Protective effect of increased O-GlcNAc cycling against 6-OHDA induced Parkinson’s disease pathology
Cell Death & Disease, Published online: 23 April 2024; doi:10.1038/s41419-024-06670-1Protective effect of increased O-GlcNAc cycling against 6-OHDA induced Parkinson’s disease pathology (Source: Cell death and disease)
Source: Cell death and disease - April 23, 2024 Category: Internal Medicine Authors: Dong Yeol Kim Sang-Min Kim Eun-Jeong Cho Hyo-Bum Kwak Inn-Oc Han Source Type: research
Fatty acid-binding protein 5 is a functional biomarker and indicator of ferroptosis in cerebral hypoxia
Cell Death & Disease, Published online: 23 April 2024; doi:10.1038/s41419-024-06681-yFatty acid-binding protein 5 is a functional biomarker and indicator of ferroptosis in cerebral hypoxia (Source: Cell death and disease)
Source: Cell death and disease - April 23, 2024 Category: Internal Medicine Authors: Hao Peng Shan Xin Susanne Pfeiffer Constanze M üller Juliane Merl-Pham Stefanie M. Hauck Patrick N. Harter Daniel Spitzer Kavi Devraj Borys Varynskyi Thomas Arzberger Stefan Momma Joel A. Schick Source Type: research
Trauma-associated extracellular histones mediate inflammation via a MYD88-IRAK1-ERK signaling axis and induce lytic cell death in human adipocytes
Cell Death & Disease, Published online: 23 April 2024; doi:10.1038/s41419-024-06676-9Trauma-associated extracellular histones mediate inflammation via a MYD88-IRAK1-ERK signaling axis and induce lytic cell death in human adipocytes (Source: Cell death and disease)
Source: Cell death and disease - April 23, 2024 Category: Internal Medicine Authors: Julian Roos Julia Zinngrebe Markus Huber-Lang Ludmila Lupu Miriam A. Schmidt Hannah Strobel Mike-Andrew Westhoff Ulrich Stifel Florian Gebhard Martin Wabitsch Tom Eirik Mollnes Klaus-Michael Debatin Rebecca Halbgebauer Pamela Fischer-Posovszky Source Type: research
GATA4 regulates the transcription of MMP9 to suppress the invasion and migration of breast cancer cells via HDAC1-mediated p65 deacetylation
Cell Death & Disease, Published online: 23 April 2024; doi:10.1038/s41419-024-06656-zGATA4 regulates the transcription of MMP9 to suppress the invasion and migration of breast cancer cells via HDAC1-mediated p65 deacetylation (Source: Cell death and disease)
Source: Cell death and disease - April 23, 2024 Category: Internal Medicine Authors: Yuxi Yang Shuangshuang Song Shujing Li Jie Kang Yulin Li Nannan Zhao Dongman Ye Fengying Qin Yixin Du Jing Sun Tao Yu Huijian Wu Source Type: research
A Prospective Multimodal Education Intervention for Providers Does Not Increase Hepatic Encephalopathy Treatment Rates
ConclusionThis MMEI did not increase HE treatment rates, suggesting that alternative strategies are needed to identify and address barriers to treatment. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 23, 2024 Category: Gastroenterology Source Type: research
Cardiopulmonary Resuscitation Outcomes and Trainee Perception of Code Status Discussions in Patients with Cirrhosis
ConclusionsWe identified significant trainee uncertainty about outcomes in patients with cirrhosis. These deficits improved after an educational intervention and gave providers more confidence in holding informed code status conversations with patients with cirrhosis, a population that faces barriers to adequate code discussions. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 23, 2024 Category: Gastroenterology Source Type: research
Advancements in biologic therapy in eosinophilic asthma
. (Source: Expert Opinion on Biological Therapy)
Source: Expert Opinion on Biological Therapy - April 23, 2024 Category: Drugs & Pharmacology Authors: Rini PatadiaThomas B. CasaleJohn FowlerShiven PatelJuan Carlos Cardeta Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, FL, USAb Department of Internal Medicine, The James Source Type: research
Claudin-7 is essential for the maintenance of colonic stem cell homoeostasis via the modulation of Wnt/Notch signalling
