The Benefits and Risks of Receiving Investigational Solid Tumor Drugs in Randomized Trials : A Systematic Review and Meta-analysis
CONCLUSION: Assignment to experimental groups produces statistically significant survival gains. However, the absolute survival gain is small, and toxicity is statistically significantly greater. The findings of this review provide reassuring evidence that patients are not meaningfully disadvantaged by assignment to comparator groups.PRIMARY FUNDING SOURCE: Canadian Institutes of Health Research.PMID:38684102 | DOI:10.7326/M23-2515 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Renata Iskander Hannah Moyer Dean Fergusson Sean McGrath Andrea Benedetti Jonathan Kimmelman Source Type: research
Medicare Negotiation's Drug Reformulation Problem
Ann Intern Med. 2024 Apr 30. doi: 10.7326/M24-0138. Online ahead of print.NO ABSTRACTPMID:38684103 | DOI:10.7326/M24-0138 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Matthew Vogel Benjamin N Rome Aaron S Kesselheim William B Feldman Source Type: research
Sodium-Glucose Cotransporter-2 Inhibitors and the Risk for Dialysis and Cardiovascular Disease in Patients With Stage 5 Chronic Kidney Disease
CONCLUSION: This emulated target trial showed that SGLT2i use was associated with a lower risk for dialysis, cardiovascular events, DKA, and AKI than no SGLT2i use in patients with T2D and stage 5 CKD.PRIMARY FUNDING SOURCE: National Health Research Institutes, Taiwan.PMID:38684099 | DOI:10.7326/M23-1874 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Fu-Shun Yen Chii-Min Hwu Jia-Sin Liu Yi-Ling Wu Keong Chong Chih-Cheng Hsu Source Type: research
The Effect of Open-Label Semaglutide on Metabolic Dysfunction-Associated Steatotic Liver Disease in People With HIV
Ann Intern Med. 2024 Apr 30. doi: 10.7326/M23-3354. Online ahead of print.NO ABSTRACTPMID:38684100 | DOI:10.7326/M23-3354 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Jordan E Lake Douglas W Kitch Amy Kantor Raja Muthupillai Karin L Klingman Christina Vernon Pablo F Belaunzaran-Zamudio Carl J Fichtenbaum Sonya Heath Hugo Perazzo Kathleen Corey Todd T Brown Alan Landay Fred Sattler Kristine M Erlandson Source Type: research
Estimated Medicare Part D Savings From Generic Drugs With a Skinny Label
Ann Intern Med. 2024 Apr 30. doi: 10.7326/M23-3212. Online ahead of print.NO ABSTRACTPMID:38684101 | DOI:10.7326/M23-3212 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Authors: Alexander C Egilman Aaron S Kesselheim Ameet Sarpatwari Benjamin N Rome Source Type: research
Annals Video Summary - Benefits and Risks of Receiving Investigational Solid Tumor Drugs in Randomized Trials
Ann Intern Med. 2024 Apr 30:eM240739. doi: 10.7326/M24-0739. Online ahead of print.NO ABSTRACTPMID:38684098 | DOI:10.7326/M24-0739 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 29, 2024 Category: Internal Medicine Source Type: research
First-trimester fetal size, accelerated growth in utero, and child neurodevelopment in a cohort study
This study aimed to explore t... (Source: BMC Medicine)
Source: BMC Medicine - April 29, 2024 Category: Internal Medicine Authors: Xinmei Chen, Hongxiu Liu, Yuanyuan Li, Wenxin Zhang, Aifen Zhou, Wei Xia and Shunqing Xu Tags: Research article Source Type: research
Colon impairments and inflammation driven by an altered gut microbiota leads to social behavior deficits rescued by hyaluronic acid and celecoxib
The exact mechanisms linking the gut microbiota and social behavior are still under investigation. We aimed to explore the role of the gut microbiota in shaping social behavior deficits using selectively bred ... (Source: BMC Medicine)
Source: BMC Medicine - April 29, 2024 Category: Internal Medicine Authors: Oryan Agranyoni, Debpali Sur, Sivan Amidror, Nuphar Shidlovsky, Anastasia Bagaev, Nissan Yissachar, Albert Pinhasov and Shiri Navon-Venezia Tags: Research article Source Type: research
Application of tandem mass spectrometry in the screening and diagnosis of mucopolysaccharidoses
