Patient-ventilator asynchrony in adult critically ill patients.
Authors: Bruni A, Garofalo E, Pelaia C, Messina A, Cammarota G, Murabito P, Corrado S, Vetrugno L, Longhini F, Navalesi P Abstract Patient-ventilator asynchrony is considered as a major clinical problem for mechanically ventilated patients. It occurs during partial ventilatory support, when the respiratory muscles and the ventilator interact to contribute generating the volume output. In this review article, we consider all studies published on patient-ventilator asynchrony in the last 25 years. We selected 62 studies. The different forms of asynchrony are first defined and classified. We also describe the methods ...
Source: Minerva Anestesiologica - February 16, 2019 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

Inhalation versus intravenous anesthesia for adults undergoing heart valve surgery: a systematic review and meta-analysis.
CONCLUSIONS: Among patients undergoing heart valve surgery, the use of inhalation anesthesia compared with TIVA failed to demonstrate superiority for survival and major postoperative complications and the evidence was insufficient to draw firm conclusions due to the limited sample size. A determination of equivalence or superiority between these two anesthetic regimens requires further researches. PMID: 30762324 [PubMed - as supplied by publisher] (Source: Minerva Anestesiologica)
Source: Minerva Anestesiologica - February 16, 2019 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

Clinical standards for patient blood management and perioperative hemostasis and coagulation management position paper of the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Care (SIAARTI).
Authors: Cinnella G, Pavesi M, De Gasperi A, Ranucci M, Mirabella L Abstract Patient blood management is currently defined as the application of evidence based medical and surgical concepts designed to maintain hemoglobin (Hb), optimize hemostasis and minimize blood loss to improve patient outcome. Blood management focus on the perioperative management of patients undergoing surgery or other invasive procedures in which significant blood loss occurs or is expected. Preventive strategies are emphasized to identify and manage anemia, reduce iatrogenic blood losses, optimize hemostasis (e.g. pharmacologic therapy, and...
Source: Minerva Anestesiologica - February 16, 2019 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

Safety of laparoscopic hepatectomy in patients with hepatocellular carcinoma and portal hypertension: interim analysis of an open prospective study
ConclusionLLR is safe in BCLC 0-A patients with CSPH, with no mortality and good short-term outcomes. Re-evaluation of the BCLC guidelines is needed. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - February 16, 2019 Category: Surgery Source Type: research

Thoracic aortic injury caused by chest tube
Publication date: Available online 14 February 2019Source: Medicina Intensiva (English Edition)Author(s): J.M. Vignau Cano, A. Bermúdez García, D. Macías Rubio (Source: Medicina Intensiva)
Source: Medicina Intensiva - February 15, 2019 Category: Intensive Care Source Type: research

Comparison of Remifentanil-Based Fast-Track and Fentanyl-Based Routine Cardiac Anesthesia for Intraoperative Device Closure of Atrial Septal Defect (ASD) in Pediatric Patients.
Authors: Huang Q, Lin LY, Lin XZ Abstract BACKGROUND The aim of this study was to evaluate the effectiveness and safety of remifentanil-based fast-track anesthesia for intraoperative device closure of atrial septal defects (ASDs). MATERIAL AND METHODS The clinical data of 152 pediatric patients who received intraoperative device closure of ASD in our hospital from January 2015 to December 2017 were retrospectively analyzed. Patients were divided into 2 groups: group F (remifentanil-based fast-track anesthesia group, n=72) and group C (fentanyl-based routine anesthesia group, n=80). The relevant data from 2 groups w...
Source: Medical Science Monitor - February 15, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Anaesthesia, Intensive Care and Perioperative Medicine A-Z: An Encyclopaedia of Principles and Practice, 6th Edition
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - February 15, 2019 Category: Anesthesiology Source Type: research

