Severe community-acquired pneumonia: Current management and future therapeutic alternatives.
Authors: Garnacho-Montero J, Barrero-García I, Gómez-Prieto MG, Martín-Loeches I Abstract INTRODUCTION: Despite advances in modern medicine, severe community-acquired pneumonia (CAP) continues to be a potentially deadly disease. Mortality rate reaches up to the 50% in patients requiring admission to the Intensive Care Unit (ICU) when developing septic shock. Areas covered: We aim to describe the optimal management of severe CAP including antibiotic therapy, future antimicrobial options, and non-antibiotic (so-called adjunctive) therapies. A literature search was performed to identify all clinic...
Source: Expert Review of Anti-Infective Therapy - August 18, 2018 Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research

Utilizing Pediatric Scoring Systems to Predict Disposition During Interfacility Transport.
Authors: Holt T, Prodanuk M, Hansen G Abstract OBJECTIVE: Determining care disposition for pediatric patients during interfacility transport is often challenging. Severity of illness scoring can assist with this process. The purpose of this retrospective study was to compare currently utilized scoring systems and their ability to reliably match pediatric transport patients' severity of illness with the level of care necessary. METHODS: The retrospective transport registry review for our region included 209 patients
Source: Prehospital Emergency Care - August 18, 2018 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research

Research on the effect of cytokine concentration on the immune level and survival conditions of elderly patients with sepsis.
Authors: Li X, Yan B Abstract The present study was carried out to investigate the effect of cytokine (CK) concentrations on the immune phenotype and survival conditions of elderly patients with sepsis. A total of 112 elderly patients with sepsis who were admitted to The Affiliated Hospital of Medical School, Ningbo University for treatment between June 2015 and June 2017 were enrolled as the subjects. According to each patient's condition, they were divided into the mild sepsis group (n=68) and the severe sepsis group (n=44). Additionally, a further 60 patients without sepsis who were admitted to the Intensive Car...
Source: Experimental and Therapeutic Medicine - August 18, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Ultrasound guided airway access
Publication date: Available online 17 August 2018Source: Brazilian Journal of Anesthesiology (English Edition)Author(s): Neusa Lages, Diana Vieira, Joana Dias, Cláudia Antunes, Tiago Jesus, Telmo Santos, Carlos CorreiaAbstractUltrasound has increasingly growing applications in anesthesia. This procedure has proven to be a novel, non-invasive and simple technique for the upper airway management, proving to be a useful tool, not only in the operating room but also in the intensive care unit and emergency department. Indeed, over the years mounting evidence has showed an increasing role of ultrasound in airway manageme...
Source: Brazilian Journal of Anesthesiology - August 18, 2018 Category: Anesthesiology Source Type: research

Interhospital transport of ARDS patients on extracorporeal membrane oxygenation
AbstractVeno-venous extracorporeal membrane oxygenation (ECMO) can be a lifesaving therapy for patients with severe acute respiratory distress syndrome (ARDS). ECMO is a technically complex and challenging procedure and should therefore only be performed in specialized centers. Transporting ARDS patients to ECMO centers for treatment can be dangerous because of the risk of hypoxemia during transport. This raises the question if ECMO should not be already initiated in the transferring hospital before transport. Over a 5-year period, we studied ARDS patients who had been transported to our department by our mobile ECMO team ...
Source: Journal of Artificial Organs - August 18, 2018 Category: Transplant Surgery Source Type: research

Presence of anaerobic bacteria in the urinary tract of catheterized ICU patients
AbstractThe purpose of our study was to examine the extent of anaerobic bacteriuria in catheterized patients in the intensive care unit (ICU) and to search for risk factors for anaerobic bacteriuria. A urine culture was collected from each patient every 2  days during their ICU stay and incubated under aerobic and anaerobic conditions. Aerobic and anaerobic blood cultures were collected as well. Demographic, clinical, and laboratory data were collected from patient files. Ninety patients were included in this study, 32 women (35.6%) and 58 men (64.4 %). A total of 663 cultures were obtained. Twenty-three patients (25....
Source: European Journal of Clinical Microbiology and Infectious Diseases - August 18, 2018 Category: Microbiology Source Type: research

