A machine learning model for predicting ICU readmissions and key risk factors: analysis from a longitudinal health records
This study aims to investigate and analyze if the relevance of ICU readmission risk factors may have changed overtime. We used MIMIC-III database with 42,307 ICU stays of 31,749 patients from a US hospital, related to medical services provided from 2001 to 2012. The dataset was initially split into two chronological subsets (2001 –2008 and 2008–2012), and then split again into train (70%) and test (30%) datasets. The training datasets were rebalanced through undersampling technique. To identify if the most relevant risk factors changes over time, 13 variables (12 features and one class) were selected and a thre...
Source: Health and Technology - April 26, 2019 Category: Information Technology Source Type: research

[Is it possible to extract intracranial pressure information based on the EEG activity?]
CONCLUSIONS: The present work provides useful information and shed light in discovering a hidden relationship between the ICP and EEG dynamics. The potential use of this relationship could lead to develop a medical device to measure ICP in a non-invasive fashion. PMID: 31017290 [PubMed - in process] (Source: Revista de Neurologia)
Source: Revista de Neurologia - April 25, 2019 Category: Neurology Authors: Sanz-Garcia A, Perez-Romero M, Pastor J, Sola RG, Vega-Zelaya L, Monasterio F, Torrecilla C, Vega G, Pulido-Rivas P, Ortega GJ Tags: Rev Neurol Source Type: research

Pregnancy and perinatal outcomes of crown−rump length discordance in the first trimester−a retrospective cohort study of dichorionic twin pregnancies after in vitro fertilization
Conclusion(s)Discordant twin pregnancies were at increased risk for one fetal loss prior to 12 weeks’ gestation. Except for birth weight discordance, there was no significant difference between CRL discordance and other adverse perinatal outcomes. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - April 25, 2019 Category: Reproduction Medicine Source Type: research

Continuous venovenous hemodiafiltration in the treatment of newborns with an inborn metabolic disease: a single center experience
Conclusion: CVVHDF is a CRRT modality that can be used to treat newborns with an inborn metabolic disease. Early diagnosis, and commencement of specific medical therapy, diet, and extracorporeal support, if needed, are likely to result in improved short- and long-term outcomes. PMID: 31014046 [PubMed - as supplied by publisher] (Source: Turkish Journal of Medical Sciences)
Source: Turkish Journal of Medical Sciences - April 25, 2019 Category: General Medicine Tags: Turk J Med Sci Source Type: research

Correction to: Early versus late initiation of renal replacement therapy impacts mortality in patients with acute kidney injury post cardiac surgery: a meta-analysis
After publication of this article [1], it was noticed that the affiliations of Honghong Zhou were incorrect. The sole affiliation should be, “Department of Nephrology, the Second Affiliated Hospital of Nanchan... (Source: Critical Care)
Source: Critical Care - April 25, 2019 Category: Intensive Care Authors: Honghong Zou, Qianwen Hong and Gaosi XU Tags: Correction Source Type: research

Biomarkers to guide antibiotic timing and administration in infected patients presenting to the emergency department
(Source: Critical Care)
Source: Critical Care - April 25, 2019 Category: Intensive Care Authors: Mari Rosenqvist, Darius Cameron Wilson, Lena Tegn ér, Maria Bengtsson-Toni, Marjaneh Peyman, Juan Gonzalez del Castillo, Kordo Saeed and Olle Melander Tags: Letter Source Type: research

Lung Ultrasound Guided Fluid Management Protocol for the Critically Ill Patient: study protocol for a multi-centre randomized controlled trial
In routine intensive care unit (ICU) practice, fluids are often administered without a safety limit, which may lead to fluid overload and decreased survival. Recently, B-lines score (BLS) has been validated as... (Source: Trials)
Source: Trials - April 25, 2019 Category: General Medicine Authors: Daniel-Mihai Rusu, Ianis Siriopol, Ioana Grigoras, Mihaela Blaj, Adi-Ionut Ciumanghel, Dimitrie Siriopol, Ionut Nistor, Mihai Onofriescu, Gigel Sandu, Beatrice Cobzaru, Dragos Viorel Scripcariu, Olguta Diaconu and Adrian Constantin Covic Tags: Study protocol Source Type: research

