American Journal of Physiology. Heart and Circulatory Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A Cell Atlas of Thoracic Aortic Perivascular Adipose Tissue: a focus on mechanotransducers
Am J Physiol Heart Circ Physiol. 2024 Mar 22. doi: 10.1152/ajpheart.00040.2024. Online ahead of print.ABSTRACTPerivascular adipose tissue (PVAT) is increasingly recognized for its function in mechanotransduction. However, major gaps remain in our understanding of the cells present in PVAT, as well as how different cells contribute to mechanotransduction. We hypothesized that snRNA seq would reveal expression of mechanotransducers, and test one (PIEZO1) to illustrate the expression and functional agreement between single-nuclei RNA sequencing (snRNAseq) and physiological measurements. To contrast two brown tissues, subscapu...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 22, 2024 Category: Physiology Authors: Janice M Thompson Stephanie W Watts Leah Terrian G Andres Contreras Cheryl Rockwell C Javier Rendon Emma Wabel Lizbeth Lockwood Sudin Bhattacharya Rance Nault Source Type: research

Role of the circulating milieu in age-related arterial dysfunction: a novel < em > ex vivo < /em > approach
This study establishes novel experimental approaches for directly assessing the effects of the circulating milieu on arterial function and implicates changes in the circulating milieu as a mechanism of in vivo arterial aging.PMID:38517225 | DOI:10.1152/ajpheart.00014.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 22, 2024 Category: Physiology Authors: Sophia A Mahoney Nicholas S VanDongen Nathan T Greenberg Ravinandan Venkatasubramanian Matthew J Rossman Michael E Widlansky Vienna E Brunt Yara Bernaldo de Quir ós Douglas R Seals Zachary S Clayton Source Type: research

Scratching beneath the surface: IL4R α blockade and the progression from myocardial ischemic injury to heart failure
Am J Physiol Heart Circ Physiol. 2024 Mar 22. doi: 10.1152/ajpheart.00150.2024. Online ahead of print.NO ABSTRACTPMID:38517226 | DOI:10.1152/ajpheart.00150.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 22, 2024 Category: Physiology Authors: Douglas H Wu Samuel E Senyo Source Type: research

Clinical Physiology: The Crucial Role of MRI in Evaluation of Peripheral Artery Disease
Am J Physiol Heart Circ Physiol. 2024 Mar 22. doi: 10.1152/ajpheart.00533.2023. Online ahead of print.ABSTRACTPeripheral artery disease (PAD) is a common vascular disease that primarily affects the lower limbs and is defined by the constriction or blockage of peripheral arteries and may involve microvascular dysfunction and tissue injury. Patients with diabetes have more prominent disease of microcirculation and develop peripheral neuropathy, autonomic dysfunction, and medial vascular calcification. Early and accurate diagnosis of PAD and disease characterization are essential for personalized management and therapy planni...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 22, 2024 Category: Physiology Authors: Nahla M H Elsaid Dana C Peters Gigi Galiana Albert J Sinusas Source Type: research

3D Object Geometry of Mitochondria-Associated Signal: 3D Analysis Pipeline for Two-Photon Image Stacks of Cerebrovascular Endothelial Mitochondria
Am J Physiol Heart Circ Physiol. 2024 Mar 22. doi: 10.1152/ajpheart.00101.2024. Online ahead of print.ABSTRACTIncreasing evidence indicates the role of mitochondrial and vascular dysfunction in aging and aging-associated pathologies; however, the exact mechanisms and chronological processes remain enigmatic. High energy demand organs, such as the brain, depend on the health of their mitochondria and vasculature in the maintenance of normal functions, therefore representing vulnerable targets for aging. This methodology paper describes an analysis pipeline for 3D mitochondria-associated signal geometry of two-photon image s...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 22, 2024 Category: Physiology Authors: Christopher R Gonzales Eric N Moca Partha K Chandra David W Busija Ibolya Rutkai Source Type: research

Surgically induced aortic coarctation in a neonatal porcine model allows for longitudinal assessment of cardiovascular changes
CONCLUSIONS: This model addresses many limitations of prior COA models including neonatal creation at an expected anatomic position with intimal injury and vessel sizes similar to humans.PMID:38488518 | DOI:10.1152/ajpheart.00087.2024 (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 15, 2024 Category: Physiology Authors: Michael Stellon Leah Gober Matthew Allen Culver Joshua Hermsen Dana Irrer Colleen Witzenburg Alejandro Rold án-Alzate Luke Lamers Source Type: research

BAG3 localizes to mitochondria in cardiac fibroblasts and regulates mitophagy
Am J Physiol Heart Circ Physiol. 2024 Mar 15. doi: 10.1152/ajpheart.00736.2023. Online ahead of print.ABSTRACTThe co-chaperone BAG3 is a central node in protein quality control in the heart. In humans and animal models, decreased BAG3 expression is associated with cardiac dysfunction and dilated cardiomyopathy. While previous studies focused on BAG3 in cardiomyocytes, cardiac fibroblasts are also critical drivers of pathologic remodeling. Yet, BAG3's role in cardiac fibroblasts is almost completely unexplored. Here, we show BAG3 is expressed in primary rat neonatal cardiac fibroblasts and preferentially localizes to mitoch...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 15, 2024 Category: Physiology Authors: Thomas G Martin Laura A Sherer Jonathan A Kirk Source Type: research

Single-cell ionic current phenotyping explains stem cell-derived cardiomyocyte action potential morphology
In this study, we use recently published, brief (10 s), dynamic voltage clamp (VC) data to provide mechanistic insights into the ionic currents contributing to AP heterogeneity - we call this approach rapid ionic current phenotyping (RICP). Features of this VC data were correlated to AP recordings from the same cells and we used computational models to generate mechanistic insights into cellular heterogeneity. This analysis uncovered several interesting links between AP morphology and ionic current density: both L-type calcium and sodium currents contribute to upstroke velocity, rapid delayed rectifier K+ current is the ma...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 15, 2024 Category: Physiology Authors: Alexander P Clark Siyu Wei Kristin Fullerton Trine Krogh-Madsen David J Christini Source Type: research