Haloperidol, Ziprasidone Found Ineffective in Treating Patients With Delirium in the ICU
Neither haloperidol nor ziprasidone, medications commonly used to treat psychosis, had any benefit over placebo in treating patients for delirium in the intensive care unit (ICU), according to astudy published Monday in theNew England Journal of Medicine.“For more than 40 years, intravenous antipsychotic medications have been used to treat delirium in hospitalized patients,” wrote E.W. Ely, M.D., of the Vanderbilt University Medical Center and colleagues. “In this double-blind, randomized, placebo-controlled trial of intravenous antipsychotic medications for the treatment of delirium in the ICU, there was...
Source: Psychiatr News - October 23, 2018 Category: Psychiatry Tags: delirium haloperidol New England Journal of Medicine ziprasidone Source Type: research

Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study
Publication date: Available online 22 October 2018Source: The Lancet Respiratory MedicineAuthor(s): Robinder G Khemani, Lincoln Smith, Yolanda M Lopez-Fernandez, Jeni Kwok, Rica Morzov, Margaret J Klein, Nadir Yehya, Douglas Willson, Martin C J Kneyber, Jon Lillie, Analia Fernandez, Christopher J L Newth, Philippe Jouvet, Neal J Thomas, Pediatric Acute Respiratory Distress syndrome Incidence and Epidemiology (PARDIE) Investigators, Eugenia Abaleke, Kate G Ackerman, Carlos Acuña, Michelle Adu-Darko, Jeremy T Affolter, Rachel AgbekoSummaryBackgroundPaediatric acute respiratory distress syndrome (PARDS) is associated w...
Source: The Lancet Respiratory Medicine - October 23, 2018 Category: Respiratory Medicine Source Type: research

Evaluation of microbiological screening in a neonatal intensive care unit to optimize empiric antibiotic use
Publication date: Available online 4 October 2018Source: Journal of Hospital InfectionAuthor(s): I. Schmeh, A. Kidszun, A. Welk, T. Schwanz, B. Jansen, E. Mildenberger (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - October 23, 2018 Category: Infectious Diseases Source Type: research

Sex and mortality in septic severe acute kidney injury
ConclusionsIn a cohort of patients with sepsis and severe AKI, female sex was associated with improved survival. The relationship between sex and survival was not altered by menopausal status or RRT intensity. (Source: Journal of Critical Care)
Source: Journal of Critical Care - October 23, 2018 Category: Gastroenterology Source Type: research

A comparison of the effects of manual hyperinflation and ventilator hyperinflation on restoring end-expiratory lung volume after endotracheal suctioning: A pilot physiologic study
ConclusionsMHI and VHI effectively restore EELV above baseline post-ES and should be considered post suctioning. (Source: Journal of Critical Care)
Source: Journal of Critical Care - October 23, 2018 Category: Gastroenterology Source Type: research

Management if antiplatelet therapy for non-elective invasive procedures of bleeding complications: proposals from the french working group on perioperative haemostatsis (gihp) and the french study group on thrombosis and haemostasis (gfht), in collaboration with the french society of anaesthesia and intensive care medicine (sfar)
Publication date: Available online 23 October 2018Source: Anaesthesia Critical Care & Pain MedicineAuthor(s): A Godier, D Garrigue, D Lasne, P Fontana, F Bonhomme, JP Collet, E de Maistre, B Ickx, Y Gruel, M Mazighi, P Nguyen, A Vincentelli, P Albaladejo, T LecompteAbstractThe French Working Group on Perioperative Haemostasis (GIHP) and the French Study Group on Haemostasis and Thrombosis (GFHT) in collaboration with the French Society for Anaesthesia and Intensive Care Medicine (SFAR) drafted up-to-date proposals on the management of antiplatelet therapy for non-elective invasive procedures or bleeding complications. ...
Source: Anaesthesia, Critical Care and Pain Medicine - October 23, 2018 Category: Anesthesiology Source Type: research

Don’t turn-off the brain
Publication date: Available online 22 October 2018Source: Medicina Intensiva (English Edition)Author(s): C. Chamorro-Jambrina, C. Chamorro-Falero (Source: Medicina Intensiva)
Source: Medicina Intensiva - October 23, 2018 Category: Intensive Care Source Type: research