Challenges of customizing electrocardiography alarms in intensive care units: A mixed methods study
ConclusionAlarm customization is nuanced and requires adequate support to develop safe and effective practices. The challenges identified can inform development of strategies to improve alarm customization. (Source: Heart and Lung: The Journal of Acute and Critical Care)
Source: Heart and Lung: The Journal of Acute and Critical Care - August 17, 2018 Category: Respiratory Medicine Source Type: research

Early Experiences with Ultra-Fast-Track Extubation after Surgery for Congenital Heart Disease at a Single Center.
Conclusion: UFT extubation decreased the ICU LOS and mechanical ventilation time, but was not associated with postoperative hospital LOS or medical expenses in patients with simple congenital cardiac disease. PMID: 30109202 [PubMed] (Source: Korean Journal of Thoracic and Cardiovascular Surgery)
Source: Korean Journal of Thoracic and Cardiovascular Surgery - August 17, 2018 Category: Cardiovascular & Thoracic Surgery Tags: Korean J Thorac Cardiovasc Surg Source Type: research

Going Along With It: Neonatal Intensive Care Nurses' Views of a Donor Milk Practice Change
Background and Purpose: Donor human milk (DHM) is used when a mother's own milk is not available. Donor human milk is available as a frozen pasteurized or commercially sterilized product. An abrupt change in practice in use of donor milk products raised concerns among nurses caring for infants in the neonatal intensive care unit (NICU). The change in practice occurred without the input of nurses and without the sharing of supportive evidence with them. The purpose of this study was to explore NICU nurses' perceptions of the practice change from using frozen pasteurized DHM to using sterilized DHM in this context. Study ...
Source: MCN: The American Journal of Maternal Child Nursing - August 17, 2018 Category: Nursing Tags: Feature Source Type: research

Early Predictors of Abdominal Hemorrhage Among Critically Ill Patients With Pancreatitis: A Prospective Cohort Study
Conclusions Abdominal hemorrhages were common among critically ill patients with pancreatitis. These early predictors may be of use in detecting patients at risk of developing them. (Source: Pancreas)
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Antifungal consumption, indications and selection of antifungal drugs in pediatric tertiary hospitals in Turkey: Results from the first national point prevalence survey
ConclusionThe majority of antifungal drugs for treatment and prophylaxis were prescribed in PHO and HSCT units, followed by intensive care units. Thus, antifungal stewardship programs should mainly focus on these patients within the availability of diagnostic tests of each hospital. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - August 17, 2018 Category: Infectious Diseases Source Type: research

Guest editorial for the IJCARS special issue on MICCAI 2017
(Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - August 17, 2018 Category: Intensive Care Source Type: research

Correlation of neutrophil CD64 with clinical profile and outcome of sepsis patients during intensive care unit stay
Conclusion: Monitoring serial nCD64 during ICU stay may be helpful in determining the clinical course of septic patients. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - August 17, 2018 Category: Intensive Care Authors: Pralay Shankar Ghosh Harshit Singh Afzal Azim Vikas Agarwal Saurabh Chaturvedi Sai Saran Prabhaker Mishra Mohan Gurjar Arvind Kumar Baronia Banani Poddar Ratender Kumar Singh Ravi Mishra Source Type: research

The platelet count and its implications in sickle cell disease patients admitted for intensive care
Conclusions: In severe sickle cell crisis thrombocytopenia is more common than thrombocytosis. In the ICU, day 1 platelet counts correlate inversely with prognostic scores and are significantly reduced in multi-organ failure and nonsurvivors. A platelet count above 175 × 109/L predicts patient survival with high specificity and positive predictive value but lacks sensitivity. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - August 17, 2018 Category: Intensive Care Authors: Durjoy K Shome Ahmed Jaradat Ahmed I Mahozi Ali S Sinan Ali Ebrahim Mohammed Alrahim Mohammad S Ebraheem Eman J Mansoor Kameela S Majed Sheikh A Azeez Pasha Source Type: research

