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The influence of ovulation induction and assisted conception on maternal and perinatal outcomes of twin pregnancies.
CONCLUSIONS: Assisted conception was associated with adverse obstetrical outcomes and lower gestational age, but after adjustment for gestational age neonatal immediate outcomes were similar to those observed in the spontaneous group. There were no many important differences in the outcomes of twin pregnancies obtained by a different type of conception. PMID: 29028104 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - October 17, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Evaluation of the role of 8-iso-PGF levels at multiple sites during intracranial hemorrhage in pediatric patients.
Authors: Qi BX, Yao H, Shang L, Sheng LP, Wang XC, Zhu L, Zhang XX, Wang JP, Fang DH Abstract OBJECTIVE: The present study was planned to explore the role of 8-isomeric-prostaglandinF2α (8-iso-PGF2α) levels at the multiple sites of cerebrospinal fluid in children with intracranial hemorrhage. PATIENTS AND METHODS: 90 children with intracranial hemorrhage were admitted to Surgery Intensive Care Unit (SICU) of our hospital from January to December 2013 and were selected as study subjects. They were divided into group A (n=30), group B (n=30) and group C (n=30). The group A was given conventional treat...
Source: European Review for Medical and Pharmacological Sciences - October 17, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

The Prognostic Value of Central Venous-to-Arterial CO2 Difference/Arterial-Central Venous O2 Difference Ratio in Septic Shock Patients with Central Venous O2 Saturation ≥80%
Conclusions: The P(v-a)CO2/C(a-v)O2 ratio is an independent predictor of ICU mortality in septic shock patients with high ScvO2 after resuscitation. It is worthy of consideration to recruit microcirculation to correct the high ratio in high ScvO2 case. (Source: Shock)
Source: Shock - October 17, 2017 Category: Emergency Medicine Tags: Clinical Science Aspects Source Type: research

Target Serum Sodium Levels During Intensive Care Unit Management of Aneurysmal Subarachnoid Hemorrhage
Introduction: Dysnatremia commonly occur in the intensive care unit (ICU) management of patients with aneurysmal subarachnoid hemorrhage (SAH). However, detailed management strategies have not been provided even by current guidelines. The purposes of this study were to examine the association of abnormal serum sodium levels with unfavorable neurologic outcomes and to identify the target range of serum sodium in patients with SAH. Methods: We retrospectively reviewed all patients who were consecutively hospitalized with a confirmed diagnosis of SAH between January 2009 and December 2015. Univariate/multivariate analyses we...
Source: Shock - October 17, 2017 Category: Emergency Medicine Tags: Clinical Science Aspects Source Type: research

[Translation and Validation of the FOUR Scale for Children and its Use as Outcome Predictor: A Pilot Study].
CONCLUSION: The FOUR scale can be applied in patients admitted with impaired consciousness in Pediatric Intensive Care Units. We think that a multicenter study would be very beneficial for confirming and generalizing these results. PMID: 29025525 [PubMed - in process] (Source: Acta Medica Portuguesa)
Source: Acta Medica Portuguesa - October 16, 2017 Category: General Medicine Tags: Acta Med Port Source Type: research

Extracorporeal membrane oxygenation in acute respiratory distress syndrome due to influenza A (H1N1)pdm09 pneumonia. A single-center experience during the 2013-2014 season
Conclusion: The survivors were relatively young and discharged with good functional status (i.e., enhancing quality-adjusted life-years-saved). Our experience shows that even a relatively new extracorporeal membrane oxygenation program can play an important role in that capacity and provide excellent outcomes for the sickest patients. (Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - October 16, 2017 Category: Intensive Care Source Type: research

Functional ability in younger and older elderlies after discharge from the intensive care unit. A prospective cohort
RESUMO Objetivo: Comparar a capacidade funcional de indiv íduos idosos (60 a 79 anos) com a dos idosos mais velhos ( ≥ 80 anos) nos primeiros 6 meses ap ós a alta da unidade de terapia intensiva. Métodos: Coorte prospectiva multicêntrica, na qual foram coletados dados referentes à internação na unidade de terapia intensiva e aos desfechos após a alta hospitalar (no pós-alta imediato, após 3 meses e após 6 meses). A força muscular foi ava liada por meio do protocolo do Medical Research Council e da dinamometria (preensão palmar); a ...
Source: Revista Brasileira de Terapia Intensiva - October 16, 2017 Category: Intensive Care Source Type: research

