Project SATURN – a real-world evidence data collaboration with existing European datasets in Osteogenesis Imperfecta to support future therapies
Regulatory marketing authorisation is not enough to ensure patient access to new medicinal products. Health Technology Assessment bodies may require data on effectiveness, relative effectiveness, and cost-effe... (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - May 2, 2024 Category: Internal Medicine Authors: L. Sangiorgi, M. Boarini, I. Westerheim, R. T. Skarberg, J. Clancy, V. Wang and M. Mordenti Tags: Position statement Source Type: research
Physical activity across midlife and health-related quality of life in Australian women: A target trial emulation using a longitudinal cohort
ConclusionsResults from the emulated RCT suggest women should be active throughout mid-age, ideally increasing activity levels to meet the guidelines by age 55, to gain the most benefits for physical health in later life. (Source: PLoS Medicine)
Source: PLoS Medicine - May 2, 2024 Category: Internal Medicine Authors: Binh Nguyen Source Type: research
The role of circular RNAs in regulating resistance to cancer immunotherapy: mechanisms and implications
Cell Death & Disease, Published online: 02 May 2024; doi:10.1038/s41419-024-06698-3The role of circular RNAs in regulating resistance to cancer immunotherapy: mechanisms and implications (Source: Cell death and disease)
Source: Cell death and disease - May 2, 2024 Category: Internal Medicine Authors: Yu Ma Ting Wang Xudong Zhang Pinghan Wang Fangyi Long Source Type: research
A novel inhibitor of the mitochondrial respiratory complex I with uncoupling properties exerts potent antitumor activity
Cell Death & Disease, Published online: 02 May 2024; doi:10.1038/s41419-024-06668-9A novel inhibitor of the mitochondrial respiratory complex I with uncoupling properties exerts potent antitumor activity (Source: Cell death and disease)
Source: Cell death and disease - May 2, 2024 Category: Internal Medicine Authors: Alaa Al Assi Sol ène Posty Fr édéric Lamarche Amel Chebel J érôme Guitton C écile Cottet-Rousselle Renaud Prudent Laurence Lafanech ère St éphane Giraud Patrick Dallemagne Peggy Suzanne Aur élie Verney Laurent Genestier Marie Castets Eric Fontain Source Type: research
A novel long non-coding RNA MIR4500HG003 promotes tumor metastasis through miR-483-3p-MMP9 axis in triple-negative breast cancer
Cell Death & Disease, Published online: 02 May 2024; doi:10.1038/s41419-024-06675-wA novel long non-coding RNA MIR4500HG003 promotes tumor metastasis through miR-483-3p-MMP9 axis in triple-negative breast cancer (Source: Cell death and disease)
Source: Cell death and disease - May 2, 2024 Category: Internal Medicine Authors: Wen-Der Lin Chia-Hao Chang Jhih-Kai Pan Forn-Chia Lin Yu-Chia Chen Ya-Jyun Chen Po-Shun Wang Wei-Qiao Hong Sheng-Yuan Chen Cheng-Han Lin Yao-Lung Kuo Wei-Pang Chung Hui-Chuan Cheng Michael Hsiao Chia-Ning Yang Pei-Jung Lu Source Type: research
Cytotoxic sigma-2 ligands trigger cancer cell death via cholesterol-induced-ER-stress
Cell Death & Disease, Published online: 02 May 2024; doi:10.1038/s41419-024-06693-8Cytotoxic sigma-2 ligands trigger cancer cell death via cholesterol-induced-ER-stress (Source: Cell death and disease)
Source: Cell death and disease - May 2, 2024 Category: Internal Medicine Authors: Rony Takchi Bethany C. Prudner Qingqing Gong Takaomi Hagi Kenneth F. Newcomer Linda X. Jin Suwanna Vangveravong Brian A. Van Tine William G. Hawkins Dirk Spitzer Source Type: research
First report of validation of the prognostic nutritional index in patients with subarachnoid hemorrhage undergoing endovascular occlusion or surgical clipping
. (Source: International Journal of Neuroscience)
Source: International Journal of Neuroscience - May 2, 2024 Category: Neuroscience Authors: Mehmet Selim GelIskender Samet DaltabanNesibe Taser KanatAyhan Kanata Department of Neurosurgery, Kanuni Research and Training Hospital, Trabzon, Turkeyb Medical Faculty, Department of Internal Medicine, Division of Hematology, Erciyes University, Kayseri Source Type: research
Coding Corner: Dazed and Confused
An 84-year-old woman with a history of dementia was admitted for worsening confusion over the last two days. Her initial workup in the emergency department is unremarkable including a normal urinalysis, basic metabolic panel, complete blood count, and CT of the head. On day two, she is increasingly combative and requires restraints. After a discussion with her family about the risks and benefits, quetiapine is added nightly. You order an electrocardiogram to check the patient’s QT interval, magnesium level, and another basic metabolic panel. On day three, she continues to require intermittent restraints along with the ad...
