Optimizing Pharmacotherapy Management of COPD: Don't Miss the Forest for the Trees
Am J Respir Crit Care Med. 2024 Apr 16. doi: 10.1164/rccm.202402-0338VP. Online ahead of print.NO ABSTRACTPMID:38626371 | DOI:10.1164/rccm.202402-0338VP (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Jean Bourbeau Mohit Bhutani Paul Hernandez Erika Penz Darcy D Marciniuk Source Type: research
Transcriptome-Wide Association Study of Idiopathic Pulmonary Fibrosis Survival Identifies < em > PTPN9 < /em > and < em > SNRPB2 < /em >
Am J Respir Crit Care Med. 2024 Apr 16. doi: 10.1164/rccm.202310-1741LE. Online ahead of print.NO ABSTRACTPMID:38626378 | DOI:10.1164/rccm.202310-1741LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Xiaowei Hu John S Kim Aabida Saferali Yong Huang Shwu-Fan Ma Grace C Bingham Catherine A Bonham Carlos Flores Peter Castaldi Craig P Hersh Michael H Cho Imre Noth Ani Manichaikul IPF Survival GWAS Consortium Source Type: research
Lung Tissue Multi-Layer Network Analysis Uncovers the Molecular Heterogeneity of COPD
CONCLUSIONS: A novel multi-layer network analysis is able to identify clinically relevant COPD patient communities. Patients with similarly low FEV1 and emphysema can have molecularly distinct small airways and immune response patterns, indicating that different endotypes can lead to similar clinical presentation.PMID:38626356 | DOI:10.1164/rccm.202303-0500OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Nuria Olvera Jon S ánchez-Valle Iker N úñez-Carpintero Joselyn Rojas-Quintero Guillaume Noell Sandra Casas-Recasens Alen Faiz Philip Hansbro Angela Guirao Rosalba Lepore Davide Cirillo Alvar Agust í Francesca Polverino Alfonso Valencia Rosa Faner Source Type: research
Disrupted BMP-9 Signaling Impairs Pulmonary Vascular Integrity in Hepatopulmonary Syndrome
CONCLUSION: The study findings suggest that portal hypertension-induced loss of BMP-9 signaling contributes to HPS development.PMID:38626313 | DOI:10.1164/rccm.202307-1289OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Fabien Robert Marie-Caroline Certain Audrey Baron Rapha ël Thuillet L éa Duhaut Mina Ottaviani Mustapha Kamel Chelgham Corinne Normand Nihel Berrebeh Nicolas Ricard Valerie Furlan Agn ès Desroches-Castan Emmanuel Gonzales Emmanuel Jacquemin Olivier Sit Source Type: research
Recessively Inherited Deficiency of Secreted WFDC2 (HE4) Causes Nasal Polyposis and Bronchiectasis
CONCLUSIONS: WFDC2 dysfunction defines a novel molecular etiology of bronchiectasis characterized by the deficiency of a secreted component of the airways. A commercially available blood test combined with genetic testing allows its diagnosis. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:38626355 | DOI:10.1164/rccm.202308-1370OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Gerard W Dougherty Lawrence E Ostrowski Tabea N öthe-Menchen Johanna Raidt Andre Schramm Heike Olbrich Weining Yin Patrick R Sears Hong Dang Amanda J Smith Achim G Beule Rim Hjeij Niels Rutjies Eric G Haarman Saskia M Maas Thomas W Ferkol Peadar G Noone Source Type: research
Autoimmunity Against Surfactant Protein B Is Associated with Pneumonitis During Checkpoint Blockade
CONCLUSIONS: Our data suggest that the co-occurrence of surfactant protein-B-specific immunoglobulin G autoantibodies and CD4+ T cells is associated with the development of pneumonitis during ICI therapy. Pre-treatment levels of these antibodies may represent a potential biomarker for elevated risk of developing pneumonitis and on-treatment levels may provide a diagnostic aid.PMID:38626354 | DOI:10.1164/rccm.202311-2136OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Nina Wyss Fiamma Berner Vincent Walter Ann-Kristin Jochum Mette T Purde Marie-Therese Abdou Tobias Sinnberg Kathrin Hofmeister Oltin T Pop Omar Hasan Ali Jens Bauer Hung-Wei Cheng Mechthild L ütge Niklas Kl ümper Stefan Diem Zeynep Kosaloglu-Yalcin Yizh Source Type: research
Plastic Bronchitis Related to Idiopathic Lymphatic Regurgitation
Am J Respir Crit Care Med. 2024 Apr 16. doi: 10.1164/rccm.202307-1246IM. Online ahead of print.NO ABSTRACTPMID:38625076 | DOI:10.1164/rccm.202307-1246IM (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Jiarui He Jun Li Huaping Dai Source Type: research
Quantitative CT in IPF: Is It Time to Act?