Outcome in Patients with Isolated Moderate to Severe Traumatic Brain Injury.
Conclusion: In-hospital mortality in isolated brain injured patients was 33%. The vast majority died after a decision to withdraw life-sustaining treatment. None of the patients were discharged with an unresponsive wakefulness syndrome. PMID: 30345113 [PubMed] (Source: Critical Care Research and Practice)
Source: Critical Care Research and Practice - October 23, 2018 Category: Intensive Care Tags: Crit Care Res Pract Source Type: research

Imaging findings of iatrogenic pharyngeal and esophageal injuries in neonates
AbstractIatrogenic injuries to the upper gastrointestinal tract in neonates are rare but may lead to significant morbidity and mortality if undiagnosed. The clinical presentation of such injuries is usually nonspecific and symptoms may be overlooked, particularly in sick preterm neonates. Therefore, it is important to recognize the findings on plain chest radiographs obtained regularly in neonatal intensive care units (NICUs) on intubated patients. The purpose of this pictorial essay is to describe the imaging findings of various iatrogenic injuries to the pharynx and esophagus in the neonatal period in a cohort of seven c...
Source: Pediatric Radiology - October 23, 2018 Category: Radiology Source Type: research

On the Feasibility of Automated Mechanical Ventilation Control Through EIT
Conclusion: The recovery of regional ventilation distributions and lung parameters is feasible with the use of EIT. These parameters may then be used in model based control schemes to provide patient-specific care. Significance: For pulmonary-intensive-care patients mechanical ventilation is a life saving intervention, requiring careful calibration of pressure settings. Both magnitudes and gradients of pressure can contribute to ventilator induced lung injury. Retrieving regional lung parameters allows the design of patient-specific ventilator controls to reduce injury. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - October 23, 2018 Category: Biomedical Engineering Source Type: research

A patient with dermo-chondro-corneal dystrophy (Fran çois syndrome) and acute dyspnea
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 23, 2018 Category: Intensive Care Source Type: research

H1N1-related ARDS requiring veno-venous extracorporeal membrane oxygenation and the heart
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 23, 2018 Category: Intensive Care Source Type: research

Benefits and risks of the P/F approach
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 23, 2018 Category: Intensive Care Source Type: research

Is there still a place for noninvasive ventilation in acute hypoxemic respiratory failure?
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 23, 2018 Category: Intensive Care Source Type: research

Focus on paediatrics 2018
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 23, 2018 Category: Intensive Care Source Type: research

Association of social deprivation with 1-year outcome of ICU survivors: results from the FROG-ICU study
ConclusionsA lower socioeconomic status was associated with lower self-reported physical component scores in the nondeprived patients. Psychiatric symptoms are frequently reported after an ICU stay, and subsequent interventions should target those fields.Trial registrationClinicalTrials.gov NCT01367093; registered on June 6, 2011. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 23, 2018 Category: Intensive Care Source Type: research

Effect of exercise-based cardiac rehabilitation on anxiety and depression in patients with myocardial infarction: A systematic review and meta-analysis
Cardiac rehabilitation (CR) has been shown to provide the best social, psychological and physical conditions for patient recovery after myocardial infarction (MI). (Source: Heart and Lung)
Source: Heart and Lung - October 23, 2018 Category: Intensive Care Authors: Xianghui Zheng, Yang Zheng, Jing Ma, Maomao Zhang, Yongxiang Zhang, Xianglan Liu, Liangqi Chen, Qingyuan Yang, Yong Sun, Jian Wu, Bo Yu Source Type: research

Heart-rate-characteristic monitoring decreases NICU length of stay
Swanson JR, King WE, Sinkin RA, Lake DE, Carlo WA, Schelonka RL, et  al. Neonatal Intensive Care Unit Length of Stay Reduction by Heart Rate Characteristics Monitoring. J Pediatr 2018;198:162-7. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 22, 2018 Category: Pediatrics Authors: Karen D. Fairchild Tags: Current Best Evidence Source Type: research

High-flow nasal cannula post-tracheal extubation in a child with upper airway obstruction: case report
RESUMO Objetivo: Relatar o caso de um lactente que necessitou de intuba ção traqueal no setor de emergência pediátrica por conta de laringite aguda grave e que, após a extubação traqueal programada, fez uso, com sucesso, da cânula nasal de alto fluxo, a qual, possivelmente, evitou a falha da extubação traqueal. Descrição do caso: Paciente masculino, 8 mese s de idade, admitido no pronto atendimento de pediatria com desconforto respiratório agudo por causa de obstrução alta de vias aéreas secundária à ...
Source: Revista Paulista de Pediatria - October 22, 2018 Category: Pediatrics Source Type: research