Predictors of Hospital Mortality and the Related Burden of Disease in Severe Traumatic Brain Injury: A Prospective Multicentric Study in Brazil
Fernando Zanela Areas1,2, Marcelo Liborio Schwarzbold1,2,3,4, Alexandre Paim Diaz1,4, Igor Kunze Rodrigues3,5,6, Daniel Santos Sousa3,7, Camila Leite Ferreira8, João Quevedo8,9, Katia Lin1,3,10, Emil Kupek3,11, Cristiane Ritter12,13, Felipe Dal Pizzol3,12,13 and Roger Walz1,2,3,10* 1Centro de Neurociências Aplicadas, Universidade Federal de Santa Catarina, Hospital Universitário, Florianópolis, Brazil 2Programa de Pós-Graduação em Neurociências, UFSC, Florianópolis, Brazil 3Programa de Pós-Graduação em Ciências Médicas, ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Associations of Anemia With Outcomes in Patients With Spontaneous Intracerebral Hemorrhage: A Meta-Analysis
Conclusions: Anemia on admission was associated with higher mortality and an increased risk of poor outcome in patients with ICH. However, the results were limited by the high heterogeneity of included studies. Prospective, multi-center or population-based, large sample cohort studies are needed in the future. Introduction Intracerebral hemorrhage (ICH) is the second most common cause of stroke and a highly lethal disease (1), which still lacks effective therapeutic interventions (2, 3). Although age, baseline ICH volume and neurological status on admission are well-known predictors of outcome of ICH (4), none of t...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Whole-Genome Sequencing of the Opportunistic Yeast Pathogen Candida inconspicua Uncovers Its Hybrid Origin
Verónica Mixão1,2, Antonio Perez Hansen3, Ester Saus1,2, Teun Boekhout4,5, Cornelia Lass-Florl3 and Toni Gabaldón1,2,6* 1Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain 2Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain 3Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria 4Westerdijk Fungal Biodiversity Institute, Utrecht, Netherlands 5Institute of Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, Netherlands 6Institució Catalana de...
Source: Frontiers in Genetics - April 25, 2019 Category: Genetics & Stem Cells Source Type: research

Iron Metabolism and Brain Development in Premature Infants
Yafeng Wang1,2,3, Yanan Wu2, Tao Li1,2,3, Xiaoyang Wang2,4 and Changlian Zhu2,3* 1Department of Neonatology (NICU), Children’s Hospital Affiliated Zhengzhou University, Zhengzhou, China 2Henan Key Laboratory of Child Brain Injury, Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China 3Department of Clinical Neuroscience, Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden 4Department of Physiology, Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Gothenburg, ...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

Systematic Evaluation of the Safety Threshold for Allograft Macrovesicular Steatosis in Cadaveric Liver Transplantation
This study was conducted strictly according to the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) (Moher et al., 2009). A systematic literature search was performed in Pubmed, Embase, and ISI Web of Science using the medical terminologies described in Table S1, with the language restriction limited to English (updated until 20 January 2019). Details of the search strategy in each database are presented in Table S1. Inclusion Criteria Given the study purpose, we attempted to conduct a broad search that included literature involving continuous risks of all post-operational outcome...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

Black, White, and Hispanic Children's Health and Function 2-13  Months After Sibling Intensive Care Unit Death
To describe children's anxiety, depression, behaviors, and school performance at 2-13  months after sibling neonatal/pediatric intensive care unit (NICU/PICU) or emergency department (ED) death and compare these outcomes by child age, sex, race/ethnicity, whether the child saw their sibling in the NICU/PICU/ED, and attended the sibling's funeral. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - April 25, 2019 Category: Pediatrics Authors: JoAnne M. Youngblut, Dorothy Brooten, Teresa Del-Moral, G. Patricia Cantwell, Balagangadhar Totapally, Changwon Yoo Tags: Original Articles Source Type: research

