The Risk Factors and Clinical Outcomes Associated with Acute Kidney Injury in Patients with COVID-19: Data from a Large Cohort in Iran
Conclusion: We found that male sex, history of CKD, hypertension, disease severity, and high serum urea were independent risk factors associated with AKI in patients with COVID-19. Also, higher stages of AKI were associated with increased risk of mortality and in-hospital complications. Our results indicate a necessity for more precise care and monitoring for AKI during hospitalization in patients with COVID-19, and lack of AKI recovery at the time of discharge is a common complication in such patients.Kidney Blood Press Res (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 27, 2021 Category: Urology & Nephrology Source Type: research

Three-dimensional ultrasound for knee osteophyte depiction: a comparative study to computed tomography
ConclusionUsing 3D US can improve the depiction of osteophytes with a cartilaginous portion compared to CT. It can also provide useful information about the presence and extent of osteophytes. Whilst algorithm improvements for automatic segmentation and registration of US are needed to provide a more robust investigation of osteophyte depiction accuracy, this investigation puts forward the potential application for 3D US in routine diagnostic evaluations and pre-operative planning of osteoarthritis. (Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - July 27, 2021 Category: Intensive Care Source Type: research

Viruses, Vol. 13, Pages 1465: Influenza Vaccine Effectiveness in Preventing Severe Outcomes in Patients Hospitalized with Laboratory-Confirmed Influenza during the 2017 –2018 Season. A Retrospective Cohort Study in Catalonia (Spain)
The objective of this study was to determine influenza vaccine effectiveness (VE) in preventing intensive care admissions and shortening the length of stay (LOS) in hospitalized laboratory-confirmed influenza cases (HLCI) in Catalonia (Spain). A retrospective cohort study was carried out during the 2017–2018 season in HLCI aged ≥18 years from 14 public hospitals. Differences in means and proportions were assessed using a t-test or a chi-square test as necessary and the differences were quantified using standardized effect measures: Cohen’s d for quantitative and Cohen’s w for categorical variables. Adj...
Source: Viruses - July 27, 2021 Category: Virology Authors: Lesly Acosta Nuria Soldevila Nuria Torner Ana Mart ínez Xavier Ayneto Cristina Rius Mireia Jan é Angela Dom ínguez the Influenza Surveillance Network of Catalonia, PIDIRAC the Influenza Surveillance Network of Catalonia, PIDIRAC Tags: Article Source Type: research

An observational cohort study to assess N-acetylglucosamine for COVID-19 treatment in the inpatient setting
This study evaluated whether N-acetylglucosamine administered orally improves clinical outcomes for patients admitted to the hospital due to COVID-19.MATERIALS AND METHODS: This single-center, prospective, observational cohort study used a retrospective control group for comparison. Multivariate analyses evaluated whether N-acetylglucosamine was an independent predictor of primary outcomes (rate of intubation, hospital length-of-stay, and mortality) and select secondary outcomes (intensive care unit [ICU] admission, ICU length-of-stay, supplemental oxygen use duration, hospice initiation, and poor clinical outcome [defined...
Source: Annals of Medicine - July 26, 2021 Category: Internal Medicine Authors: Ameer E Hassan Source Type: research

Phase I/II Clinical Trial of Autologous Activated Platelet-Rich Plasma (aaPRP) in the Treatment of Severe Coronavirus Disease 2019 (COVID-19) Patients
CONCLUSIONS: Our results of the phase I/II trial demonstrated that the use of aaPRP in severe COVID-19 patients was safe and not associated with serious adverse events, which showed that aaPRP was a promising adjunctive therapy for severe COVID-19 patients.PMID:34306612 | PMC:PMC8285191 | DOI:10.1155/2021/5531873 (Source: International Journal of Inflammation)
Source: International Journal of Inflammation - July 26, 2021 Category: Allergy & Immunology Authors: Karina Karina Iis Rosliana Imam Rosadi Siti Sobariah Louis Martin Christoffel Rita Novariani Siti Rosidah Novy Fatkhurohman Yuli Hertati Nurlaela Puspitaningrum Wismo Reja Subroto Irsyah Afini Difky Ernanda Source Type: research

Protein Binding and Population Pharmacokinetics of Dexmedetomidine after Prolonged Infusions in Adult Critically Ill Patients
Clin Ther. 2021 Jul 22:S0149-2918(21)00234-4. doi: 10.1016/j.clinthera.2021.06.004. Online ahead of print.ABSTRACTPURPOSE: Dexmedetomidine (DEX) is a highly selective α2-adrenoceptor agonist with high protein binding of 94%. Critical illness may affect protein binding and the pharmacokinetic (PK) parameters of many drugs, including DEX. In critically ill patients receiving prolonged infusions of DEX, there is little information documenting the relationship between key pathophysiologic factors and DEX protein binding or PK parameters. The purpose of this study was to characterize the protein binding and PK profile of ...
Source: Clinical Therapeutics - July 26, 2021 Category: Drugs & Pharmacology Authors: Xiaoyu Yan Andrew Ho Wai Tse Anna Lee Lin Zhang Mengbi Yang Zhong Zuo Gavin Matthew Joynt Source Type: research

