT and for the duration of the CPT or B) at the onset of the CPT and terminated 30 s prior to the end of the CPT (condition ord...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 23, 2024 Category: Physiology Authors: Adam M S Luchkanych Cameron J Morse Natasha G Boyes M Rafique Khan Rory A Marshall Jude S Morton Corey R Tomczak T Dylan Olver Source Type: research

Differences in cardiac adaptation to exercise in male and female athletes assessed by non-invasive techniques - a state of the art review
Am J Physiol Heart Circ Physiol. 2024 Feb 23. doi: 10.1152/ajpheart.00756.2023. Online ahead of print.ABSTRACTAthlete's heart is generally regarded as a physiological adaptation to regular training, with specific morphological and functional alterations in the cardiovascular system. Development of the non-invasive imaging techniques over the last several years enabled better assessment of cardiac remodeling in athletes, which may eventually mimic certain pathological conditions with the potential for sudden cardiac death, or disease progression. The current literature provides a compelling overview of the available methods...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 23, 2024 Category: Physiology Authors: Zofia Lasocka-Koriat Zuzanna Lewicka-Potocka Anna Kaleta-Duss Anna Siekierzycka Leszek Kalinowski Ewa Lewicka Alicja D ąbrowska-Kugacka Source Type: research

Impact of coronary hyperemia on collateral flow correction of coronary microvascular resistance indices
Conclusion - We validated the calculation method for Pw-corrected MR in a Doppler-velocity derived population. In addition, we found a significant impact of hyperemic conditions on the measurement of Pw and the derivation of Pw-corrected HMR.PMID:38391315 | DOI:10.1152/ajpheart.00771.2023 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 23, 2024 Category: Physiology Authors: Coen K M Boerhout Anna van Veelen Rutger G T Feenstra Elize A M de Jong Hanae F Namba Marcel A M Beijk Jose P Henriques Jan J Piek Tim P van de Hoef Source Type: research

IL-33 supplementation improves uterine artery resistance and maternal hypertension in response to placental ischemia
Am J Physiol Heart Circ Physiol. 2024 Feb 16. doi: 10.1152/ajpheart.00045.2024. Online ahead of print.ABSTRACTPreeclampsia (PE), a leading cause of maternal/fetal morbidity and mortality, is a hypertensive pregnancy disorder with end-organ damage that manifests after 20 weeks of gestation. PE is characterized by chronic immune activation and endothelial dysfunction. Clinical studies report reduced IL-33 signaling in PE. We use the Reduced Uterine Perfusion Pressure (RUPP) rat model, which mimics many PE characteristics including reduced IL-33, to identify mechanisms mediating PE pathophysiology. We hypothesized that IL-33 ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 16, 2024 Category: Physiology Authors: Xi Wang Corbin Shields Geilda Tardo Gregory Peacock Emily Hester Marissa Anderson Jan M Williams Denise Cornelius Source Type: research

The gut microbiome as a modulator of arterial function and age-related arterial dysfunction
Am J Physiol Heart Circ Physiol. 2024 Feb 16. doi: 10.1152/ajpheart.00764.2023. Online ahead of print.ABSTRACTThe arterial system is integral to the proper function of all other organs and tissues. Arterial function is impaired with aging, and arterial dysfunction contributes to the development of numerous age-related diseases, including cardiovascular diseases. The gut microbiome has emerged as an important regulator of both normal host physiological function and impairments in function with aging. The purpose of this review is to summarize more recently published literature demonstrating the role of the gut microbiome in...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 16, 2024 Category: Physiology Authors: Abigail G Longtine Nathan T Greenberg Yara Bernaldo de Quir ós Vienna E Brunt Source Type: research

Real-Time Visualization of Dextran Extravasation in Intermittent Hypoxia Mice using Non-Invasive SWIR Imaging
CONCLUSION: The SWIR imaging technique allows non-invasive real-time monitoring of dextran extravasation in vivo. Dextran-70 extravasation is increased after exposure to IH, suggesting an increased vessel permeability in this mice model of obstructive sleep apnea.PMID:38363213 | DOI:10.1152/ajpheart.00787.2023 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 16, 2024 Category: Physiology Authors: Xavier Le Gu ével V éronique Josserand Olfa Harki Vladimir A Baulin Maxime Henry Anne Briancon-Marjollet Source Type: research

Role of Macrophages in Regression of Myocardial Fibrosis Following Alleviation of Left Ventricular Pressure Overload
The objective was to determine temporal changes in myocardial macrophage phenotype in TAC and unTAC and determine whether macrophage depletion alters collagen degradation after unTAC. Myocardial macrophage abundance and phenotype were assessed by immunohistochemistry, flow cytometry, and gene expression by rt-PCR in control(non-TAC),2wkTAC,4wkTAC, and 2wk,4wk, and 6wkunTAC. Myocardial cytokine profiles and collagen degrading enzymes were determined by immunoassay and immunoblots. Initial collagen degradation were detected with collagen hybridizing peptide(CHP). At unTAC, macrophages were depleted with clodronate liposomes ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 16, 2024 Category: Physiology Authors: Lily S Neff Rachel M Biggs Yuhua Zhang An O Van Laer Catalin F Baicu Suganya Subramanian Stefano Berto Kristine DeLeon-Pennell Michael R Zile Amy D Bradshaw Source Type: research

Sex-based differences in short and longer-term diet-induced metabolic heart disease
Am J Physiol Heart Circ Physiol. 2024 Feb 16. doi: 10.1152/ajpheart.00467.2023. Online ahead of print.ABSTRACTSex-based differences in the development of obesity-induced cardio-metabolic dysfunction are well documented, however the specific mechanisms are not completely understood. Obesity has been linked to dysregulation of the epitranscriptome, but the role of N6-methyladenosine (m6A) RNA methylation has not been investigated in relation to the sex differences during obesity-induced cardiac dysfunction. In the current study, male and female C57BL/6J mice were subjected to short- and long-term high-fat/high-sucrose (HFHS)...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 16, 2024 Category: Physiology Authors: Amanda J Croft Conagh Kelly Dongqing Chen Tatt Jhong Haw Lucy A Murtha Lohis Balachandran Andrew J Boyle Aaron L Sverdlov Doan T M Ngo Source Type: research

Exercise-induced cardiac troponin release in athletes with versus without coronary atherosclerosis
CONCLUSIONS: Serial sampling of hs-cTnT and hs-cTnI concentrations during and following an exhaustive endurance exercise test did not reveal differences in exercise-induced cTn release between athletes with versus without coronary atherosclerosis. These findings suggest that a high CACS or a >50% stenosis in any coronary artery does not aggravate exercise-induced cTn release in middle aged and older athletes.PMID:38363583 | DOI:10.1152/ajpheart.00021.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 16, 2024 Category: Physiology Authors: Sylvan L J E Janssen Femke de Vries Alma M A Mingels Geert Kleinnibbelink Maria T E Hopman Arend Mosterd Birgitta K Velthuis Vincent L Aengevaeren Thijs M H Eijsvogels Source Type: research