American Journal of Physiology. Heart and Circulatory Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Exercise testing unmasks exaggerated blood pressure independent of fibrinolytic response in Black but not White postmenopausal females
Am J Physiol Heart Circ Physiol. 2024 Feb 9. doi: 10.1152/ajpheart.00023.2024. Online ahead of print.ABSTRACTExercise testing unmasks more exaggerated systolic blood pressure responses (SBP) in Black compared to White male adults. Such responses, if translatable to females, may detect racial disparities particularly relevant during menopause. Given the endothelial involvement in BP regulation and as a source of fibrinolytic markers, it follows that fibrinolytic and BP response to exercise could be linked. Thus, we examined BP and fibrinolytic responses to exercise testing in Black and White postmenopausal females. Postmeno...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 9, 2024 Category: Physiology Authors: Jo ão L Marôco Linda M Szymanski Tracy Baynard Bo Fernhall Source Type: research

Narrowing the gap toward successful translational research in cardiovascular disease
Am J Physiol Heart Circ Physiol. 2024 Feb 2. doi: 10.1152/ajpheart.00038.2024. Online ahead of print.NO ABSTRACTPMID:38305750 | DOI:10.1152/ajpheart.00038.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 2, 2024 Category: Physiology Authors: Gemma Vilahur Sebastia Alcover Marta Magaldi Source Type: research

Atherosclerosis as the Damocles' sword of human evolution: Insights from non-human apes, ancient human remains, and isolated modern human populations
Am J Physiol Heart Circ Physiol. 2024 Feb 2. doi: 10.1152/ajpheart.00744.2023. Online ahead of print.ABSTRACTAtherosclerosis contributes to the majority of deaths worldwide, and classic descriptions of atherosclerosis include lipid accumulation, old age, and cigarette smoking. The role of the immune system in atherogenesis is becoming increasingly accepted. Evolutionary biology provides evidence for significantly different immune responses between humans and chimpanzees, especially regarding the caspase-12 and the inflammasome, T-cell inhibitory sialic acid-recognizing lectin expression, and possibly an overreactive innate...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 2, 2024 Category: Physiology Authors: Annora Ai-Wei Kumar Gavin Huangfu Gemma A Figtree Girish Dwivedi Source Type: research

Unlocking the Dark Matter: Noncoding RNAs and RNA Modifications in Cardiac Aging
Am J Physiol Heart Circ Physiol. 2024 Feb 2. doi: 10.1152/ajpheart.00532.2023. Online ahead of print.ABSTRACTCardiac aging is a multifaceted process that encompasses structural and functional alterations culminating in heart failure. As the elderly population continues to expand, there is a growing urgent need for interventions to combat age-related cardiac functional decline. Noncoding RNAs have emerged as critical regulators of cellular and biochemical processes underlying cardiac disease. This review summarizes our current understanding of how noncoding RNAs function in the heart during aging, with particular emphasis o...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 2, 2024 Category: Physiology Authors: Jiayi Kang James Rhee Chunyan Wang Yolander Yang Guoping Li Haobo Li Source Type: research

The Heart-Bone Connection: Relationships between Myocardial Infarction and Osteoporotic Fracture
Am J Physiol Heart Circ Physiol. 2024 Feb 2. doi: 10.1152/ajpheart.00576.2023. Online ahead of print.ABSTRACTMyocardial infarction (MI) and osteoporotic fracture (Fx) are two of the leading causes of mortality and morbidity worldwide. Although these traumatic injuries are treated as if they are independent, there is epidemiological evidence linking the incidence of Fx and MI, thus raising the question whether each of these events can actively influence the risk of the other. Atherosclerotic cardiovascular disease and osteoporosis, the chronic conditions leading to MI and Fx, are known to have shared pathoetiology. Furtherm...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 2, 2024 Category: Physiology Authors: Priscilla M Tjandra Crystal M Ripplinger Blaine A Christiansen Source Type: research

