Direct cardiac versus systemic effects of inorganic nitrite on human left ventricular function
Conclusions These results indicate that inorganic nitrite has modest direct effects on human LV diastolic function, independent of LV loading conditions and without affecting LV systolic properties. The systemic administration of nitrite has larger effects on LV diastolic function which are related to reduction in both preload and afterload. These effects of inorganic nitrite indicate a favourable profile for conditions characterized by LV diastolic dysfunction, e.g. heart failure with preserved ejection fraction.PMID:34018850 | DOI:10.1152/ajpheart.00081.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 21, 2021 Category: Physiology Authors: Kevin O'Gallagher Ana R Cabaco Matthew Ryan Ali Roomi Haotian Gu Luke Dancy Narbeh Melikian Phil Chowienczyk Andrew J Webb Ajay M Shah Source Type: research

Adipocyte deletion of HuR induces spontaneous cardiac hypertrophy and fibrosis
Am J Physiol Heart Circ Physiol. 2021 May 21. doi: 10.1152/ajpheart.00957.2020. Online ahead of print.ABSTRACTAdipose tissue homeostasis plays a central role in cardiovascular physiology, and the presence of thermogenically active brown adipose tissue (BAT) has recently been associated with cardiometabolic health. We have previously shown that adipose tissue-specific deletion of HuR (Adipo-HuR-/-) reduces BAT-mediated adaptive thermogenesis, and the goal of this work was to identify the cardiovascular impacts of Adipo-HuR-/-. We found that Adipo-HuR-/- mice exhibit a hypercontractile phenotype that is accompanied by increa...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 21, 2021 Category: Physiology Authors: Adrienne R Guarnieri Sarah R Anthony Anamarie Gozdiff Lisa C Green Salma M Fleifil Samuel Slone Michelle L Nieman Perwez Alam Joshua B Benoit A Phillip Owens Onur Kanisicak Michael Tranter Source Type: research

Transthyretin amyloid fibrils alter primary fibroblast structure, function and inflammatory gene expression
Am J Physiol Heart Circ Physiol. 2021 May 21. doi: 10.1152/ajpheart.00073.2021. Online ahead of print.ABSTRACTAge-related wild type transthyretin amyloidosis (wtATTR) is characterized by systemic deposition of amyloidogenic fibrils of misfolded transthyretin (TTR) in the connective tissue of many organs. In the heart this leads to cardiac dysfunction, which is a significant cause of age-related heart failure. The hypothesis tested is that TTR affects cardiac fibroblasts in ways that may contribute to fibrosis. When primary cardiac fibroblasts were cultured on TTR-deposited substrates, the F-actin cytoskeleton disorganized,...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 21, 2021 Category: Physiology Authors: Kyle T Dittloff Antonio Iezzi Justin X Zhong Priya Mohindra Tejal A Desai Brenda Russell Source Type: research

Differential Responses of Resistance Arterioles to Elevated Intraluminal Pressure in Blacks and Whites
Am J Physiol Heart Circ Physiol. 2021 May 21. doi: 10.1152/ajpheart.01023.2020. Online ahead of print.ABSTRACTBlack Americans have an earlier onset, higher average blood pressure, and higher rates of hypertension-related mortality and morbidity, compared to whites. The racial difference may be related to microvasculature, the major regulatory site of blood pressure. The goal of this study was to compare the response of resistance vessels to high intraluminal pressure between black and white participants. A total of 38 vessels were obtained from human fat samples (21 black, 17 white; mean age 32 ± 12 years and BMI 26...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 21, 2021 Category: Physiology Authors: Ahmad Sabbahi Assem Ellythy Chueh-Lung Hwang Shane A Phillips Source Type: research

Effects of cardiorespiratory fitness and exercise training on cerebrovascular blood flow and reactivity: a systematic review with meta-analyses
CONCLUSIONS: High CRF positively effects cerebrovascular function, including decreased CVRi and increased CVRCO2 however, global cerebral blood flow and MCAv is primarily unchanged following an exercise intervention in healthy and clinical populations.PMID:34018848 | DOI:10.1152/ajpheart.00880.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 21, 2021 Category: Physiology Authors: Emily C Smith Faith K Pizzey Christopher D Askew Gregore I Mielke Philip N Ainslie Jeff S Coombes Tom G Bailey Source Type: research

The underlying mechanism of inter-site discrepancies in ejection time measurements from arterial waveforms and its validation in the Framingham Heart Study
Am J Physiol Heart Circ Physiol. 2021 May 21. doi: 10.1152/ajpheart.00096.2021. Online ahead of print.ABSTRACTRadial applanation tonometry is a well-established method for clinical hemodynamic assessment and is also becoming popular in wrist-worn fitness trackers. The time difference between the foot and the dicrotic notch of the arterial pressure waveform is a well-accepted approximation for the left ventricular ejection time (ET). However, several clinical studies have shown that ET measured from the radial pressure waveform deviates from that measured centrally. In this work, we consider the systolic wave and the dicrot...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 21, 2021 Category: Physiology Authors: Jing Liu Niema M Pahlevan Source Type: research