Contrast-induced acute kidney injury: the importance of diagnostic criteria for establishing prevalence and prognosis in the intensive care unit
Conclusion: The diagnosis of contrast-induced nephropathy was the most sensitive criterion for renal replacement therapy and death, whereas KDIGO showed the highest specificity; there was no correlation between contrast volume and progression to contrast-induced acute kidney injury, contrast-induced nephropathy, support dialysis or death in the assessed population. (Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - October 16, 2017 Category: Intensive Care Source Type: research

Systemic inflammatory response syndrome criteria and the prediction of hospital mortality in critically ill patients: a retrospective cohort study
RESUMO Objetivo: Determinar se os crit érios para definição de síndrome de resposta inflamatória sistêmica podem predizer a mortalidade hospitalar em uma coorte brasileira de pacientes críticos. Métodos: Conduzimos um estudo retrospectivo de coorte em um hospital terciário privado localizado na cidade de São Paulo (SP). Extraí mos as informações da base de dados de uma unidade de terapia intensiva para adultos (Sistema EpimedTM). Comparamos o SAPS 3 e o modelo da síndrome de resposta inflamatória sistêmica de forma...
Source: Revista Brasileira de Terapia Intensiva - October 16, 2017 Category: Intensive Care Source Type: research

Immediate postoperative of bariatric surgery in the intensive care unit versus an inpatient unit. A retrospective study with 828 patients
RESUMO Objetivo: Comparar a incid ência de complicações e a duração da hospitalização de pacientes submetidos à cirurgia bariátrica internados na unidade de terapia intensiva ou de internação pós-cirúrgica. Métodos: Estudo observacional, retrospectivo, que incluiu 828 pacientes admitidos entre janeiro de 2010 e fevere iro de 2015 em pós-operatório imediato de cirurgia bariátrica em um hospital. Os dados foram coletados em prontuários eletrônicos. As variáveis contínuas foram compa...
Source: Revista Brasileira de Terapia Intensiva - October 16, 2017 Category: Intensive Care Source Type: research

Antimicrobial drug-related problems in a neonatal intensive care unit
Conclusion: The use of antimicrobials in the neonatal intensive care is mainly associated with problems related to medication effectivenes s, predominantly the prescription of subdoses of antimicrobials, especially aminoglycosides. (Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - October 16, 2017 Category: Intensive Care Source Type: research

Delirium in a Latin American intensive care unit. A prospective cohort study of mechanically ventilated patients
Conclusion: This Latin American prospective cohort investigation confirmed specific factors important for the development of delirium and the outcome of death among general intensive care unit patients. In both analyses, we found that the duration of mechanical ventilation was a predictor of untoward outcomes. (Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - October 16, 2017 Category: Intensive Care Source Type: research

Fluid overload in children undergoing mechanical ventilation
RESUMO Os pacientes admitidos em uma unidade de terapia intensiva est ão sujeitos à sobrecarga fluídica acumulada e recebem volume endovenoso pela ressuscitação agressiva, preconizada nas recomendações de tratamento do choque séptico, além de outras fontes de líquidos relacionadas às medicações e ao suporte nutricional. A estratégia liberal de oferta hí drica tem sido associada a maiores morbidade e mortalidade. Apesar de haver poucos estudos prospectivos pediátricos, novas estratégias estão sendo p...
Source: Revista Brasileira de Terapia Intensiva - October 16, 2017 Category: Intensive Care Source Type: research

Dysglycemia in the critically ill patient: current evidence and future perspectives
RESUMEN La disglucemia en el paciente cr ítico (hiperglucemia, hipoglucemia, variabilidad de la glucemia y el tiempo en rango) es un marcador de severidad de la enfermedad crítica asociada a mayor mortalidad. Sin embargo, dicho impacto parece atenuarse en los pacientes con diabetes mellitus, en particular en aquellos con mal control gluc émico premórbido lo cual ha sido denominado "paradoja de la diabetes". Este fenómeno determina que en los nuevos protocolos de control de la glucemia deban ser contemplados los valores de hemoglobina glucosilada (HbA1c) al ingreso a unidad de cu...
Source: Revista Brasileira de Terapia Intensiva - October 16, 2017 Category: Intensive Care Source Type: research

