Exercise in Hypertrophic Cardiomyopathy: Restrict or Rethink??
Am J Physiol Heart Circ Physiol. 2021 Mar 26. doi: 10.1152/ajpheart.00850.2020. Online ahead of print.ABSTRACTThe detailed physiological consequences of aerobic training, in patients with hypertrophic cardiomyopathy (HCM) are not well understood. In athletes and non-athletes with HCM, there are two hypothetical concerns with respect to exercise: exercise-related worsening of the phenotype (e.g. promoting hypertrophy, fibrosis), and/or triggering of arrhythmia. The former concern is unproven and animal studies suggest an opposite effect, where exercise has been shown to be protective. The main reason for exercise restrictio...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 26, 2021 Category: Physiology Authors: Adaya Weissler Snir Kim A Connelly Jack M Goodman David Dorian Paul Dorian Source Type: research

Racial and Socioeconomic Disparity Associates with Differences in Cardiac DNA Methylation among Men with End-Stage Heart Failure
Am J Physiol Heart Circ Physiol. 2021 Mar 26. doi: 10.1152/ajpheart.00036.2021. Online ahead of print.ABSTRACTHeart Failure (HF) is a multifactorial syndrome that remains a leading cause of worldwide morbidity. Despite its high prevalence, only half of HF patients respond to guideline-directed medical management, prompting therapeutic efforts to confront the molecular underpinnings of its heterogeneity. In the current study, we examined epigenetics as a yet unexplored source of heterogeneity among patients with end-stage HF. Specifically, a multicohort-based study was designed to quantify cardiac genome-wide cytosine-p-gua...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 26, 2021 Category: Physiology Authors: Mark E Pepin Chae-Myeong Ha Luke A Potter Sayan Bakshi Joseph P Barchue Ayman Haj Asaad Steven M Pogwizd Salpy V Pamboukian Bertha A Hidalgo Selwyn M Vickers Adam R Wende Source Type: research

Regenerative Crosstalk between Cardiac Cells and Macrophages
Am J Physiol Heart Circ Physiol. 2021 Mar 26. doi: 10.1152/ajpheart.00056.2021. Online ahead of print.ABSTRACTAside from the first week postnatal, murine heart regeneration is restricted and responses to damage follow classic fibrotic remodeling. Recent transcriptomic analyses have suggested that significant crosstalk with the sterile immune response could maintain a more embryonic-like signaling network that promotes acute, transient responses. However with age, this response-likely mediated by neonatal yolk sac macrophages-then transitions to classical macrophage-mediated, cardiac fibroblast (CF)-based remodeling of the ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 26, 2021 Category: Physiology Authors: Alexander J Whitehead Adam J Engler Source Type: research

Letter to the editor: Gravity in the brain: how compressive ischemic changes in the weight-bearing brainstem autonomic nuclei may contribute to vascular endothelial dysfunction elsewhere in the body following sleep deprivation
Am J Physiol Heart Circ Physiol. 2021 Apr 1;320(4):H1415-H1416. doi: 10.1152/ajpheart.00059.2021.NO ABSTRACTPMID:33759589 | DOI:10.1152/ajpheart.00059.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 24, 2021 Category: Physiology Authors: J Howard Jaster Source Type: research

Letter to the editor: Gravity in the brain: how compressive ischemic changes in the weight-bearing brainstem autonomic nuclei may contribute to vascular endothelial dysfunction elsewhere in the body following sleep deprivation
Am J Physiol Heart Circ Physiol. 2021 Apr 1;320(4):H1415-H1416. doi: 10.1152/ajpheart.00059.2021.NO ABSTRACTPMID:33759589 | DOI:10.1152/ajpheart.00059.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 24, 2021 Category: Physiology Authors: J Howard Jaster Source Type: research

Letter to the editor: Gravity in the brain: how compressive ischemic changes in the weight-bearing brainstem autonomic nuclei may contribute to vascular endothelial dysfunction elsewhere in the body following sleep deprivation
Am J Physiol Heart Circ Physiol. 2021 Apr 1;320(4):H1415-H1416. doi: 10.1152/ajpheart.00059.2021.NO ABSTRACTPMID:33759589 | DOI:10.1152/ajpheart.00059.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 24, 2021 Category: Physiology Authors: J Howard Jaster Source Type: research

Chronic Perinatal Hypoxia Delays Cardiac Maturation in a Mouse Model for Cyanotic Congenital Heart Disease
CONCLUSIONS: We investigated the impact of chronic hypoxia on the developing heart. Perinatal hypoxia was associated with changes in gene expression and cardiac function. Persistent changes to the electrophysiologic substrate and contractile function warrant further investigation and may contribute to adverse outcomes observed in the cyanotic CHD population.PMID:33739154 | DOI:10.1152/ajpheart.00870.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 19, 2021 Category: Physiology Authors: Jennifer Romanowicz Devon Guerrelli Zaenab Dhari Colm Mulvany Marissa Reilly Luther Swift Nimisha Vasandani Manelle Ramadan Linda Leatherbury Nobuyuki Ishibashi Nikki Gillum Posnack Source Type: research