Direct cardiac versus systemic effects of inorganic nitrite on human left ventricular function
Conclusions These results indicate that inorganic nitrite has modest direct effects on human LV diastolic function, independent of LV loading conditions and without affecting LV systolic properties. The systemic administration of nitrite has larger effects on LV diastolic function which are related to reduction in both preload and afterload. These effects of inorganic nitrite indicate a favourable profile for conditions characterized by LV diastolic dysfunction, e.g. heart failure with preserved ejection fraction.PMID:34018850 | DOI:10.1152/ajpheart.00081.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 21, 2021 Category: Physiology Authors: Kevin O'Gallagher Ana R Cabaco Matthew Ryan Ali Roomi Haotian Gu Luke Dancy Narbeh Melikian Phil Chowienczyk Andrew J Webb Ajay M Shah Source Type: research

Adipocyte deletion of HuR induces spontaneous cardiac hypertrophy and fibrosis
Am J Physiol Heart Circ Physiol. 2021 May 21. doi: 10.1152/ajpheart.00957.2020. Online ahead of print.ABSTRACTAdipose tissue homeostasis plays a central role in cardiovascular physiology, and the presence of thermogenically active brown adipose tissue (BAT) has recently been associated with cardiometabolic health. We have previously shown that adipose tissue-specific deletion of HuR (Adipo-HuR-/-) reduces BAT-mediated adaptive thermogenesis, and the goal of this work was to identify the cardiovascular impacts of Adipo-HuR-/-. We found that Adipo-HuR-/- mice exhibit a hypercontractile phenotype that is accompanied by increa...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 21, 2021 Category: Physiology Authors: Adrienne R Guarnieri Sarah R Anthony Anamarie Gozdiff Lisa C Green Salma M Fleifil Samuel Slone Michelle L Nieman Perwez Alam Joshua B Benoit A Phillip Owens Onur Kanisicak Michael Tranter Source Type: research

Transthyretin amyloid fibrils alter primary fibroblast structure, function and inflammatory gene expression
Am J Physiol Heart Circ Physiol. 2021 May 21. doi: 10.1152/ajpheart.00073.2021. Online ahead of print.ABSTRACTAge-related wild type transthyretin amyloidosis (wtATTR) is characterized by systemic deposition of amyloidogenic fibrils of misfolded transthyretin (TTR) in the connective tissue of many organs. In the heart this leads to cardiac dysfunction, which is a significant cause of age-related heart failure. The hypothesis tested is that TTR affects cardiac fibroblasts in ways that may contribute to fibrosis. When primary cardiac fibroblasts were cultured on TTR-deposited substrates, the F-actin cytoskeleton disorganized,...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 21, 2021 Category: Physiology Authors: Kyle T Dittloff Antonio Iezzi Justin X Zhong Priya Mohindra Tejal A Desai Brenda Russell Source Type: research

Differential Responses of Resistance Arterioles to Elevated Intraluminal Pressure in Blacks and Whites
Am J Physiol Heart Circ Physiol. 2021 May 21. doi: 10.1152/ajpheart.01023.2020. Online ahead of print.ABSTRACTBlack Americans have an earlier onset, higher average blood pressure, and higher rates of hypertension-related mortality and morbidity, compared to whites. The racial difference may be related to microvasculature, the major regulatory site of blood pressure. The goal of this study was to compare the response of resistance vessels to high intraluminal pressure between black and white participants. A total of 38 vessels were obtained from human fat samples (21 black, 17 white; mean age 32 ± 12 years and BMI 26...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 21, 2021 Category: Physiology Authors: Ahmad Sabbahi Assem Ellythy Chueh-Lung Hwang Shane A Phillips Source Type: research

Effects of cardiorespiratory fitness and exercise training on cerebrovascular blood flow and reactivity: a systematic review with meta-analyses
CONCLUSIONS: High CRF positively effects cerebrovascular function, including decreased CVRi and increased CVRCO2 however, global cerebral blood flow and MCAv is primarily unchanged following an exercise intervention in healthy and clinical populations.PMID:34018848 | DOI:10.1152/ajpheart.00880.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 21, 2021 Category: Physiology Authors: Emily C Smith Faith K Pizzey Christopher D Askew Gregore I Mielke Philip N Ainslie Jeff S Coombes Tom G Bailey Source Type: research

The underlying mechanism of inter-site discrepancies in ejection time measurements from arterial waveforms and its validation in the Framingham Heart Study
Am J Physiol Heart Circ Physiol. 2021 May 21. doi: 10.1152/ajpheart.00096.2021. Online ahead of print.ABSTRACTRadial applanation tonometry is a well-established method for clinical hemodynamic assessment and is also becoming popular in wrist-worn fitness trackers. The time difference between the foot and the dicrotic notch of the arterial pressure waveform is a well-accepted approximation for the left ventricular ejection time (ET). However, several clinical studies have shown that ET measured from the radial pressure waveform deviates from that measured centrally. In this work, we consider the systolic wave and the dicrot...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 21, 2021 Category: Physiology Authors: Jing Liu Niema M Pahlevan Source Type: research

Direct cardiac versus systemic effects of inorganic nitrite on human left ventricular function
Conclusions These results indicate that inorganic nitrite has modest direct effects on human LV diastolic function, independent of LV loading conditions and without affecting LV systolic properties. The systemic administration of nitrite has larger effects on LV diastolic function which are related to reduction in both preload and afterload. These effects of inorganic nitrite indicate a favourable profile for conditions characterized by LV diastolic dysfunction, e.g. heart failure with preserved ejection fraction.PMID:34018850 | DOI:10.1152/ajpheart.00081.2021 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 21, 2021 Category: Physiology Authors: Kevin O'Gallagher Ana R Cabaco Matthew Ryan Ali Roomi Haotian Gu Luke Dancy Narbeh Melikian Phil Chowienczyk Andrew J Webb Ajay M Shah Source Type: research