Importance of specialized paediatric and neonatal transport. Current situation in Spain: Towards a more equitable and universal future
An Pediatr (Barc). 2021 Jul 22:S1695-4033(21)00221-6. doi: 10.1016/j.anpedi.2021.06.011. Online ahead of print.ABSTRACTSpecialized paediatric and neonatal transport is a useful and essential resource in the interhospital transfer of these patients. It allows bringing the material and personal resources of an intensive care unit closer to the regional hospitals where the patient can be found. The benefits of these teams are very well demonstrated in the literature. These units should be part of the emergency systems, while it would be recommended that they would be staff integrated in the tertiary hospitals, in order to mai...
Source: Anales de Pediatria - July 26, 2021 Category: Pediatrics Authors: Nuria Mill án García Del Real Laura S ánchez García Yolanda Ballesteros Diez Raquel Rodr íguez Merlo Alberto Salas Ballest ín Raquel Jord án Lucas Nieves de Lucas Garc ía Source Type: research

The Beneficial Role of Auricular Point Pressure in Insomnia and Anxiety in Isolated COVID-19 Patients
Evid Based Complement Alternat Med. 2021 Jul 8;2021:6611942. doi: 10.1155/2021/6611942. eCollection 2021.ABSTRACTBACKGROUND: Coronavirus disease 2019 (COVID-19) causes psychological distress and can have a negative impact on the general mental health and rehabilitation in affected patients under currently implemented isolation guidelines. Auricular point pressure (APP) as well-established technique in traditional Chinese medicine may help to relieve sleep disturbance and anxiety in COVID-19 patients.METHODS: During the early phase of the epidemic/pandemic, patients were enrolled in this study (02/2020 until 03/2020 n = 84)...
Source: Evidence-based Complementary and Alternative Medicine - July 26, 2021 Category: Complementary Medicine Authors: Yueming Luo Chuanren Ling Yangchen Liu Chong Deng Ana Maria Waaga-Gasser Minggui Chen Zehui He Erhui Chen Lin Wei Shimiao Luo Xiaozhen Gong Hong Ye Jing Zhu Shan Song Qiuting Wang Shunmin Li Martin Gasser Meizhen Lin Source Type: research

Negative pressure wound therapy in the treatment of deep sternal wound infections - a critical appraisal
Scand Cardiovasc J. 2021 Jul 24:1-6. doi: 10.1080/14017431.2021.1955963. Online ahead of print.ABSTRACTIntroduction. Negative pressure wound therapy (NPWT) has widely become the first-line option in the treatment of deep sternal wound infections. After several positive reports in comparison with conventional treatment, very recent studies comparing NPWT with early reconstruction have favored the latter. Our aim was to evaluate the effectiveness and safety of NPWT in comparison with early flap reconstruction. Materials and methods. We concluded a retrospective analysis of 125 patients with deep sternal wound infection treat...
Source: Scandinavian Cardiovascular Journal - July 26, 2021 Category: Cardiology Authors: Heidi-Mari Myllykangas Leena T Berg Annastina Husso Jari Halonen Source Type: research

The risk factors for postoperative acute respiratory distress syndrome in Stanford type a acute aortic dissection patients
This study included 64 patients with Stanford type A AAD who underwent Sun's procedure. The patients were divided into an ARDS group (PaO2/FiO2
Source: American Journal of Translational Research - July 26, 2021 Category: Research Authors: Yongbo Zhao Yuehong Yue Yanzhi Wang Weichao Zhao Guangxing Feng Source Type: research

Factors Predicting Outcome in Intensive Care Unit-Admitted COVID-19 Patients: Using Clinical, Laboratory, and Radiologic Characteristics
CONCLUSION: A combination of underlying diseases, vital signs, and radiologic factors might have prognostic value for mortality rate prediction in ICU-admitted COVID-19 patients.PMID:34306751 | PMC:PMC8285200 | DOI:10.1155/2021/9941570 (Source: Critical Care Research and Practice)
Source: Critical Care Research and Practice - July 26, 2021 Category: Intensive Care Authors: Aminreza Abkhoo Elaheh Shaker Mohammad-Mehdi Mehrabinejad Javid Azadbakht Nahid Sadighi Faeze Salahshour Source Type: research