Testosterone and exercise: Effects on fitness, body composition and strength in middle-to-older aged men with low-normal serum testosterone levels
Am J Physiol Heart Circ Physiol. 2021 Mar 19. doi: 10.1152/ajpheart.00010.2021. Online ahead of print.ABSTRACTAs men age, serum testosterone (T) concentrations decrease, as do fitness, strength and lean mass. Whether testosterone treatment confers additive benefit to reverse these changes when combined with exercise training in middle-to-older aged men remains unclear. We assessed the effects of T treatment and exercise, alone and in combination, on aerobic capacity (VO2peak), body composition and muscular strength in men 50-70yrs, waist circumference ≥95cm and low-normal serum T (6-14nmol·L-1). Participants (n=8...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 19, 2021 Category: Physiology Authors: Lauren C Chasland Bu B Yeap Andrew J Maiorana Yi X Chan Barbara A Maslen Brian R Cooke Lawrence Dembo Louise H Naylor Daniel J Green Source Type: research

Soluble guanylate cyclase stimulation in late gestation does not mitigate asymmetric IUGR or cardiovascular risk induced by placental ischemia in the rat
This study tested the hypothesis that stimulation of sGC until birth attenuates asymmetric IUGR mitigating increased cardiovascular risk in offspring. Sham or RUPP surgery was performed at gestational day 14 (G14); vehicle or sGC stimulator, Riociguat (10mg/kg/day, s.c.) were administered G14 until birth. Birth weight was reduced in offspring from RUPP (intrauterine growth restricted or IUGR), sGC RUPP (sGC IUGR), and sGC Sham (sGC Control) compared to Sham (Control). Crown circumference was maintained but abdominal circumference was reduced in IUGR and sGC IUGR compared to Control indicative of asymmetrical growth. Gestat...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 19, 2021 Category: Physiology Authors: Laura E Coats Bhavisha A Bakrania Daniel R Bamrick-Fernandez Allison M Ariatti Adam Z Rawls Norma B Ojeda Barbara T Alexander Source Type: research

Chronic Perinatal Hypoxia Delays Cardiac Maturation in a Mouse Model for Cyanotic Congenital Heart Disease
CONCLUSIONS: We investigated the impact of chronic hypoxia on the developing heart. Perinatal hypoxia was associated with changes in gene expression and cardiac function. Persistent changes to the electrophysiologic substrate and contractile function warrant further investigation and may contribute to adverse outcomes observed in the cyanotic CHD population.PMID:33739154 | DOI:10.1152/ajpheart.00870.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 19, 2021 Category: Physiology Authors: Jennifer Romanowicz Devon Guerrelli Zaenab Dhari Colm Mulvany Marissa Reilly Luther Swift Nimisha Vasandani Manelle Ramadan Linda Leatherbury Nobuyuki Ishibashi Nikki Gillum Posnack Source Type: research

Testosterone and exercise: Effects on fitness, body composition and strength in middle-to-older aged men with low-normal serum testosterone levels
Am J Physiol Heart Circ Physiol. 2021 Mar 19. doi: 10.1152/ajpheart.00010.2021. Online ahead of print.ABSTRACTAs men age, serum testosterone (T) concentrations decrease, as do fitness, strength and lean mass. Whether testosterone treatment confers additive benefit to reverse these changes when combined with exercise training in middle-to-older aged men remains unclear. We assessed the effects of T treatment and exercise, alone and in combination, on aerobic capacity (VO2peak), body composition and muscular strength in men 50-70yrs, waist circumference ≥95cm and low-normal serum T (6-14nmol·L-1). Participants (n=8...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 19, 2021 Category: Physiology Authors: Lauren C Chasland Bu B Yeap Andrew J Maiorana Yi X Chan Barbara A Maslen Brian R Cooke Lawrence Dembo Louise H Naylor Daniel J Green Source Type: research

Soluble guanylate cyclase stimulation in late gestation does not mitigate asymmetric IUGR or cardiovascular risk induced by placental ischemia in the rat
This study tested the hypothesis that stimulation of sGC until birth attenuates asymmetric IUGR mitigating increased cardiovascular risk in offspring. Sham or RUPP surgery was performed at gestational day 14 (G14); vehicle or sGC stimulator, Riociguat (10mg/kg/day, s.c.) were administered G14 until birth. Birth weight was reduced in offspring from RUPP (intrauterine growth restricted or IUGR), sGC RUPP (sGC IUGR), and sGC Sham (sGC Control) compared to Sham (Control). Crown circumference was maintained but abdominal circumference was reduced in IUGR and sGC IUGR compared to Control indicative of asymmetrical growth. Gestat...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 19, 2021 Category: Physiology Authors: Laura E Coats Bhavisha A Bakrania Daniel R Bamrick-Fernandez Allison M Ariatti Adam Z Rawls Norma B Ojeda Barbara T Alexander Source Type: research