Adipocyte deletion of HuR induces spontaneous cardiac hypertrophy and fibrosis
Am J Physiol Heart Circ Physiol. 2021 May 21. doi: 10.1152/ajpheart.00957.2020. Online ahead of print.ABSTRACTAdipose tissue homeostasis plays a central role in cardiovascular physiology, and the presence of thermogenically active brown adipose tissue (BAT) has recently been associated with cardiometabolic health. We have previously shown that adipose tissue-specific deletion of HuR (Adipo-HuR-/-) reduces BAT-mediated adaptive thermogenesis, and the goal of this work was to identify the cardiovascular impacts of Adipo-HuR-/-. We found that Adipo-HuR-/- mice exhibit a hypercontractile phenotype that is accompanied by increa...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 21, 2021 Category: Physiology Authors: Adrienne R Guarnieri Sarah R Anthony Anamarie Gozdiff Lisa C Green Salma M Fleifil Samuel Slone Michelle L Nieman Perwez Alam Joshua B Benoit A Phillip Owens Onur Kanisicak Michael Tranter Source Type: research

Transthyretin amyloid fibrils alter primary fibroblast structure, function and inflammatory gene expression
Am J Physiol Heart Circ Physiol. 2021 May 21. doi: 10.1152/ajpheart.00073.2021. Online ahead of print.ABSTRACTAge-related wild type transthyretin amyloidosis (wtATTR) is characterized by systemic deposition of amyloidogenic fibrils of misfolded transthyretin (TTR) in the connective tissue of many organs. In the heart this leads to cardiac dysfunction, which is a significant cause of age-related heart failure. The hypothesis tested is that TTR affects cardiac fibroblasts in ways that may contribute to fibrosis. When primary cardiac fibroblasts were cultured on TTR-deposited substrates, the F-actin cytoskeleton disorganized,...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 21, 2021 Category: Physiology Authors: Kyle T Dittloff Antonio Iezzi Justin X Zhong Priya Mohindra Tejal A Desai Brenda Russell Source Type: research

Differential Responses of Resistance Arterioles to Elevated Intraluminal Pressure in Blacks and Whites
Am J Physiol Heart Circ Physiol. 2021 May 21. doi: 10.1152/ajpheart.01023.2020. Online ahead of print.ABSTRACTBlack Americans have an earlier onset, higher average blood pressure, and higher rates of hypertension-related mortality and morbidity, compared to whites. The racial difference may be related to microvasculature, the major regulatory site of blood pressure. The goal of this study was to compare the response of resistance vessels to high intraluminal pressure between black and white participants. A total of 38 vessels were obtained from human fat samples (21 black, 17 white; mean age 32 ± 12 years and BMI 26...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 21, 2021 Category: Physiology Authors: Ahmad Sabbahi Assem Ellythy Chueh-Lung Hwang Shane A Phillips Source Type: research

Mechanistic Insights into Cell-free Hemoglobin-induced Injury During Septic Shock
CONCLUSIONS: In the absence and presence of infection, CFH infusions resulted in pulmonary hypertension, cardiogenic shock and multi-organ failure, likely through NO scavenging. In the presence of infection alone, CFH infusions worsened oxygen exchange and lung injury, presumably by supplying iron that promoted bacterial growth. CFH elevation, a known consequence of clinical septic shock, adversely impacts sepsis outcomes through more than one mechanism and is a biologically plausible, non-antibiotic, non-cytokine target for therapeutic intervention.PMID:33989079 | DOI:10.1152/ajpheart.00092.2021 (Source: American Journal ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Jeffrey Wang Willard N Applefeld Junfeng Sun Steven B Solomon Jing Feng Zoe G Couse Thomas F Risoleo Robert L Danner Jes ús Tejero Juan Lertora Elmira Alipour Swati Basu Vandana Sachdev Daniel B Kim-Shapiro Mark T Gladwin Harvey G Klein Charles Natanson Source Type: research

Impacts of Circulating microRNAs in Exercise-Induced Vascular Remodeling
This article provides an overview of the emerging field of sports/performance genomics with a focus on the role of microRNAs as novel functional diagnostic and prognostic tools, and discusses present knowledge in the context of athletic vascular remodeling. This review concludes with current advantages and limitations, touching upon future directions and implications for applying contemporary systems biology knowledge of exercise-induced physiology to better understand how disruption can lead to pathology.PMID:33989080 | DOI:10.1152/ajpheart.00894.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Gary P Van Guilder Claudia C Preston Thayne A Munce Randolph S Faustino Source Type: research

BAG3 Expression and Sarcomere Localization in the Human Heart are Linked to HSF-1 and are Differentially Affected by Sex and Disease
Am J Physiol Heart Circ Physiol. 2021 May 14. doi: 10.1152/ajpheart.00419.2020. Online ahead of print.ABSTRACTMutations to the sarcomere-localized co-chaperone protein Bcl2-associated athanogene 3 (BAG3) are associated with dilated cardiomyopathy (DCM) and display greater penetrance in male patients. Decreased protein expression of BAG3 is also associated with non-genetic heart failure, however, the factors regulating cardiac BAG3 expression are unknown. Using left ventricular (LV) tissue from non-failing and DCM human samples we found that whole LV BAG3 expression was not significantly impacted by DCM or sex, however, myo...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Thomas G Martin Sara Tawfik Christine S Moravec Toni R Pak Jonathan A Kirk Source Type: research