Risk of adverse pregnancy outcomes by pre-pregnancy Body Mass Index among Italian population: a retrospective population-based cohort study on 27,807 deliveries
AbstractPurposeTo estimate the impact of increasing pre-pregnancy Body Mass Index (BMI) on the risk of adverse maternal and perinatal outcomes, in patients who delivered in an Italian tertiary care Obstetric department.MethodsData, related to women who delivered at Sant ’Anna Hospital, Turin, between 2011 and 2015, were collected retrospectively from the hospital database. According to BMI, women were considered as normal weight, overweight, and class 1, 2 and 3 obese (WHO criteria). Logistic regression analysis studied the impact of BMI on maternal and neonatal outcomes, adjusting results for maternal age and parity...
Source: Archives of Gynecology and Obstetrics - February 15, 2019 Category: OBGYN Source Type: research

Cost-effectiveness analysis of endovascular versus open repair of abdominal aortic aneurysm in a high-volume center
Endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAAs) is the standard treatment for anatomically suitable patients. EVAR has been associated with a lower perioperative morbidity and mortality compared with open surgical repair (OSR) at the expense of increased reinterventions and costs. We aimed to compare the outcomes of EVAR and OSR for elective AAA repair. The primary end point was cost per QALY at 3  years. Secondary end points were perioperative morbidity and mortality; freedom from reintervention; length of hospital, high-dependency unit, and intensive care unit stay; and freedom from all-cau...
Source: Journal of Vascular Surgery - February 15, 2019 Category: Surgery Authors: Patrick Canning, Wael Tawfick, Nicola Whelan, Niamh Hynes, Sherif Sultan Source Type: research

Information needs of families on the health/disease of preterm infants in a neonatal intensive care unit
Conclusion: it has been found that the information needs of family members are wide, and different means are employed to satisfy them, ranging from the traditional and every day to the use of technological means to find data and used for different purposes.RESUMEN Objetivo: presentar y discutir acciones y estrategias utilizadas por profesores que ense ñan el juego terapéutico en los Cursos de Graduación en Enfermería. Método: investigación cualitativa, que utilizó el Interacionismo Simbólico como referencial teórico y metodológico la Teoría Fundam...
Source: Texto e Contexto - Enfermagem - February 14, 2019 Category: International Medicine & Public Health Source Type: research

The Impact of Comorbidity Burden on Complications, Length of Stay, and Direct Hospital Costs After Minimally Invasive Transforaminal Lumbar Interbody Fusion
Conclusion. Greater comorbidity burden as reflected by higher CCI was associated with increased postoperative complication rates following primary, single-level MIS-TLIF. However, this did not lead to prolongations in hospital stay or increased total direct hospital costs. This lack of association may suggest that the limited tissue trauma and operative exposure utilized in minimally invasive approaches may limit the utility of CCI as a predictor of surgical outcomes and costs. Level of Evidence: 4 (Source: Spine)
Source: Spine - February 14, 2019 Category: Orthopaedics Tags: SURGERY Source Type: research

Traumatic brain injury in China
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): Ji-Yao Jiang, Guo-Yi Gao, Jun-Feng Feng, Qing Mao, Li-Gang Chen, Xiao-Feng Yang, Jin-Fang Liu, Yu-Hai Wang, Bing-Hui Qiu, Xian-Jian HuangSummaryChina has more patients with traumatic brain injury (TBI) than most other countries in the world, making this condition a major public health concern. Population-based mortality of TBI in China is estimated to be approximately 13 cases per 100 000 people, which is similar to the rates reported in other countries. The implementation of various measures, such as safety legislation for road traffi...
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research

Evaluation of an “all-in-one” seven-day WGS solution in the investigation of a Staphylococcus aureus outbreak in a neonatal Intensive Care Unit
ConclusionThe use of the Episeq solution allowed us to quickly demonstrate the polyclonal profile of the MSSA population in neonates and thus rule out the suspicion of a global outbreak. However, wgSNP analysis showed the transmission and persistence of one ST over 6 months in the NICU and enabled the infection control team to adapt its response. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - February 14, 2019 Category: Infectious Diseases Source Type: research