Association between Patient Body Mass Index and Use of Critical Care Services after Elective Hysterectomy: A Single Institutional Study of 109 Patients
Objective: The aim of this study is to investigate whether obesity is independently associated with the use of intensive care unit (ICU) resources after hysterectomy. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - October 22, 2018 Category: OBGYN Authors: S. Mehta, M. Schneiter, M. Monsour, W. Wiley, C. Le, K. Brown, J. Lee, M. Robinson, E. Elsamadicy Source Type: research

Experiences of adolescents and their families in the short-term after scoliosis surgery
Conclusion Nurses should meet the adolescents and their families and allow them to express their feelings before surgery. Informing them before surgery is important in terms of relieving their anxiety and enhancing their adaptation. Creating an appropriate environment in recovery rooms and intensive care units where the adolescents can frequently see their parents may help them have better psychology. In addition, education programs that will be offered at discharge should be designed and interactive methods should be used to allow them to share their thoughts about their future. (Source: Acta Paulista de Enfermagem)
Source: Acta Paulista de Enfermagem - October 22, 2018 Category: Nursing Source Type: research

HLH - Unusual Trigger and Positive Outcome.
We report an unusual case of HLH, in a 34 year old male, who was admitted with Subarachnoid hemorrhage and cerebellar contusion in a Neurosurgical Intensive care unit, whose trigger is not clear. PMID: 30341881 [PubMed - in process] (Source: Journal of the Association of Physicians of India)
Source: Journal of the Association of Physicians of India - October 22, 2018 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

CAR 1. Carotid Endarterectomy for Asymptomatic Carotid Artery Stenosis: Can We Predict Who Will Need Intensive Care Unit Postoperative Care?
All asymptomatic patients benefit from 3 to 6 hours of neurologic and intra-arterial blood pressure (BP) monitoring after carotid endarterectomy (CEA). However, only a minority of patients will require routine postoperative monitoring in a high-dependency unit or intensive care unit (HDU/ICU). The aim of this paper was to identify preoperative and intraoperative predictors of HDU/ICU postoperative monitoring need. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - October 22, 2018 Category: Surgery Authors: Andreia Coelho, Miguel Lobo, Ricardo Gouveia, Clara Nogueira, Jacinta Campos, Rita Augusto, Nuno Coelho, Alexandra Canedo Source Type: research

Are injury admissions on weekends and weeknights different from weekday admissions?
ConclusionsInjury pattern and resource utilization are related to time. Therefore, injury prevention and intervention efforts should account for hours of a day and days of a week, particularly in relation with age, gender, and ethnicity. (Source: European Journal of Trauma and Emergency Surgery)
Source: European Journal of Trauma and Emergency Surgery - October 22, 2018 Category: Emergency Medicine Source Type: research

Does the Term Intensive Care Unit Promote Aggressive Treatment?
This Viewpoint examines how the termintensive care unit may contribute to patient and physician expectations of more invasive and aggressive therapies, and suggests that a change in the nomenclature may be a first step in realigning patient and physician expectations from burdensome treatment towoard a more patient-centered approach. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - October 22, 2018 Category: Internal Medicine Source Type: research

Monitoring of neuromuscular blockade: a comparison of train-of-four and the Campbell diagram
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 22, 2018 Category: Intensive Care Source Type: research

New molecular semi-quantification tool provides reliable microbiological evidence for pulmonary infection
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 22, 2018 Category: Intensive Care Source Type: research

Simulation study on X-ray phase contrast imaging with dual-phase gratings
ConclusionDual-phase gratings can be used and optimized for a medical X-ray source and detector. The obtained visibilities are somewhat lower than for other Talbot –Lau interferometers and are a tradeoff between setup length and spatial resolution (or additional phase stepping, respectively). However, these disadvantage appears minor compared to the overall better photon statistics, and the fact that dual-phase grating setups can be expected to scale to high er X-ray energies. (Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - October 22, 2018 Category: Intensive Care Source Type: research