High prevalence of CTX-M-1 group in ESBL-producing enterobacteriaceae infection in intensive care units in southern Chile
Publication date: Available online 24 April 2019Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Monica Pavez, Claudia Troncoso, Irma Osses, Rodrigo Salazar, Vijna Illesca, Patricia Reydet, Claudio Rodriguez, Carolina Chain, Carla Concha, Leticia BarrientosAbstractEnterobacteria-producing extended-spectrum β-lactamases (ESBL) play an important role in healthcare infections, increasing hospitalization time, morbidity and mortality rates. Among several ESBLs that emerge from these pathogens, CTX-M-type enzymes had the most successful global spread in different epidemiological settings. Latin America presen...
Source: The Brazilian Journal of Infectious Diseases - April 24, 2019 Category: Infectious Diseases Source Type: research

Chronic Diarrhea Secondary to Newly Diagnosed VIPoma
We present a case of a male with 6 months of diarrhea and malaise who was found to have significant kidney injury and hypokalemia requiring admission to the medical intensive care unit. Subsequent laboratory evaluation while admitted eventually showed a low stool osmotic gap ( –11 mOsm/kg) consistent with secretory diarrhea, in addition to significantly elevated VIP levels at 940 pg/mL (normal #x3c;75). Cross-sectional imaging with functional Gallium-68 dotatate PET-CT confirmed metastatic functional neuroendocrine tumor indicative of a VIPoma. Pathology on subsequent m etastatic liver lesion aspiration was consisten...
Source: Case Reports in Gastroenterology - April 24, 2019 Category: Gastroenterology Source Type: research

Perception of pain in post-surgical patients in intensive care units.
Authors: López-Alfaro MP, Echarte-Nuin I, Fernández-Sangil P, Moyano-Berardo BM, Goñi-Viguria R Abstract INTRODUCTION: Pain assessment and treatment are essential for ensuring quality of care as well as for improving patient's satisfaction and clinical outcomes. OBJECTIVES: 1) To describe pain perception of surgical patients admitted to our Intensive Care Unit(ICU). 2) To compare the patients' pain perception with the assessment carried out by nurses. 3) To correlate International Pain Outcomes Questionnaire results with socio-demographical data. METHODOLOGY: A prospective descriptive o...
Source: Enfermeria Intensiva - April 24, 2019 Category: Nursing Tags: Enferm Intensiva Source Type: research

Predictive value of plasma cytokines for acute kidney injury following lung resection surgery: Prospective observational study
ConclusionsIncreased postoperative plasma cytokine levels are associated with acute kidney injury after lung resection surgery in our study, which worsens the prognosis. Plasma interleukin-6 may be used as an early indicator for patients at risk of developing acute kidney injury after lung resection surgery.ResumoJustificativa e objetivosos pacientes submetidos à cirurgia de ressecção pulmonar apresentam risco de desenvolver lesão renal aguda pós-operatória. A determinação dos níveis de citocinas permite detectar uma resposta inflamatória precoce. Invest...
Source: Brazilian Journal of Anesthesiology - April 24, 2019 Category: Anesthesiology Source Type: research

Long-term results of liver transplantation for polycystic liver disease: Single-center experience in China.
In conclusion, liver transplantation is the only curative procedure for PLD, and the present study indicated that it is relatively and safe and leads to good long-term prognosis and high quality of life. Based on our experience and results, liver transplantation is a primary option for cases of PLD with progressive or advanced symptomatic disease where previous other forms of therapy to palliate symptoms have been insufficient. PMID: 31007749 [PubMed] (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 24, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Changes of rScO2 and ScvO2 in children with sepsis-related encephalopathy with different prognoses and clinical features.
Authors: Guo J, Cheng Y, Wang Q, Su J, Cui L, Jin Z Abstract Clinical features of sepsis-associated encephalopathy in children with different prognoses were analyzed and the changes of regional cerebral oxygen saturation (rScO2) and central venous oxygen saturation (ScvO2) were measured. Eighty children with sepsis-related encephalopathy, admitted to the Pediatric Intensive Care Unit (PICU) of the Children's Hospital Affiliated to Zhengzhou University, were enrolled in this study and post-intensive care syndrome (PICS) scoring was performed within 24 h after admission. Patients were separated into groups according ...
Source: Experimental and Therapeutic Medicine - April 24, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Peritoneal Dialysis versus Diuretics in Children after Congenital Heart Surgery
ConclusionsThe meta-analysis did not identify differences between the two groups with regards to negative fluid balance after postoperative day 1, incidence of peritonitis or length of intensive care unit stay. There is a need for large, prospective multicenter studies to further evaluate the benefits and complications associated to peritoneal dialysis utilization in selected children after congenital heart surgery. Since some of the outcomes were present in only 2 studies, results from the pooled analysis may be underpower. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - April 24, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Information for Authors
(Source: Heart and Lung)
Source: Heart and Lung - April 24, 2019 Category: Intensive Care Source Type: research