Source: The Hospitalist - May 1, 2024 Category: Hospital Management Authors: Ronda Whitaker Tags: Business of Medicine Clinical Guidelines Source Type: research
Black Patients More Likely to Experience Security Emergency Responses
Colby Feeney, MD, FHM
Clinical question: Do race and ethnicity predict the use of security emergency responses (SER) in a non-psychiatric inpatient setting?
Background: Studies have demonstrated increased restraint use in certain racial groups in the emergency department (ED) and inpatient psychiatry settings. While there is also literature to suggest increased use of security for nonwhite patients, there is little known about the association between race and ethnicity identification and the use of SERs and restraints in the non-psychiatric inpatient setting.
Study design: Retrospective cohort study
Setting: Single tertia...
Source: The Hospitalist - May 1, 2024 Category: Hospital Management Authors: Ronda Whitaker Tags: Advocacy Diversity in Medicine In the Literature Source Type: research
The Characteristics and Management Considerations of Late-onset Rheumatoid Arthritis
Intern Med. 2024 May 2. doi: 10.2169/internalmedicine.3786-24. Online ahead of print.NO ABSTRACTPMID:38692913 | DOI:10.2169/internalmedicine.3786-24 (Source: Internal Medicine)
Source: Internal Medicine - May 1, 2024 Category: Internal Medicine Authors: Ryusuke Yoshimi Hideaki Nakajima Source Type: research
Positive anti-nuclear antibody in patients with polyclonal hypergammaglobulinemia suggests the presence of multiple distinct comorbidities
Conclusion These results establish a previously underappreciated unique immunological state of multimorbidity in PHGG and indicate that the gamma-globulin levels and ANAs could serve as markers for the clinical assessment of comorbidities in PHGG.PMID:38692914 | DOI:10.2169/internalmedicine.3594-24 (Source: Internal Medicine)
Source: Internal Medicine - May 1, 2024 Category: Internal Medicine Authors: Yasutaka Masuda Ken Morita Mineo Kurokawa Source Type: research
A preliminary survey of rheumatologists on the management of late-onset rheumatoid arthritis in Japan
Conclusion This preliminary survey highlighted various rheumatologists' perspectives regarding the management of LORA.PMID:38692915 | DOI:10.2169/internalmedicine.3288-23 (Source: Internal Medicine)
Source: Internal Medicine - May 1, 2024 Category: Internal Medicine Authors: Satoshi Takanashi Yuko Kaneko Yutaka Kawahito Takashi Kida Takahiko Sugihara Toshihisa Kojima Ryozo Harada Michinori Ishitoku Shintaro Hirata Motomu Hashimoto Toshihiko Hidaka Asami Abe Hajime Ishikawa Hiromu Ito Mitsumasa Kishimoto Kazuo Matsui Toshihiro Source Type: research
Chronic bromine intoxication complicated with Fanconi syndrome: A case report
In this report, we describe a unique case of an 80-year-old woman who developed chronic bromine poisoning due to the prolonged ingestion of over-the-counter (OTC) medication containing bromovalerylurea (BVU), thus leading to the onset of drug-induced partial Fanconi syndrome and resultant osteomalacia. The patient's condition improved following the cessation of bromide intake. This case highlights the potential risks of chronic BVU exposure and the importance of caution regarding the use of OTC medications containing BVU.PMID:38692916 | DOI:10.2169/internalmedicine.3128-23 (Source: Internal Medicine)
Source: Internal Medicine - May 1, 2024 Category: Internal Medicine Authors: Yusuke Makio Taku Harada Kazushi Yamasato Toshiyuki Nakanishi Mori Nakai Source Type: research
Status epilepticus with unilateral brain edema in COVID-19
Intern Med. 2024 May 2. doi: 10.2169/internalmedicine.3080-23. Online ahead of print.NO ABSTRACTPMID:38692917 | DOI:10.2169/internalmedicine.3080-23 (Source: Internal Medicine)
Source: Internal Medicine - May 1, 2024 Category: Internal Medicine Authors: Yasuhiro Aso Teruaki Masuda Noriyuki Kimura Etsuro Matsubara Source Type: research
