The effects of dietary soy content on cerebral artery function and behavior in ovariectomized female mice
Conclusion: In summary, we found that ovariectomy impairs insulin-mediated vasodilation in cerebral arteries, but a diet containing soy mitigates these effects. These findings highlight the importance of considering dietary soy when performing vascular and behavioral tests in mice, particularly in females.PMID:38156886 | DOI:10.1152/ajpheart.00618.2023 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 29, 2023 Category: Physiology Authors: Mackenzie N Kehmeier Aleena Khurana Bradley R Bedell Abigail E Cullen Audrey T Cannon Grant D Henson Ashley E Walker Source Type: research

Fine Tuning Contractility: Atrial Sarcomere Function in Health and Disease
Am J Physiol Heart Circ Physiol. 2023 Dec 29. doi: 10.1152/ajpheart.00252.2023. Online ahead of print.ABSTRACTThe molecular mechanisms of sarcomere proteins underlie the contractile function of the heart. While our understanding of the sarcomere has grown tremendously, the focus has been on ventricular sarcomere isoforms due to the critical role of the ventricle in health and disease. However, atrial specific or enriched myofilament protein isoforms, as well as isoforms that become expressed in disease, provide insight into ways this complex molecular machine is fine-tuned. Here, we explore how atrial-enriched sarcomere pr...
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 29, 2023 Category: Physiology Authors: Hope V Burnham Hannah E Cizauskas David Y Barefield Source Type: research

The effects of dietary soy content on cerebral artery function and behavior in ovariectomized female mice
Conclusion: In summary, we found that ovariectomy impairs insulin-mediated vasodilation in cerebral arteries, but a diet containing soy mitigates these effects. These findings highlight the importance of considering dietary soy when performing vascular and behavioral tests in mice, particularly in females.PMID:38156886 | DOI:10.1152/ajpheart.00618.2023 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 29, 2023 Category: Physiology Authors: Mackenzie N Kehmeier Aleena Khurana Bradley R Bedell Abigail E Cullen Audrey T Cannon Grant D Henson Ashley E Walker Source Type: research

Fine Tuning Contractility: Atrial Sarcomere Function in Health and Disease
Am J Physiol Heart Circ Physiol. 2023 Dec 29. doi: 10.1152/ajpheart.00252.2023. Online ahead of print.ABSTRACTThe molecular mechanisms of sarcomere proteins underlie the contractile function of the heart. While our understanding of the sarcomere has grown tremendously, the focus has been on ventricular sarcomere isoforms due to the critical role of the ventricle in health and disease. However, atrial specific or enriched myofilament protein isoforms, as well as isoforms that become expressed in disease, provide insight into ways this complex molecular machine is fine-tuned. Here, we explore how atrial-enriched sarcomere pr...
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 29, 2023 Category: Physiology Authors: Hope V Burnham Hannah E Cizauskas David Y Barefield Source Type: research

Reducing Thrombotic Risks in Video Gamers: Investigating the Benefits of Walking and Compression Sleeves on Blood Hemodynamics
This study aimed to compare lower leg graduated compression sleeves and a 6-minute walking break during prolonged gaming on blood flow and hemodynamics in competitive esport players to help mitigate this risk. Ten healthy gamers (19.6 ±1.2y, 9 men) consented to participate in this mixed-model cross-over design study that consisted of three visits: Visit 1: participants engaged in continuous 2-hour video game play wearing no compression (Continuous). Visit 2 and 3 involved 2-hour play wearing compression sleeves (Compression), and 2-hour game play interrupted at 1-hour by a 6-minute walk (Walk). Doppler ultrasound measurem...
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 22, 2023 Category: Physiology Authors: Joanne DiFrancisco-Donoghue Kelly Borges Timothy Li Olivia Ballone Hallie Zwibel Peter C Douris Source Type: research

The FXYD1 protein plays a protective role against pulmonary hypertension and arterial remodelling via redox and inflammatory mechanisms
CONCLUSIONS: The absence of FXYD1 in mice results in LV inflammation and cardiopulmonary redox signaling changes that predispose to pathophysiological features of PH, suggesting FXYD1 may be protective.PMID:38133617 | DOI:10.1152/ajpheart.00090.2023 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 22, 2023 Category: Physiology Authors: Thomas S Hansen Keyvan Karimi Galougahi Owen Tang Michael Tsang Marielle Scherrer-Crosbie Elena Arystarkhova Kathleen Sweadner Christina Bursill Kristen J Bubb Gemma A Figtree Source Type: research