Heart conduction system defects and sustained ventricular tachycardia complications in a patient with granulomatosis with polyangiitis. A case report and literature review
RESUMO A granulomatose com poliangi íte é um raro distúrbio inflamatório sistêmico que se caracteriza por vasculite de pequenas artérias, arteríolas e capilares, associada a lesões granulomatosas necrotizantes. Este artigo relata o caso de uma paciente com diagnóstico prévio de granulomatose com poliangiíte, admitida à uni dade de terapia intensiva com quadro de crises convulsivas e instabilidade hemodinâmica em razão de bloqueio atrioventricular completo. Estas manifestações se associaram a múltiplos epis&o...
Source: Revista Brasileira de Terapia Intensiva - October 16, 2017 Category: Intensive Care Source Type: research

Influence of dentistry professionals and oral health assistance protocols on intensive care unit nursing staff. A survey study
RESUMO A granulomatose com poliangi íte é um raro distúrbio inflamatório sistêmico que se caracteriza por vasculite de pequenas artérias, arteríolas e capilares, associada a lesões granulomatosas necrotizantes. Este artigo relata o caso de uma paciente com diagnóstico prévio de granulomatose com poliangiíte, admitida à uni dade de terapia intensiva com quadro de crises convulsivas e instabilidade hemodinâmica em razão de bloqueio atrioventricular completo. Estas manifestações se associaram a múltiplos epis&o...
Source: Revista Brasileira de Terapia Intensiva - October 16, 2017 Category: Intensive Care Source Type: research

Oral histoplasmosis
RESUMO A granulomatose com poliangi íte é um raro distúrbio inflamatório sistêmico que se caracteriza por vasculite de pequenas artérias, arteríolas e capilares, associada a lesões granulomatosas necrotizantes. Este artigo relata o caso de uma paciente com diagnóstico prévio de granulomatose com poliangiíte, admitida à uni dade de terapia intensiva com quadro de crises convulsivas e instabilidade hemodinâmica em razão de bloqueio atrioventricular completo. Estas manifestações se associaram a múltiplos epis&o...
Source: Revista Brasileira de Terapia Intensiva - October 16, 2017 Category: Intensive Care Source Type: research

Accidental breakage of needle during subclavian vein catheterization: an adversity uncalled for!
RESUMO A granulomatose com poliangi íte é um raro distúrbio inflamatório sistêmico que se caracteriza por vasculite de pequenas artérias, arteríolas e capilares, associada a lesões granulomatosas necrotizantes. Este artigo relata o caso de uma paciente com diagnóstico prévio de granulomatose com poliangiíte, admitida à uni dade de terapia intensiva com quadro de crises convulsivas e instabilidade hemodinâmica em razão de bloqueio atrioventricular completo. Estas manifestações se associaram a múltiplos epis&o...
Source: Revista Brasileira de Terapia Intensiva - October 16, 2017 Category: Intensive Care Source Type: research

Clinical Features and Antimicrobial Resistance of Bacterial Agents of Ventilator-Associated Tracheobronchitis in Hamedan, Iran.
This study was conducted to evaluate the clinical course, etiology, and antimicrobial resistance of bacterial agents of VAT in ICUs in Hamedan, Iran. METHODS: During a 12-month period, all patients with VAT in a medical and a surgical ICU were included. The criteria for the diagnosis of VAT were fever, mucus production, a positive culture of tracheal secretions, and the absence of lung infiltration. Clinical course, including changes in temperature and tracheal secretions, and outcomes were followed. The endotracheal aspirates were cultured on blood agar and chocolate agar, and antimicrobial susceptibility testing of i...
Source: Oman Medical Journal - October 16, 2017 Category: Middle East Health Tags: Oman Med J Source Type: research