Frailty: an independent predictor of burns mortality following in-patient admission
In the context of an aging developed world population [1], burn care teams can expect to manage increasing numbers of frail elderly patients with complex medical and social needs [2,3]. It is widely accepted that elderly patients tend to have a higher mortality risk and poorer outcome than younger patients with similar burn injuries, particularly as burn size and depth increases [4 –11]. When caring for elderly patients, medical teams are not only faced with the clinical challenge of providing the highest standards of burn care in the context of multiple medical comorbidities but also face the ethical challenge of se...
Source: Burns : Journal of the International Society for Burn Injuries - October 22, 2018 Category: Cosmetic Surgery Authors: Joseph Ward, Georgina Phillips, Ishan Radotra, Sarah Smailes, Peter Dziewulski, Jufen Zhang, Niall Martin Source Type: research

Weaning From Mechanical Ventilation
Withdrawing invasive mechanical ventilation from patients who require ventilatory support is one of the best studied areas in intensive care medicine. A series of studies dating back 25 years has shown that most patients need to be liberated, rather than gradually withdrawn (weaned), from mechanical ventilation. The time point for liberation is identified by use of a spontaneous breathing trial, whereby after having shown clinical improvement in the initial reason for ventilation and satisfying several safety criteria, patients are provided with minimal or no ventilatory assistance and their ability to tolerate and maintai...
Source: JAMA - Journal of the American Medical Association - October 22, 2018 Category: General Medicine Source Type: research

Decontamination of Oral or Digestive Tract for Patients in the Intensive Care Unit
The study by Wittekamp and colleagues in this issue ofJAMA evaluating strategies for decontamination of mechanically ventilated patients in the intensive care unit (ICU) fills an important gap in the evidence regarding these practices. Since the first use of selective decontamination of the digestive tract (SDD) in critically ill patients in the 1980s, the effectiveness of this approach to prevent ICU-acquired infections and reduce ICU-related mortality has been a continuous source of debate. In addition, the use of SDD or selective oropharyngeal decontamination (SOD) entails the continuous use of antibiotics among patient...
Source: JAMA - Journal of the American Medical Association - October 22, 2018 Category: General Medicine Source Type: research

Effects of Decontamination Strategies on Drug-Resistant Bloodstream Infections in Ventilated Patients
This cluster randomized trial compares associations between commonly used decontamination strategies (chlorhexidine 2% mouthwash, selective oropharyngeal decontamination, and selective digestive tract decontamination) and occurrence of intensive care unit (ICU) –acquired bloodstream infections with multidrug-resistant gram-negative bacteria in ICUs with moderate to high levels of antibiotic resistance. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - October 22, 2018 Category: General Medicine Source Type: research

Multimodal image registration for liver radioembolization planning and patient assessment
ConclusionThe proposed registration solutions enable the combined use of information from multimodal imaging and provide an excellent basis for patient assessment and primary planning for liver radioembolization. (Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - October 22, 2018 Category: Intensive Care Source Type: research

When timing and dose of nutrition support were examined, the modified Nutrition Risk in Critically Ill (mNUTRIC) score did not differentiate high-risk patients who would derive the most benefit from nutrition support: a prospective cohort study
The timing and dose of exclusive nutrition support (ENS) have not been investigated in previous studies aimed at validating the modified Nutrition Risk in Critically Ill (mNUTRIC) score. We therefore evaluated... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - October 22, 2018 Category: Intensive Care Authors: Charles Chin Han Lew, Gabriel Jun Yung Wong, Ka Po Cheung, Robert J. L. Fraser, Ai Ping Chua, Mary Foong Fong Chong and Michelle Miller Tags: Research Source Type: research

Evaluation of unfractionated heparin versus low-molecular-weight heparin and fondaparinux for pharmacologic venous thromboembolic prophylaxis in critically ill patients with cancer.
CONCLUSIONS: The use of a LMWH VTE prophylaxis was not associated with a reduction in the incidence of in-hospital VTE as compared to UFH, but was associated with significant reduction in clinically important bleeding events and incidence of HIT in critically ill patients with cancer. This article is protected by copyright. All rights reserved. PMID: 30347498 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 22, 2018 Category: Hematology Authors: Van Matre ET, Reynolds PM, MacLaren R, Mueller SW, Wright GC, Moss M, Burnham EL, Ho PM, Vandivier RW, Kiser TH Tags: J Thromb Haemost Source Type: research