Sepsis incidence and mortality are underestimated in Australian intensive care unit administrative data.
Authors: Pilcher D, Huckson S, Hicks P PMID: 30758055 [PubMed - as supplied by publisher] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - February 14, 2019 Category: General Medicine Tags: Med J Aust Source Type: research

Trauma intensive care in a terror-ravaged, resource-constrained setting: Are we prepared for the emerging challenge?
ConclusionMajor trauma contributes significantly to local intensive care admissions, with terrorism- related trauma now an emerging challenging cause of major trauma in our region. The observed poor outcomes in this study are a reflection of the quality of available intensive care, and lends credence to the concept of appropriately resourced, specialised intensive care units for optimisation of care. (Source: African Journal of Emergency Medicine)
Source: African Journal of Emergency Medicine - February 14, 2019 Category: Emergency Medicine Source Type: research

Outcomes of the Conversion of the Fontan-Kreutzer Operation to a Total Cavopulmonary Connection for the Failing Univentricular Circulation
Abstract Background: The Fontan-Kreutzer procedure (FK) was widely performed in the past, but in the long-term generated many complications resulting in univentricular circulation failure. The conversion to total cavopulmonary connection (TCPC) is one of the options for treatment. Objective: To evaluate the results of conversion from FK to TCPC. Methods: A retrospective review of medical records for patients who underwent the conversion of FK to TCPC in the period of 1985 to 2016. Significance p
Source: Arquivos Brasileiros de Cardiologia - February 14, 2019 Category: Cardiology Source Type: research

Fontan-Kreutzer Conversion to Total Cavopulmonary Surgery due to Failing Univentricular Circulation. A Feasible Therapeutic Option?
Abstract Background: The Fontan-Kreutzer procedure (FK) was widely performed in the past, but in the long-term generated many complications resulting in univentricular circulation failure. The conversion to total cavopulmonary connection (TCPC) is one of the options for treatment. Objective: To evaluate the results of conversion from FK to TCPC. Methods: A retrospective review of medical records for patients who underwent the conversion of FK to TCPC in the period of 1985 to 2016. Significance p
Source: Arquivos Brasileiros de Cardiologia - February 14, 2019 Category: Cardiology Source Type: research

Metagenomic study on the composition of culturable and non-culturable bacteria in tap water and biofilms at intensive care units.
This study sheds light on the prevalence of unculturable bacterial flora in the biofilm ignored by the microbiological standard methods. This study was performed on tap and bulk water from ICUs; however, it indicates the need for further studies to investigate the function and activity of the microbial diversity in order to assess the real risk presented by this water microflora on patients' health. PMID: 30758305 [PubMed - in process] (Source: Journal of Water and Health)
Source: Journal of Water and Health - February 14, 2019 Category: Environmental Health Tags: J Water Health Source Type: research

Mechanical thrombectomy in acute ischemic stroke, knowing our results
Publication date: Available online 14 February 2019Source: Medicina Intensiva (English Edition)Author(s): F. Pino Sánchez, A. Fernández Carmon, M.V. Muñoz Marina, E. Fernández Mondéja (Source: Medicina Intensiva)
Source: Medicina Intensiva - February 14, 2019 Category: Intensive Care Source Type: research

Spontaneous acute subdural hematoma. An unusual presentation of ruptured cerebral aneurysm
Publication date: Available online 14 February 2019Source: Medicina Intensiva (English Edition)Author(s): M.D. Freire Aragón, M. Adriaensens Pérez, A.J. Marín Caballos (Source: Medicina Intensiva)
Source: Medicina Intensiva - February 14, 2019 Category: Intensive Care Source Type: research

In reply to “Mechanical thrombectomy in acute ischemic stroke, knowing our results”
Publication date: Available online 13 February 2019Source: Medicina Intensiva (English Edition)Author(s): L. Viña Soria, D. Escudero Augusto, S. Calleja Puerta, P. Vega Valdés, L. López Amor, L. Martín Iglesias (Source: Medicina Intensiva)
Source: Medicina Intensiva - February 14, 2019 Category: Intensive Care Source Type: research