Pertussis and Pertussis like Illness: Pediatric Experience in Oman.
Authors: Al Maani A, Al Qayoudhi A, Nazir HF, Omar H, Al Jardani A, Al Muharrmi Z, Wali Y Abstract OBJECTIVES: A resurgence of pertussis or whooping cough has been observed worldwide despite broad vaccination coverage. Pertussis like illness (PLI) refers to a clinical syndrome compatible with pertussis infection but lacking laboratory confirmation or an epidemiological link to a confirmed case. Our study aimed to estimate the contribution of Bordetella pertussis infection and identifying predictors of its diagnosis in a cohort of children with PLI. METHODS: Demographic and clinical information were retrospectiv...
Source: Oman Medical Journal - October 16, 2017 Category: Middle East Health Tags: Oman Med J Source Type: research

An audit of traumatic brain injury (TBI) in a busy developing-world trauma service exposes a significant deficit in resources available to manage severe TBI.
CONCLUSION: There is a significant burden of TBI managed by the PMTS. Critical care resources available to manage patients with TBI are inadequate. PMID: 29025454 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - October 16, 2017 Category: African Health Tags: S Afr Med J Source Type: research

Non-infectious Fever After Acute Spinal Cord Injury in the Intensive Care Unit.
Authors: Ülger F, Pehlivanlar Küçük M, Öztürk ÇE, Aksoy İ, Küçük AO, Murat N Abstract Objective The aim of the present study is to evaluate the frequency, etiology, risk factors and clinical outcomes in acute traumatic SCI patients who develop fever and to evaluate the relationship between fever and mortality. Design Retrospective data were collected between January 2007 and August 2016 from patients diagnosed with persistent fever from SCI cases observed in the ICU. Participants Among 5370 intensive care patients, 435 SCI patients were evaluated for the pres...
Source: Journal of Spinal Cord Medicine - October 16, 2017 Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research

Home supply of emergency oral steroids and reduction in asthma healthcare utilization
Abstract ObjectiveTo determine if children with moderate‐to‐severe persistent asthma have decreased healthcare utilization after receiving a prescription and instructions to use an at home emergency supply of oral steroids during asthma exacerbations. MethodsA quasi‐experimental design study with a historical control from retrospective chart review was performed for patients aged 2‐18 years seen in a tertiary care pediatric pulmonary clinic for moderate to severe persistent asthma. Baseline utilization of the emergency department, inpatient hospital, and pediatric intensive care unit for asthma exacerbations was co...
Source: Pediatric Pulmonology - October 16, 2017 Category: Respiratory Medicine Authors: Lisa M. Sarzynski, Tiffany Turner, David R. Stukus, Elizabeth Allen Tags: ORIGINAL ARTICLE: ASTHMA Source Type: research

Factors associated with demoralisation syndrome in patients before and after cardiac surgery
Aims and objectivesTo investigate the incidence of and contributors to demoralisation syndrome among patients before and after cardiac surgery. BackgroundDemoralisation syndrome is a common but neglected phenomenon in nursing practice. Patients who require cardiac surgery experience demoralisation syndrome more often than they experience depression. DesignA prospective correlational design was applied. MethodsA convenience sample of 76 participants undergoing cardiac surgery was recruited from the cardiovascular wards of two medical centres in Taiwan. The instruments applied included the Demoralization Scale (DS), the Pati...
Source: Journal of Clinical Nursing - October 16, 2017 Category: Nursing Authors: Hsiu ‐Yun Liao, Chaw‐Chi Chiu, Ying‐Ying Ko, Hsing‐Mei Chen Tags: ORIGINAL ARTICLE Source Type: research

Antibiotic stewardship in the newborn surgical patient: A  quality improvement project in the neonatal intensive care unit
There is significant diversity in the utilization of antibiotics for neonates undergoing surgical procedures. Our institution standardized antibiotic administration for surgical neonates, in which no empiric antibiotics were given to infants with surgical conditions postnatally, and antibiotics are given no more than 72  hours perioperatively. (Source: Surgery)
Source: Surgery - October 16, 2017 Category: Surgery Authors: Sarah Walker, Ankur Datta, Roxanne L. Massoumi, Erica R. Gross, Michael Uhing, Marjorie J. Arca Tags: Society of University Surgeons Source Type: research