Am J Respir Crit Care Med. 2024 Apr 16. doi: 10.1164/rccm.202403-0659ED. Online ahead of print.NO ABSTRACTPMID:38625082 | DOI:10.1164/rccm.202403-0659ED (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Lucio Calandriello Source Type: research
Methicillin-Resistant < em > Staphylococcus aureus < /em > Carriage among Neonate Mothers, Healthcare Workers, and Environmental Samples in Neonatal Intensive Care Units: A Systematic Review
CONCLUSION: With a significant heterogeneity, our systematic review found high MRSA carriage rates in neonate mothers, healthcare workers, and across various environmental surfaces in NICUs, posing a potential risk of nosocomial infections. Urgent interventions, including regular screening and decolonization of MRSA carriers, reinforcing infection control measures, and enhancing cleaning and disinfection procedures within NICUs, are crucial. This trial is registered with CRD42023407114.PMID:38623471 | PMC:PMC11018372 | DOI:10.1155/2024/5675786 (Source: Biomed Res)
Source: Biomed Res - April 16, 2024 Category: Research Authors: Nene Kaah Keneh Sebastien Kenmoe Arnol Bowo-Ngandji Jane-Francis Tatah Kihla Akoachere Hortense Gonsu Kamga Roland Ndip Ndip Jean Thierry Ebogo-Belobo Cyprien Kengne-Nd é Donatien Serge Mbaga Nicholas Tendongfor Jean Paul Assam Assam Lucy Mande Ndip Sera Source Type: research
Clinical and Imaging Characteristics of SARS-CoV-2 Breakthrough Infection in Hospitalized Immunocompromised Patients
CONCLUSION: Immunocompromised patients with COVID-19 breakthrough infection showed an increased risk of severe clinical outcome, severe pneumonia based on chest radiographs, and typical CT pneumonia. In particular, patients status post solid organ transplantation was specifically found to be associated with a higher risk of all three outcomes than hospitalized immunocompetent patients.PMID:38627873 | DOI:10.3348/kjr.2023.0992 (Source: Korean J Radiol)
Source: Korean J Radiol - April 16, 2024 Category: Radiology Authors: Jong Eun Lee Jinwoo Kim Minhee Hwang Yun-Hyeon Kim Myung Jin Chung Won Gi Jeong Yeon Joo Jeong Source Type: research
Clinical and Imaging Characteristics of SARS-CoV-2 Breakthrough Infection in Hospitalized Immunocompromised Patients
CONCLUSION: Immunocompromised patients with COVID-19 breakthrough infection showed an increased risk of severe clinical outcome, severe pneumonia based on chest radiographs, and typical CT pneumonia. In particular, patients status post solid organ transplantation was specifically found to be associated with a higher risk of all three outcomes than hospitalized immunocompetent patients.PMID:38627873 | DOI:10.3348/kjr.2023.0992 (Source: Korean Journal of Radiology)
Source: Korean Journal of Radiology - April 16, 2024 Category: Radiology Authors: Jong Eun Lee Jinwoo Kim Minhee Hwang Yun-Hyeon Kim Myung Jin Chung Won Gi Jeong Yeon Joo Jeong Source Type: research
Computed Tomography-Based Body Composition is Related to Perioperative Morbidity in Older Lung Transplant Recipients
CONCLUSION: Body composition parameters determined in pretransplant chest CT scans in older LTx candidates might aid in identifying high-risk patients with a worse perioperative outcome after LTx.PMID:38626904 | DOI:10.1055/s-0044-1782683 (Source: The Thoracic and Cardiovascular Surgeon)
Source: The Thoracic and Cardiovascular Surgeon - April 16, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Daria Kifjak Helmut Prosch Stefan Schwarz Peter Jaksch Michael Weber Konrad Hoetzenecker Thomas Schweiger Source Type: research
Partial versus Complete Sternotomy for Aortic Valve Replacement-Multicenter Study
CONCLUSION: In a large, German multicenter cohort, MACCE rates were comparable in surgical aortic valve replacement through partial upper and complete sternotomies. Shorter ICU stay and lower rates of Dressler's syndrome and rehospitalization were in favor of the partial sternotomy group.PMID:38626902 | DOI:10.1055/s-0044-1782685 (Source: The Thoracic and Cardiovascular Surgeon)
Source: The Thoracic and Cardiovascular Surgeon - April 16, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Nora Goebel Tomasz Stankowski Francesco Pollari Kambiz Hassan Helena Jueckstock Jens Schubel Christian Sellin Thorsten Zielezinski Yacine Elhmidi Falk-Udo Sack Richard Feyrer Hilmar Doerge Harald Hausmann Parwis Massoudy Michael Schmoeckel Samer Hakmi The Source Type: research
Isolated or Combined Ascending Aortic Replacement through a Partial Sternotomy: Early and Midterm Outcomes
CONCLUSION: The surgical ascending aorta replacement through a partial sternotomy is associated with longer operative times, but this does not affect the early as well as the long-term follow-up.PMID:38626901 | DOI:10.1055/s-0044-1782186 (Source: The Thoracic and Cardiovascular Surgeon)
Source: The Thoracic and Cardiovascular Surgeon - April 16, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Matthias Angerer Francesco Pollari Wolfgang Hitzl Lucia Weber Joachim Sirch Theodor Fischlein Source Type: research
Antimicrobial Use and Carbapenem-Resistant Enterobacterales in Korea: A Nationwide Case-Control Study With Propensity Score Matching
CONCLUSION: The utilization of broad-spectrum antibiotics and the presence of comorbidities are associated with increasing development of CRE. This study emphasizes the importance of antimicrobial stewardship in reducing broad-spectrum antibiotic use and CRE disease burden in Korea.PMID:38622938 | DOI:10.3346/jkms.2024.39.e132 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - April 16, 2024 Category: Biomedical Science Authors: Ki Tae Kwon Yoonjung Kim Shin-Woo Kim Hyun-Ha Chang Soyoon Hwang Sohyun Bae Eunkyung Nam Source Type: research