Genetic Relatedness of Staphylococcus haemolyticus in Gut and Skin of Preterm Neonates and Breast Milk of Their Mothers
Background: Staphylococcus haemolyticus is a common colonizer and cause of late-onset sepsis (LOS) in preterm neonates. By describing genetic relatedness, we aimed to determine whether mother’s breast milk (BM) is a source of S. haemolyticus colonizing neonatal gut and skin and/or causing LOS. Methods: S. haemolyticus was isolated from stool and skin swabs of 49 BM-fed preterm neonates admitted to neonatal intensive care unit, 20 healthy BM-fed term neonates and BM of mothers once a week and typed by multilocus variable number tandem repeat analysis and multilocus sequence typing. Virulence-related genes were de...
Source: The Pediatric Infectious Disease Journal - February 14, 2019 Category: Infectious Diseases Tags: Maternal-Neonatal Reports Source Type: research

Predictive Value of Soluble Programmed Death-1 for Severe Sepsis and Septic Shock During the First Week in an Intensive Care Unit
In this study, we evaluated the predictive value of soluble PD-1 (sPD-1) for severity and 28-day mortality in patients with severe sepsis and septic shock during the first week in an intensive care unit (ICU). Methods: In this prospective cohort study, patients were classified into the severe sepsis group or the septic shock group according to the severity of their condition on ICU admission. All patients were also separated into the survivor or nonsurvivor groups according to their 28-day outcomes. Peripheral blood sPD-1 and soluble PD-L1 (sPD-L1) levels, PD-1 expression on CD4+ and CD8+ T cells, and PD-L1 expression o...
Source: Shock - February 14, 2019 Category: Emergency Medicine Tags: Clinical Science Aspects Source Type: research

Do Sepsis-3 Criteria Facilitate Earlier Recognition of Sepsis and Septic Shock? A Retrospective Cohort Study
Background: New Sepsis-3 criteria are supposed to “facilitate earlier recognition … of patients with sepsis.” To test this, we performed novel and direct comparisons of Sepsis-1 vs. Sepsis-3 criteria with respect to time differences of sepsis onset. Methods: In a cohort of intensive care unit (ICU) patients prospectively diagnosed with severe sepsis or septic shock according to Sepsis-1 criteria between 01/2010 and 12/2015, the time differences between meeting Sepsis-1 vs. Sepsis-3 criteria as time of sepsis onset and the corresponding differences in illness severity were tested. Similar comparisons...
Source: Shock - February 14, 2019 Category: Emergency Medicine Tags: Clinical Science Aspects Source Type: research

Association Between Muscle Wasting and Muscle Strength in Patients Who Developed Severe Sepsis And Septic Shock
Purpose: To evaluate the association between the rectus femoris cross-sectional area (RFCSA) and the muscular strength obtained at the bedside in patients forwarded to the intensive care unit (ICU) for severe sepsis and septic shock. Methods: An observational study of prospective cohort. RFCSA was assessed by ultrasound on the following day of the ICU admission and monitored during hospitalization. The patients performed clinical tests of muscle strength (Medical Research Council (MRC) scale and handgrip dynamometry), when they could understand the verbal commands of the examiners. Results: In 37 patients hospitali...
Source: Shock - February 14, 2019 Category: Emergency Medicine Tags: Clinical Science Aspects Source Type: research

Alkaline Phosphatase Activity and Endotoxemia After Infant Cardiothoracic Surgery
Objective: Infant cardiopulmonary bypass (CPB) increases intestinal permeability leading to endotoxemia. Alkaline phosphatase (AP) reduces endotoxin toxicity in vitro but its effects on endotoxemia in human disease are poorly understood. We assessed the association between serum AP activity and endotoxemia in infants undergoing CPB and determined the effect of ex vivo addition of AP on endotoxemia. Methods: Prospective cohort study of 62 infants ≤120 days of age undergoing CPB. AP activity and Endotoxin Activity Assay (EAA) were measured pre-operatively, during rewarming, and 24 h after cardiac intensive care unit ...
Source: Shock - February 14, 2019 Category: Emergency Medicine Tags: Clinical Science Aspects Source Type: research