Muscle specific differences in expression and phosphorylation of the Janus kinase 2/ Signal Transducer and Activator of Transcription 3 following long ‐term mechanical ventilation and immobilization in rats
ConclusionThe JAK2/STAT3 pathway was differentially activated in plantaris, intercostal, and diaphragm muscles in response to the ICU condition. Thus, JAK2/STAT3 inhibitors may provide an attractive pharmacological intervention strategy in immobilized ICU patients, but further experimental studies are required in the study of muscle‐specific effects on muscle mass and function in response to both short‐ and long‐term exposure to the ICU condition prior to the translation into clinical research and practice.This article is protected by copyright. All rights reserved. (Source: Acta Physiologica)
Source: Acta Physiologica - October 15, 2017 Category: Physiology Authors: Heba Salah, Wen Fury, Jesper Gromada, Yu Bai, Tamar Tchkonia, James L. Kirkland, Lars Larsson Tags: Regular Paper Source Type: research

Comments on preoperative severe hypoalbuminemia is associated with an increased risk of postoperative delirium in elderly patients: Results of a secondary analysis
We have read the study conducted by Zhang and colleagues [1] that was published in journal of critical care, enthusiastically and meticulously. The authors tried to evaluate the association between the severity of preoperative hypoalbuminemia and the occurrence of postoperative delirium after adjusting for confounders [1]. (Source: Journal of Critical Care)
Source: Journal of Critical Care - October 15, 2017 Category: Intensive Care Authors: Saeid Safiri, Hamid Mansourpour, Erfan Ayubi Source Type: research

End-organ recovery post-ventricular assist device can prognosticate survival
This study examines our institutional ventricular assist devices (VADs) experience over two decades to understand trends towards predictors of mortality. (Source: Journal of Critical Care)
Source: Journal of Critical Care - October 15, 2017 Category: Intensive Care Authors: Joseph Philip, Dalia Lopez-Colon, Ravi S. Samraj, Giridhar Kaliki-Venkata, Maria V. Irwin, Biagio A. Pietra, Frederick J. Fricker, Mark S. Bleiweis Source Type: research

Predictors of hemodynamic derangement during intubation in the critically ill: A nested case-control study of hemodynamic management - Part II
Our primary aim was to identify predictors of immediate hemodynamic decompensation during the peri-intubation period. (Source: Journal of Critical Care)
Source: Journal of Critical Care - October 15, 2017 Category: Intensive Care Authors: Nathan J. Smischney, Mohamed O. Seisa, Katherine J. Heise, Robert A. Wiegand, Kyle D. Busack, Jillian L. Deangelis, Theodore O. Loftsgard, Darrell R. Schroeder, Daniel A. Diedrich Source Type: research

HIV-positive patients in the intensive care unit: A retrospective audit.
CONCLUSIONS: Respiratory illnesses remain the main indication for ICU in HIV-positive patients. HIV infection is often diagnosed late, with patients presenting with life-threatening illnesses. Severity of illness as indicated by a high APACHE ΙΙ score, multiple organ dysfunction requiring inotropic support and RRT, rather than receipt of HAART, CD4 count and diagnosis at ICU admission, are predictors of ICU and hospital mortality. PMID: 29022532 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - October 14, 2017 Category: African Health Tags: S Afr Med J Source Type: research

Genotyping of PPAR- γ gene polymorphism in Egyptian neonates affected with sepsis disease and its severity
Conclusion PPAR-γ gene has been suggested to be a candidate gene for neonatal sepsis. Therefore, Pro12Ala polymorphism might be useful in predicting the risk factor of neonatal sepsis and its severity. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - October 14, 2017 Category: Genetics & Stem Cells Source Type: research