Guidelines for the measurement of vascular function and structure in isolated arteries and veins
Am J Physiol Heart Circ Physiol. 2021 May 14. doi: 10.1152/ajpheart.01021.2020. Online ahead of print.ABSTRACTThe measurement of vascular function in isolated vessels has revealed important insights into the structural, functional, and biomechanical features of the normal and diseased cardiovascular system, and has provided a molecular understanding of the cells that constitutes arteries and veins and their interaction. Further, this approach has allowed the discovery of vital pharmacological treatments for cardiovascular diseases. However, the expansion of the vascular physiology field has also brought new concerns over s...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Camilla F Wenceslau Cameron G McCarthy Scott Earley Sarah K England Jessica A Filosa Styliani Goulopoulou David D Gutterman Brant E Isakson Nancy L Kanagy Luis A Martinez-Lemus Swapnil K Sonkusare Pratish Thakore Aaron J Trask Stephanie W Watts R Clinton Source Type: research

Neuregulin-1 Compensates for Endothelial Nitric Oxide Synthase Deficiency
CONCLUSION: This study indicates that administration of endothelium-derived NRG1 can compensate for eNOS deficiency in the heart and kidneys.PMID:33989083 | DOI:10.1152/ajpheart.00914.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Hadis Shakeri Jente R A Boen Sofie De Moudt Jhana O Hendrickx Arthur J A Leloup Griet Jacobs Guido R Y De Meyer Gilles W De Keulenaer Pieter-Jan D F Guns Vincent F M Segers Source Type: research

Aerobic exercise training reduces cardiac function and coronary flow-induced vasodilation in mice lacking adiponectin
Am J Physiol Heart Circ Physiol. 2021 May 14. doi: 10.1152/ajpheart.00885.2020. Online ahead of print.ABSTRACTWe tested the hypothesis that adiponectin deficiency attenuates coronary microvascular and cardiac function and prevents exercise training-induced adaptations of the coronary microvasculature and the myocardium in adult mice. Adult wild-type (WT) or adiponectin knockout (adiponectin KO) mice underwent treadmill exercise training or remained sedentary for 8-10 weeks. Systolic and diastolic function were assessed before and after exercise training or cage confinement. Vasoreactivity of coronary resistance arteries wa...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Jacob T Caldwell Karissa M Dieseldorff Jones Hyerim Park Jose R Pinto Payal Ghosh Emily C Reid-Foley Brody Ulrich Michael D Delp Brad J Behnke Judy M Muller-Delp Source Type: research

Mechanistic Insights into Cell-free Hemoglobin-induced Injury During Septic Shock
CONCLUSIONS: In the absence and presence of infection, CFH infusions resulted in pulmonary hypertension, cardiogenic shock and multi-organ failure, likely through NO scavenging. In the presence of infection alone, CFH infusions worsened oxygen exchange and lung injury, presumably by supplying iron that promoted bacterial growth. CFH elevation, a known consequence of clinical septic shock, adversely impacts sepsis outcomes through more than one mechanism and is a biologically plausible, non-antibiotic, non-cytokine target for therapeutic intervention.PMID:33989079 | DOI:10.1152/ajpheart.00092.2021 (Source: American Journal ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Jeffrey Wang Willard N Applefeld Junfeng Sun Steven B Solomon Jing Feng Zoe G Couse Thomas F Risoleo Robert L Danner Jes ús Tejero Juan Lertora Elmira Alipour Swati Basu Vandana Sachdev Daniel B Kim-Shapiro Mark T Gladwin Harvey G Klein Charles Natanson Source Type: research

Impacts of Circulating microRNAs in Exercise-Induced Vascular Remodeling
This article provides an overview of the emerging field of sports/performance genomics with a focus on the role of microRNAs as novel functional diagnostic and prognostic tools, and discusses present knowledge in the context of athletic vascular remodeling. This review concludes with current advantages and limitations, touching upon future directions and implications for applying contemporary systems biology knowledge of exercise-induced physiology to better understand how disruption can lead to pathology.PMID:33989080 | DOI:10.1152/ajpheart.00894.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Gary P Van Guilder Claudia C Preston Thayne A Munce Randolph S Faustino Source Type: research

BAG3 Expression and Sarcomere Localization in the Human Heart are Linked to HSF-1 and are Differentially Affected by Sex and Disease
Am J Physiol Heart Circ Physiol. 2021 May 14. doi: 10.1152/ajpheart.00419.2020. Online ahead of print.ABSTRACTMutations to the sarcomere-localized co-chaperone protein Bcl2-associated athanogene 3 (BAG3) are associated with dilated cardiomyopathy (DCM) and display greater penetrance in male patients. Decreased protein expression of BAG3 is also associated with non-genetic heart failure, however, the factors regulating cardiac BAG3 expression are unknown. Using left ventricular (LV) tissue from non-failing and DCM human samples we found that whole LV BAG3 expression was not significantly impacted by DCM or sex, however, myo...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Thomas G Martin Sara Tawfik Christine S Moravec Toni R Pak Jonathan A Kirk Source Type: research