Information for Readers
(Source: Heart and Lung)
Source: Heart and Lung - April 24, 2019 Category: Intensive Care Source Type: research

Board of Directors
(Source: Heart and Lung)
Source: Heart and Lung - April 24, 2019 Category: Intensive Care Source Type: research

Table of Contents
(Source: Heart and Lung)
Source: Heart and Lung - April 24, 2019 Category: Intensive Care Source Type: research

Nighttime and non-business days are not associated with increased risk of in-hospital mortality in patients with severe sepsis in intensive care units in Japan: The JAAM FORECAST study
ConclusionsNighttime and weekends were not associated with increased in-hospital mortality of severe sepsis. (Source: Journal of Critical Care)
Source: Journal of Critical Care - April 24, 2019 Category: Gastroenterology Source Type: research

The Healthcare Conflict Scale: development, validation and reliability testing of a tool for use across clinical settings.
Authors: Forbat L, Mnatzaganian G, Barclay S Abstract Despite the widespread incidence of conflict and its detrimental impact across a range of health-care settings, there is no validated tool with which to measure it. This paper describes the international innovation of a tool to measure staff-family conflict in pediatrics, intensive care, emergency, palliative care, and nursing homes. Sixty-two health-care workers contributed to focus group discussions to refine a draft tool developed from the literature. Subsequently, 101 health-care workers applied the tool to fictionalized vignettes. The psychometric propertie...
Source: Journal of Interprofessional Care - April 24, 2019 Category: Health Management Tags: J Interprof Care Source Type: research

Trial sequential analysis suggested the potential overestimated effect of carbonic anhydrase inhibitor for respiratory failure and metabolic alkalosis
(Source: Critical Care)
Source: Critical Care - April 24, 2019 Category: Intensive Care Authors: Meng-Si Luo, Hui-Zi Li, Guan-Jiang Huang and Lun Wu Tags: Letter Source Type: research

Response to “Incidence of hypotension according to the discontinuation order of vasopressors: a matter of pharmacokinetics”
(Source: Critical Care)
Source: Critical Care - April 24, 2019 Category: Intensive Care Authors: Kyeongman Jeon, Jae-Uk Song and Gee Young Suh Tags: Letter Source Type: research

Intelligently learning from data
(Source: Critical Care)
Source: Critical Care - April 24, 2019 Category: Intensive Care Authors: Edward Palmer, Roman Klapaukh, Steve Harris and Mervyn Singer Tags: Editorial Source Type: research

Determinants of Doppler-based renal resistive index in patients with septic shock: impact of hemodynamic parameters, acute kidney injury and predisposing factors
Increased renal resistive index (RI) measured by Doppler ultrasonography has been shown to be associated with acute kidney injury (AKI) in septic patients. However, its clinical use is limited by poor sensitiv... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - April 24, 2019 Category: Intensive Care Authors: Fran çois Beloncle, Natacha Rousseau, Jean-François Hamel, Alexis Donzeau, Anne-Lise Foucher, Marc-Antoine Custaud, Pierre Asfar, René Robert and Nicolas Lerolle Tags: Research Source Type: research

Diaphragm thickening in cardiac surgery: a perioperative prospective ultrasound study
Diaphragm paresis is common after cardiac surgery and may delay the weaning from the ventilator. Our objective was to evaluate diaphragm thickening during weaning and secondly the muscle thickness as a marker ... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - April 24, 2019 Category: Intensive Care Authors: Pierre-Henri Moury, Adrien Cuisinier, Michel Durand, Jean-Luc Bosson, Olivier Chavanon, Jean-Fran çois Payen, Samir Jaber and Pierre Albaladejo Tags: Research Source Type: research