Retrospective evaluation of patients who leave against medical advice in a tertiary teaching care institute
Conclusions: About 3.3% of patients left hospital against medical advice in our retrospective analysis. Most of these cases did so from ward followed by ICU. Financial reasons and expected poor outcome played a significant role. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - August 17, 2018 Category: Intensive Care Authors: Nikhil Gautam JP Sharma Anita Sharma Vivek Verma Poonam Arora Parshotam Lal Gautam Source Type: research

A prospective study of fungal colonization and invasive fungal disease in long-term mechanically ventilated patients in a respiratory intensive care unit
Conclusion: Long-term mechanical ventilation (>7 days) is strongly associated with fungal colonization of the respiratory tract and urinary tract. Appropriate prophylactic antifungals may be given and infection control practices to be observed to ensure minimum colonization and therefore infection in such settings. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - August 17, 2018 Category: Intensive Care Authors: Amartya Chakraborti Anand Jaiswal Pushpendra Kumar Verma Ritu Singhal Source Type: research

Role of intra-abdominal pressure in early acute kidney injury: A prospective cohort study in critically Ill obstetric patients
Conclusions: IAH and AKI are common in critically ill obstetric patients. While IAP does not correlate with early AKI, NGAL is useful to predict AKI. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - August 17, 2018 Category: Intensive Care Authors: Asha Tyagi Shubham Lahan Gaurav Verma Shukla Das Mahendra Kumar Source Type: research

Balanced crystalloids versus isotonic saline in critically ill patients: systematic review and meta-analysis
ConclusionBalanced crystalloids and isotonic saline have no difference on various clinical outcomes including in-hospital mortality, AKI, overall ICU mortality, and new RRT. Further powerful clinical trials are required to determine the relationship between crystalloid fluid type and clinical outcomes. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - August 17, 2018 Category: Intensive Care Source Type: research

Effect of reading to preterm infants on measures of cardiorespiratory stability in the neonatal intensive care unit
Effect of reading to preterm infants on measures of cardiorespiratory stability in the neonatal intensive care unit, Published online: 17 August 2018; doi:10.1038/s41372-018-0198-4Effect of reading to preterm infants on measures of cardiorespiratory stability in the neonatal intensive care unit (Source: Journal of Perinatology)
Source: Journal of Perinatology - August 17, 2018 Category: Perinatology & Neonatology Authors: Melissa Scala Suna Seo Juniper Lee-Park Christina McClure Maria Scala Judith Jones Palafoutas Kabir Abubakar Source Type: research

Transcutaneous bilirubinometer use and practices surrounding jaundice in 150 California newborn intensive care units
Transcutaneous bilirubinometer use and practices surrounding jaundice in 150 California newborn intensive care units, Published online: 17 August 2018; doi:10.1038/s41372-018-0154-3Transcutaneous bilirubinometer use and practices surrounding jaundice in 150 California newborn intensive care units (Source: Journal of Perinatology)
Source: Journal of Perinatology - August 17, 2018 Category: Perinatology & Neonatology Authors: Dilip R. Bhatt Alexandria I. Kristensen-Cabrera Henry C. Lee Sunjeeve Weerasinghe David K. Stevenson Vinod K. Bhutani M. Jeffrey Maisels Rangasamy Ramanathan Source Type: research

High and Intensive Care in Psychiatry: Validating the HIC Monitor as a Tool for Assessing the Quality of Psychiatric Intensive Care Units
This study aims to validate the HIC monitor as a model-fidelity scale to the High and Intensive Care (HIC) model, a recently developed model for acute psychiatric wards. To assess the psychometric properties of the HIC monitor, 37 audits were held on closed inpatient wards at 20 psychiatric hospitals in the Netherlands. Interrater reliability, construct validity and content validity were examined. Our results suggest that the HIC monitor has good psychometric properties. It can be used as a tool for assessing the implementation of the HIC model on acute psychiatric wards in the Netherlands, and for quality assessment and i...
Source: Administration and Policy in Mental Health and Mental Health Services Research - August 17, 2018 Category: Psychiatry Source Type: research

