American Journal of Physiology. Heart and Circulatory Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

IL-33 supplementation improves uterine artery resistance and maternal hypertension in response to placental ischemia
Am J Physiol Heart Circ Physiol. 2024 Feb 16. doi: 10.1152/ajpheart.00045.2024. Online ahead of print.ABSTRACTPreeclampsia (PE), a leading cause of maternal/fetal morbidity and mortality, is a hypertensive pregnancy disorder with end-organ damage that manifests after 20 weeks of gestation. PE is characterized by chronic immune activation and endothelial dysfunction. Clinical studies report reduced IL-33 signaling in PE. We use the Reduced Uterine Perfusion Pressure (RUPP) rat model, which mimics many PE characteristics including reduced IL-33, to identify mechanisms mediating PE pathophysiology. We hypothesized that IL-33 ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 16, 2024 Category: Physiology Authors: Xi Wang Corbin Shields Geilda Tardo Gregory Peacock Emily Hester Marissa Anderson Jan M Williams Denise Cornelius Source Type: research

The gut microbiome as a modulator of arterial function and age-related arterial dysfunction
Am J Physiol Heart Circ Physiol. 2024 Feb 16. doi: 10.1152/ajpheart.00764.2023. Online ahead of print.ABSTRACTThe arterial system is integral to the proper function of all other organs and tissues. Arterial function is impaired with aging, and arterial dysfunction contributes to the development of numerous age-related diseases, including cardiovascular diseases. The gut microbiome has emerged as an important regulator of both normal host physiological function and impairments in function with aging. The purpose of this review is to summarize more recently published literature demonstrating the role of the gut microbiome in...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 16, 2024 Category: Physiology Authors: Abigail G Longtine Nathan T Greenberg Yara Bernaldo de Quir ós Vienna E Brunt Source Type: research

Real-Time Visualization of Dextran Extravasation in Intermittent Hypoxia Mice using Non-Invasive SWIR Imaging
CONCLUSION: The SWIR imaging technique allows non-invasive real-time monitoring of dextran extravasation in vivo. Dextran-70 extravasation is increased after exposure to IH, suggesting an increased vessel permeability in this mice model of obstructive sleep apnea.PMID:38363213 | DOI:10.1152/ajpheart.00787.2023 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 16, 2024 Category: Physiology Authors: Xavier Le Gu ével V éronique Josserand Olfa Harki Vladimir A Baulin Maxime Henry Anne Briancon-Marjollet Source Type: research

Role of Macrophages in Regression of Myocardial Fibrosis Following Alleviation of Left Ventricular Pressure Overload
The objective was to determine temporal changes in myocardial macrophage phenotype in TAC and unTAC and determine whether macrophage depletion alters collagen degradation after unTAC. Myocardial macrophage abundance and phenotype were assessed by immunohistochemistry, flow cytometry, and gene expression by rt-PCR in control(non-TAC),2wkTAC,4wkTAC, and 2wk,4wk, and 6wkunTAC. Myocardial cytokine profiles and collagen degrading enzymes were determined by immunoassay and immunoblots. Initial collagen degradation were detected with collagen hybridizing peptide(CHP). At unTAC, macrophages were depleted with clodronate liposomes ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 16, 2024 Category: Physiology Authors: Lily S Neff Rachel M Biggs Yuhua Zhang An O Van Laer Catalin F Baicu Suganya Subramanian Stefano Berto Kristine DeLeon-Pennell Michael R Zile Amy D Bradshaw Source Type: research

Sex-based differences in short and longer-term diet-induced metabolic heart disease
Am J Physiol Heart Circ Physiol. 2024 Feb 16. doi: 10.1152/ajpheart.00467.2023. Online ahead of print.ABSTRACTSex-based differences in the development of obesity-induced cardio-metabolic dysfunction are well documented, however the specific mechanisms are not completely understood. Obesity has been linked to dysregulation of the epitranscriptome, but the role of N6-methyladenosine (m6A) RNA methylation has not been investigated in relation to the sex differences during obesity-induced cardiac dysfunction. In the current study, male and female C57BL/6J mice were subjected to short- and long-term high-fat/high-sucrose (HFHS)...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 16, 2024 Category: Physiology Authors: Amanda J Croft Conagh Kelly Dongqing Chen Tatt Jhong Haw Lucy A Murtha Lohis Balachandran Andrew J Boyle Aaron L Sverdlov Doan T M Ngo Source Type: research

Exercise-induced cardiac troponin release in athletes with versus without coronary atherosclerosis
CONCLUSIONS: Serial sampling of hs-cTnT and hs-cTnI concentrations during and following an exhaustive endurance exercise test did not reveal differences in exercise-induced cTn release between athletes with versus without coronary atherosclerosis. These findings suggest that a high CACS or a >50% stenosis in any coronary artery does not aggravate exercise-induced cTn release in middle aged and older athletes.PMID:38363583 | DOI:10.1152/ajpheart.00021.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 16, 2024 Category: Physiology Authors: Sylvan L J E Janssen Femke de Vries Alma M A Mingels Geert Kleinnibbelink Maria T E Hopman Arend Mosterd Birgitta K Velthuis Vincent L Aengevaeren Thijs M H Eijsvogels Source Type: research

Cardiac reverse remodelling in a mouse model with many phenotypical features of heart failure with preserved ejection fraction: effects of modifying lifestyle
Am J Physiol Heart Circ Physiol. 2024 Feb 16. doi: 10.1152/ajpheart.00462.2023. Online ahead of print.ABSTRACTMultiple factors cause heart failure with preserved ejection fraction (HFpEF) and involve various systems. HFpEF prevalence is rapidly rising, and its prognosis remains poor after the first hospitalization. Adopting a more active lifestyle has been shown to provide beneficial clinical outcomes for HFpEF patients. Using a two-hit HFpEF murine model, we studied cardiac reverse remodelling (RR) after stopping the causing stress and introducing voluntary exercise (VE). We checked in 2-month-old male and female C57Bl6/J...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 16, 2024 Category: Physiology Authors: Mohamed Lamine Aidara Elisabeth Walsh-Wilkinson Sara- Ève Thibodeau Emylie-Ann Labb é Audrey Morin-Grandmont Genevieve Gagnon Dominique K Boudreau Marie Arsenault Yohan Boss é Jacques Couet Source Type: research