High throughput methods for cardiac cellular electrophysiology studies: The road to personalized medicine
Am J Physiol Heart Circ Physiol. 2024 Jan 26. doi: 10.1152/ajpheart.00599.2023. Online ahead of print.ABSTRACTPersonalized medicine refers to the tailored application of medical treatment at an individual level, taking into account the specific genotype or phenotype of each patient for targeted therapy. In the context of cardiovascular diseases, implementing personalized medicine is challenging due to the high costs involved and the slow pace of identifying the pathogenicity of genetic variants, deciphering molecular mechanisms of disease and testing treatment approaches. Scalable cellular models such as human induced plur...
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 26, 2024 Category: Physiology Authors: Fitzwilliam Seibertz Niels Voigt Source Type: research

An anti-sense oligonucleotide efficiently suppresses splicing of an alternative exon in vascular smooth muscle in vivo
This study aimed to develop a gene-based therapy to suppress splicing of Mypt1 E24 thereby switching MP enzyme to the NO-responsive isoform. CRISPR/Cas9 constructs were effective at editing of Mypt1 E24 in vitro, however targeting of vascular smooth muscle in vivo with AAV9 was inefficient. In contrast an octo-guanidine conjugated anti-sense oligonucleotide targeting the 5' splice site of Mypt1 E24 was highly efficient in vivo. It reduced the percent splicing inclusion of Mypt1 E24 from 80 to 10% in mesenteric arteries. The maximal and half-maximal effects occurred at 12.5 and 6.25 mg/kg, respectively. The effect persisted...
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 26, 2024 Category: Physiology Authors: Celio Damacena de Angelis Mariam Meddeb Nelson Chen Steven A Fisher Source Type: research

A Guide to Establishing, Implementing, and Optimizing Diversity, Equity, Inclusion, and Accessibility (DEIA) Committees
Am J Physiol Heart Circ Physiol. 2024 Jan 26. doi: 10.1152/ajpheart.00583.2023. Online ahead of print.ABSTRACTDiversity, equity, inclusion, and accessibility (DEIA) efforts are increasingly recognized as critical for success of academic institutions. These efforts are facilitated mainly through the formation of dedicated DEIA committees. DEIA committees enhance professional development and create a more inclusive environment, which benefits all members of the institution. While leadership and faculty membership have recognized the importance and necessity of DEIA, the roles of DEIA committees may be more ambiguous. While l...
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 26, 2024 Category: Physiology Authors: Maigen Bethea Sophielle Silvers Latisha Franklin Ren ã A S Robinson Lillian J Brady Neng Vue Heather K Beasley Annet Kirabo Celestine N Wanjalla Haysetta D Shuler Antentor Hinton Melanie R McReynolds Source Type: research

Hemodynamic simulation of complete transposition of the great arteries for optimal treatment strategies based on its circulatory physiology
Am J Physiol Heart Circ Physiol. 2024 Jan 26. doi: 10.1152/ajpheart.00668.2023. Online ahead of print.ABSTRACTOur study aimed to elucidate the role of different shunts and provide novel insights into optimal treatment approaches for complete transposition of the great arteries (TGA), which is characterized by unique and complicated circulatory dynamics. We constructed a computational cardiovascular TGA model and manipulated cardiovascular parameters, such as atrial septal defect (ASD) and patent ductus arteriosus (PDA) sizes, to quantify their effects on oxygenation and hemodynamics. Additionally, ASD flow patterns were in...
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 26, 2024 Category: Physiology Authors: Kaname Sato Koichi Takamizawa Yosuke Ogawa Yu Tanaka Kazuhiro Shiraga Hitomi Masuda Hikoro Matsui Ryo Inuzuka Hideaki Senzaki Source Type: research

Rheological, cardiorespiratory and cerebrovascular effects of pentoxifylline following acclimatization to 3800 meters
Am J Physiol Heart Circ Physiol. 2024 Jan 19. doi: 10.1152/ajpheart.00783.2023. Online ahead of print.ABSTRACTPentoxifylline is a non-selective phosphodiesterase inhibitor used for the treatment of peripheral artery disease. Pentoxifylline acts through cyclic adenosine monophosphate, thereby enhancing red blood cell deformability, causing vasodilation and decreasing inflammation, and potentially stimulating ventilation. We conducted a double-blind, placebo-controlled, crossover, counterbalanced study to test the hypothesis that pentoxifylline could lower blood viscosity, enhance cerebral blood flow and decrease pulmonary a...
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 19, 2024 Category: Physiology Authors: Andrew R Steele Connor A Howe Travis D Gibbons Katharine Foster Alexandra M Williams Hannah G Caldwell L Madden Brewster Jennifer Duffy Justin A Monteleone Prajan Subedi James D Anholm Mike Stembridge Philip N Ainslie Joshua C Tremblay Source Type: research