Functional outcomes in adults with tuberculous meningitis admitted to the ICU: a multicenter cohort study
Tuberculous meningitis (TBM) is a devastating infection in tuberculosis endemic areas with limited access to intensive care. Functional outcomes of severe adult TBM patients admitted to the ICU in nonendemic a... (Source: Critical Care)
Source: Critical Care - August 17, 2018 Category: Intensive Care Authors: Marie Cantier, Adeline Morisot, Emmanuel Gu érot, Bruno Megarbane, Keyvan Razazi, Damien Contou, Eric Mariotte, Emmanuel Canet, Etienne De Montmollin, Vincent Dubée, Eric Boulet, Stéphane Gaudry, Guillaume Voiriot, Julien Mayaux, Frédéric Pène, Math Tags: Research Source Type: research

Challenges of customizing electrocardiography alarms in intensive care units: A mixed methods study
Customizing monitor alarm settings to individual patients can reduce alarm fatigue in intensive care units (ICUs), but has not been widely studied. (Source: Heart and Lung)
Source: Heart and Lung - August 17, 2018 Category: Intensive Care Authors: Halley Ruppel, Marjorie Funk, Holly Powell Kennedy, Christopher P. Bonafide, Shu-Fen Wung, Robin Whittemore Source Type: research

Erector Spinae Plane Block for Open-Heart Surgery: A Potential Tool for Improved Analgesia
Enhanced recovery programs for noncardiac surgery have permeated hospitals across the globe. An important target for these programs is improved analgesia through multimodal, opioid-sparing strategies. Krishna et al. have provided us with the largest reported study of the use of erector spinae plane (ESP) block that exists in the current literature.1 Their results with this regional technique are promising: reduced pain, opioid consumption, time to extubation, time to mobilization, and length of intensive care unit stay. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - August 17, 2018 Category: Anesthesiology Authors: Christopher Noss, Keith J. Anderson, Alexander J. Gregory Tags: Editorial Source Type: research

Clinical effects of reported synthetic cannabinoid exposure in patients admitted to the intensive care unit
To characterize the clinical presentation and hospital course of patients with reported synthetic cannabinoid (SC) exposure requiring Intensive Care Unit (ICU) admission. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - August 17, 2018 Category: Emergency Medicine Authors: Michael Tatusov, Maryann Mazer-Amirshahi, Aleeza Abbasi, Munish Goyal Source Type: research

Children ’s intensive care units are failing to monitor breathing adequately
(Source: BMJ News)
Source: BMJ News - August 16, 2018 Category: General Medicine Source Type: research

Epidemiological evaluation of an Acinetobacter baumannii outbreak observed at an intensive care unit.
CONCLUSION: We detected that all outbreak-related isolates contained the same OXA-type carbapenemase genes. Phenotypic similarity, based on the analysis of antimicrobial susceptibility patterns, was correlated with genotypic similarity. These results suggest that monitoring antimicrobial resistance patterns with daily culture surveillance follow-ups, coupled with the use of amplification based methods to detect that clonal relationships are important for the early identification of outbreaks and rapid deployment of proper countermeasures to halt the spread of the causative agent. PMID: 30106413 [PubMed - in process] (S...
Source: Saudi Medical Journal - August 16, 2018 Category: Middle East Health Tags: Saudi Med J Source Type: research

In-Hospital Delays Result in Worse Patient Outcomes and Higher Cost after Cardiac Surgery
ConclusionsOperational assessment and DWD can be used to help staff manage increasing case volume by improving efficiency while maintaining quality of care at reduced cost to the system. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - August 16, 2018 Category: Cardiovascular & Thoracic Surgery Source Type: research

Spine Trauma From Personal Watercraft Usage
Conclusion. PWC usage may result in spine fractures with a moderate percentage requiring orthopedic surgery. Additional studies should examine how hull or seat modifications can lessen the risk of axial loads leading to spine fractures. PWC patients with spine fractures should also be evaluated for abdominal/GU and cerebral injuries at presentation. Level of Evidence: 4 (Source: Spine)
Source: Spine - August 16, 2018 Category: Orthopaedics Tags: Surgery Source Type: research