High-fidelity computational simulation to refine strategies for lung-protective ventilation in paediatric acute respiratory distress syndrome
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - February 14, 2019 Category: Intensive Care Source Type: research

Narrative reviews from a fraudulent author: reasons to retract
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - February 14, 2019 Category: Intensive Care Source Type: research

Influence of antibiotic pressure on multi-drug resistant Klebsiella pneumoniae colonisation in critically ill patients
ConclusionIndividual antibiotic administration and the global antibiotic pressure of cephalosporins and carbapenems are associated to an increased colonisation by MDRK. pneumoniae strains. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - February 14, 2019 Category: Infectious Diseases Source Type: research

Predicting tachycardia as a surrogate for instability in the intensive care unit
AbstractTachycardia is a strong though non-specific marker of cardiovascular stress that proceeds hemodynamic instability. We designed a predictive model of tachycardia using multi-granular intensive care unit (ICU) data by creating a risk score and dynamic trajectory. A subset of clinical and numerical signals were extracted from the Multiparameter Intelligent Monitoring in Intensive Care II database. A tachycardia episode was defined as heart rate ≥ 130/min lasting for ≥ 5 min, with ≥ 10% density. Regularized logistic regression (LR) and random forest (RF) classifiers were trained to cr...
Source: Journal of Clinical Monitoring and Computing - February 14, 2019 Category: Information Technology Source Type: research

Perioperative Treatment of Brain Arteriovenous Malformations Between 2006 and 2014: The Helsinki Protocol
ConclusionsThe Helsinki protocol for postoperative treatment of bAVMs was found to produce comparable results to a more complex treatment algorithm. DPH was associated with high SMG, complex venous drainage pattern, male gender and high intravenous fluid intake. Our findings support the use of SMG in defining patient ’s postoperative treatment as the DPHs in our study occurred in patients with grade 2–5. (Source: Neurocritical Care)
Source: Neurocritical Care - February 14, 2019 Category: Neurology Source Type: research

Predicting clinical outcome in patients undergoing VA-ECMO
(Source: Critical Care)
Source: Critical Care - February 14, 2019 Category: Intensive Care Authors: Antoine Kimmoun and Bruno Levy Tags: Editorial Source Type: research

Assessment of intestinal perfusion by a new balloon-tipped transpyloric probe
(Source: Critical Care)
Source: Critical Care - February 14, 2019 Category: Intensive Care Authors: Samir G. Sakka Tags: Letter Source Type: research

NephroCheck: should we consider urine osmolality?
(Source: Critical Care)
Source: Critical Care - February 14, 2019 Category: Intensive Care Authors: Alberto Noto, Andrea Cortegiani and Antonio David Tags: Letter Source Type: research

[Imaging of bacteria in burn wounds treated with split-thicknessgrafts in MEEK/MESH technique: a pilot study with first experiences in clinical wound evaluation with autofluorescence].
CONCLUSION: The representation of the fluorescence exciter load shows high concentrations of pathogens both in the MEEK silk layer as well as in foam linkers. Overall split-thickness grafts according to the MEEK technique showed a higher healing rate compared to MESH technique. Screening of burns wounds with autofluorescence imaging can be helpful for an additive wound assessment. Split-thickness graft covers should be applied only for a minimum time period required to ensure stable grafting. PMID: 30754065 [PubMed - as supplied by publisher] (Source: Handchirurgie Mikrochirurgie Plastische Chirurgie)
Source: Handchirurgie Mikrochirurgie Plastische Chirurgie - February 13, 2019 Category: Cosmetic Surgery Tags: Handchir Mikrochir Plast Chir Source Type: research

