American Journal of Physiology. Heart and Circulatory Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Calcium signaling in endothelial and vascular smooth muscle cells; sex differences and the influence of estrogens and androgens
Am J Physiol Heart Circ Physiol. 2024 Feb 9. doi: 10.1152/ajpheart.00600.2023. Online ahead of print.ABSTRACTCalcium signaling in vascular endothelial cells (ECs) and smooth muscle cells (VSMC) is essential for the regulation of vascular tone. However, the changes to intracellular Ca2+ concentrations are often influenced by sex differences. Furthermore, a large body of evidence shows that sex hormone imbalance leads to dysregulation of Ca2+ signaling and this is a key factor in the pathogenesis of cardiovascular diseases. In this review, the effects of estrogens and androgens on vascular calcium-handling proteins are discu...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 9, 2024 Category: Physiology Authors: Daniel Asunci ón-Alvarez Javier Palacios Roberto O Yba ñez-Julca Cristhian N Rodriguez-Silva Chukwuemeka Nwokocha Fredi Cifuentes David J Greensmith Source Type: research

HDL-C and Apolipoprotein A-I are Independently Associated with Skeletal Muscle Mitochondrial Function in Healthy Humans
In conclusion, higher levels of HDL-C, Apo A-I, and larger mean HDL size were independently associated with enhanced skeletal muscle mitochondrial function in healthy humans.PMID:38334968 | DOI:10.1152/ajpheart.00017.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 9, 2024 Category: Physiology Authors: John M Giacona Ursa B Bezan Petric Weerapat Kositanurit Jijia Wang Suzanne Saldanha Benjamin E Young Ghazi Khan Margery A Connelly Scott A Smith Anand Rohatgi Wanpen Vongpatanasin Source Type: research

Effect of electrical muscle stimulation on cerebrovascular function and cognitive performance
Am J Physiol Heart Circ Physiol. 2024 Feb 9. doi: 10.1152/ajpheart.00032.2024. Online ahead of print.ABSTRACTIt is known that electrical muscle stimulation (EMS) can enhance physical function, but its impact on cognition and cerebral hemodynamics is not well-understood. Thus, the purpose of this study was to investigate the effects of one EMS session on cerebrovascular function and cognitive performance. The 17 recruited young healthy participants randomly undertook either a 25-min session of EMS or a resting control session (CTRL group). Cerebral blood flow velocity (CBFv) in the middle and posterior cerebral arteries (ri...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 9, 2024 Category: Physiology Authors: Mael Descollonges Paul Marmier Mathieu Marillier Ehsan Jafari Julien V Brugniaux Gaelle Deley Source Type: research

Expanding The Supply of Donor Hearts Through Donation After Circulatory Death
Am J Physiol Heart Circ Physiol. 2024 Feb 9. doi: 10.1152/ajpheart.00049.2024. Online ahead of print.NO ABSTRACTPMID:38334970 | DOI:10.1152/ajpheart.00049.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 9, 2024 Category: Physiology Authors: Marian Urban Kim F Duncan Source Type: research

Deletion of DWORF does not affect cardiac function in ageing and in PLN-R14del cardiomyopathy
Am J Physiol Heart Circ Physiol. 2024 Feb 9. doi: 10.1152/ajpheart.00741.2023. Online ahead of print.ABSTRACTThe phospholamban (PLN) pathogenic gene variant p.Arg14del causes cardiomyopathy, which is characterized by perinuclear PLN protein clustering and can lead to severe heart failure (HF). Elevated expression of Dwarf open reading frame (DWORF), a protein counteracting the function of PLN in the sarcoplasmic reticulum (SR), can delay disease progression in a PLN-R14del mouse model. Here, we evaluated whether deletion of DWORF (DWORF-/-) would have an opposite effect and accelerate age-dependent disease progression in w...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 9, 2024 Category: Physiology Authors: Nienke M Stege Vivian Oliveira Nunes Teixeira Sietske N Zijlstra Anna M Feringa Rudolf A de Boer Herman H W Sillj é Source Type: research