Assessing the Work Activities Related to Musculoskeletal Disorder among Critical Care Nurses
Crit Care Res Pract. 2021 Jun 29;2021:8896806. doi: 10.1155/2021/8896806. eCollection 2021.ABSTRACTNurses are physically exhausted with an incidence of work-related musculoskeletal disorders (MSDs), especially those working in critical care units that require exhaustive physical efforts to fulfill patients' needs. The current study aims to assess work activities related to the occurrence of MSDs in nurses working in critical care units. A descriptive cross-sectional study was conducted on a sample of 100 nurses of critical care units, and the data were collected via a survey questionnaire. The study was conducted at King F...
Source: Critical Care Research and Practice - July 26, 2021 Category: Intensive Care Authors: Aesha Abdullah Aleid Hend Abdelmonem Eid Elshnawie Ahmed Ammar Source Type: research

Classification of large-scale image database of various skin diseases using deep learning
ConclusionThis study presents a deep learning-based classification of 59 skin diseases using multiple photographic images of a patient. The experimental results demonstrated that the proposed classification reinforced by metric learning and aggregation of multiple input images was effective in the classification of patients with diverse skin diseases and imaging conditions. (Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - July 26, 2021 Category: Intensive Care Source Type: research

Duration and management of sepsis-associated hypotension at rapid response team call-outs to patients subsequently admitted to the intensive care unit: A case series
Sepsis-related hypotension in hospital patients is a common reason for rapid response team (RRT) attendance and transfer to intensive care, but little is known about the duration and management of hypotension during these RRT call-outs. (Source: Australian Critical Care)
Source: Australian Critical Care - July 26, 2021 Category: Nursing Authors: Lauren Schramko, Timothy Paterson, Matthew H. Anstey Tags: Brief research report Source Type: research

Practice Patterns of Family Physicians With and Without Addiction Medicine Board Certification
Discussion: While only a small proportion of family physicians carry dual ADM board certification, those that do disproportionately serve vulnerable populations while retaining broad scope of care. Further work is needed to examine whether SUD treatment access could be addressed by implementing models that support dually certified physicians in consultative and educational efforts that would amplify their impact across the primary care workforce. (Source: Journal of the American Board of Family Medicine)
Source: Journal of the American Board of Family Medicine - July 26, 2021 Category: Primary Care Authors: Tong, S. T., Morgan, Z. J., Bazemore, A. W., Eden, A. R., Fitzgerald, R. M., Peterson, L. E. Tags: Brief Reports Source Type: research

Effect of positive end-expiratory pressure on additional passive ventilation generated by CPR compressions in a porcine model
Compressions given during cardiopulmonary resuscitation generate small, ineffective passive ventilations through oscillating waves. Positive end-expiratory pressure increases the volume of these passive ventil... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - July 26, 2021 Category: Surgery Authors: Yosef Levenbrown, Md Jobayer Hossain, James P. Keith, Katlyn Burr, Anne Hesek and Thomas H. Shaffer Tags: Research Articles Source Type: research

Timely Family Meetings or Time-Limited Trials?
This study has several strengths. By using a quality improvement design instead of a more traditional interventional study in which patient consent is typically required, the investigators were able to examine the data for consecutive eligible patients, thereby maximizing the study population while reducing the risk of selection bias. Involvement of multiple centers also helps to increase the sample size and generalizability. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - July 26, 2021 Category: Internal Medicine Source Type: research

Timely Family Meetings or Time-Limited Trials? —Reply
In Reply We thank Admane and Hui for their insightful comments on our article. Effects of secular trends and external influences, such as changes in intensive care unit (ICU) staffing or other hospital initiatives to reduce ICU length of stay (LOS), are important to consider given the pre-post study design. To our knowledge, there were no new policies to reduce ICU use, nor were there major changes in staffing, culture, and leadership during the study period. In addition, several findings from our study suggest that the effects of secular trends and external influences on outcomes were small. First, interrupted time series...
Source: JAMA Internal Medicine - July 26, 2021 Category: Internal Medicine Source Type: research

Impact of a restrictive antibiotic policy on the acquisition of extended-spectrum beta-lactamase-producing Enterobacteriaceae in an endemic region: a before-and-after, propensity-matched cohort study in a Caribbean intensive care unit
High-level antibiotic consumption plays a critical role in the selection and spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) in the ICU. Implementation of a stewardship program in... (Source: Critical Care)
Source: Critical Care - July 26, 2021 Category: Intensive Care Authors: Christophe Le Terrier, Marco Vinetti, Paul Bonjean, R égine Richard, Bruno Jarrige, Bertrand Pons, Benjamin Madeux, Pascale Piednoir, Fanny Ardisson, Elain Elie, Frédéric Martino, Marc Valette, Edouard Ollier, Sébastien Breurec, Michel Carles and Guil Tags: Research Source Type: research