Building blocks for institutional preparation of CTL019 delivery
Publication date: September 2017 Source:Cytotherapy, Volume 19, Issue 9 Author(s): Joseph McGuirk, Edmund K. Waller, Muna Qayed, Sunil Abhyankar, Solveig Ericson, Peter Holman, Christopher Keir, G. Douglas Myers Chimeric antigen receptor (CAR) T-cell therapy is an investigational immunocellular therapy that reprograms a patient's cytotoxic T cells to engage and eliminate malignant cells. CAR T-cell therapies targeting the CD19 antigen have demonstrated high efficacy in clinical trials for patients with B-cell malignancies and may potentially be available on a broader scale in the future. CAR T-cell therapy begins with the...
Source: Cytotherapy - October 14, 2017 Category: Cytology Source Type: research

Developing minimum clinical standards for physiotherapy in South African intensive care units: a mixed method approach
Volume 19, Issue sup1, October 2017, Page 31-33 . (Source: European Journal of Physiotherapy)
Source: European Journal of Physiotherapy - October 14, 2017 Category: Rehabilitation Authors: Natascha Plani Heleen van Aswegen Shane Patman Susan Hanekom Source Type: research

Computer-based radiological longitudinal evaluation of meningiomas following stereotactic radiosurgery
ConclusionOur algorithm yields more reliable and accurate tumor volume change measurements than other stand-alone segmentation methods. It may be a useful tool for quantitative meningioma prognosis evaluation after SRS. (Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - October 14, 2017 Category: Intensive Care Source Type: research

Super-refractory nonconvulsive status epilepticus due to self-poisoning with metaldehyde
Conclusion This clinical case highlights that in comatose patients as consequence of metaldehyde poisoning, a v-EEG evaluation should be perform in order to rule out the existence of NCSE. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - October 14, 2017 Category: Neuroscience Source Type: research

High serum soluble CD40L levels previously to liver transplantation in patients with hepatocellular carcinoma are associated with mortality at one year: Methodological issues
We read the paper by Lorente and colleagues that was published in 2017, with great interest [1]. The authors purposed to assess whether there is an association between circulating soluble form CD40L (sCD40L) levels and survival in patients with hepatocellular carcinoma underwent to liver transplantation (LT). Based on logistic regression, they found that serum sCD40L levels higher than 321pg/mL and age of LT deceased donor were associated with death at 1year. Undoubtedly, the authors have conducted valuable study but some methodological and statistical points need to be considered. (Source: Journal of Critical Care)
Source: Journal of Critical Care - October 14, 2017 Category: Intensive Care Authors: Saeid Safiri, Ahad Ashrafi-Asgarabad Source Type: research

Outbreak Caused by Escherichia coli O18: K1: H7 Sequence Type 95 in a Neonatal Intensive Care Unit in Barcelona, Spain
Conclusions: All the E. coli isolates responsible for this outbreak belonged to a single clone suggesting a common source of infection, and it was categorized as O18:K1:H7. Despite the bacteria’s pathogenicity has an important role in the severity of infection, the host-associated factors were crucial for the fatal outcomes. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - October 13, 2017 Category: Infectious Diseases Tags: Maternal-Neonatal Reports Source Type: research

Pharyngeal Myiasis Caused by Sheep Botfly, Oestrus ovis (Diptera: Oestridae) Larva, Tabriz, East Azarbaijan Province, Iran: a Case Report.
This report aims to present a case of pharyngeal myiasis caused by the larvae of Oestrus ovis (Diptera: Oestridae). A 55-yr old drug addict living in the Shahindeje village of Western Azerbaijan Province, northwestern Iran was referred to the Emam Reza Hospital in Tabriz, having a medical history of Chronic Obstructive Pulmonary Disease (COPD) and hospitalized due to respiratory distress, 20 days ago. He was intubated with a mechanical ventilator (MV) because of his respiratory distress condition. There was an evidence of the presence of pulmonary nodules in his lungs following diagnosis, and a CT scan revealed a cavity in...
Source: Iranian Journal of Arthropod-Borne Diseases - October 13, 2017 Category: Infectious Diseases Tags: J Arthropod Borne Dis Source Type: research