Co-Occurrence of Post-Intensive Care Syndrome Problems Among 406 Survivors of Critical Illness*
Objectives: To describe the frequency of co-occurring newly acquired cognitive impairment, disability in activities of daily livings, and depression among survivors of a critical illness and to evaluate predictors of being free of post-intensive care syndrome problems. Design: Prospective cohort study. Setting: Medical and surgical ICUs from five U.S. centers. Patients: Patients with respiratory failure or shock, excluding those with preexisting cognitive impairment or disability in activities of daily livings. Interventions: None. Measurements and Main Results: At 3 and 12 months after hospital discharge,...
Source: Critical Care Medicine - August 16, 2018 Category: Emergency Medicine Tags: Feature Articles Source Type: research

Diabetes and Glucose Dysregulation and Transition to Delirium in ICU Patients
Conclusions: Diabetes mellitus was not associated with the development of ICU delirium. For hypoglycemia, only a nonsignificant odds ratio for ICU delirium could be noted. Hyperglycemia and the occurrence of hyperglycemia and hypoglycemia on the same day were associated with ICU delirium but only in patients without diabetes. Our study supports the institution of measures to prevent glucose dysregulation in nondiabetic ICU patients and contributes to the understanding of the determinants of delirium. (Source: Critical Care Medicine)
Source: Critical Care Medicine - August 16, 2018 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

The Evolution of Post Intensive Care Syndrome
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - August 16, 2018 Category: Emergency Medicine Tags: Editorials Source Type: research

(Update of a) systematic review on the impact of elective early term ( & lt;  39th gestational week) caesarean sections on maternal and neonatal health - a protocol
DiscussionOur aim is to reach a higher validity in the assessment of the time point of elective caesarean sections by performing a meta-analysis to support recommendations for clinical practice. We assume to identify less randomized controlled trials but a large number of cohort studies analyzing the given question. We will discuss similarities and differences in included studies as well as methodological strengths and weaknesses.Systematic review registrationPROSPEROCRD42017078231 (Source: Systematic Reviews)
Source: Systematic Reviews - August 16, 2018 Category: International Medicine & Public Health Source Type: research

Palliative care in intensive care units: why, where, what, who, when, how
Palliative care is patient and family-centered care that optimizes quality of life by anticipating, preventing, and treating suffering when “curative” therapies are futile. In the Intensive Care Unit (ICU), cr... (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - August 16, 2018 Category: Anesthesiology Authors: Sebastiano Mercadante, Cesare Gregoretti and Andrea Cortegiani Tags: Review Source Type: research

Could ultrasound-guided internal jugular vein catheter insertion replace the use of chest X-ray?
(Source: Critical Care)
Source: Critical Care - August 16, 2018 Category: Intensive Care Authors: William F. Amaya-Zu ñiga and Fernando Raffán-Sanabria Tags: Letter Source Type: research

Adjuvant vitamin C in cardiac arrest patients undergoing renal replacement therapy: an appeal for a higher high-dose
(Source: Critical Care)
Source: Critical Care - August 16, 2018 Category: Intensive Care Authors: Patrick M. Honore, David De Bels, Thierry Preseau, Sebastien Redant, Rachid Attou and Herbert D. Spapen Tags: Letter Source Type: research

Bilateral Paravertebral Block versus Thoracic Epidural Analgesia for Pain Control Post-Cardiac Surgery: A Randomized Controlled Trial
The objective of this study is to compare the effect of ultrasound-guided bilateral thoracic paravertebral block with thoracic epidural block on pain control after cardiac surgery. Materials and Methods Between March 2016 and 2017, 145 patients who had cardiac surgery through median sternotomy were randomized by stratified blocked randomization into two groups. Group I (n = 70 patients) had bilateral ultrasound-guided thoracic paravertebral block and Group II (n = 75 patients) had thoracic epidural analgesia. The primary end point was the postoperative visual analogue scale (VAS). The du...
Source: The Thoracic and Cardiovascular Surgeon - August 16, 2018 Category: Cardiovascular & Thoracic Surgery Authors: El Shora, Hatem A. El Beleehy, Ahmed A. Abdelwahab, Amr A. Ali, Gaser A. Omran, Tarek E. Hassan, Essam A. Arafat, Amr A. Tags: Original Cardiovascular Source Type: research