Plasma Antioxidant Potential at Admission is Associated with Length of ICU Stay in Child with Sepsis: A Pilot Study.
CONCLUSION: We conclude for first time that FRAP level at ICU admission is independently associated with LSICU in pediatric patients. PMID: 30339057 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - October 21, 2018 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Impact of prenatal exercise on neonatal and childhood outcomes: a systematic review and meta-analysis.
CONCLUSIONS: Prenatal exercise is safe and beneficial for the fetus. Maternal exercise was associated with reduced odds of macrosomia (abnormally large babies) and was not associated with neonatal complications or adverse childhood outcomes. PMID: 30337465 [PubMed - in process] (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - October 21, 2018 Category: Sports Medicine Authors: Davenport MH, Meah VL, Ruchat SM, Davies GA, Skow RJ, Barrowman N, Adamo KB, Poitras VJ, Gray CE, Jaramillo Garcia A, Sobierajski F, Riske L, James M, Kathol AJ, Nuspl M, Marchand AA, Nagpal TS, Slater LG, Weeks A, Barakat R, Mottola MF Tags: Br J Sports Med Source Type: research

Beat around the bush for VA-LRTI
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 21, 2018 Category: Intensive Care Source Type: research

Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis
AbstractPurposeA causal biomarker for acute respiratory distress syndrome (ARDS) could fuel precision therapy options. Plasma angiopoietin-2 (ANG2), a vascular permeability marker, is a strong candidate on the basis of experimental and observational evidence. We used genetic causal inference methods —Mendelian randomization and mediation—to infer potential effects of plasma ANG2.MethodsWe genotyped 703 septic subjects, measured ICU admission plasma ANG2, and performed a quantitative trait loci (QTL) analysis to determine variants in theANGPT2 gene associated with plasma ANG2 (p 
Source: Intensive Care Medicine - October 21, 2018 Category: Intensive Care Source Type: research

Safety and tolerability of a single administration of AR-301, a human monoclonal antibody, in ICU patients with severe pneumonia caused by Staphylococcus aureus : first-in-human trial
AbstractPurposeHospital-acquired bacterial pneumonia (HABP) is a critical concern in hospitals with ventilator-associated bacterial pneumonia (VABP) remaining the most common infection in the ICU, often due toStaphylococcus aureus, an increasingly difficult to treat pathogen. Anti-infective monoclonal antibodies (mAb) may provide new, promising treatment options. This randomized, double-blinded, placebo-controlled study aimed at assessing the safety and pharmacokinetics of AR-301, anS. aureus alpha toxin-neutralizing mAb, and exploring its clinical and microbiologic outcomes when used adjunctively with standard-of-care ant...
Source: Intensive Care Medicine - October 21, 2018 Category: Intensive Care Source Type: research

Impact of a multifaceted prevention program on ventilator-associated pneumonia including selective oropharyngeal decontamination
We describe the impact of a multifaceted program for decreasing ventilator-associated pneumonia (VAP) after implementing nine preventive measures, including selective oropharyngeal decontamination (SOD).MethodsWe compared VAP rates during an 8-month pre-intervention period, a 12-month intervention period, and an 11-month post-intervention period in a cohort of patients who received mechanical ventilation (MV) for  >  48 h. The primary objective was to assess the effect on first VAP occurrence, using a Cox cause-specific proportional hazards model. Secondary objectives included the impact on emergence ...
Source: Intensive Care Medicine - October 21, 2018 Category: Intensive Care Source Type: research

Small volume resuscitation with 20% albumin in intensive care: physiological effects
AbstractPurposeWe set out to assess the resuscitation fluid requirements and physiological and clinical responses of intensive care unit (ICU) patients resuscitated with 20% albumin versus 4 –5% albumin.MethodsWe performed a randomised controlled trial in 321 adult patients requiring fluid resuscitation within 48  h of admission to three ICUs in Australia and the UK.ResultsThe cumulative volume of resuscitation fluid at 48  h (primary outcome) was lower in the 20% albumin group than in the 4–5% albumin group [median difference − 600 ml, 95% confidence interval (CI) − 800...
Source: Intensive Care Medicine - October 21, 2018 Category: Intensive Care Source Type: research

A multicenter randomized controlled trial of a 3-L/kg/min versus 2-L/kg/min high-flow nasal cannula flow rate in young infants with severe viral bronchiolitis (TRAMONTANE 2)
ConclusionIn young infants with AVB supported with HFNC, 3  L/kg/min did not reduce the risk of failure compared with 2 L/kg/min. This clinical trial was recorded on the National Library of Medicine registry (NCT02824744). (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 21, 2018 Category: Intensive Care Source Type: research