RABBIT risk score and ICU admission due to infection in patients with rheumatoid arthritis
AbstractRheumatoid arthritis (RA) patients are at increased risk of infection. Aim of the present study was to investigate whether RA patients admitted to an intensive care unit (ICU) due to infection have higher Rheumatoid Arthritis Observation of Biologic Therapy (RABBIT) risk scores compared to control RA patients. Seventy-four RA patients (32.4% male) admitted to an ICU due to infection (from January 2002 to December 2013) and 74 frequency-matched control RA patients (16.2% male) were included in this cross-sectional study. There was strong evidence for a higher RABBIT risk score in ICU patients (median 2.0; IQR 1.3 &n...
Source: Clinical Rheumatology - October 13, 2017 Category: Rheumatology Source Type: research

Safety Study of Autologous Adult Bone Marrow Derived Mesenchymal Stromal Cells in Idiopathic Pulmonary Fibrosis - Pilot Data
Conclusions BMSC central line infusion in “no option” IPF cases provided an insight into the strategies in improving the quality of life for patient and thereby increasing the therapeutic window period for lung transplantation. (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - October 13, 2017 Category: Research Source Type: research

Bedside implantation of a new temporary vena cava inferior filter - Safety and efficacy results of the European ANGEL-Registry
Pulmonary embolism (PE) is a frequently occurring complication in critically ill patients. Simultaneous occurrence of PE and life-threatening bleeding, may render medical anticoagulation impossible. For these patients, inferior vena cava filters (IVCF) present a valuable therapeutic alternative. The Angel ® catheter is a novel IVCF that provides temporary protection from PE and is implanted at bedside.The primary objective of the European Angel® catheter registry is to evaluate the safety and efficacy of this IVCF. (Source: Journal of Critical Care)
Source: Journal of Critical Care - October 13, 2017 Category: Intensive Care Authors: Stefan Baumann, Tobias Becher, Konstantinos Giannakopoulos, Claude Jabbour, Marlon Rutsch, Christian Fastner, Ibrahim El-Battrawy, Uzair Ansari, Dirk Lossnitzer, Michael Behnes, Angelika Alonso, Thomas Kirschning, Guido Michels, Daniel Stern, Ruediger Dis Source Type: research

Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections.
de Lange DW, Deliberato RO, Lima SS, Maravić-Stojković V, Verduri A, Cao B, Shehabi Y, Beishuizen A, Jensen JS, Corti C, Van Oers JA, Falsey AR, de Jong E, Oliveira CF, Beghe B, Briel M, Mueller B Abstract BACKGROUND: Acute respiratory infections (ARIs) comprise of a large and heterogeneous group of infections including bacterial, viral, and other aetiologies. In recent years, procalcitonin (PCT), a blood marker for bacterial infections, has emerged as a promising tool to improve decisions about antibiotic therapy (PCT-guided antibiotic therapy). Several randomised controlled trials (RCTs) have demonstrated the...
Source: Cochrane Database of Systematic Reviews - October 13, 2017 Category: General Medicine Authors: Schuetz P, Wirz Y, Sager R, Christ-Crain M, Stolz D, Tamm M, Bouadma L, Luyt CE, Wolff M, Chastre J, Tubach F, Kristoffersen KB, Burkhardt O, Welte T, Schroeder S, Nobre V, Wei L, Bucher HC, Bhatnagar N, Annane D, Reinhart K, Branche A, Damas P, Nijsten M Tags: Cochrane Database Syst Rev Source Type: research

Point-of-care transcranial Doppler by intensivists
AbstractIn the unconscious patient, there is a diagnostic void between the neurologic physical exam, and more invasive, costly and potentially harmful investigations. Transcranial color-coded sonography and two-dimensional transcranial Doppler imaging of the brain have the potential to be a middle ground to bridge this gap for certain diagnoses. With the increasing availability of point-of-care ultrasound devices, coupled with the need for rapid diagnosis of deteriorating neurologic patients, intensivists may be trained to perform point-of-care transcranial Doppler at the bedside. The feasibility and value of this techniqu...
Source: Critical Ultrasound Journal - October 13, 2017 Category: Radiology Source Type: research