Chronic Perinatal Hypoxia Delays Cardiac Maturation in a Mouse Model for Cyanotic Congenital Heart Disease
CONCLUSIONS: We investigated the impact of chronic hypoxia on the developing heart. Perinatal hypoxia was associated with changes in gene expression and cardiac function. Persistent changes to the electrophysiologic substrate and contractile function warrant further investigation and may contribute to adverse outcomes observed in the cyanotic CHD population.PMID:33739154 | DOI:10.1152/ajpheart.00870.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 19, 2021 Category: Physiology Authors: Jennifer Romanowicz Devon Guerrelli Zaenab Dhari Colm Mulvany Marissa Reilly Luther Swift Nimisha Vasandani Manelle Ramadan Linda Leatherbury Nobuyuki Ishibashi Nikki Gillum Posnack Source Type: research

Testosterone and exercise: Effects on fitness, body composition and strength in middle-to-older aged men with low-normal serum testosterone levels
Am J Physiol Heart Circ Physiol. 2021 Mar 19. doi: 10.1152/ajpheart.00010.2021. Online ahead of print.ABSTRACTAs men age, serum testosterone (T) concentrations decrease, as do fitness, strength and lean mass. Whether testosterone treatment confers additive benefit to reverse these changes when combined with exercise training in middle-to-older aged men remains unclear. We assessed the effects of T treatment and exercise, alone and in combination, on aerobic capacity (VO2peak), body composition and muscular strength in men 50-70yrs, waist circumference ≥95cm and low-normal serum T (6-14nmol·L-1). Participants (n=8...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 19, 2021 Category: Physiology Authors: Lauren C Chasland Bu B Yeap Andrew J Maiorana Yi X Chan Barbara A Maslen Brian R Cooke Lawrence Dembo Louise H Naylor Daniel J Green Source Type: research

Soluble guanylate cyclase stimulation in late gestation does not mitigate asymmetric IUGR or cardiovascular risk induced by placental ischemia in the rat
This study tested the hypothesis that stimulation of sGC until birth attenuates asymmetric IUGR mitigating increased cardiovascular risk in offspring. Sham or RUPP surgery was performed at gestational day 14 (G14); vehicle or sGC stimulator, Riociguat (10mg/kg/day, s.c.) were administered G14 until birth. Birth weight was reduced in offspring from RUPP (intrauterine growth restricted or IUGR), sGC RUPP (sGC IUGR), and sGC Sham (sGC Control) compared to Sham (Control). Crown circumference was maintained but abdominal circumference was reduced in IUGR and sGC IUGR compared to Control indicative of asymmetrical growth. Gestat...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 19, 2021 Category: Physiology Authors: Laura E Coats Bhavisha A Bakrania Daniel R Bamrick-Fernandez Allison M Ariatti Adam Z Rawls Norma B Ojeda Barbara T Alexander Source Type: research

Chronic Perinatal Hypoxia Delays Cardiac Maturation in a Mouse Model for Cyanotic Congenital Heart Disease
CONCLUSIONS: We investigated the impact of chronic hypoxia on the developing heart. Perinatal hypoxia was associated with changes in gene expression and cardiac function. Persistent changes to the electrophysiologic substrate and contractile function warrant further investigation and may contribute to adverse outcomes observed in the cyanotic CHD population.PMID:33739154 | DOI:10.1152/ajpheart.00870.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 19, 2021 Category: Physiology Authors: Jennifer Romanowicz Devon Guerrelli Zaenab Dhari Colm Mulvany Marissa Reilly Luther Swift Nimisha Vasandani Manelle Ramadan Linda Leatherbury Nobuyuki Ishibashi Nikki Gillum Posnack Source Type: research

Testosterone and exercise: Effects on fitness, body composition and strength in middle-to-older aged men with low-normal serum testosterone levels
Am J Physiol Heart Circ Physiol. 2021 Mar 19. doi: 10.1152/ajpheart.00010.2021. Online ahead of print.ABSTRACTAs men age, serum testosterone (T) concentrations decrease, as do fitness, strength and lean mass. Whether testosterone treatment confers additive benefit to reverse these changes when combined with exercise training in middle-to-older aged men remains unclear. We assessed the effects of T treatment and exercise, alone and in combination, on aerobic capacity (VO2peak), body composition and muscular strength in men 50-70yrs, waist circumference ≥95cm and low-normal serum T (6-14nmol·L-1). Participants (n=8...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 19, 2021 Category: Physiology Authors: Lauren C Chasland Bu B Yeap Andrew J Maiorana Yi X Chan Barbara A Maslen Brian R Cooke Lawrence Dembo Louise H Naylor Daniel J Green Source Type: research