Cardiorespiratory abnormalities in ICU survivors of COVID-19 with Post-acute Sequelae of SARS-CoV-2 infection are unrelated to invasive mechanical ventilation
Am J Physiol Heart Circ Physiol. 2024 Feb 9. doi: 10.1152/ajpheart.00073.2024. Online ahead of print.ABSTRACTPost-acute Sequelae of SARS-CoV-2 infection (PASC) often leads to exertional intolerance and reduced exercise capacity, particularly in individuals previously admitted to an intensive care unit (ICU). However, the impact of invasive mechanical ventilation (IMV) on PASC-associated cardiorespiratory abnormalities during exercise remains poorly understood. This single-center, cross-sectional study aimed to gather knowledge on this topic. Fifty-two patients with PASC recruited ~6 months after ICU discharge were clustere...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 9, 2024 Category: Physiology Authors: Igor Longobardi Danilo Marcelo Leite do Prado Danieli Castro Oliveira de Andrade Karla Fabiana Goessler Gersiel Nascimento de Oliveira J únior Rafael de Almeida Azevedo Alice Erwig Leit ão Jhonnatan Vasconcelos Pereira Santos Ana L úcia de Sá Pinto Br Source Type: research

Stretch-Induced Compliance mechanism in pregnancy-induced cardiac hypertrophy and the impact of cardiovascular risk factors
CONCLUSION: A distinct functional response to SIC was observed between 1stT and 3rdT, which was influenced by CVR factors. The LV of 3rdT pregnant women was hypertrophied, showing a structural limitation to dilate with AVO, while the lower LV filling pressure values suggest increased diastolic compliance.PMID:38334973 | DOI:10.1152/ajpheart.00701.2023 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 9, 2024 Category: Physiology Authors: Ana Filipa da Silva Ferreira Maria Jo ão Maia Azevedo Juliana Pereira Morais Jo ão Almeida-Coelho Andr é M Leite-Moreira Andr é P Lourenço Francisca Almeida Saraiva S ílvia Oliveira Diaz Ana Filipa Amador Carla Sousa Ana Paula Machado Benedita Sampa Source Type: research

Cardiac functional adaptation to resistance and endurance exercise training: A randomised cross-over study
This study investigated changes in left ventricular (LV) systolic and diastolic function following endurance (END) and resistance (RES) training in healthy participants. 64 individuals participated in a randomized cross-over design trial, involving 12-weeks of END and RES training, separated by a 12-week washout. Echocardiograms assessed systolic function (ejection fraction (EF), and global longitudinal strain (GLS)), diastolic function (mitral valve early velocity (E), tissue Doppler velocity (e'), their ratio (E/e')), and left atrial volume indexed to body surface area (LA ESVi). LV mass (LVM) increased with both RES (Δ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 9, 2024 Category: Physiology Authors: Daniel J Green Channa E Marsh Hannah J Thomas Barbara A Maslen Julie Collis Leanne Lester Louise H Naylor Source Type: research

Exercise testing unmasks exaggerated blood pressure independent of fibrinolytic response in Black but not White postmenopausal females
Am J Physiol Heart Circ Physiol. 2024 Feb 9. doi: 10.1152/ajpheart.00023.2024. Online ahead of print.ABSTRACTExercise testing unmasks more exaggerated systolic blood pressure responses (SBP) in Black compared to White male adults. Such responses, if translatable to females, may detect racial disparities particularly relevant during menopause. Given the endothelial involvement in BP regulation and as a source of fibrinolytic markers, it follows that fibrinolytic and BP response to exercise could be linked. Thus, we examined BP and fibrinolytic responses to exercise testing in Black and White postmenopausal females. Postmeno...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 9, 2024 Category: Physiology Authors: Jo ão L Marôco Linda M Szymanski Tracy Baynard Bo Fernhall Source Type: research

Narrowing the gap toward successful translational research in cardiovascular disease
Am J Physiol Heart Circ Physiol. 2024 Feb 2. doi: 10.1152/ajpheart.00038.2024. Online ahead of print.NO ABSTRACTPMID:38305750 | DOI:10.1152/ajpheart.00038.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 2, 2024 Category: Physiology Authors: Gemma Vilahur Sebastia Alcover Marta Magaldi Source Type: research