Electronic Hookah (Waterpipe) Vaping Reduces Vascular Endothelial Function: The Role of Nicotine
Am J Physiol Heart Circ Physiol. 2023 Dec 22. doi: 10.1152/ajpheart.00710.2023. Online ahead of print.ABSTRACTVaping has risen substantially in recent years, particularly among young adults. While e-hookah vaping acutely reduces endothelial function, the role of nicotine and the mechanisms by which it may impairs endothelial function remain understudied. In a randomized cross-over study, we investigated the acute effects of vaping e-hookah, with and without nicotine, as compared to sham on endothelial function assessed by brachial artery flow-mediated dilation (FMD), among 18 overtly healthy young adults. To determine the ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 22, 2023 Category: Physiology Authors: Mary Rezk-Hanna Matthew J Rossman Katelyn Ludwig Primadya Sakti Chiao-Wei Cheng Mary-Lynn Brecht Neal L Benowitz Douglas R Seals Source Type: research

Differences in heart rate responses to upright posture are associated with variations in the high-frequency power of heart rate variability
Am J Physiol Heart Circ Physiol. 2023 Dec 22. doi: 10.1152/ajpheart.00567.2023. Online ahead of print.ABSTRACTHigh resting heart rate is a cardiovascular risk factor, but limited data exists on the underlying hemodynamics and reproducibility of supine-to-upright increase in heart rate. We recorded non-invasive hemodynamics in 574 volunteers (age 44.9 years, BMI 26.4 kg/m2, 49% male) during passive head-up tilt (HUT) using whole-body impedance cardiography and radial artery tonometry. Heart rate regulation was evaluated using heart rate variability (HRV) analyses. Comparisons were made between quartiles of supine-to-upright...
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 22, 2023 Category: Physiology Authors: Heidi Bouquin Jenni K Koskela Antti Tikkakoski Milja Honkonen Timo P Hiltunen Jukka T Mustonen Ilkka H P örsti Source Type: research

Differences in vasomotor function of mesenteric arteries between Ossabaw minipigs with predisposition to metabolic syndrome and G öttingen minipigs
Am J Physiol Heart Circ Physiol. 2023 Dec 22. doi: 10.1152/ajpheart.00719.2023. Online ahead of print.ABSTRACTMetabolic syndrome predisposes and contributes to the development and progression of atherosclerosis. The minipig strain "Ossabaw" is characterized by a predisposition to develop metabolic syndrome. We compared vasomotor function in Ossabaw minipigs before they develop their diseased phenotype to that of Göttingen minipigs- without such genetic predisposition. Mesenteric arteries of adult Ossabaw and Göttingen minipigs were dissected post mortem and mounted on a myograph for isometric force measurements. Maximal ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 22, 2023 Category: Physiology Authors: Chantal Eickelmann Helmut Raphael Lieder Michael Sturek Gerd Heusch Petra Kleinbongard Source Type: research

Comprehensive Left Atrial Flow Component Analysis Reveals Abnormal Flow Patterns in Paroxysmal Atrial Fibrillation
Am J Physiol Heart Circ Physiol. 2023 Dec 22. doi: 10.1152/ajpheart.00614.2023. Online ahead of print.ABSTRACTLeft atrial (LA) blood flow plays an important role in diseases such as atrial fibrillation (AF) and atrial cardiomyopathy since alterations in the blood flow might lead to thrombus formation and stroke. Using traditional techniques such as echocardiography, atrial flow velocities can be measured at the pulmonary veins and the mitral valve, but a comprehensive understanding of the three-dimensional atrial flow field is missing. Previously, ventricular flow has been analyzed using flow component analysis, revealing ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 22, 2023 Category: Physiology Authors: Sophia B äck Jonas Lantz Iulia Skoda Lilian Henriksson Anders Persson Lars O Karlsson Carl-Johan Carlh äll Tino Ebbers Source Type: research