Soluble guanylate cyclase stimulation in late gestation does not mitigate asymmetric IUGR or cardiovascular risk induced by placental ischemia in the rat
This study tested the hypothesis that stimulation of sGC until birth attenuates asymmetric IUGR mitigating increased cardiovascular risk in offspring. Sham or RUPP surgery was performed at gestational day 14 (G14); vehicle or sGC stimulator, Riociguat (10mg/kg/day, s.c.) were administered G14 until birth. Birth weight was reduced in offspring from RUPP (intrauterine growth restricted or IUGR), sGC RUPP (sGC IUGR), and sGC Sham (sGC Control) compared to Sham (Control). Crown circumference was maintained but abdominal circumference was reduced in IUGR and sGC IUGR compared to Control indicative of asymmetrical growth. Gestat...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 19, 2021 Category: Physiology Authors: Laura E Coats Bhavisha A Bakrania Daniel R Bamrick-Fernandez Allison M Ariatti Adam Z Rawls Norma B Ojeda Barbara T Alexander Source Type: research

Effect of endothelial glycocalyx on water and low density lipoprotein (LDL) transport through the rat abdominal aorta
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00861.2020. Online ahead of print.ABSTRACTThe surface of vascular endothelial cells (ECs) is covered by a protective negatively charged layer known as the endothelial glycocalyx. Herein, we hypothesized its transport barrier and mechanosensory role in transmural water flux and low density lipoprotein (LDL) transport in an isolated rat abdominal aorta perfused under 85 mm Hg and 20 dyn/cm2 ex vivo. The endothelial glycocalyx was digested by hyaluronidase (HAase) from bovine tests. Water infiltration velocity (Vw) was measured by a graduated pipette. LDL cov...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Hongyan Kang Jiali Yang Weichen Zhang Jinyan Lu Xuejiao Ma Anqiang Sun Xiaoyan Deng Source Type: research

Role of perivascular nerve and sensory neurotransmitter dysfunction in inflammatory bowel disease
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00037.2021. Online ahead of print.ABSTRACTInflammatory Bowel Disease (IBD) is associated with both impaired intestinal blood flow and increased risk of cardiovascular disease, but the functional role of perivascular nerves that control vasomotor function of mesenteric arteries (MAs) perfusing the intestine during IBD is unknown. Because perivascular sensory nerves and their transmitters calcitonin gene-related peptide (CGRP) and substance P (SP) are important mediators of both vasodilation and inflammatory responses, our objective was to identify IBD-relat...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Charles E Norton Elizabeth A Grunz-Borgmann Marcia L Hart Benjamin W Jones Craig L Franklin Erika M Boerman Source Type: research

Impact of hyperleptinemia during placental ischemia-induced hypertension in pregnant rats
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00724.2019. Online ahead of print.ABSTRACTThe prevalence of preeclampsia and obesity have increased. While obesity is a major risk factor for preeclampsia, the mechanisms linking these morbidities are poorly understood. Circulating leptin levels increase in proportion to fat mass. Infusion of this adipokine elicits hypertension in non-pregnant rats, but less is known about how hyperleptinemia impacts blood pressure during placental ischemia, an initiating event in the pathophysiology of hypertension in preeclampsia. We tested the hypothesis that hyperlepti...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Ana C Palei Hunter L Martin Barbara A Wilson Christopher D Anderson Joey P Granger Frank T Spradley Source Type: research

Personalized physiologic flow waveforms improve wave reflection estimates compared to triangular flow waveforms in adults
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00747.2020. Online ahead of print.ABSTRACTCentral aortic pressure waveforms contain valuable prognostic information in addition to central systolic pressure. Using pressure-flow relations, wave separation analysis can be used to decompose aortic pressure waveforms into forward- (Pf) and backward-travelling (Pb) components. Reflection magnitude, the ratio of pressure amplitudes (RM=Pb/Pf), is a predictor of heart failure and all-cause mortality. Aortic flow can be measured via Doppler echocardiography or estimated using a triangular flow waveform; however, ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Ninette Shenouda Joseph M Stock Jordan C Patik Julio A Chirinos David G Edwards Source Type: research

We are the Change We Seek
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00090.2021. Online ahead of print.NO ABSTRACTPMID:33710925 | DOI:10.1152/ajpheart.00090.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Merry L Lindsey Zamaneh Kassiri Kara Hansell Keehan Keith R Brunt Jason R Carter Jonathan A Kirk Amanda J LeBlanc Petra Kleinbongard Crystal M Ripplinger Source Type: research

Exercise alters Cardiac Function Independent of Acute Systemic Inflammation in Healthy Men
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00809.2020. Online ahead of print.ABSTRACTAcute elevations in inflammatory cytokines have been demonstrated to increase aortic and left ventricular stiffness and reduce endothelial function in healthy subjects. As vascular and cardiac function are often transiently reduced following prolonged exercise, it is possible that cytokines released during exercise may contribute to these alterations. The a priori aims of this study were to determine if vaccine-induced increases in inflammatory-cytokines would reduce vascular and left ventricular function, whether ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Alexandra M Coates Heather L Petrick Philip J Millar Jamie F Burr Source Type: research