International Consensus Recommendations for Anesthetic and Intensive Care Management of Lung Transplantation. An EACTAIC, SCA, ISHLT, ESOT, ESTS, and AST Approved document
For patients with end-stage lung disease, LTx remains the only therapeutic option towards better chance of survival as well as improved quality of life. According to the International Society for Heart and Lung Transplantation (ISHLT) Transplant Registry, the number of LTx procedures has been rising despite limitations in available and suitable donor lungs and in the face of persistent donor shortages (1). The modern era of LTx is characterized by increasing complexity of recipient candidates including those receiving bridging extracorporeal support, a trend towards acceptance of suboptimal or extended criteria donors and ...
Source: The Journal of Heart and Lung Transplantation - July 26, 2021 Category: Transplant Surgery Authors: Nandor Marczin, Eric E.C. de Waal, Peter M.A. Hopkins, Michael S. Mulligan, Andre Simon, Andrew D. Shaw, Dirk Van Raemdonck, Arne Neyrinck, Cynthia J. Gries, Lars Algotsson, Laszlo Szegedi, Vera von Dossow Tags: Consensus Statement Source Type: research

Perianesthesia Care of the Oncologic Patients Undergoing Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy: A Retrospective Study
CONCLUSIONS: CRS + HIPEC is a major surgery with numerous challenges to the perianesthesia care team regarding hemodynamic adjustment, pain control, and postoperative complications, which demand training and future studies from the perianesthesia care team.PMID:34303613 | DOI:10.1016/j.jopan.2020.10.016 (Source: Journal of Perianesthesia Nursing)
Source: Journal of Perianesthesia Nursing - July 25, 2021 Category: Nursing Authors: Dan Li Shi Huang Fei Zhang Ryan D Ball Heng Huang Source Type: research

Albumin corrected anion gap for predicting in-hospital mortality among intensive care patients with sepsis: A retrospective propensity score matching analysis
CONCLUSIONS: ACAG has the highest predictive value for in-hospital mortality of intensive care patients with sepsis, which is better than albumin and AG. Using ACAG to predict the in-hospital mortality to guide clinical applications may obtain the highest net benefit.PMID:34303712 | DOI:10.1016/j.cca.2021.07.021 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - July 25, 2021 Category: Chemistry Authors: Youfan Jiang Tianyang Hu Zhengwei Zhang Source Type: research

Chasing Certainty After Cardiac Arrest: Can a Technological Innovation Solve a Moral Dilemma?
AbstractWhen information on a coma patient ’s expected outcome is uncertain, a moral dilemma arises in clinical practice: if life-sustaining treatment is continued, the patient may survive with unacceptably poor neurological prospects, but if withdrawn a patient who could have recovered may die. Continuous electroencephalogram-monitoring (cEEG) is expected to substantially improve neuroprognostication for patients in coma after cardiac arrest. This raises expectations that decisions whether or not to withdraw will become easier. This paper investigates that expectation, exploring cEEG’s impacts when i...
Source: Neuroethics - July 25, 2021 Category: Medical Ethics Source Type: research

Polyhexamethylene biguanide discs versus unmedicated dressings for prevention of central venous catheter –associated infection in the intensive care unit: A pilot randomised controlled trial to assess protocol safety and feasibility
Central venous catheters are prone to infectious complications, affecting morbidity, mortality and healthcare costs. Polyhexamethylene biguanide-impregnated discs at the catheter insertion site may prevent local and bloodstream infection; however, efficacy has not been established in a critical care setting. (Source: Australian Critical Care)
Source: Australian Critical Care - July 25, 2021 Category: Nursing Authors: India Pearse, Nicole Marsh, Claire M. Rickard, Amanda J. Ullman, Emily Larsen, Anita Pelecanos, Nicola McGuinness, Lacey Irvine, Ivan L. Rapchuk, Marc Ziegenfuss, Amanda Corley Tags: Research paper Source Type: research

Pharmacokinetic/Pharmacodynamic Dosage Individualization of Cefepime in Critically Ill Patients: A Case Study
Conclusion: This case report illustrates how physiological, microbiological, and drug concentration data can be used for model-based dosage individualization of cefepime in intensive care unit patients. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - July 24, 2021 Category: Drugs & Pharmacology Tags: Grand Rounds Source Type: research

Adverse Events of Prone Positioning in Mechanically Ventilated Adults with Acute Respiratory Distress Syndrome
CONCLUSIONS: We identified>40 adverse events reported in prone positioning ARDS studies, involving additional AEs not yet reported by previous systematic reviews. The pooled adverse event proportions collected in this review could guide research and clinical practice decisions, and the strategies to mitigate adverse events could promote future consensus-based recommendations.PMID:34301802 | DOI:10.4187/respcare.09194 (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Felipe Gonz ález-Seguel Juan Jos é Pinto-Concha Nadine Aranis Jaime Leppe Source Type: research