Guidelines for the measurement of vascular function and structure in isolated arteries and veins
Am J Physiol Heart Circ Physiol. 2021 May 14. doi: 10.1152/ajpheart.01021.2020. Online ahead of print.ABSTRACTThe measurement of vascular function in isolated vessels has revealed important insights into the structural, functional, and biomechanical features of the normal and diseased cardiovascular system, and has provided a molecular understanding of the cells that constitutes arteries and veins and their interaction. Further, this approach has allowed the discovery of vital pharmacological treatments for cardiovascular diseases. However, the expansion of the vascular physiology field has also brought new concerns over s...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Camilla F Wenceslau Cameron G McCarthy Scott Earley Sarah K England Jessica A Filosa Styliani Goulopoulou David D Gutterman Brant E Isakson Nancy L Kanagy Luis A Martinez-Lemus Swapnil K Sonkusare Pratish Thakore Aaron J Trask Stephanie W Watts R Clinton Source Type: research

Neuregulin-1 Compensates for Endothelial Nitric Oxide Synthase Deficiency
CONCLUSION: This study indicates that administration of endothelium-derived NRG1 can compensate for eNOS deficiency in the heart and kidneys.PMID:33989083 | DOI:10.1152/ajpheart.00914.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Hadis Shakeri Jente R A Boen Sofie De Moudt Jhana O Hendrickx Arthur J A Leloup Griet Jacobs Guido R Y De Meyer Gilles W De Keulenaer Pieter-Jan D F Guns Vincent F M Segers Source Type: research

Aerobic exercise training reduces cardiac function and coronary flow-induced vasodilation in mice lacking adiponectin
Am J Physiol Heart Circ Physiol. 2021 May 14. doi: 10.1152/ajpheart.00885.2020. Online ahead of print.ABSTRACTWe tested the hypothesis that adiponectin deficiency attenuates coronary microvascular and cardiac function and prevents exercise training-induced adaptations of the coronary microvasculature and the myocardium in adult mice. Adult wild-type (WT) or adiponectin knockout (adiponectin KO) mice underwent treadmill exercise training or remained sedentary for 8-10 weeks. Systolic and diastolic function were assessed before and after exercise training or cage confinement. Vasoreactivity of coronary resistance arteries wa...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Jacob T Caldwell Karissa M Dieseldorff Jones Hyerim Park Jose R Pinto Payal Ghosh Emily C Reid-Foley Brody Ulrich Michael D Delp Brad J Behnke Judy M Muller-Delp Source Type: research

Mechanistic Insights into Cell-free Hemoglobin-induced Injury During Septic Shock
CONCLUSIONS: In the absence and presence of infection, CFH infusions resulted in pulmonary hypertension, cardiogenic shock and multi-organ failure, likely through NO scavenging. In the presence of infection alone, CFH infusions worsened oxygen exchange and lung injury, presumably by supplying iron that promoted bacterial growth. CFH elevation, a known consequence of clinical septic shock, adversely impacts sepsis outcomes through more than one mechanism and is a biologically plausible, non-antibiotic, non-cytokine target for therapeutic intervention.PMID:33989079 | DOI:10.1152/ajpheart.00092.2021 (Source: American Journal ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Jeffrey Wang Willard N Applefeld Junfeng Sun Steven B Solomon Jing Feng Zoe G Couse Thomas F Risoleo Robert L Danner Jes ús Tejero Juan Lertora Elmira Alipour Swati Basu Vandana Sachdev Daniel B Kim-Shapiro Mark T Gladwin Harvey G Klein Charles Natanson Source Type: research

Impacts of Circulating microRNAs in Exercise-Induced Vascular Remodeling
This article provides an overview of the emerging field of sports/performance genomics with a focus on the role of microRNAs as novel functional diagnostic and prognostic tools, and discusses present knowledge in the context of athletic vascular remodeling. This review concludes with current advantages and limitations, touching upon future directions and implications for applying contemporary systems biology knowledge of exercise-induced physiology to better understand how disruption can lead to pathology.PMID:33989080 | DOI:10.1152/ajpheart.00894.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Gary P Van Guilder Claudia C Preston Thayne A Munce Randolph S Faustino Source Type: research

BAG3 Expression and Sarcomere Localization in the Human Heart are Linked to HSF-1 and are Differentially Affected by Sex and Disease
Am J Physiol Heart Circ Physiol. 2021 May 14. doi: 10.1152/ajpheart.00419.2020. Online ahead of print.ABSTRACTMutations to the sarcomere-localized co-chaperone protein Bcl2-associated athanogene 3 (BAG3) are associated with dilated cardiomyopathy (DCM) and display greater penetrance in male patients. Decreased protein expression of BAG3 is also associated with non-genetic heart failure, however, the factors regulating cardiac BAG3 expression are unknown. Using left ventricular (LV) tissue from non-failing and DCM human samples we found that whole LV BAG3 expression was not significantly impacted by DCM or sex, however, myo...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Thomas G Martin Sara Tawfik Christine S Moravec Toni R Pak Jonathan A Kirk Source Type: research