Global Reach 2018: Dysfunctional Extracellular Microvesicles in Andean Highlander Males with Excessive Erythrocytosis
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00016.2021. Online ahead of print.ABSTRACTHigh altitude-related excessive erythrocytosis (EE) is associated with increased cardiovascular risk. The experimental aim of this study was to determine the effects of microvesicles isolated from Andean highlanders with EE on endothelial cell inflammation, oxidative stress, apoptosis and nitric oxide (NO) production.Twenty-six male residents of Cerro de Pasco, Peru (4,340 m) were studied: 12 highlanders without EE (age: 40±4 yr; BMI: 26.4±1.7; Hb: 17.4±0.5 g/dL, SpO2: 86.9±1.0%) and 14 ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: L Madden Brewster Anthony R Bain Vinicius Pacheco Garcia Hannah K Fandl Rachel Stone Noah M DeSouza Jared J Greiner Michael M Tymko Gustavo A Vizcardo-Galindo Romulo J Figueroa-Mujica Francisco C Villafuerte Philip N Ainslie Christopher A DeSouza Source Type: research

Effect of endothelial glycocalyx on water and low density lipoprotein (LDL) transport through the rat abdominal aorta
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00861.2020. Online ahead of print.ABSTRACTThe surface of vascular endothelial cells (ECs) is covered by a protective negatively charged layer known as the endothelial glycocalyx. Herein, we hypothesized its transport barrier and mechanosensory role in transmural water flux and low density lipoprotein (LDL) transport in an isolated rat abdominal aorta perfused under 85 mm Hg and 20 dyn/cm2 ex vivo. The endothelial glycocalyx was digested by hyaluronidase (HAase) from bovine tests. Water infiltration velocity (Vw) was measured by a graduated pipette. LDL cov...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Hongyan Kang Jiali Yang Weichen Zhang Jinyan Lu Xuejiao Ma Anqiang Sun Xiaoyan Deng Source Type: research

Role of perivascular nerve and sensory neurotransmitter dysfunction in inflammatory bowel disease
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00037.2021. Online ahead of print.ABSTRACTInflammatory Bowel Disease (IBD) is associated with both impaired intestinal blood flow and increased risk of cardiovascular disease, but the functional role of perivascular nerves that control vasomotor function of mesenteric arteries (MAs) perfusing the intestine during IBD is unknown. Because perivascular sensory nerves and their transmitters calcitonin gene-related peptide (CGRP) and substance P (SP) are important mediators of both vasodilation and inflammatory responses, our objective was to identify IBD-relat...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Charles E Norton Elizabeth A Grunz-Borgmann Marcia L Hart Benjamin W Jones Craig L Franklin Erika M Boerman Source Type: research

Impact of hyperleptinemia during placental ischemia-induced hypertension in pregnant rats
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00724.2019. Online ahead of print.ABSTRACTThe prevalence of preeclampsia and obesity have increased. While obesity is a major risk factor for preeclampsia, the mechanisms linking these morbidities are poorly understood. Circulating leptin levels increase in proportion to fat mass. Infusion of this adipokine elicits hypertension in non-pregnant rats, but less is known about how hyperleptinemia impacts blood pressure during placental ischemia, an initiating event in the pathophysiology of hypertension in preeclampsia. We tested the hypothesis that hyperlepti...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Ana C Palei Hunter L Martin Barbara A Wilson Christopher D Anderson Joey P Granger Frank T Spradley Source Type: research

Personalized physiologic flow waveforms improve wave reflection estimates compared to triangular flow waveforms in adults
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00747.2020. Online ahead of print.ABSTRACTCentral aortic pressure waveforms contain valuable prognostic information in addition to central systolic pressure. Using pressure-flow relations, wave separation analysis can be used to decompose aortic pressure waveforms into forward- (Pf) and backward-travelling (Pb) components. Reflection magnitude, the ratio of pressure amplitudes (RM=Pb/Pf), is a predictor of heart failure and all-cause mortality. Aortic flow can be measured via Doppler echocardiography or estimated using a triangular flow waveform; however, ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Ninette Shenouda Joseph M Stock Jordan C Patik Julio A Chirinos David G Edwards Source Type: research

We are the Change We Seek
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00090.2021. Online ahead of print.NO ABSTRACTPMID:33710925 | DOI:10.1152/ajpheart.00090.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Merry L Lindsey Zamaneh Kassiri Kara Hansell Keehan Keith R Brunt Jason R Carter Jonathan A Kirk Amanda J LeBlanc Petra Kleinbongard Crystal M Ripplinger Source Type: research

Exercise alters Cardiac Function Independent of Acute Systemic Inflammation in Healthy Men
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00809.2020. Online ahead of print.ABSTRACTAcute elevations in inflammatory cytokines have been demonstrated to increase aortic and left ventricular stiffness and reduce endothelial function in healthy subjects. As vascular and cardiac function are often transiently reduced following prolonged exercise, it is possible that cytokines released during exercise may contribute to these alterations. The a priori aims of this study were to determine if vaccine-induced increases in inflammatory-cytokines would reduce vascular and left ventricular function, whether ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Alexandra M Coates Heather L Petrick Philip J Millar Jamie F Burr Source Type: research