Effects of regional perfusion block in healthy and injured lungs
Severe hypoperfusion can cause lung damage. We studied the effects of regional perfusion block in normal lungs and in the lungs that had been conditioned by lavage with 500  ml saline and high V ... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - October 13, 2017 Category: Surgery Authors: Barbara Cambiaghi, Francesco Vasques, Onnen M örer, Christian Ritter, Tommaso Mauri, Nils Kunze-Szikszay, Karin Holke, Francesca Collino, Giorgia Maiolo, Francesca Rapetti, Elias Schulze-Kalthoff, Tommaso Tonetti, Günter Hahn, Michael Quintel and Lucian Tags: Research Source Type: research

Pharmacokinetics of S ‐ketamine during prolonged sedation at the pediatric intensive care unit
ConclusionSubstantial interpatient variability in pharmacokinetics in children complicates the development of adequate dosage regimen for continuous sedation. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - October 13, 2017 Category: Anesthesiology Authors: Robert B. Flint, Carole N. M. Brouwer, Anne S. C. Kr änzlin, Loraine Lie‐A‐Huen, Albert P. Bos, Ron A. A. Mathôt Tags: RESEARCH REPORT Source Type: research

Veno-Arterial-ECMO in the Intensive Care Unit:From Technical Aspects to Clinical Practice
Publication date: Available online 13 October 2017 Source:Anaesthesia Critical Care & Pain Medicine Author(s): Arthur Le Gall, Arnaud Follin, Bernard Cholley, Jean Mantz, Nadia Aissaoui, Romain Pirracchio The use of Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) as a salvage therapy in cardiogenic shock is becoming of current practice. While VA-ECMO is potentially a life-saving technique, results are sometimes mitigated, emphasising the need for selecting the right indication in the right patient. This relies upon a clear definition of the individual therapeutic project, including the potential for re...
Source: Anaesthesia, Critical Care and Pain Medicine - October 13, 2017 Category: Anesthesiology Source Type: research

The Effect of a Pediatric Intensive Care Severity-Tiered Pathway for Status Asthmaticus on Quality Measures and Outcomes
Pediatric Allergy, Immunology, and Pulmonology , Vol. 0, No. 0. (Source: Pediatric, Allergy, Immunology, and Pulmonology)
Source: Pediatric, Allergy, Immunology, and Pulmonology - October 13, 2017 Category: Respiratory Medicine Authors: Molly Phillips John Fahrenbach Mridul Khanolkar Jason M. Kane Source Type: research

Nutrition Therapy in Sepsis
Sepsis is characterized by early massive catabolism, lean body mass (LBM) loss, and escalating hypermetabolism persisting for months to years. Early enteral nutrition should attempt to correct micronutrient/vitamin deficiencies, deliver adequate protein and moderated nonprotein calories, as well-nourished patients can generate reasonable endogenous energy. After resuscitation, increasing protein/calories are needed to attenuate LBM loss and promote recovery. Malnutrition screening is essential, and parenteral nutrition can be safely added when enteral nutrition is failing based on preillness malnutrition. Following dischar...
Source: Critical Care Clinics - October 13, 2017 Category: Intensive Care Authors: Paul E. Wischmeyer Source Type: research

Generalized lymphoma with a displacing mass in the orbital cavity of a Pacific parrotlet ( Forpus coelestis )
AbstractIn this case report, a 4.5-year-old Pacific parrotlet (Forpus coelestis) with a generalized hematopoietic neoplasia is described. The patient was presented with severe unilateral exophthalmos of the right eye and a poor general health condition. Neither in the general nor the ophthalmologic, nor the subsequent microbiological and mycological examination signs of infection were detected, and molecular tests forChlamydia psittaci were negative. As the bird ’s condition decreased despite intensive care treatment, euthanasia was performed. Postmortem examination revealed a large, space-occupying, bloody mass in t...
Source: Comparative Clinical Pathology - October 12, 2017 Category: Pathology Source Type: research

External Validation of Survival-Predicting Models for Acute Myocardial Infarction with Extracorporeal Cardiopulmonary Resuscitation in a Chinese Single-Center Cohort.
CONCLUSIONS The ECPR and SHOCK models possess important abilities to predict intrahospital outcomes of AMI patients treated with E-CPR. PMID: 28993606 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 12, 2017 Category: Research Tags: Med Sci Monit Source Type: research