Randomized Trial of Miniaturized versus Standard Extracorporeal Circulation in Aortic Valve Surgery
Publication date: Available online 13 February 2019Source: The Annals of Thoracic SurgeryAuthor(s): Frank R. Halfwerk, Kees Knol, Silvia Mariani, Jan G. Grandjean, Gianclaudio MecozziAbstractBackgroundComplications related to extracorporeal circulation remain serious. While a Minimal Invasive Extra Corporeal Circulation (MiECC) system was developed to cope with these complications, its effectivity on patient-related outcomes such as blood loss remain uncertain. Therefore, the aim of this study is to compare MiECC to an advanced standard system with respect to blood loss.MethodsA total of 128 adult patients undergoing elect...
Source: The Annals of Thoracic Surgery - February 13, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

[Obtaining Informed Consent for Anesthesia in Elective Surgery at a Tertiary-Care Hospital: Practices and Ethical-Legal Context].
CONCLUSION: Despite its importance, the practice of written informed consent for anesthesia in this institution is not yet implemented on a regular basis. PMID: 30753804 [PubMed - in process] (Source: Acta Medica Portuguesa)
Source: Acta Medica Portuguesa - February 13, 2019 Category: General Medicine Tags: Acta Med Port Source Type: research

Psychometric Evaluation of a Measure of Factors Influencing Hand Hygiene Behaviour to Inform Intervention
Publication date: Available online 13 February 2019Source: Journal of Hospital InfectionAuthor(s): Sinéad Lydon, Cathriona Greally, Omar Tujjar, Kiran Reddy, Kathryn Lambe, Caoimhe Madden, Chloe Walsh, Susan Fox, Paul O’ConnorAbstracttBackgroundAlthough the hand hygiene (HH) procedure is simple, the related behaviour is complex and is not readily understood, explained, or changed. There is a need for practical tools to provide data that can guide healthcare managers and practitioners not only on the ‘what’ (the standards that must be met), but also the ‘how’ (guidance on how to achieve ...
Source: Journal of Hospital Infection - February 13, 2019 Category: Infectious Diseases Source Type: research

Permanent damage of the sciatic nerve in an 8-year-old girl with newly diagnosed type 1 diabetes.
Authors: Giza S, Litou E, Kotanidou EP, Kleisarchaki AN, Koliatos P, Tzirtzipis T, Tsinopoulou VR, Tychalas A, Evangeliou A, Galli-Tsinopoulou A Abstract Neuropathy, a complication of type 1 diabetes (T1D), is a heterogeneous group, and chronic polyneuropathy is the most common form in adults. Αn 8-year-old girl admitted with severe diabetic ketoacidosis was diagnosed with T1D. She was managed with intravenous fluids and insulin and was subsequently commenced on multiple daily subcutaneous injections of insulin. On the 7th day of hospitalisation, a right foot drop with sensory loss on the dorsal surface and c...
Source: Paediatrics and international child health - February 13, 2019 Category: Pediatrics Tags: Paediatr Int Child Health Source Type: research

A study into the feasibility of using HRV variables to guide treatment in patients with paroxystic sympathetic hyperactivity in a neurointensive step-down unit.
DISCUSSION: The cohort was small, the setting the immediate postictal period of intensive care with multidisciplinary rehabilitation. Still, changes in frequency domain were detected following therapeutic efforts. This opens up the venue of on-line monitoring of the intended therapeutic effect. PMID: 30741702 [PubMed - as supplied by publisher] (Source: NeuroRehabilitation)
Source: NeuroRehabilitation - February 13, 2019 Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research

NSE concentrations and haemolysis after cardiac arrest
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - February 13, 2019 Category: Intensive Care Source Type: research

A new extra-thoracic, in-plane, longitudinal, real-time, ultrasound-guided access to the axillary vein
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - February 13, 2019 Category: Intensive Care Source Type: research

Achieving ethnic equality in the Israel trauma healthcare system: the case of the elderly population
AbstractObjectiveTo determine if ethnic disparities exist with regard to the risk of injury and injury outcomes among elderly hospitalized casualties in Israel.MethodsA retrospective study based on data from the Israeli National Trauma Registry between 2008 and 2017. Data included demographic, injury and hospitalization characteristics. Descriptive statistics and adjusted logistic regression were used to examine the differences between Jewish and Arab casualties, aged 65 and older.ResultThe study included 96,795 casualties. The proportion of elderly hospitalized casualties was 2.8 times greater than their proportion in the...
Source: Israel Journal of Health Policy Research - February 13, 2019 Category: International Medicine & Public Health Source Type: research