Global Reach 2018: Dysfunctional Extracellular Microvesicles in Andean Highlander Males with Excessive Erythrocytosis
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00016.2021. Online ahead of print.ABSTRACTHigh altitude-related excessive erythrocytosis (EE) is associated with increased cardiovascular risk. The experimental aim of this study was to determine the effects of microvesicles isolated from Andean highlanders with EE on endothelial cell inflammation, oxidative stress, apoptosis and nitric oxide (NO) production.Twenty-six male residents of Cerro de Pasco, Peru (4,340 m) were studied: 12 highlanders without EE (age: 40±4 yr; BMI: 26.4±1.7; Hb: 17.4±0.5 g/dL, SpO2: 86.9±1.0%) and 14 ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: L Madden Brewster Anthony R Bain Vinicius P Pacheco Garcia Hannah K Fandl Rachel Stone Noah M DeSouza Jared J Greiner Michael M Tymko Gustavo A Vizcardo-Galindo Romulo J Figueroa-Mujica Francisco C Villafuerte Philip N Ainslie Christopher A DeSouza Source Type: research

Effect of endothelial glycocalyx on water and low density lipoprotein (LDL) transport through the rat abdominal aorta
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00861.2020. Online ahead of print.ABSTRACTThe surface of vascular endothelial cells (ECs) is covered by a protective negatively charged layer known as the endothelial glycocalyx. Herein, we hypothesized its transport barrier and mechanosensory role in transmural water flux and low density lipoprotein (LDL) transport in an isolated rat abdominal aorta perfused under 85 mm Hg and 20 dyn/cm2 ex vivo. The endothelial glycocalyx was digested by hyaluronidase (HAase) from bovine tests. Water infiltration velocity (Vw) was measured by a graduated pipette. LDL cov...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Hongyan Kang Jiali Yang Weichen Zhang Jinyan Lu Xuejiao Ma Anqiang Sun Xiaoyan Deng Source Type: research

Role of perivascular nerve and sensory neurotransmitter dysfunction in inflammatory bowel disease
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00037.2021. Online ahead of print.ABSTRACTInflammatory Bowel Disease (IBD) is associated with both impaired intestinal blood flow and increased risk of cardiovascular disease, but the functional role of perivascular nerves that control vasomotor function of mesenteric arteries (MAs) perfusing the intestine during IBD is unknown. Because perivascular sensory nerves and their transmitters calcitonin gene-related peptide (CGRP) and substance P (SP) are important mediators of both vasodilation and inflammatory responses, our objective was to identify IBD-relat...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Charles E Norton Elizabeth A Grunz-Borgmann Marcia L Hart Benjamin W Jones Craig L Franklin Erika M Boerman Source Type: research

Impact of hyperleptinemia during placental ischemia-induced hypertension in pregnant rats
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00724.2019. Online ahead of print.ABSTRACTThe prevalence of preeclampsia and obesity have increased. While obesity is a major risk factor for preeclampsia, the mechanisms linking these morbidities are poorly understood. Circulating leptin levels increase in proportion to fat mass. Infusion of this adipokine elicits hypertension in non-pregnant rats, but less is known about how hyperleptinemia impacts blood pressure during placental ischemia, an initiating event in the pathophysiology of hypertension in preeclampsia. We tested the hypothesis that hyperlepti...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Ana C Palei Hunter L Martin Barbara A Wilson Christopher D Anderson Joey P Granger Frank T Spradley Source Type: research

Personalized physiologic flow waveforms improve wave reflection estimates compared to triangular flow waveforms in adults
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00747.2020. Online ahead of print.ABSTRACTCentral aortic pressure waveforms contain valuable prognostic information in addition to central systolic pressure. Using pressure-flow relations, wave separation analysis can be used to decompose aortic pressure waveforms into forward- (Pf) and backward-travelling (Pb) components. Reflection magnitude, the ratio of pressure amplitudes (RM=Pb/Pf), is a predictor of heart failure and all-cause mortality. Aortic flow can be measured via Doppler echocardiography or estimated using a triangular flow waveform; however, ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Ninette Shenouda Joseph M Stock Jordan C Patik Julio A Chirinos David G Edwards Source Type: research

We are the Change We Seek
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00090.2021. Online ahead of print.NO ABSTRACTPMID:33710925 | DOI:10.1152/ajpheart.00090.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Merry L Lindsey Zamaneh Kassiri Kara Hansell Keehan Keith R Brunt Jason R Carter Jonathan A Kirk Amanda J LeBlanc Petra Kleinbongard Crystal M Ripplinger Source Type: research