A multicentre randomized pilot trial on the effectiveness of different levels of cooling in comatose survivors of out-of-hospital cardiac arrest: the FROST-I trial
ConclusionsThere were no statistically significant differences in neurological outcomes among the different levels of TTM. However, future research should explore the efficacy of TTM at 32  °C.Clinical trial registrationClinicalTrials.gov unique identifier: NCT02035839 (http://clinicaltrials.gov). (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 21, 2018 Category: Intensive Care Source Type: research

Outcomes comparison in patients admitted to low complexity rural and urban intensive care units in the Veterans Health Administration
Publication date: Available online 19 October 2018Source: Journal of Critical CareAuthor(s): Amy M.J. O'Shea, Spyridon Fortis, Mary Vaughan Sarrazin, Jane Moeckli, W.C. Yarbrough, Heather Schacht ReisingerAbstractPurposeTo evaluate mortality, length of stay, and inter-hospital transfer in the Veteran Health Administration (VHA) among low complexity Intensive Care Unit (ICU) patients.Materials and methodRetrospective study of adult ICU admissions identified in VHA Medical SAS®; 2010–2015 at Veterans Affairs (VA) Medical Centers. Facilities classified by the Rural Urban Commuting Area code algorithm as large rural ...
Source: Journal of Critical Care - October 20, 2018 Category: Gastroenterology Source Type: research

Noninvasive ventilation in acute hypoxemic respiratory failure: A systematic review and meta-analysis
ConclusionsNIV showed a significant protective effect for intubation in immunosuppressed patients (cancer and transplants) and in patients with APE/CAP. However, the benefits of NIV for other etiologies are not clear and more trials are needed to prove these effects. (Source: Journal of Critical Care)
Source: Journal of Critical Care - October 20, 2018 Category: Gastroenterology Source Type: research

Recent advances in biosensors for diagnosis and detection of sepsis: A comprehensive review
Publication date: Available online 19 October 2018Source: Biosensors and BioelectronicsAuthor(s): Sanni Kumar, Suryasnata Tripathy, Anupam Jyoti, Shiv Govind SinghAbstractSepsis is one of the leading causes of mortality among critically ill patients globally. According to WHO report 2018,it is estimated to affect beyond 30 million people worldwide every year.It causes loss of human lives, which arise from infection and inflammation and long term stay in intensive care unit (ICU) in hospitals. Despite the availability of satisfactory prognostic markers contributing to the diagnosis of sepsis, millions of people die even aft...
Source: Biosensors and Bioelectronics - October 20, 2018 Category: Biotechnology Source Type: research

Characterization of potential drug-drug interactions in patients hospitalized in the intensive care unit of a tertiary hospital in Bogot á
Conclusions: Given their high frequency and potential negative impact, the systematic monitoring of prescriptions in intensive care units to detect interactions is important. Such monitoring contributes to the rational use of medicines and to improve the quality of care. PMID: 30335246 [PubMed - in process] (Source: Biomedica : Revista del Instituto Nacional de Salud)
Source: Biomedica : Revista del Instituto Nacional de Salud - October 20, 2018 Category: International Medicine & Public Health Tags: Biomedica Source Type: research

Drug utilization study of two generic antibiotics in a tertiary hospital in Bogot á
Conclusions: This study contributes evidence regarding the therapeutic performance of two generic antibiotics used in tertiary hospitals. There were no reports of therapeutic failure during the study period. In the cases of non-response, pharmacokinetic alterations, unfavorable clinical conditions, and inappropriate choice of antimicrobial treatment were identified as frequent factors. PMID: 30335245 [PubMed - in process] (Source: Biomedica : Revista del Instituto Nacional de Salud)
Source: Biomedica : Revista del Instituto Nacional de Salud - October 20, 2018 Category: International Medicine & Public Health Tags: Biomedica Source Type: research

Airway Clearance of the Term Newborn
Purpose: The purpose of this study was to explore airway clearance practices for the preterm newborn in the neonatal intensive care unit (NICU). Study Design and Methods: This descriptive, retrospective medical record review analyzed airway clearance practices in a level III regional NICU from 2016 to 2017 in preterm newborns ranging from 32 weeks to 36 weeks and 6 days. There were 87 preterm newborns and 384 suctioning events reviewed during the entire length of stay. Practices reviewed include device used, frequency, color, consistency, and tolerance of airway clearance. Method of nursing documentation for these pra...
Source: MCN: The American Journal of Maternal Child Nursing - October 20, 2018 Category: Nursing Tags: Feature Source Type: research