Composed endotypes to guide antibiotic discontinuation in sepsis
Overuse of empiric antibiotic therapy in the ICU is responsible for promoting the dissemination of multidrug-resistant (MDR) bacteria. Shortened antibiotic treatment duration could contribute to palliating the... (Source: Critical Care)
Source: Critical Care - April 24, 2019 Category: Intensive Care Authors: Jesus F. Bermejo-Martin, David Andaluz-Ojeda, Marta Martin-Fernandez, Cesar Aldecoa and Raquel Almansa Tags: Editorial Source Type: research

Resveratrol Promotes Diabetic Wound Healing via SIRT1-FOXO1-c-Myc Signaling Pathway-Mediated Angiogenesis
Conclusion: Our findings indicate that the positive role of RES in diabetic wound healing via its SIRT1-dependent endothelial protection and pro-angiogenic effects involves the inhibition of FOXO1 and the de-repression of c-Myc expression. Introduction Diabetes mellitus is a metabolic disease with an increasing incidence worldwide (Zimmet et al., 2014). The disease often leads to the development of serious complications such as microangiopathy, mainly including retinopathy, nephropathy, neuropathy, and diabetic non-healing skin ulcers (Zheng et al., 2018). Diabetic non-healing skin ulcers such as foot ulcers are ca...
Source: Frontiers in Pharmacology - April 24, 2019 Category: Drugs & Pharmacology Source Type: research

More Maternal Vascular Malperfusion and Chorioamnionitis in Placentas After Expectant Management vs. Immediate Delivery in Fetal Growth Restriction at (Near) Term: A Further Analysis of the DIGITAT Trial
Marjon E. Feenstra1†, Mirthe H. Schoots2†, Torsten Plösch1, Jelmer R. Prins1, Sicco A. Scherjon1, Albertus Timmer2, Harry van Goor2 and Sanne J. Gordijn1* 1Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands 2Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands Objective: Management of late fetal growth restriction (FGR) is limited to adequate fetal monitoring and optimal timing of delivery. The Disproportionate Intrauterine Growth Intervention ...
Source: Frontiers in Endocrinology - April 24, 2019 Category: Endocrinology Source Type: research

Editorial: Telomeres and Epigenetics in Endocrinology
This study was hypothesis-driven; the genetic variants were selected for being previously and substantially genotyped. The big sample size and the rich panel of other biomarkers allowed the authors to conduct much more detailed analyses on this topic. The third article by Provenzi et al. proposed their perspectives on the role of telomeres in premature birth and discussed the potential implications for early adversity and care in the neonatal intensive care unit (Pavanello et al.). Indeed, the speculation of telomeres in aging begins in the premature aging syndrome. It is thus interesting to examine if telomeres also play...
Source: Frontiers in Endocrinology - April 24, 2019 Category: Endocrinology Source Type: research

Beneficial Effects of Remifentanil Against Excitotoxic Brain Damage in Newborn Mice
Conclusions: In vivo exposure to remifentanil exerts a beneficial effect against excitotoxicity on the developing mouse brain, which is associated with a reduction in the size of ibotenate-induced brain lesion as well as prevention of some behavioral deficits in young mice. The long-term effect of neonatal exposure to remifentanil should be investigated. Introduction The potential neurotoxicity of anesthetics in the perinatal period prompted the US Food and Drug Administration (FDA) to release a drug safety communication warning in 2016 that stated, “repeated or lengthy use of general anesthetics or sedation ...
Source: Frontiers in Neurology - April 24, 2019 Category: Neurology Source Type: research

A Novel Homozygous Non-sense Mutation in the Catalytic Domain of MTHFR Causes Severe 5,10-Methylenetetrahydrofolate Reductase Deficiency
Conclusion: We identified a novel non-sense mutation in MTHFR gene in a single Egyptian family with severe MTHFR deficiency. The present investigation is clinically important, as it adds to the growing list of MTHFR mutations, which might help in genetic counseling of families of affected children and proper genotype-phenotype correlation. Background Severe 5,10-Methylenetetrahydrofolate reductase (MTHFR; OMIM 236250) deficiency is a rare inborn error of metabolism and inherited in an autosomal recessive fashion. It is a very common disorder of folate metabolism and is clinically characterized with low plasma methion...
Source: Frontiers in Neurology - April 24, 2019 Category: Neurology Source Type: research