Surgical treatment strategies in pediatric trauma patients: ETC vs. DCO —an analysis of 316 pediatric trauma patients from the TraumaRegister DGU ®
ConclusionUse of external fixation increases with age and plays a minor role in the very young trauma population. However, this does not produce a difference in outcome between children and adults. (Source: European Journal of Trauma and Emergency Surgery)
Source: European Journal of Trauma and Emergency Surgery - February 13, 2019 Category: Emergency Medicine Source Type: research

Interest of Eosinophil Count in Bacterial Infections to Predict Antimicrobial Therapy Efficacy
To the Editor We read with great interest the article published by Kulaylat et al concerning the use of peripheral eosinopenia to predict the outcomes of 2065 patients withClostridium difficile infections (CDIs). In multivariate analysis, the authors found that undetectable eosinophil count was associated with increased in-hospital mortality and therefore was a marker of sepsis severity and admission in intensive care units. As CDI is one of the most common causes of nosocomial infection in the Unites States and has a high mortality rate, some points could be discussed. (Source: JAMA Surgery)
Source: JAMA Surgery - February 13, 2019 Category: Sports Medicine Source Type: research

The different weight of indications for cardiac surgery in patients with infective endocarditis
The optimal management of infective endocarditis (IE) relies on a close collaboration between a broad range of medical specialties, including cardiology, infectious diseases, internal medicine, neurology, intensive care, microbiology, and radiology. In addition, cardiac surgeons and anesthesiologists are involved in around 60 –70% of cases - those who present theoretical indication(s) for cardiac surgery [1] - to evaluate the individual risk/benefit balance of this procedure. To confirm, or deny, cardiac surgery in patients with IE, is probably one of the most difficult medical decisions in modern medicine, as the be...
Source: International Journal of Cardiology - February 13, 2019 Category: Cardiology Authors: Pierre Tattevin, Silvia Limonta Tags: Editorial Source Type: research

Effects of chloride content of intravenous crystalloid solutions in critically ill adult patients: a meta-analysis with trial sequential analysis of randomized trials
Intravenous crystalloid solutions are administered commonly for critically ill patients. We performed this meta-analysis of randomized trials with trial sequential analysis (TSA) to evaluate effects of chlorid... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - February 13, 2019 Category: Intensive Care Authors: Ming Xue, Xiwen Zhang, Feng Liu, Wei Chang, Jianfeng Xie, Jingyuan Xu, Yi Yang and Haibo Qiu Tags: Research Source Type: research

Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury
The acute respiratory distress syndrome (ARDS) is characterized by disruption of the alveolar-capillary barrier resulting in accumulation of proteinaceous edema and increased inflammatory cells in the alveolar... (Source: Critical Care)
Source: Critical Care - February 13, 2019 Category: Intensive Care Authors: Yue Zhou, Pengfei Li, Andrew J. Goodwin, James A. Cook, Perry V. Halushka, Eugene Chang, Basilia Zingarelli and Hongkuan Fan Tags: Research Source Type: research

Cerebral metabolism is not affected by moderate hyperventilation in patients with traumatic brain injury
Hyperventilation-induced hypocapnia (HV) reduces elevated intracranial pressure (ICP), a dangerous and potentially fatal complication of traumatic brain injury (TBI). HV decreases the arteriolar diameter of in... (Source: Critical Care)
Source: Critical Care - February 13, 2019 Category: Intensive Care Authors: Giovanna Brandi, Nino Stocchetti, Alberto Pagnamenta, Federica Stretti, Peter Steiger and Stephanie Klinzing Tags: Research Source Type: research

Current place of probiotics for VAP
(Source: Critical Care)
Source: Critical Care - February 13, 2019 Category: Intensive Care Authors: Harjeet Singh Virk and W. Joost Wiersinga Tags: Editorial Source Type: research