Sitting leg vasculopathy: potential adaptations beyond the endothelium
Am J Physiol Heart Circ Physiol. 2024 Jan 19. doi: 10.1152/ajpheart.00489.2023. Online ahead of print.ABSTRACTIncreased sitting time, the most common form of sedentary behavior, is an independent risk factor for all-cause and cardiovascular disease mortality; however, the mechanisms linking sitting to cardiovascular risk remain largely elusive. Studies over the last decade have led to the concept that excessive time spent in the sitting position, and the ensuing reduction in leg blood flow-induced shear stress, causes endothelial dysfunction. This conclusion has been mainly supported by studies using flow-mediated dilation...
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 19, 2024 Category: Physiology Authors: Larissa Ferreira-Santos Luis A Martinez-Lemus Jaume Padilla Source Type: research

Fibroblasts and platelets, a face-to-face dialogue at the heart of cardiac fibrosis
Am J Physiol Heart Circ Physiol. 2024 Jan 19. doi: 10.1152/ajpheart.00559.2023. Online ahead of print.ABSTRACTMyocardial fibrosis is a feature found in most cardiac diseases and a key element contributing to heart failure and its progression. It has therefore become a subject of particular interest in cardiac research. Mechanisms leading to pathological cardiac remodeling and heart failure are diverse, including effects on cardiac fibroblasts, the main players in cardiac extracellular matrix synthesis, but also on cardiomyocytes, immune cells, endothelial cells, and more recently, platelets. Although transforming growth fa...
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 19, 2024 Category: Physiology Authors: C écile Dufeys Julie Bodart Luc Bertrand Christophe Beauloye Sandrine Horman Source Type: research

An in-silico study of the effects of cardiovascular ageing on carotid flow waveforms and indices in a virtual population
This study highlights the potential of carotid waveforms as a valuable tool for the assessment of cardiovascular aging.PMID:38214900 | DOI:10.1152/ajpheart.00304.2023 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 12, 2024 Category: Physiology Authors: Irene Suriani R Arthur Bouwman Massimo Mischi Kevin D Lau Source Type: research

Initiating your coronation
Am J Physiol Heart Circ Physiol. 2024 Mar 1;326(3):H563-H567. doi: 10.1152/ajpheart.00750.2023. Epub 2024 Jan 12.ABSTRACTEarning an advanced degree in biomedical sciences can be a challenging experience, and recent data indicate high levels of stress and anxiety among the current generation of learners. We propose here a new illustration for all graduate students to visualize their didactic journey as a coronation process. Before their coronation, trainees must undergo rigorous preparation. During the training, four key attributes, best described by the acronym COST (Credibility, Opportunity, Strength, and Tenacity), are c...
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 12, 2024 Category: Physiology Authors: Letha Woods Douglas L Robinson Source Type: research

Sleep Disturbance and Sympathetic Neural Reactivity in Postmenopausal Females
Am J Physiol Heart Circ Physiol. 2024 Jan 12. doi: 10.1152/ajpheart.00724.2023. Online ahead of print.ABSTRACTSleep disturbance (SD), one of the most common menopausal symptoms, contributes to autonomic dysfunction and is linked to hypertension and cardiovascular risk. Longitudinal studies suggest that hyperreactivity of blood pressure (BP) to a stressor can predict future development of hypertension. It remains unknown if postmenopausal females who experience SD demonstrate greater hemodynamic and sympathetic neural hyperreactivity to a stressor. We hypothesized that postmenopausal females with reported SD would exhibit i...
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 12, 2024 Category: Physiology Authors: Chowdhury Tasnova Tahsin Miguel Anselmo Emma Lee William Stokes Ida T Fonkoue Marnie L Vanden Noven Jason R Carter Manda L Keller-Ross Source Type: research