Exercise alters Cardiac Function Independent of Acute Systemic Inflammation in Healthy Men
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00809.2020. Online ahead of print.ABSTRACTAcute elevations in inflammatory cytokines have been demonstrated to increase aortic and left ventricular stiffness and reduce endothelial function in healthy subjects. As vascular and cardiac function are often transiently reduced following prolonged exercise, it is possible that cytokines released during exercise may contribute to these alterations. The a priori aims of this study were to determine if vaccine-induced increases in inflammatory-cytokines would reduce vascular and left ventricular function, whether ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Alexandra M Coates Heather L Petrick Philip J Millar Jamie F Burr Source Type: research

Global Reach 2018: Dysfunctional Extracellular Microvesicles in Andean Highlander Males with Excessive Erythrocytosis
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00016.2021. Online ahead of print.ABSTRACTHigh altitude-related excessive erythrocytosis (EE) is associated with increased cardiovascular risk. The experimental aim of this study was to determine the effects of microvesicles isolated from Andean highlanders with EE on endothelial cell inflammation, oxidative stress, apoptosis and nitric oxide (NO) production.Twenty-six male residents of Cerro de Pasco, Peru (4,340 m) were studied: 12 highlanders without EE (age: 40±4 yr; BMI: 26.4±1.7; Hb: 17.4±0.5 g/dL, SpO2: 86.9±1.0%) and 14 ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: L Madden Brewster Anthony R Bain Vinicius P Pacheco Garcia Hannah K Fandl Rachel Stone Noah M DeSouza Jared J Greiner Michael M Tymko Gustavo A Vizcardo-Galindo Romulo J Figueroa-Mujica Francisco C Villafuerte Philip N Ainslie Christopher A DeSouza Source Type: research

Effect of endothelial glycocalyx on water and low density lipoprotein (LDL) transport through the rat abdominal aorta
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00861.2020. Online ahead of print.ABSTRACTThe surface of vascular endothelial cells (ECs) is covered by a protective negatively charged layer known as the endothelial glycocalyx. Herein, we hypothesized its transport barrier and mechanosensory role in transmural water flux and low density lipoprotein (LDL) transport in an isolated rat abdominal aorta perfused under 85 mm Hg and 20 dyn/cm2 ex vivo. The endothelial glycocalyx was digested by hyaluronidase (HAase) from bovine tests. Water infiltration velocity (Vw) was measured by a graduated pipette. LDL cov...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Hongyan Kang Jiali Yang Weichen Zhang Jinyan Lu Xuejiao Ma Anqiang Sun Xiaoyan Deng Source Type: research

Role of perivascular nerve and sensory neurotransmitter dysfunction in inflammatory bowel disease
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00037.2021. Online ahead of print.ABSTRACTInflammatory Bowel Disease (IBD) is associated with both impaired intestinal blood flow and increased risk of cardiovascular disease, but the functional role of perivascular nerves that control vasomotor function of mesenteric arteries (MAs) perfusing the intestine during IBD is unknown. Because perivascular sensory nerves and their transmitters calcitonin gene-related peptide (CGRP) and substance P (SP) are important mediators of both vasodilation and inflammatory responses, our objective was to identify IBD-relat...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Charles E Norton Elizabeth A Grunz-Borgmann Marcia L Hart Benjamin W Jones Craig L Franklin Erika M Boerman Source Type: research

Impact of hyperleptinemia during placental ischemia-induced hypertension in pregnant rats
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00724.2019. Online ahead of print.ABSTRACTThe prevalence of preeclampsia and obesity have increased. While obesity is a major risk factor for preeclampsia, the mechanisms linking these morbidities are poorly understood. Circulating leptin levels increase in proportion to fat mass. Infusion of this adipokine elicits hypertension in non-pregnant rats, but less is known about how hyperleptinemia impacts blood pressure during placental ischemia, an initiating event in the pathophysiology of hypertension in preeclampsia. We tested the hypothesis that hyperlepti...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Ana C Palei Hunter L Martin Barbara A Wilson Christopher D Anderson Joey P Granger Frank T Spradley Source Type: research

Personalized physiologic flow waveforms improve wave reflection estimates compared to triangular flow waveforms in adults
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00747.2020. Online ahead of print.ABSTRACTCentral aortic pressure waveforms contain valuable prognostic information in addition to central systolic pressure. Using pressure-flow relations, wave separation analysis can be used to decompose aortic pressure waveforms into forward- (Pf) and backward-travelling (Pb) components. Reflection magnitude, the ratio of pressure amplitudes (RM=Pb/Pf), is a predictor of heart failure and all-cause mortality. Aortic flow can be measured via Doppler echocardiography or estimated using a triangular flow waveform; however, ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Ninette Shenouda Joseph M Stock Jordan C Patik Julio A Chirinos David G Edwards Source Type: research

We are the Change We Seek
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00090.2021. Online ahead of print.NO ABSTRACTPMID:33710925 | DOI:10.1152/ajpheart.00090.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Merry L Lindsey Zamaneh Kassiri Kara Hansell Keehan Keith R Brunt Jason R Carter Jonathan A Kirk Amanda J LeBlanc Petra Kleinbongard Crystal M Ripplinger Source Type: research