Considering the impact of age and sex on cardiac cytoskeletal components
Am J Physiol Heart Circ Physiol. 2023 Dec 22. doi: 10.1152/ajpheart.00619.2023. Online ahead of print.ABSTRACTThe cardiac cytoskeletal components are integral to cardiomyocyte function and are responsible for contraction, sustaining cell structure, and providing scaffolding to direct signaling. Cytoskeletal components have been implicated in cardiac pathology; however, less attention has been paid to age-related modifications of cardiac cytoskeletal components and how these contribute to dysfunction with increased age. Moreover, significant sex differences in cardiac aging have been identified, but we still lack a complete...
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 22, 2023 Category: Physiology Authors: Timothy L M Jones Kathleen C Woulfe Source Type: research

Aldosterone and Aldosterone Synthase Inhibitors in Cardiorenal Disease
Am J Physiol Heart Circ Physiol. 2023 Dec 22. doi: 10.1152/ajpheart.00419.2023. Online ahead of print.ABSTRACTModulation of the renin-angiotensin-aldosterone system is a foundation of therapy for cardiovascular and kidney diseases. Excess aldosterone plays an important role in cardiovascular disease, contributing to inflammation, fibrosis and dysfunction in the heart, kidneys, and vasculature through both genomic, mineralocorticoid receptor (MR)-mediated, as well as non-genomic mechanisms. MR antagonists have been a key therapy for attenuating the pathologic effects of aldosterone but are associated with some side effects ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 22, 2023 Category: Physiology Authors: Subodh Verma Avinash Pandey Arjun K Pandey Javed Butler John S Lee Hwee Teoh C David Mazer Mikhail N Kosiborod Francesco Cosentino Stefan D Anker Kim A Connelly Deepak L Bhatt Source Type: research

Reducing Thrombotic Risks in Video Gamers: Investigating the Benefits of Walking and Compression Sleeves on Blood Hemodynamics
This study aimed to compare lower leg graduated compression sleeves and a 6-minute walking break during prolonged gaming on blood flow and hemodynamics in competitive esport players to help mitigate this risk. Ten healthy gamers (19.6 ±1.2y, 9 men) consented to participate in this mixed-model cross-over design study that consisted of three visits: Visit 1: participants engaged in continuous 2-hour video game play wearing no compression (Continuous). Visit 2 and 3 involved 2-hour play wearing compression sleeves (Compression), and 2-hour game play interrupted at 1-hour by a 6-minute walk (Walk). Doppler ultrasound measurem...
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 22, 2023 Category: Physiology Authors: Joanne DiFrancisco-Donoghue Kelly Borges Timothy Li Olivia Ballone Hallie Zwibel Peter C Douris Source Type: research

The FXYD1 protein plays a protective role against pulmonary hypertension and arterial remodelling via redox and inflammatory mechanisms
CONCLUSIONS: The absence of FXYD1 in mice results in LV inflammation and cardiopulmonary redox signaling changes that predispose to pathophysiological features of PH, suggesting FXYD1 may be protective.PMID:38133617 | DOI:10.1152/ajpheart.00090.2023 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 22, 2023 Category: Physiology Authors: Thomas S Hansen Keyvan Karimi Galougahi Owen Tang Michael Tsang Marielle Scherrer-Crosbie Elena Arystarkhova Kathleen Sweadner Christina Bursill Kristen J Bubb Gemma A Figtree Source Type: research

Electronic Hookah (Waterpipe) Vaping Reduces Vascular Endothelial Function: The Role of Nicotine
Am J Physiol Heart Circ Physiol. 2023 Dec 22. doi: 10.1152/ajpheart.00710.2023. Online ahead of print.ABSTRACTVaping has risen substantially in recent years, particularly among young adults. While e-hookah vaping acutely reduces endothelial function, the role of nicotine and the mechanisms by which it may impairs endothelial function remain understudied. In a randomized cross-over study, we investigated the acute effects of vaping e-hookah, with and without nicotine, as compared to sham on endothelial function assessed by brachial artery flow-mediated dilation (FMD), among 18 overtly healthy young adults. To determine the ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 22, 2023 Category: Physiology Authors: Mary Rezk-Hanna Matthew J Rossman Katelyn Ludwig Primadya Sakti Chiao-Wei Cheng Mary-Lynn Brecht Neal L Benowitz Douglas R Seals Source Type: research