Impact of bronchial colonization with Candida spp. on the risk of bacterial ventilator-associated pneumonia in the ICU: the FUNGIBACT prospective cohort study
ConclusionIn patients with mechanical ventilation for more than 4  days and multiple organ failure, bronchial colonization withCandida spp. was not associated with VAP, even after adjustment for immune function. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - April 24, 2019 Category: Intensive Care Source Type: research

ICU staffing models and patient outcomes
AbstractThe study by Ogura et al. investigated the association between the structures of intensive care units (ICUs) affecting patient outcomes. A major limitation of this study is that the types of ICUs had not clearly been defined, and the provided definition had been made subjectively. Making an additional questionnaire or site-visits to completely define the types and to clarify the time-coverage is suggested. It would also be worthwhile to analyze whether the existence and density of “certified intensivists” and their involvement contribute to the outcome to determine whether physician quality affects crit...
Source: Journal of Intensive Care - April 24, 2019 Category: Intensive Care Source Type: research

International Analgesia, Sedation, and Delirium Practices: a prospective cohort study
AbstractBackgroundWhile understanding of critical illness and delirium continue to evolve, the impact on clinical practice is often unknown and delayed. Our purpose was to provide insight into practice changes by characterizing analgesia and sedation usage and occurrence of delirium in different years and international regions.MethodsWe performed a retrospective analysis of two multicenter, international, prospective cohort studies. Mechanically ventilated adults were followed for up to 28  days in 2010 and 2016. Proportion of days utilizing sedation, analgesia, and performance of a spontaneous awakening trial (SAT)...
Source: Journal of Intensive Care - April 24, 2019 Category: Intensive Care Source Type: research

Glutamate Transport and Preterm Brain Injury
Silvia Pregnolato1*, Elavazhagan Chakkarapani1, Anthony R. Isles2 and Karen Luyt1 1Department of Neonatal Neurology, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom 2Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom Preterm birth complications are the leading cause of child death worldwide and a top global health priority. Among the survivors, the risk of life-long disabilities is high, including cerebral palsy and impairment of movement, cognition, and behavior. U...
Source: Frontiers in Physiology - April 24, 2019 Category: Physiology Source Type: research

The Fungal CYP51s: Their Functions, Structures, Related Drug Resistance, and Inhibitors
Conclusion and Perspectives CYP51 plays a crucial role in fungal invasive growth, hyphae formation and virulence, and inhibitors targeting CYP51 have always been an important component of antifungal agents. Further researches on fungal CYP51s might set about from the following aspects: First, while the detailed crystal structures of several susceptible pathogenic fungi CYP51 have been elaborated, those of drug-resistant variants are still in hypothesis. If those structures were elucidated, targeting at common drug-resistant CYP51 protein variants could probably be promising. Second, it deserves more in-depth researches to...
Source: Frontiers in Microbiology - April 24, 2019 Category: Microbiology Source Type: research

Same, Same But Different: How the Interplay of Legal Procedures and Structural Factors Can Influence the Use of Coercion
In conclusion, it should be noted that a reduction of coercion in psychiatric settings appears promising if legal procedures and oversight are combined with multiprofessional, patient-centred, and recovery-oriented clinical work relevant to the complexity of any acute crisis situation.Author ContributionsLM, JM, AH, and AW conceived and wrote the paper.Conflict of Interest StatementThe authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.AcknowledgmentsWe acknowledge support from the German Research Foundation...
Source: Frontiers in Psychiatry - April 24, 2019 Category: Psychiatry Source Type: research

Anaphylaxis in Elderly Patients —Data From the European Anaphylaxis Registry
Anaphylaxis in Elderly Patients—Data From the European Anaphylaxis Registry Stefanie Aurich1†, Sabine Dölle-Bierke2†, Wojciech Francuzik2, Maria Beatrice Bilo3, George Christoff4,5, Montserrat Fernandez-Rivas6, Thomas Hawranek7, Claudia Pföhler8, Iwona Poziomkowska-Gȩsicka9, Jean-Marie Renaudin10, Eva Oppel11, Kathrin Scherer12, Regina Treudler1‡ and Margitta Worm2*‡on behalf of The Network for Online Registration of Anaphylaxis(NORA)§ 1Department of Dermatology, Venereology and Allergology, LICA-Comprehensive Allergy Center, University Hospital, Leipzig, Germany 2Di...
Source: Frontiers in Immunology - April 24, 2019 Category: Allergy & Immunology Source Type: research