Nurses' and physicians' approaches to delirium management in the intensive care unit: A focus group investigation
Delirium in the intensive care unit (ICU) is common, but reliable evidence-based recommendations are still limited. (Source: Australian Critical Care)
Source: Australian Critical Care - August 16, 2018 Category: Nursing Authors: M.O. Collet, T. Thomsen, I. Egerod Tags: Research paper Source Type: research

Glycaemic variability and its association with enteral and parenteral nutrition in critically ill ventilated patients
Extremes of dysglycaemia as well as glycaemic variability are associated with excess mortality in critically ill patients. Glycaemic variability is an increasingly important measure of glucose control in the intensive care unit (ICU) due to this association; however, there is limited data pertaining to the relationship between exogenous glucose from nutrition and glycaemic variability and clinical outcomes. The primary aim of this study was to determine if glycaemic variability is associated with an increase in mortality. (Source: Clinical Nutrition)
Source: Clinical Nutrition - August 16, 2018 Category: Nutrition Authors: Ra ’eesa Doola, Ristan M. Greer, Rod Hurford, Christopher Flatley, Josephine M. Forbes, Alwyn S. Todd, Chris J. Joyce, David J. Sturgess Tags: Original article Source Type: research

Outcomes of surgery for necrotizing enterocolitis and spontaneous intestinal perforation in Finland during 1986 –2014
Necrotizing enterocolitis (NEC) and spontaneous intestinal perforation (SIP) are the most common abdominal surgical conditions in preemies. Associated mortality remains high and long periods of parenteral nutrition (PN) may be required. We assessed the developments in the outcomes of surgically treated NEC and SIP in the two largest Finnish neonatal intensive care units (NICU). (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - August 16, 2018 Category: Surgery Authors: Kristiina Karila, Annaleena Anttila, Tarja Iber, Mikko Pakarinen, Antti Koivusalo Source Type: research

Paediatric intensive care and neonatal intensive care airway management in the United Kingdom: the PIC ‐NIC survey
Anaesthesia, EarlyView. (Source: Anaesthesia)
Source: Anaesthesia - August 16, 2018 Category: Anesthesiology Authors: K. E. Foy , E. Mew , T. M. Cook , J. Bower , P. Knight , S. Dean , K. Herneman , B. Marden , F. E. Kelly Source Type: research

Bilateral Paravertebral Block versus Thoracic Epidural Analgesia for Pain Control Post-Cardiac Surgery: A Randomized Controlled Trial.
The objective of this study is to compare the effect of ultrasound-guided bilateral thoracic paravertebral block with thoracic epidural block on pain control after cardiac surgery. MATERIALS AND METHODS:  Between March 2016 and 2017, 145 patients who had cardiac surgery through median sternotomy were randomized by stratified blocked randomization into two groups. Group I (n = 70 patients) had bilateral ultrasound-guided thoracic paravertebral block and Group II (n = 75 patients) had thoracic epidural analgesia. The primary end point was the postoperative visual analogue scale (VAS). Th...
Source: The Thoracic and Cardiovascular Surgeon - August 16, 2018 Category: Cardiovascular & Thoracic Surgery Authors: El Shora HA, El Beleehy AA, Abdelwahab AA, Ali GA, Omran TE, Hassan EA, Arafat AA Tags: Thorac Cardiovasc Surg Source Type: research

The effect of diaries written by relatives for intensive care patients on posttraumatic stress (DRIP study): protocol for a randomized controlled trial and mixed methods study
Critically ill patients and their relatives have complex needs for support during their stay in the intensive care unit (ICU) and the post-ICU rehabilitation period. Diaries written by nurses have proven benef... (Source: BMC Nursing)
Source: BMC Nursing - August 16, 2018 Category: Nursing Authors: Anne H øjager Nielsen, Sanne Angel, Ingrid Egerod and Torben Bæk Hansen Tags: Study protocol Source Type: research