Guidelines for the measurement of vascular function and structure in isolated arteries and veins
Am J Physiol Heart Circ Physiol. 2021 May 14. doi: 10.1152/ajpheart.01021.2020. Online ahead of print.ABSTRACTThe measurement of vascular function in isolated vessels has revealed important insights into the structural, functional, and biomechanical features of the normal and diseased cardiovascular system, and has provided a molecular understanding of the cells that constitutes arteries and veins and their interaction. Further, this approach has allowed the discovery of vital pharmacological treatments for cardiovascular diseases. However, the expansion of the vascular physiology field has also brought new concerns over s...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Camilla F Wenceslau Cameron G McCarthy Scott Earley Sarah K England Jessica A Filosa Styliani Goulopoulou David D Gutterman Brant E Isakson Nancy L Kanagy Luis A Martinez-Lemus Swapnil K Sonkusare Pratish Thakore Aaron J Trask Stephanie W Watts R Clinton Source Type: research

Neuregulin-1 Compensates for Endothelial Nitric Oxide Synthase Deficiency
CONCLUSION: This study indicates that administration of endothelium-derived NRG1 can compensate for eNOS deficiency in the heart and kidneys.PMID:33989083 | DOI:10.1152/ajpheart.00914.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Hadis Shakeri Jente R A Boen Sofie De Moudt Jhana O Hendrickx Arthur J A Leloup Griet Jacobs Guido R Y De Meyer Gilles W De Keulenaer Pieter-Jan D F Guns Vincent F M Segers Source Type: research

Aerobic exercise training reduces cardiac function and coronary flow-induced vasodilation in mice lacking adiponectin
Am J Physiol Heart Circ Physiol. 2021 May 14. doi: 10.1152/ajpheart.00885.2020. Online ahead of print.ABSTRACTWe tested the hypothesis that adiponectin deficiency attenuates coronary microvascular and cardiac function and prevents exercise training-induced adaptations of the coronary microvasculature and the myocardium in adult mice. Adult wild-type (WT) or adiponectin knockout (adiponectin KO) mice underwent treadmill exercise training or remained sedentary for 8-10 weeks. Systolic and diastolic function were assessed before and after exercise training or cage confinement. Vasoreactivity of coronary resistance arteries wa...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Jacob T Caldwell Karissa M Dieseldorff Jones Hyerim Park Jose R Pinto Payal Ghosh Emily C Reid-Foley Brody Ulrich Michael D Delp Brad J Behnke Judy M Muller-Delp Source Type: research

Mechanistic Insights into Cell-free Hemoglobin-induced Injury During Septic Shock
CONCLUSIONS: In the absence and presence of infection, CFH infusions resulted in pulmonary hypertension, cardiogenic shock and multi-organ failure, likely through NO scavenging. In the presence of infection alone, CFH infusions worsened oxygen exchange and lung injury, presumably by supplying iron that promoted bacterial growth. CFH elevation, a known consequence of clinical septic shock, adversely impacts sepsis outcomes through more than one mechanism and is a biologically plausible, non-antibiotic, non-cytokine target for therapeutic intervention.PMID:33989079 | DOI:10.1152/ajpheart.00092.2021 (Source: American Journal ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Jeffrey Wang Willard N Applefeld Junfeng Sun Steven B Solomon Jing Feng Zoe G Couse Thomas F Risoleo Robert L Danner Jes ús Tejero Juan Lertora Elmira Alipour Swati Basu Vandana Sachdev Daniel B Kim-Shapiro Mark T Gladwin Harvey G Klein Charles Natanson Source Type: research

Impacts of Circulating microRNAs in Exercise-Induced Vascular Remodeling
This article provides an overview of the emerging field of sports/performance genomics with a focus on the role of microRNAs as novel functional diagnostic and prognostic tools, and discusses present knowledge in the context of athletic vascular remodeling. This review concludes with current advantages and limitations, touching upon future directions and implications for applying contemporary systems biology knowledge of exercise-induced physiology to better understand how disruption can lead to pathology.PMID:33989080 | DOI:10.1152/ajpheart.00894.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Gary P Van Guilder Claudia C Preston Thayne A Munce Randolph S Faustino Source Type: research

BAG3 Expression and Sarcomere Localization in the Human Heart are Linked to HSF-1 and are Differentially Affected by Sex and Disease
Am J Physiol Heart Circ Physiol. 2021 May 14. doi: 10.1152/ajpheart.00419.2020. Online ahead of print.ABSTRACTMutations to the sarcomere-localized co-chaperone protein Bcl2-associated athanogene 3 (BAG3) are associated with dilated cardiomyopathy (DCM) and display greater penetrance in male patients. Decreased protein expression of BAG3 is also associated with non-genetic heart failure, however, the factors regulating cardiac BAG3 expression are unknown. Using left ventricular (LV) tissue from non-failing and DCM human samples we found that whole LV BAG3 expression was not significantly impacted by DCM or sex, however, myo...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Thomas G Martin Sara Tawfik Christine S Moravec Toni R Pak Jonathan A Kirk Source Type: research