Mucopolysaccharidoses (MPSs) are caused by a deficiency in the enzymes needed to degrade glycosaminoglycans (GAGs) in the lysosome. The storage of GAGs leads to the involvement of several systems and even to t... (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - April 29, 2024 Category: Internal Medicine Authors: Jing-Wen Li, Shao-Jia Mao, Yun-Qi Chao, Chen-Xi Hu, Yan-Jie Qian, Yang-Li Dai, Ke Huang, Zheng Shen and Chao-Chun Zou Tags: Review Source Type: research
Correction: Autotaxin inhibition attenuates the aortic valve calcification by suppressing inflammation-driven fibro-calcific remodeling of valvular interstitial cells
(Source: BMC Medicine)
Source: BMC Medicine - April 29, 2024 Category: Internal Medicine Authors: Dohee Yoon, Bongkun Choi, Ji-Eun Kim, Eun-Young Kim, Soo-Hyun Chung, Hyo-Jin Min, Yoolim Sung, Eun-Ju Chang and Jae-Kwan Song Tags: Correction Source Type: research
Correction: Identification of a novel bile marker clusterin and a public online prediction platform based on deep learning for cholangiocarcinoma
(Source: BMC Medicine)
Source: BMC Medicine - April 29, 2024 Category: Internal Medicine Authors: Long Gao, Yanyan Lin, Ping Yue, Shuyan Li, Yong Zhang, Ningning Mi, Mingzhen Bai, Wenkang Fu, Zhili Xia, Ningzu Jiang, Jie Cao, Man Yang, Yanni Ma, Fanxiang Zhang, Chao Zhang, Joseph W. Leung & hellip; Tags: Correction Source Type: research
Suicide mortality following the implementation of tobacco packaging and pricing policies in Korea: an interrupted time-series analysis
To prevent tobacco use in Korea, the national quitline number was added to tobacco packages in December 2012, tobacco prices were raised by 80% in January 2015, and graphic health warning labels were placed on... (Source: BMC Medicine)
Source: BMC Medicine - April 29, 2024 Category: Internal Medicine Authors: Taiyue Jin, Juhee Seo, Shinhee Ye, Seulbi Lee, Eun Young Park, Jin-Kyoung Oh, Changwoo Han and Byungmi Kim Tags: Research article Source Type: research
Epidemiology of autoimmune liver disease in Korea: evidence from a nationwide real-world database
Autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) are all immune-mediated chronic inflammatory liver diseases. Autoimmune liver diseases are rare, making i... (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - April 29, 2024 Category: Internal Medicine Authors: Jihye Lim and Hwa Jung Kim Tags: Research Source Type: research
Internal Medicine Applicants ’ Experiences with Program Signaling and Second Looks: A Multi-institutional Survey
The Association of American Medical Colleges (AAMC) piloted a supplemental application for the standard residency application in the Electronic Residency Application Service (ERAS) during the 2021-2022 residency cycle. Specifically, the supplemental application provided applicants the opportunity to indicate geographic and program preferences1. During the most recent residency application cycle, internal medicine applicants could signal interest in seven programs. While AAMC provides broad findings on the supplemental application from previous application cycles, limited data exist regarding interviews granted from program...
Source: The American Journal of Medicine - April 29, 2024 Category: General Medicine Authors: Katherine R. Schafer, Marc Heincelman, William Adams, Reeni A. Abraham, Brian Kwan, Meghan Sebasky, Jennifer G. Foster, Matthew Fitz Tags: AAIM Perspectives Source Type: research
Anticoagulants in poisoning
Blood coagulation is the result of a complex cascade of proteases that produce an insoluble fibrin polymer from soluble fibrinogen. Abnormal or excessive coagulation can cause venous thromboembolic disorders or arterial thromboembolic disease. Parenteral and oral anticoagulants have demonstrated efficacy in treating these conditions. Haemorrhage is a predicable consequence of anticoagulant poisoning. Treatment involves the general management of haemorrhage, and the administration of specific antidotes for individual anticoagulants is discussed. (Source: Medicine)
Source: Medicine - April 29, 2024 Category: Internal Medicine Authors: James Coulson Tags: Poisonous substances Source Type: research