Exercise alters Cardiac Function Independent of Acute Systemic Inflammation in Healthy Men
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00809.2020. Online ahead of print.ABSTRACTAcute elevations in inflammatory cytokines have been demonstrated to increase aortic and left ventricular stiffness and reduce endothelial function in healthy subjects. As vascular and cardiac function are often transiently reduced following prolonged exercise, it is possible that cytokines released during exercise may contribute to these alterations. The a priori aims of this study were to determine if vaccine-induced increases in inflammatory-cytokines would reduce vascular and left ventricular function, whether ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Alexandra M Coates Heather L Petrick Philip J Millar Jamie F Burr Source Type: research

Global Reach 2018: Dysfunctional Extracellular Microvesicles in Andean Highlander Males with Excessive Erythrocytosis
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00016.2021. Online ahead of print.ABSTRACTHigh altitude-related excessive erythrocytosis (EE) is associated with increased cardiovascular risk. The experimental aim of this study was to determine the effects of microvesicles isolated from Andean highlanders with EE on endothelial cell inflammation, oxidative stress, apoptosis and nitric oxide (NO) production.Twenty-six male residents of Cerro de Pasco, Peru (4,340 m) were studied: 12 highlanders without EE (age: 40±4 yr; BMI: 26.4±1.7; Hb: 17.4±0.5 g/dL, SpO2: 86.9±1.0%) and 14 ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: L Madden Brewster Anthony R Bain Vinicius P Pacheco Garcia Hannah K Fandl Rachel Stone Noah M DeSouza Jared J Greiner Michael M Tymko Gustavo A Vizcardo-Galindo Romulo J Figueroa-Mujica Francisco C Villafuerte Philip N Ainslie Christopher A DeSouza Source Type: research

Effect of endothelial glycocalyx on water and low density lipoprotein (LDL) transport through the rat abdominal aorta
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00861.2020. Online ahead of print.ABSTRACTThe surface of vascular endothelial cells (ECs) is covered by a protective negatively charged layer known as the endothelial glycocalyx. Herein, we hypothesized its transport barrier and mechanosensory role in transmural water flux and low density lipoprotein (LDL) transport in an isolated rat abdominal aorta perfused under 85 mm Hg and 20 dyn/cm2 ex vivo. The endothelial glycocalyx was digested by hyaluronidase (HAase) from bovine tests. Water infiltration velocity (Vw) was measured by a graduated pipette. LDL cov...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Hongyan Kang Jiali Yang Weichen Zhang Jinyan Lu Xuejiao Ma Anqiang Sun Xiaoyan Deng Source Type: research

Role of perivascular nerve and sensory neurotransmitter dysfunction in inflammatory bowel disease
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00037.2021. Online ahead of print.ABSTRACTInflammatory Bowel Disease (IBD) is associated with both impaired intestinal blood flow and increased risk of cardiovascular disease, but the functional role of perivascular nerves that control vasomotor function of mesenteric arteries (MAs) perfusing the intestine during IBD is unknown. Because perivascular sensory nerves and their transmitters calcitonin gene-related peptide (CGRP) and substance P (SP) are important mediators of both vasodilation and inflammatory responses, our objective was to identify IBD-relat...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Charles E Norton Elizabeth A Grunz-Borgmann Marcia L Hart Benjamin W Jones Craig L Franklin Erika M Boerman Source Type: research

Impact of hyperleptinemia during placental ischemia-induced hypertension in pregnant rats
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00724.2019. Online ahead of print.ABSTRACTThe prevalence of preeclampsia and obesity have increased. While obesity is a major risk factor for preeclampsia, the mechanisms linking these morbidities are poorly understood. Circulating leptin levels increase in proportion to fat mass. Infusion of this adipokine elicits hypertension in non-pregnant rats, but less is known about how hyperleptinemia impacts blood pressure during placental ischemia, an initiating event in the pathophysiology of hypertension in preeclampsia. We tested the hypothesis that hyperlepti...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Ana C Palei Hunter L Martin Barbara A Wilson Christopher D Anderson Joey P Granger Frank T Spradley Source Type: research

Personalized physiologic flow waveforms improve wave reflection estimates compared to triangular flow waveforms in adults
Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00747.2020. Online ahead of print.ABSTRACTCentral aortic pressure waveforms contain valuable prognostic information in addition to central systolic pressure. Using pressure-flow relations, wave separation analysis can be used to decompose aortic pressure waveforms into forward- (Pf) and backward-travelling (Pb) components. Reflection magnitude, the ratio of pressure amplitudes (RM=Pb/Pf), is a predictor of heart failure and all-cause mortality. Aortic flow can be measured via Doppler echocardiography or estimated using a triangular flow waveform; however, ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 12, 2021 Category: Physiology Authors: Ninette Shenouda Joseph M Stock Jordan C Patik Julio A Chirinos David G Edwards Source Type: research