Guidelines for the measurement of vascular function and structure in isolated arteries and veins
Am J Physiol Heart Circ Physiol. 2021 May 14. doi: 10.1152/ajpheart.01021.2020. Online ahead of print.ABSTRACTThe measurement of vascular function in isolated vessels has revealed important insights into the structural, functional, and biomechanical features of the normal and diseased cardiovascular system, and has provided a molecular understanding of the cells that constitutes arteries and veins and their interaction. Further, this approach has allowed the discovery of vital pharmacological treatments for cardiovascular diseases. However, the expansion of the vascular physiology field has also brought new concerns over s...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Camilla F Wenceslau Cameron G McCarthy Scott Earley Sarah K England Jessica A Filosa Styliani Goulopoulou David D Gutterman Brant E Isakson Nancy L Kanagy Luis A Martinez-Lemus Swapnil K Sonkusare Pratish Thakore Aaron J Trask Stephanie W Watts R Clinton Source Type: research

Neuregulin-1 Compensates for Endothelial Nitric Oxide Synthase Deficiency
CONCLUSION: This study indicates that administration of endothelium-derived NRG1 can compensate for eNOS deficiency in the heart and kidneys.PMID:33989083 | DOI:10.1152/ajpheart.00914.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Hadis Shakeri Jente R A Boen Sofie De Moudt Jhana O Hendrickx Arthur J A Leloup Griet Jacobs Guido R Y De Meyer Gilles W De Keulenaer Pieter-Jan D F Guns Vincent F M Segers Source Type: research

Aerobic exercise training reduces cardiac function and coronary flow-induced vasodilation in mice lacking adiponectin
Am J Physiol Heart Circ Physiol. 2021 May 14. doi: 10.1152/ajpheart.00885.2020. Online ahead of print.ABSTRACTWe tested the hypothesis that adiponectin deficiency attenuates coronary microvascular and cardiac function and prevents exercise training-induced adaptations of the coronary microvasculature and the myocardium in adult mice. Adult wild-type (WT) or adiponectin knockout (adiponectin KO) mice underwent treadmill exercise training or remained sedentary for 8-10 weeks. Systolic and diastolic function were assessed before and after exercise training or cage confinement. Vasoreactivity of coronary resistance arteries wa...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Jacob T Caldwell Karissa M Dieseldorff Jones Hyerim Park Jose R Pinto Payal Ghosh Emily C Reid-Foley Brody Ulrich Michael D Delp Brad J Behnke Judy M Muller-Delp Source Type: research

Mechanistic Insights into Cell-free Hemoglobin-induced Injury During Septic Shock
CONCLUSIONS: In the absence and presence of infection, CFH infusions resulted in pulmonary hypertension, cardiogenic shock and multi-organ failure, likely through NO scavenging. In the presence of infection alone, CFH infusions worsened oxygen exchange and lung injury, presumably by supplying iron that promoted bacterial growth. CFH elevation, a known consequence of clinical septic shock, adversely impacts sepsis outcomes through more than one mechanism and is a biologically plausible, non-antibiotic, non-cytokine target for therapeutic intervention.PMID:33989079 | DOI:10.1152/ajpheart.00092.2021 (Source: American Journal ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Jeffrey Wang Willard N Applefeld Junfeng Sun Steven B Solomon Jing Feng Zoe G Couse Thomas F Risoleo Robert L Danner Jes ús Tejero Juan Lertora Elmira Alipour Swati Basu Vandana Sachdev Daniel B Kim-Shapiro Mark T Gladwin Harvey G Klein Charles Natanson Source Type: research

Impacts of Circulating microRNAs in Exercise-Induced Vascular Remodeling
This article provides an overview of the emerging field of sports/performance genomics with a focus on the role of microRNAs as novel functional diagnostic and prognostic tools, and discusses present knowledge in the context of athletic vascular remodeling. This review concludes with current advantages and limitations, touching upon future directions and implications for applying contemporary systems biology knowledge of exercise-induced physiology to better understand how disruption can lead to pathology.PMID:33989080 | DOI:10.1152/ajpheart.00894.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Gary P Van Guilder Claudia C Preston Thayne A Munce Randolph S Faustino Source Type: research

BAG3 Expression and Sarcomere Localization in the Human Heart are Linked to HSF-1 and are Differentially Affected by Sex and Disease
Am J Physiol Heart Circ Physiol. 2021 May 14. doi: 10.1152/ajpheart.00419.2020. Online ahead of print.ABSTRACTMutations to the sarcomere-localized co-chaperone protein Bcl2-associated athanogene 3 (BAG3) are associated with dilated cardiomyopathy (DCM) and display greater penetrance in male patients. Decreased protein expression of BAG3 is also associated with non-genetic heart failure, however, the factors regulating cardiac BAG3 expression are unknown. Using left ventricular (LV) tissue from non-failing and DCM human samples we found that whole LV BAG3 expression was not significantly impacted by DCM or sex, however, myo...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Thomas G Martin Sara Tawfik Christine S Moravec Toni R Pak Jonathan A Kirk Source Type: research

Guidelines for the measurement of vascular function and structure in isolated arteries and veins
Am J Physiol Heart Circ Physiol. 2021 May 14. doi: 10.1152/ajpheart.01021.2020. Online ahead of print.ABSTRACTThe measurement of vascular function in isolated vessels has revealed important insights into the structural, functional, and biomechanical features of the normal and diseased cardiovascular system, and has provided a molecular understanding of the cells that constitutes arteries and veins and their interaction. Further, this approach has allowed the discovery of vital pharmacological treatments for cardiovascular diseases. However, the expansion of the vascular physiology field has also brought new concerns over s...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Camilla F Wenceslau Cameron G McCarthy Scott Earley Sarah K England Jessica A Filosa Styliani Goulopoulou David D Gutterman Brant E Isakson Nancy L Kanagy Luis A Martinez-Lemus Swapnil K Sonkusare Pratish Thakore Aaron J Trask Stephanie W Watts R Clinton Source Type: research

