American Journal of Physiology. Heart and Circulatory Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Advanced maternal age alters cardiac functional and structural adaptations to pregnancy in rats
Am J Physiol Heart Circ Physiol. 2024 Mar 8. doi: 10.1152/ajpheart.00057.2024. Online ahead of print.ABSTRACTA significant number of pregnancies occur at advanced maternal age (>35 years), which is a risk factor for pregnancy complications. Healthy pregnancies require massive hemodynamic adaptations, including an increased blood volume and cardiac output. There is growing evidence that these cardiovascular adaptations are impaired with age, however, little is known about maternal cardiac function with advanced age. We hypothesized that cardiac adaptations to pregnancy are impaired with advanced maternal age. Younger (4 ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 8, 2024 Category: Physiology Authors: Amy L Wooldridge Raven Kirschenman Floor Spaans Mazhar Pasha Sandra T Davidge Christy-Lynn M Cooke Source Type: research

Characterizing the influence of Cardiorespiratory Fitness on Left Atrial size and function in the general population
Am J Physiol Heart Circ Physiol. 2024 Mar 8. doi: 10.1152/ajpheart.00422.2023. Online ahead of print.ABSTRACTIncreased left atrial (LA) size and reduced LA function have been associated with heart failure and atrial fibrillation (AF) in at risk populations. However, atrial remodeling has also been associated with exercise training and the relationship between fitness, LA size and function has not been defined across the fitness spectrum. In a cross-sectional study of 559 ostensibly healthy participants, comprising 304 males (mean age 46 ± 20 years) and 255 females (mean age 47 ± 15 years), we sought to define the relatio...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 8, 2024 Category: Physiology Authors: Luke Spencer Leah Wright Stephen J Foulkes Stephanie J Rowe Hayley T Dillon Rachel Climie Ashley Bigaran Kristel Janssens Amy Mitchell Imogen Wallace Anniina Lindqvist Lauren Burnham David L Prior Erin J Howden Andr é La Gerche Source Type: research

Transient Low Shear Stress Preconditioning Influences Long-term Endothelial Traction and Alignment under High Shear Flow
Am J Physiol Heart Circ Physiol. 2024 Mar 8. doi: 10.1152/ajpheart.00067.2024. Online ahead of print.ABSTRACTEndothelial cells (ECs) within the vascular system encounter fluid shear stress (FSS). High, laminar FSS promotes vasodilation and anti-inflammatory responses, while low or disturbed FSS induces dysfunction and inflammation. However, the adaptation of ECs to dynamically changing FSS patterns remains underexplored. Here, by combining traction force microscopy with a custom flow chamber, we examined human umbilical vein endothelial cells adapting their traction during transitions from short-term low shear to long-term...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 8, 2024 Category: Physiology Authors: Mohanish K Chandurkar Nikhil Mittal Shaina P Royer-Weeden Steven D Lehmann Etienne B Michels Samuel E Haarman Scott A Severance Yeonwoo Rho Sangyoon J Han Source Type: research

Beat-to-beat cardiac repolarization lability increases during hypoxemia and arousals in obstructive sleep apnea patients
Am J Physiol Heart Circ Physiol. 2024 Mar 1. doi: 10.1152/ajpheart.00760.2023. Online ahead of print.ABSTRACTObstructive sleep apnea (OSA) is associated with the progression of cardiovascular diseases, arrhythmias, and sudden cardiac death (SCD). However, the acute impacts of OSA and its consequences on heart function are not yet fully elucidated. We hypothesized that desaturation events acutely destabilize ventricular repolarization, and the presence of accompanying arousals magnifies this destabilization. Ventricular repolarization lability measures, comprising heart rate corrected QT (QTc), short-time-variability of QT ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 1, 2024 Category: Physiology Authors: Serajeddin Ebrahimian Saara Sillanm äki Salla Hietakoste Antti Kulkas Juha T öyräs Raquel Bailon David Hernando Carolina Lombardi Ludger Grote Maria R Bonsignore Tarja Saaresranta Jean-Louis P épin Timo Lepp änen Samu Kainulainen Source Type: research

GLP-1 receptor agonists and vascular protection
Am J Physiol Heart Circ Physiol. 2024 Mar 1. doi: 10.1152/ajpheart.00574.2023. Online ahead of print.ABSTRACTAtherosclerotic cardiovascular disease is a chronic condition that often co-presents with type 2 diabetes and obesity. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are incretin mimetics endorsed by major professional societies for improving glycemic status and reducing atherosclerotic risk in people living with type 2 diabetes. While the cardioprotective efficacy of GLP-1RAs and their relationship with traditional risk factors are well-established, there is a paucity of publications that have summarized the ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 1, 2024 Category: Physiology Authors: Brady Park Ehab Bakbak Hwee Teoh Aishwarya Krishnaraj Fallon Dennis Adrian Quan Ori D Rotstein Javed Butler David A Hess Subodh Verma Source Type: research

Global IL4R α Blockade Exacerbates Heart Failure After an Ischemic Event in Mice and Humans
Am J Physiol Heart Circ Physiol. 2024 Mar 1. doi: 10.1152/ajpheart.00010.2024. Online ahead of print.ABSTRACTIschemic heart failure continues to be a highly prevalent disease among westernized countries and there is great interest in understanding mechanisms preventing or exacerbating disease progression. Literature suggests an important role for activation of interleukin 13 or interleukin 4 signaling in improving ischemic heart failure outcomes after myocardial infarction in mice. Dupilumab, a neutralizing antibody that inhibits the shared IL13/IL4 receptor subunit IL4Rα, is widely used for conditions such as ectopic der...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 1, 2024 Category: Physiology Authors: Santiago Alvarez-Argote Victor Alencar Almedia Makenna C Knas Sydney L Buday Michaela Patterson Caitlin C O'Meara Source Type: research

Short-term vascular responses to spring and fall daylight savings time shifts
This study emphasizes the need for further research to determine the mechanisms of increased cardiovascular disease risk with DST that help explain epidemiological trends.PMID:38426867 | DOI:10.1152/ajpheart.00034.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 1, 2024 Category: Physiology Authors: Dara Al-Bakry Chloe E Athaide Rishiga Pathmarajan Tara Kuhn Laura E Middleton Jason S Au Source Type: research