Atherosclerosis as the Damocles' sword of human evolution: Insights from non-human apes, ancient human remains, and isolated modern human populations
Am J Physiol Heart Circ Physiol. 2024 Feb 2. doi: 10.1152/ajpheart.00744.2023. Online ahead of print.ABSTRACTAtherosclerosis contributes to the majority of deaths worldwide, and classic descriptions of atherosclerosis include lipid accumulation, old age, and cigarette smoking. The role of the immune system in atherogenesis is becoming increasingly accepted. Evolutionary biology provides evidence for significantly different immune responses between humans and chimpanzees, especially regarding the caspase-12 and the inflammasome, T-cell inhibitory sialic acid-recognizing lectin expression, and possibly an overreactive innate...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 2, 2024 Category: Physiology Authors: Annora Ai-Wei Kumar Gavin Huangfu Gemma A Figtree Girish Dwivedi Source Type: research

Unlocking the Dark Matter: Noncoding RNAs and RNA Modifications in Cardiac Aging
Am J Physiol Heart Circ Physiol. 2024 Feb 2. doi: 10.1152/ajpheart.00532.2023. Online ahead of print.ABSTRACTCardiac aging is a multifaceted process that encompasses structural and functional alterations culminating in heart failure. As the elderly population continues to expand, there is a growing urgent need for interventions to combat age-related cardiac functional decline. Noncoding RNAs have emerged as critical regulators of cellular and biochemical processes underlying cardiac disease. This review summarizes our current understanding of how noncoding RNAs function in the heart during aging, with particular emphasis o...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 2, 2024 Category: Physiology Authors: Jiayi Kang James Rhee Chunyan Wang Yolander Yang Guoping Li Haobo Li Source Type: research

The Heart-Bone Connection: Relationships between Myocardial Infarction and Osteoporotic Fracture
Am J Physiol Heart Circ Physiol. 2024 Feb 2. doi: 10.1152/ajpheart.00576.2023. Online ahead of print.ABSTRACTMyocardial infarction (MI) and osteoporotic fracture (Fx) are two of the leading causes of mortality and morbidity worldwide. Although these traumatic injuries are treated as if they are independent, there is epidemiological evidence linking the incidence of Fx and MI, thus raising the question whether each of these events can actively influence the risk of the other. Atherosclerotic cardiovascular disease and osteoporosis, the chronic conditions leading to MI and Fx, are known to have shared pathoetiology. Furtherm...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 2, 2024 Category: Physiology Authors: Priscilla M Tjandra Crystal M Ripplinger Blaine A Christiansen Source Type: research

High throughput methods for cardiac cellular electrophysiology studies: The road to personalized medicine
Am J Physiol Heart Circ Physiol. 2024 Jan 26. doi: 10.1152/ajpheart.00599.2023. Online ahead of print.ABSTRACTPersonalized medicine refers to the tailored application of medical treatment at an individual level, taking into account the specific genotype or phenotype of each patient for targeted therapy. In the context of cardiovascular diseases, implementing personalized medicine is challenging due to the high costs involved and the slow pace of identifying the pathogenicity of genetic variants, deciphering molecular mechanisms of disease and testing treatment approaches. Scalable cellular models such as human induced plur...
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 26, 2024 Category: Physiology Authors: Fitzwilliam Seibertz Niels Voigt Source Type: research

An anti-sense oligonucleotide efficiently suppresses splicing of an alternative exon in vascular smooth muscle in vivo
This study aimed to develop a gene-based therapy to suppress splicing of Mypt1 E24 thereby switching MP enzyme to the NO-responsive isoform. CRISPR/Cas9 constructs were effective at editing of Mypt1 E24 in vitro, however targeting of vascular smooth muscle in vivo with AAV9 was inefficient. In contrast an octo-guanidine conjugated anti-sense oligonucleotide targeting the 5' splice site of Mypt1 E24 was highly efficient in vivo. It reduced the percent splicing inclusion of Mypt1 E24 from 80 to 10% in mesenteric arteries. The maximal and half-maximal effects occurred at 12.5 and 6.25 mg/kg, respectively. The effect persisted...
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 26, 2024 Category: Physiology Authors: Celio Damacena de Angelis Mariam Meddeb Nelson Chen Steven A Fisher Source Type: research