Cell Death & Disease, Published online: 23 April 2024; doi:10.1038/s41419-024-06658-xClaudin-7 is essential for the maintenance of colonic stem cell homoeostasis via the modulation of Wnt/Notch signalling (Source: Cell death and disease)
Source: Cell death and disease - April 23, 2024 Category: Internal Medicine Authors: Kun Wang Yin Liu Huimin Li Xiaoqing Liang Mengdi Hao Dajin Yuan Lei Ding Source Type: research
Impact of COVID-19 pandemic on depression incidence and healthcare service use among patients with depression: an interrupted time-series analysis from a 9-year population-based study
Most studies on the impact of the COVID-19 pandemic on depression burden focused on the earlier pandemic phase specific to lockdowns, but the longer-term impact of the pandemic is less well-studied. In this po... (Source: BMC Medicine)
Source: BMC Medicine - April 22, 2024 Category: Internal Medicine Authors: Vivien Kin Yi Chan, Yi Chai, Sandra Sau Man Chan, Hao Luo, Mark Jit, Martin Knapp, David Makram Bishai, Michael Yuxuan Ni, Ian Chi Kei Wong and Xue Li Tags: Research article Source Type: research
A Toolkit for Delirium Identification and Promoting Partnerships Between Carers and Nurses: A Pilot Pre –Post Feasibility Study
ConclusionThe prevention and management of delirium are imperative for safe and quality care for patients, carers, and staff. Further comprehensive and in-depth research is required to better understand underlying mechanisms of change and explore facets of nursing practice influenced by this innovative approach. (Source: Journal of General Internal Medicine)
Source: Journal of General Internal Medicine - April 22, 2024 Category: Internal Medicine Source Type: research
S100A1: a promising therapeutic target for heart failure
. (Source: Expert Opinion on Therapeutic Targets)
Source: Expert Opinion on Therapeutic Targets - April 22, 2024 Category: Drugs & Pharmacology Authors: Dorothea NollDorothea KehrPatrick MostJulia Ritterhoffa Molecular and Translational Cardiology, Department of Internal Medicine III, Heidelberg University Hospital, Heidelberg, Germanyb German Center for Cardiovascular Research (DZHK), Partner Site Heidel Source Type: research
Hepatic Sirt6 activation abrogates acute liver failure
Cell Death & Disease, Published online: 22 April 2024; doi:10.1038/s41419-024-06537-5Hepatic Sirt6 activation abrogates acute liver failure (Source: Cell death and disease)
Source: Cell death and disease - April 22, 2024 Category: Internal Medicine Authors: Jinque Luo Huan Liu Yanni Xu Nanhui Yu Rebbeca A. Steiner Xiaoqian Wu Shuyi Si Zheng Gen Jin Source Type: research
Antihypertensive Medication and Fracture Risk in Older VA Nursing Home Residents
This cohort study using a target trial emulation approach assesses whether initiating antihypertensive medication is associated with increased fracture risk among older long-term Veterans Health Administration nursing home residents. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - April 22, 2024 Category: Internal Medicine Source Type: research
Blood Pressure Management and Falls in Nursing Home Residents
In this study, Dave et al harness national Veterans Health Administration (VHA) clinical data to examine the association between initiation of a new antihypertensive agent with the incidence of fall-related fractures in residents at VHA nursing homes, or community living centers. In this carefully designed study, residents who received a new antihypertensive agent had more than 2-fold greater risk of fractures compared with those who did not (adjusted hazard ratio [aHR], 2.42 [95% CI, 1.43-4.08]). This practice was also associated with 1.8-fold greater risk of serious falls (HR, 1.80 [95% CI, 1.52-2.13]) and 1.7-fold great...
Source: JAMA Internal Medicine - April 22, 2024 Category: Internal Medicine Source Type: research
Errors in Results and Discussion
This article was corrected online. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - April 22, 2024 Category: Internal Medicine Source Type: research