Combination of Dexmedetomidine and Ketamine for Magnetic Resonance Imaging Sedation
Joong-Goo Kim1,2, Han-Bin Lee2 and Sang-Beom Jeon2* 1Department of Neurology, Jeju National University Hospital, Jeju, South Korea 2Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea Objectives: The use of dexmedetomidine and ketamine (DEX–KET) combination for magnetic resonance imaging (MRI) sedation has not been evaluated. We investigated the efficacy and safety of DEX–KET for sedation of patients undergoing MRI of the brain. Methods: This quasi-experimental study was conducted to compare the DEX–KET combination and midazolam for MRI sed...
Source: Frontiers in Neurology - April 24, 2019 Category: Neurology Source Type: research

A Network Comparative Meta-analysis of Percutaneous Dilatational Tracheostomies Using Anatomic Landmarks, Bronchoscopic, and Ultrasound Guidance Versus Open Surgical Tracheostomy
ConclusionsThe results of our network meta-analysis show that all tracheostomy techniques are comparable with respect to associated procedure-related complications, but all three percutaneous techniques take far less procedure time compared to the surgical tracheostomy. (Source: Lung)
Source: Lung - April 24, 2019 Category: Respiratory Medicine Source Type: research

Understanding the role of host response in influenza pneumonitis
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - April 24, 2019 Category: Intensive Care Source Type: research

Lung nodule classification using deep Local –Global networks
AbstractPurposeLung nodules have very diverse shapes and sizes, which makes classifying them as benign/malignant a challenging problem. In this paper, we propose a novel method to predict the malignancy of nodules that have the capability to analyze the shape and size of a nodule using a global feature extractor, as well as the density and structure of the nodule using a local feature extractor.MethodsWe propose to use Residual Blocks with a 3  × 3 kernel size for local feature extraction and Non-Local Blocks to extract the global features. The Non-Local Block has the ability to extract global features ...
Source: International Journal of Computer Assisted Radiology and Surgery - April 24, 2019 Category: Intensive Care Source Type: research

Balloon pulmonary angioplasty attenuates sleep apnea in patients with chronic thromboembolic pulmonary hypertension
Balloon pulmonary angioplasty (BPA) improves pulmonary hemodynamics in chronic thromboembolic pulmonary hypertension (CTEPH) patients. However, whether it affects the severity of sleep apnea (SA) remains unknown. We investigated the effect of BPA on the severity of SA in CTEPH patients. (Source: Heart and Lung)
Source: Heart and Lung - April 24, 2019 Category: Intensive Care Authors: Takashi Kohno, Ryoma Fukuoka, Takashi Kawakami, Masaharu Kataoka, Mai Kimura, Motoaki Sano, Keiichi Fukuda Source Type: research

[Research Articles] Diagnosis of genetic diseases in seriously ill children by rapid whole-genome sequencing and automated phenotyping and interpretation
We describe a platform for population-scale, provisional diagnosis of genetic diseases with automated phenotyping and interpretation. Genome sequencing was expedited by bead-based genome library preparation directly from blood samples and sequencing of paired 100-nt reads in 15.5 hours. Clinical natural language processing (CNLP) automatically extracted children’s deep phenomes from electronic health records with 80% precision and 93% recall. In 101 children with 105 genetic diseases, a mean of 4.3 CNLP-extracted phenotypic features matched the expected phenotypic features of those diseases, compared with a match of ...
Source: Science Translational Medicine - April 24, 2019 Category: Biomedical Science Authors: Clark, M. M., Hildreth, A., Batalov, S., Ding, Y., Chowdhury, S., Watkins, K., Ellsworth, K., Camp, B., Kint, C. I., Yacoubian, C., Farnaes, L., Bainbridge, M. N., Beebe, C., Braun, J. J. A., Bray, M., Carroll, J., Cakici, J. A., Caylor, S. A., Clarke, C. Tags: Research Articles Source Type: research