Preterm White Matter Injury: A Prospective Cohort Study
Indian Pediatr. 2021 Jul 23:S097475591600356. Online ahead of print.ABSTRACTOBJECTIVE: To determine the incidence and risk factors of preterm white matter injury (WMI; periventricular-intraventricular hemorrhage (PIVH) and/or periventricular leukomalacia (PVL)).DESIGN: Prospective cohort study.SETTING: Level-3 neonatal intensive care unit.PATIENTS: Inborn preterm neonates (n=140) delivered at
Source: Indian Pediatrics - July 24, 2021 Category: Pediatrics Authors: Mohsin Raj Mantoo Ashok K Deorari Manisha Jana Ramesh Agarwal Jeeva Sankar Anu Thukral Source Type: research

Tyrosine kinase inhibitors for acute respiratory failure due to non-small-cell lung cancer involvement in intensive care unit
Chest. 2021 Jul 21:S0012-3692(21)01358-1. doi: 10.1016/j.chest.2021.06.079. Online ahead of print.NO ABSTRACTPMID:34302842 | DOI:10.1016/j.chest.2021.06.079 (Source: Chest)
Source: Chest - July 24, 2021 Category: Respiratory Medicine Authors: Y Tandjaoui-Lambiotte Y Akrour A Gibelin F Gonzalez A Stoclin A S Moreau P Jaubert A Oppenheimer B Duchemann S Gaudry GRRROH study group: F El Kouari E De Montmollin M Pineton de Chambrun F Wallet A Lautrette N Dufour D Contou J D Ricard R Persichini J Ma Source Type: research

Adverse Events of Prone Positioning in Mechanically Ventilated Adults with Acute Respiratory Distress Syndrome
CONCLUSIONS: We identified>40 adverse events reported in prone positioning ARDS studies, involving additional AEs not yet reported by previous systematic reviews. The pooled adverse event proportions collected in this review could guide research and clinical practice decisions, and the strategies to mitigate adverse events could promote future consensus-based recommendations.PMID:34301802 | DOI:10.4187/respcare.09194 (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2021 Category: Respiratory Medicine Authors: Felipe Gonz ález-Seguel Juan Jos é Pinto-Concha Nadine Aranis Jaime Leppe Source Type: research

Preterm White Matter Injury: A Prospective Cohort Study
Indian Pediatr. 2021 Jul 23:S097475591600356. Online ahead of print.ABSTRACTOBJECTIVE: To determine the incidence and risk factors of preterm white matter injury (WMI; periventricular-intraventricular hemorrhage (PIVH) and/or periventricular leukomalacia (PVL)).DESIGN: Prospective cohort study.SETTING: Level-3 neonatal intensive care unit.PATIENTS: Inborn preterm neonates (n=140) delivered at
Source: Indian Pediatrics - July 24, 2021 Category: Pediatrics Authors: Mohsin Raj Mantoo Ashok K Deorari Manisha Jana Ramesh Agarwal Jeeva Sankar Anu Thukral Source Type: research

Tyrosine kinase inhibitors for acute respiratory failure due to non-small-cell lung cancer involvement in intensive care unit
Chest. 2021 Jul 21:S0012-3692(21)01358-1. doi: 10.1016/j.chest.2021.06.079. Online ahead of print.NO ABSTRACTPMID:34302842 | DOI:10.1016/j.chest.2021.06.079 (Source: Chest)
Source: Chest - July 24, 2021 Category: Respiratory Medicine Authors: Y Tandjaoui-Lambiotte Y Akrour A Gibelin F Gonzalez A Stoclin A S Moreau P Jaubert A Oppenheimer B Duchemann S Gaudry GRRROH study group: F El Kouari E De Montmollin M Pineton de Chambrun F Wallet A Lautrette N Dufour D Contou J D Ricard R Persichini J Ma Source Type: research

Comparison between the effects of normal saline with and without heparin for the prevention and management of arterial catheter occlusion: a triple-blinded randomized trial
ConclusionNormal saline with and without heparin showed similar efficiency for both the prevention of occlusion and the results of coagulation. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - July 24, 2021 Category: Anesthesiology Source Type: research

Multisystem inflammatory syndrome in children during the coronavirus disease pandemic of 2019: a review of clinical features and acute phase management
We describe its epidemiology, pathophysiology, diagnosis (which varies based on definition used) and treatment options based on published recommendations. A systematic literature search we conducte d through MEDLINE yielded 518 abstracts and identified five studies that reported more than 100 cases of MIS-C and their mortality. Most cases developed multiorgan dysfunction, including cardiovascular, dermatologic, neurological, renal, and respiratory issues, and required intensive care unit (ICU) admission. Many patients admitted to the ICU needed inotrope support and invasive mechanical ventilation, and the most severe cases...
Source: Journal of Anesthesia - July 24, 2021 Category: Anesthesiology Source Type: research