Optimizing Vancomycin Monitoring in Pediatric Patients
Conclusions: In conclusion, targeting vancomycin trough levels above 15 µg/mL in pediatrics would overshoot the target AUC0–24h above 400 and expose them to unnecessary adverse events. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - August 15, 2018 Category: Infectious Diseases Tags: Antimicrobial Reports Source Type: research

Editorial Board
Publication date: September 2018Source: Anaesthesia & Intensive Care Medicine, Volume 19, Issue 9Author(s): (Source: Anaesthesia and intensive care medicine)
Source: Anaesthesia and intensive care medicine - August 15, 2018 Category: Anesthesiology Source Type: research

Contents
Publication date: September 2018Source: Anaesthesia & Intensive Care Medicine, Volume 19, Issue 9Author(s): (Source: Anaesthesia and intensive care medicine)
Source: Anaesthesia and intensive care medicine - August 15, 2018 Category: Anesthesiology Source Type: research

Assessment of central venous catheterization and complications in a tertiary pediatric intensive care unit.
baz D Abstract Tolunay İ, Yıldızdaş RD, Elçi H, Alabaz D. Assessment of central venous catheterization and complications in a tertiary pediatric intensive care unit. Turk J Pediatr 2018; 60: 63-69. In catheter-using units as pediatric intensive care, it is important to know the complications that may occur during the insertion and use of central venous catheterization (CVC), and to take appropriate measures in order to reduce the mortality and morbidity of critical patients. The aim of this study was to evaluate CVC and catheter related complications in our tertiary pediatric intensive care unit. For th...
Source: The Turkish Journal of Pediatrics - August 15, 2018 Category: Pediatrics Authors: Tolunay İ, Yıldızdaş RD, Elçi H, Alabaz D Tags: Turk J Pediatr Source Type: research

Linezolid-Induced Lactic Acidosis Sets Stage for Surgery to Rule Out Mesenteric Ischemia: A Case Report
An 81-year-old woman with extensive peripheral vascular and coronary artery disease was admitted to the intensive care unit with a deep heel abscess and urinary tract infection. When cultures from the heel ulcer yielded vancomycin-resistant enterococci, she was started on the antibiotic linezolid. After several days of intravenous linezolid therapy, she developed severe lactic acidosis (pH 6.89) and elevation of pancreatic enzymes. An emergent exploratory laparotomy was performed to rule out mesenteric ischemia. Findings from the laparotomy were negative, and after elimination of other differential diagnoses, the metabolic...
Source: A&A Case Reports - August 15, 2018 Category: Anesthesiology Tags: Case Reports Source Type: research

The Prognostic Value of Simplified EEG in Out-of-Hospital Cardiac Arrest Patients
AbstractBackgroundWe previously validated simplified electroencephalogram (EEG) tracings obtained by a bispectral index (BIS) device against standard EEG. This retrospective study now investigated whether BIS EEG tracings can predict neurological outcome after cardiac arrest (CA).MethodsBilateral BIS monitoring (BIS VISTA ™, Aspect Medical Systems, Inc. Norwood, USA) was started following intensive care unit admission. Six, 12, 18, 24, 36 and 48 h after targeted temperature management (TTM) at 33 °C was started, BIS EEG tracings were extracted and reviewed by two neurophysiologists for the presence of s...
Source: Neurocritical Care - August 15, 2018 Category: Neurology Source Type: research

Peptide binding to cleaved CD31 dampens ischemia/reperfusion-induced intestinal injury
CD31 is a key transmembrane neutrophil immunoregulatory receptor. Mesenteric ischemia/reperfusion-induced neutrophil activation leads to a massive cleavage and shedding of the most extracellular domains of CD3... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - August 15, 2018 Category: Surgery Authors: Quoc Thang Hoang, Alexandre Nuzzo, Liliane Louedec, Sandrine Delbosc, Francesco Andreata, Jamila Khallou-Laschet, Maksud Assadi, Philippe Montravers, Dan Longrois, Olivier Corcos, Giuseppina Caligiuri, Antonino Nicoletti, Jean-Baptiste Michel and Alexy Tr Tags: Research Source Type: research