American Journal of Physiology. Heart and Circulatory Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Looking Backward to Plan for Forward
Am J Physiol Heart Circ Physiol. 2024 Mar 29. doi: 10.1152/ajpheart.00154.2024. Online ahead of print.NO ABSTRACTPMID:38551484 | DOI:10.1152/ajpheart.00154.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 29, 2024 Category: Physiology Authors: Merry L Lindsey Jonathan A Kirk Amanda J LeBlanc Keith R Brunt Jason R Carter Kara Hansell Keehan Crystal M Ripplinger Petra Kleinbongard Zamaneh Kassiri Source Type: research

Cardiac Mitochondrial Metabolism During Pregnancy and the Postpartum Period
Am J Physiol Heart Circ Physiol. 2024 Mar 29. doi: 10.1152/ajpheart.00127.2024. Online ahead of print.ABSTRACTThe goal of the present study was to characterize changes in mitochondrial respiration in the maternal heart during pregnancy and after birth. Timed pregnancy studies were performed in 12-week-old female FVB/NJ mice, and cardiac mitochondria were isolated from the following groups of mice: non-pregnant (NP), mid-pregnancy (MP), late-pregnancy (LP), and 1-week post-birth (PB). Similar to our previous studies, we observed increased heart size during all stages of pregnancy (e.g., MP and LP) and post-birth (e.g., PB) ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 29, 2024 Category: Physiology Authors: Emily B Schulman-Geltzer Kyle L Fulghum Richa A Singhal Bradford G Hill Helen E Collins Source Type: research

Chronic nicotine exposure is associated with electrophysiological and sympathetic remodeling in the intact rabbit heart
Am J Physiol Heart Circ Physiol. 2024 Mar 29. doi: 10.1152/ajpheart.00749.2023. Online ahead of print.ABSTRACTNicotine is the primary addictive component in tobacco products. Through its actions on the heart and autonomic nervous system, nicotine exposure is associated with electrophysiological changes and increased arrhythmia susceptibility. To assess underlying mechanisms, we treated rabbits with transdermal nicotine (NIC, 21 mg/day) or control (CT) patches for 28 days prior to performing dual optical mapping of transmembrane potential (RH237) and intracellular Ca2+ (Rhod-2 AM) in isolated hearts with intact sympathetic ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 29, 2024 Category: Physiology Authors: Amanda Guevara Charlotte E R Smith Jessica L Caldwell Lena Ngo Lilian R Mott I-Ju Lee Srinivas Tapa Zhen Wang Lianguo Wang William R Woodward G Andre Ng Beth A Habecker Crystal M Ripplinger Source Type: research

Curvature mediated source and sink effects on the genesis of premature ventricular complexes in long QT syndrome
In conclusion, besides the increase of RG and occurrence of EADs caused by QT prolongation, the geometry of the RG border plays important roles in PVC genesis, which can greatly increase the risk of arrhythmias in cardiac diseases.PMID:38551483 | DOI:10.1152/ajpheart.00004.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 29, 2024 Category: Physiology Authors: Yuhao Zhang Zhaoyang Zhang Zhilin Qu Source Type: research

Role of the circulating milieu in age-related arterial dysfunction: a novel < em > ex vivo < /em > approach
This study establishes novel experimental approaches for directly assessing the effects of the circulating milieu on arterial function and implicates changes in the circulating milieu as a mechanism of in vivo arterial aging.PMID:38517225 | DOI:10.1152/ajpheart.00014.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 22, 2024 Category: Physiology Authors: Sophia A Mahoney Nicholas S VanDongen Nathan T Greenberg Ravinandan Venkatasubramanian Matthew J Rossman Michael E Widlansky Vienna E Brunt Yara Bernaldo de Quir ós Douglas R Seals Zachary S Clayton Source Type: research

Scratching beneath the surface: IL4R α blockade and the progression from myocardial ischemic injury to heart failure
Am J Physiol Heart Circ Physiol. 2024 Mar 22. doi: 10.1152/ajpheart.00150.2024. Online ahead of print.NO ABSTRACTPMID:38517226 | DOI:10.1152/ajpheart.00150.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 22, 2024 Category: Physiology Authors: Douglas H Wu Samuel E Senyo Source Type: research

Clinical Physiology: The Crucial Role of MRI in Evaluation of Peripheral Artery Disease
Am J Physiol Heart Circ Physiol. 2024 Mar 22. doi: 10.1152/ajpheart.00533.2023. Online ahead of print.ABSTRACTPeripheral artery disease (PAD) is a common vascular disease that primarily affects the lower limbs and is defined by the constriction or blockage of peripheral arteries and may involve microvascular dysfunction and tissue injury. Patients with diabetes have more prominent disease of microcirculation and develop peripheral neuropathy, autonomic dysfunction, and medial vascular calcification. Early and accurate diagnosis of PAD and disease characterization are essential for personalized management and therapy planni...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 22, 2024 Category: Physiology Authors: Nahla M H Elsaid Dana C Peters Gigi Galiana Albert J Sinusas Source Type: research

3D Object Geometry of Mitochondria-Associated Signal: 3D Analysis Pipeline for Two-Photon Image Stacks of Cerebrovascular Endothelial Mitochondria
Am J Physiol Heart Circ Physiol. 2024 Mar 22. doi: 10.1152/ajpheart.00101.2024. Online ahead of print.ABSTRACTIncreasing evidence indicates the role of mitochondrial and vascular dysfunction in aging and aging-associated pathologies; however, the exact mechanisms and chronological processes remain enigmatic. High energy demand organs, such as the brain, depend on the health of their mitochondria and vasculature in the maintenance of normal functions, therefore representing vulnerable targets for aging. This methodology paper describes an analysis pipeline for 3D mitochondria-associated signal geometry of two-photon image s...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 22, 2024 Category: Physiology Authors: Christopher R Gonzales Eric N Moca Partha K Chandra David W Busija Ibolya Rutkai Source Type: research

A Cell Atlas of Thoracic Aortic Perivascular Adipose Tissue: a focus on mechanotransducers
Am J Physiol Heart Circ Physiol. 2024 Mar 22. doi: 10.1152/ajpheart.00040.2024. Online ahead of print.ABSTRACTPerivascular adipose tissue (PVAT) is increasingly recognized for its function in mechanotransduction. However, major gaps remain in our understanding of the cells present in PVAT, as well as how different cells contribute to mechanotransduction. We hypothesized that snRNA seq would reveal expression of mechanotransducers, and test one (PIEZO1) to illustrate the expression and functional agreement between single-nuclei RNA sequencing (snRNAseq) and physiological measurements. To contrast two brown tissues, subscapu...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 22, 2024 Category: Physiology Authors: Janice M Thompson Stephanie W Watts Leah Terrian G Andres Contreras Cheryl Rockwell C Javier Rendon Emma Wabel Lizbeth Lockwood Sudin Bhattacharya Rance Nault Source Type: research