Management of arterial partial pressure of carbon dioxide in the first week after traumatic brain injury: results from the CENTER-TBI study
AbstractPurposeTo describe the management of arterial partial pressure of carbon dioxide (PaCO2) in severe traumatic brain-injured (TBI) patients, and the optimal target of PaCO2 in patients with high intracranial pressure (ICP).MethodsSecondary analysis of CENTER-TBI, a multicentre, prospective, observational, cohort study. The primary aim was to describe current practice in PaCO2 management during the first week of intensive care unit (ICU) after TBI, focusing on the lowest PaCO2 values. We also assessed PaCO2 management in patients with and without ICP monitoring (ICPm), and with and without intracranial hypertension. W...
Source: Intensive Care Medicine - July 24, 2021 Category: Intensive Care Source Type: research

Objective assessment of surgeon kinematics during simulated laparoscopic surgery: a preliminary evaluation of the effect of high body mass index models
ConclusionsOur findings indicate that performing laparoscopic surgery on a high BMI model worsens upper body motion efficiency and efficacy, and increases dynamic workload, producing conditions that are more physically demanding when compared to operating on a 20  kg/m2 model. These findings also suggest that the head, torso, and upper arm segments are especially affected by high BMI models and therefore exposure to patients with high BMIs may increase the risk of musculoskeletal injury when performing laparoscopic surgery. (Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - July 24, 2021 Category: Intensive Care Source Type: research

Nutrition Delivery and Growth Outcomes in Infants with Long-Gap Esophageal Atresia Who Undergo the Foker Process
Abbreviations: Foker Process (FP), long-gap esophageal atresia (LGEA), weight-for-age z score (WAZ), parenteral nutrition (PN), enteral nutrition (EN), World Health Organization (WHO), Center for Disease Control (CDC), Functional Oral Intake Scale (FOIS), speech and language pathologist (SLP), interquartile ranges (IQR), confidence interval (CI), intensive care unit (ICU), central line associated blood stream infection (CLABSI), urinary tract infection (UTI), American Society for Parental and Enteral Nutrition (ASPEN), minimally invasive (MIS), Congenital Heart Disease (CHD), association of vertebral defects, anal atresia,...
Source: Journal of Pediatric Surgery - July 24, 2021 Category: Surgery Authors: Amanda W. Harrington, Jane Riebold, Kayla Hernandez, Steven J. Staffa, Wendy Jo Svetanoff, David Zurakowski, Thomas Hamilton, Russell Jennings, Nilesh M. Mehta, Benjamin Zendejas Source Type: research

Rationale and study design of an early care, therapeutic education, and psychological intervention program for the management of post-intensive care syndrome and chronic pain after COVID-19 infection (PAIN-COVID): study protocol for a randomized controlled trial
Critically ill patients with COVID-19 are an especially susceptible population to develop post-intensive care syndrome (PICS) due to acute respiratory distress syndrome (ARDS). Patients can suffer acute severe... (Source: Trials)
Source: Trials - July 24, 2021 Category: General Medicine Authors: Antonio Ojeda, Andrea Calvo, Tomas Cu ñat, Ricard Mellado Artigas, Oscar Comino-Trinidad, Jorge Aliaga, Marilyn Arias, Maribel Ahuir, Carlos Ferrando and Christian Dürsteler Tags: Study protocol Source Type: research

Mortality of septic shock patients is associated with impaired mitochondrial oxidative coupling efficiency in lymphocytes: a prospective cohort study
Septic shock is a life-threatening condition that challenges immune cells to reprogram their mitochondrial metabolism towards to increase ATP synthesis for building an appropriate immunity. This could print me... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - July 24, 2021 Category: Surgery Authors: Wagner Luis Nedel, Afonso Kopczynski, Marcelo Salimen Rodolphi, Nathan Ryzewski Strogulski, Marco De Bastiani, Tiago Hermes Maeso Montes, Jose Abruzzi Jr, Antonio Galina, Tamas L. Horvath and Luis Valmor Portela Tags: Research Articles Source Type: research