Neuregulin-1 Compensates for Endothelial Nitric Oxide Synthase Deficiency
CONCLUSION: This study indicates that administration of endothelium-derived NRG1 can compensate for eNOS deficiency in the heart and kidneys.PMID:33989083 | DOI:10.1152/ajpheart.00914.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Hadis Shakeri Jente R A Boen Sofie De Moudt Jhana O Hendrickx Arthur J A Leloup Griet Jacobs Guido R Y De Meyer Gilles W De Keulenaer Pieter-Jan D F Guns Vincent F M Segers Source Type: research

Aerobic exercise training reduces cardiac function and coronary flow-induced vasodilation in mice lacking adiponectin
Am J Physiol Heart Circ Physiol. 2021 May 14. doi: 10.1152/ajpheart.00885.2020. Online ahead of print.ABSTRACTWe tested the hypothesis that adiponectin deficiency attenuates coronary microvascular and cardiac function and prevents exercise training-induced adaptations of the coronary microvasculature and the myocardium in adult mice. Adult wild-type (WT) or adiponectin knockout (adiponectin KO) mice underwent treadmill exercise training or remained sedentary for 8-10 weeks. Systolic and diastolic function were assessed before and after exercise training or cage confinement. Vasoreactivity of coronary resistance arteries wa...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Jacob T Caldwell Karissa M Dieseldorff Jones Hyerim Park Jose R Pinto Payal Ghosh Emily C Reid-Foley Brody Ulrich Michael D Delp Brad J Behnke Judy M Muller-Delp Source Type: research

Mechanistic Insights into Cell-free Hemoglobin-induced Injury During Septic Shock
CONCLUSIONS: In the absence and presence of infection, CFH infusions resulted in pulmonary hypertension, cardiogenic shock and multi-organ failure, likely through NO scavenging. In the presence of infection alone, CFH infusions worsened oxygen exchange and lung injury, presumably by supplying iron that promoted bacterial growth. CFH elevation, a known consequence of clinical septic shock, adversely impacts sepsis outcomes through more than one mechanism and is a biologically plausible, non-antibiotic, non-cytokine target for therapeutic intervention.PMID:33989079 | DOI:10.1152/ajpheart.00092.2021 (Source: American Journal ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Jeffrey Wang Willard N Applefeld Junfeng Sun Steven B Solomon Jing Feng Zoe G Couse Thomas F Risoleo Robert L Danner Jes ús Tejero Juan Lertora Elmira Alipour Swati Basu Vandana Sachdev Daniel B Kim-Shapiro Mark T Gladwin Harvey G Klein Charles Natanson Source Type: research

Impacts of Circulating microRNAs in Exercise-Induced Vascular Remodeling
This article provides an overview of the emerging field of sports/performance genomics with a focus on the role of microRNAs as novel functional diagnostic and prognostic tools, and discusses present knowledge in the context of athletic vascular remodeling. This review concludes with current advantages and limitations, touching upon future directions and implications for applying contemporary systems biology knowledge of exercise-induced physiology to better understand how disruption can lead to pathology.PMID:33989080 | DOI:10.1152/ajpheart.00894.2020 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Gary P Van Guilder Claudia C Preston Thayne A Munce Randolph S Faustino Source Type: research

BAG3 Expression and Sarcomere Localization in the Human Heart are Linked to HSF-1 and are Differentially Affected by Sex and Disease
Am J Physiol Heart Circ Physiol. 2021 May 14. doi: 10.1152/ajpheart.00419.2020. Online ahead of print.ABSTRACTMutations to the sarcomere-localized co-chaperone protein Bcl2-associated athanogene 3 (BAG3) are associated with dilated cardiomyopathy (DCM) and display greater penetrance in male patients. Decreased protein expression of BAG3 is also associated with non-genetic heart failure, however, the factors regulating cardiac BAG3 expression are unknown. Using left ventricular (LV) tissue from non-failing and DCM human samples we found that whole LV BAG3 expression was not significantly impacted by DCM or sex, however, myo...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Thomas G Martin Sara Tawfik Christine S Moravec Toni R Pak Jonathan A Kirk Source Type: research

Guidelines for the measurement of vascular function and structure in isolated arteries and veins
Am J Physiol Heart Circ Physiol. 2021 May 14. doi: 10.1152/ajpheart.01021.2020. Online ahead of print.ABSTRACTThe measurement of vascular function in isolated vessels has revealed important insights into the structural, functional, and biomechanical features of the normal and diseased cardiovascular system, and has provided a molecular understanding of the cells that constitutes arteries and veins and their interaction. Further, this approach has allowed the discovery of vital pharmacological treatments for cardiovascular diseases. However, the expansion of the vascular physiology field has also brought new concerns over s...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 14, 2021 Category: Physiology Authors: Camilla F Wenceslau Cameron G McCarthy Scott Earley Sarah K England Jessica A Filosa Styliani Goulopoulou David D Gutterman Brant E Isakson Nancy L Kanagy Luis A Martinez-Lemus Swapnil K Sonkusare Pratish Thakore Aaron J Trask Stephanie W Watts R Clinton Source Type: research