Effect of rapid methicillin-resistant Staphylococcus aureus nasal polymerase chain reaction screening on vancomycin use in the intensive care unit
Am J Health Syst Pharm. 2021 Jul 23:zxab296. doi: 10.1093/ajhp/zxab296. Online ahead of print.ABSTRACTPURPOSE: To determine the impact of a pharmacist-driven methicillin-resistant Staphylococcus aureus (MRSA) nasal polymerase chain reaction (PCR) screen on vancomycin duration in critically ill patients with suspected pneumonia.METHODS: This was a retrospective, quasi-experimental study at a 613-bed academic medical center with 67 intensive care beds. Adult patients admitted to the intensive care unit (ICU) between 2017 and 2019 for 24 hours or longer and empirically started on intravenous vancomycin for pneumonia were incl...
Source: American Journal of Health-System Pharmacy : AJHP - July 23, 2021 Category: Drugs & Pharmacology Authors: Calvin Diep Lina Meng Samaneh Pourali Matthew M Hitchcock William Alegria Rebecca Swayngim Ran Ran Niaz Banaei Stan Deresinski Marisa Holubar Source Type: research

Transmission of paediatric respiratory syncytial virus and influenza in the wake of the COVID-19 pandemic
Euro Surveill. 2021 Jul;26(29). doi: 10.2807/1560-7917.ES.2021.26.29.2100186.ABSTRACTThe non-pharmaceutical interventions implemented to slow the spread of SARS-CoV-2 have had consequences on the transmission of other respiratory viruses, most notably paediatric respiratory syncytial virus (RSV) and influenza. At the beginning of 2020, lockdown measures in the southern hemisphere led to a winter season with a marked reduction in both infections. Intermittent lockdowns in the northern hemisphere also appeared to interrupt transmission during winter 2020/21. However, a number of southern and northern hemisphere countries hav...
Source: Euro Surveill - July 23, 2021 Category: Infectious Diseases Authors: Thomas C Williams Ian Sinha Ian G Barr Maria Zambon Source Type: research

Impact of Parenteral Nutrition Guideline Implementation on Growth of Very Low Birth Weight Infants in a Neonatal Intensive Care Unit
CONCLUSION: No difference was observed in the weight velocity of very low birth weight neonates less than 1,250 grams at birth when using the implemented guideline for PN writing at our institution. This article is protected by copyright. All rights reserved.PMID:34297359 | DOI:10.1002/jpen.2237 (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
Source: JPEN Journal Of Parenteral And Enteral Nutrition - July 23, 2021 Category: Nutrition Authors: Jordan L Phillips Kristen M Jones Priyanka H Patel Alex C Lopilato Tanvi Kamdar Source Type: research

Impact of induction chemotherapy with intermediate-dosed cytarabine and subsequent allogeneic stem cell transplantation on the outcome of high-risk acute myeloid leukemia
J Cancer Res Clin Oncol. 2021 Jul 23. doi: 10.1007/s00432-021-03733-0. Online ahead of print.ABSTRACTBACKGROUND: Acute myeloid leukemia (AML) with antecedent hematological disease (s-AML) and treatment-related AML (t-AML) predicts poor prognosis. Intensive treatment protocols of those high-risk patients should consider allogeneic stem cell transplantation (allo-HSCT) in first complete remission (CR). Despite allo-HSCT, relapse rate remains high. Induction chemotherapy with liposomal cytarabine and daunorubicin (CPX-351) has been approved for patients with AML with myeloid-related changes (AML-MRC) or t-AML based on improve...
Source: Clin Med Res - July 23, 2021 Category: Research Authors: Maximilian Fleischmann Ulf Schnetzke Jochen J Frietsch Herbert G Sayer Karin Schrenk Jakob Hammersen Anita Glaser Inken Hilgendorf Andreas Hochhaus Sebastian Scholl Source Type: research

Schwangerschaft und irreversibler Hirnfunktionsausfall – ein ethischer Kommentar
Anasthesiol Intensivmed Notfallmed Schmerzther. 2021 Jul;56(7-08):551-556. doi: 10.1055/a-1469-9376. Epub 2021 Jul 23.NO ABSTRACTPMID:34298575 | DOI:10.1055/a-1469-9376 (Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS)
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - July 23, 2021 Category: Intensive Care Authors: Gerald Neitzke Source Type: research

Juristischer Kommentar zu: Schwangerschaft und irreversibler Hirnfunktionsausfall
Anasthesiol Intensivmed Notfallmed Schmerzther. 2021 Jul;56(7-08):544-548. doi: 10.1055/a-1337-1303. Epub 2021 Jul 23.NO ABSTRACTPMID:34298574 | DOI:10.1055/a-1337-1303 (Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS)
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - July 23, 2021 Category: Intensive Care Authors: Elmar Biermann Source Type: research

Ethical, Psychosocial and Legal Aspects of the Treatment of Pregnant Patients with Brain Death
Anasthesiol Intensivmed Notfallmed Schmerzther. 2021 Jul;56(7-08):536-543. doi: 10.1055/a-1203-2826. Epub 2021 Jul 23.ABSTRACTThe therapy of brain-dead pregnant women is an extreme example not only of the possibilities in current critical care, but also of resulting ethical, social and legal controversies, an area not familiar to most clinicians. Based on the case of a patient with fatal traumatic brain injury, a previously unknown early pregnancy and stated will to donate organs, we will discuss several aspects using published case reports: therapeutic goals, especially palliative care vs. continuation; implications of br...
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - July 23, 2021 Category: Intensive Care Authors: Ann-Kristin Reinhold Christian K Markus Markus Kredel Rainer Beckmann Wolfgang Muellges Monika Rehn Achim W öckel Patrick Meybohm Norbert Roewer Peter Kranke Source Type: research

Pregnancy and Irreversible Loss of Brain Functions - Case Report
Anasthesiol Intensivmed Notfallmed Schmerzther. 2021 Jul;56(7-08):526-535. doi: 10.1055/a-1203-3031. Epub 2021 Jul 23.ABSTRACTA 29-year-old woman suffered major traumatic brain injury caused by a car accident. As diagnostic measures had revealed an early pregnancy (9th week), treatment on the intensive care unit was continued for 5 months, after unfavourable cerebral prognosis was followed by an irreversible loss of brain function in the 10th week of pregnancy. After assisted vaginal delivery of a healthy child in the 31th week of pregnancy on the critical care unit, organ procurement took place according to the presumed w...
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - July 23, 2021 Category: Intensive Care Authors: Markus Kredel Ann-Kristin Reinhold Johannes Wirbelauer Wolfgang Muellges Ekkehard Kunze Monika Rehn Achim W öckel Michael Lassmann Christian K Markus Patrick Meybohm Peter Kranke Source Type: research

Perioperative Atrial Fibrillation
Anasthesiol Intensivmed Notfallmed Schmerzther. 2021 Jul;56(7-08):516-525. doi: 10.1055/a-1180-0619. Epub 2021 Jul 23.ABSTRACTNew atrial fibrillation is a risk factor for increased morbidity and mortality in the perioperative phase. The prevalence and incidence of atrial fibrillation depend on age, previous illnesses and the intercurrent diagnoses in the perioperative phase. Pathomechanisms for both permanent and acute forms of atrial fibrillation relate to electrophysiological, histopathological and other pathophysiological abnormalities. In the perioperative phase, decompensated heart failure, systemic inflammation, seps...
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - July 23, 2021 Category: Intensive Care Authors: Marc Bodenstein Daniel Rohn Michael Schuster Source Type: research

Prevention of Surgical Site Infections
Anasthesiol Intensivmed Notfallmed Schmerzther. 2021 Jul;56(7-08):502-515. doi: 10.1055/a-1249-5169. Epub 2021 Jul 23.ABSTRACTThe burden of surgical site infections (SSIs) is increasing. The number of surgical procedures continues to rise, and surgical patients present increasingly complex comorbidities. Half of SSIs are deemed preventable using evidence-based strategies. It is recommended for patients to bathe or shower prior to surgery. Hair should be removed only with a clipper. Shaving is strongly discouraged at all times. Antimicrobial prophylaxis should be administered only when indicated, based on guidelines, and ti...
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - July 23, 2021 Category: Intensive Care Authors: Stefan Utzolino Christian Eckmann Johan Friso Lock Source Type: research

Infection Prevention in the Intensive Care Unit (ICU)
Anasthesiol Intensivmed Notfallmed Schmerzther. 2021 Jul;56(7-08):485-501. doi: 10.1055/a-1249-5156. Epub 2021 Jul 23.ABSTRACTSecondary to the underlying disease, the need for invasive devices and frequent drug-induced changes in immunocompetence and microbiota, critically ill patients have a high risk of suffering nosocomial infections. According to data from the European Centre for Disease Prevention and Control (ECDC) this affects 8,4% of patients treated in an ICU for more than 48 hours. Key points of infection prevention are maintenance of the patients' microbiota and sometimes individually chosen interventions to its...
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - July 23, 2021 Category: Intensive Care Authors: Sebastian Schulz-St übner Source Type: research

Infection Control in Anesthesia
Anasthesiol Intensivmed Notfallmed Schmerzther. 2021 Jul;56(7-08):474-484. doi: 10.1055/a-1249-5093. Epub 2021 Jul 23.ABSTRACTThe anaesthesiological care of patients in the operating room involves many activities that can lead to an infection. Hand hygiene is the most effective single measure for the prevention of nosocomial infections. Hand disinfectant dispensers should be placed within easy reach. When preparing infusions and drugs to be administered intravenously, the introduction of microorganisms cannot be completely ruled out, even if all hygienic requirements are observed. Therefore, parenterals without preservativ...
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - July 23, 2021 Category: Intensive Care Authors: Marzia Bonsignore Irit Nachtigall Source Type: research