Avian influenza (bird flu)
My local park has notices up about an outbreak. Here are sources of latest official information (for the UK). Travel related information is at the end of the post. In addition to the sites below try your local authority ' s website.Animal and Plant Health Agency reports relating to wild birdsDEFRA and APHA, preliminary outbreak assessment, for Europe, Russia and the UK - includes Weekly disease reportsDEFRA and APHA, guidanceDepartment of Agriculture, Environment and Rural Affairs (Northern Ireland), Avian influenzaHealth and Safety Executive, Avian influenza(PDF) (information particularly for those i...
Source: Browsing - January 26, 2022 Category: Databases & Libraries Tags: avian influenza Source Type: blogs
Fight Aging! Newsletter, January 17th 2022
In conclusion, fibroblasts in monolayers cultured with soluble pentosidine and tridimensional in vitro skin constructs exposed to the combination of AGEs and UVA promote an inflammatory state and an alteration of the dermal compartment in relation to an elastosis-like environment. (Source: Fight Aging!)
Source: Fight Aging! - January 16, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescent Cells Negatively Affect T Helper Cell Differentiation
The accumulation of senescent cells with age harms tissues and cell behavior throughout the body. Senescent cells generate a pro-growth, pro-inflammation mix of molecules, the senescence-associated secretory phenotype (SASP). Researchers are still comparatively early in the process of producing a complete list of problems caused by the SASP. One of the better studied SASP components is TGF-β, and here researchers demonstrates that it causes disarray in the normal behavior of T-helper cells of the adaptive immune system. Applying senolytic treatments that selectively destroy senescent cells can reverse this aspect of aging...
Source: Fight Aging! - January 13, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A brief note on epidemiology
Mark Sumner at DK has aroundup of news from overwhelmed health care systems around the country. This seems to be getting very little attention from national media, for some reason -- this is a list of local stories, which don ' t seem to have gotten the attention of editors at CNN or the New York Times.This is definitely bad news in the present, but it ' s better news in the long run. The Covid-19 variant that ' s causing this is extremely contagious -- as contagious a measles, apparently. That means you can become infected just by briefly being in the vicinity of an infectious person. One thing that ' s really unpleasant ...
Source: Stayin' Alive - January 8, 2022 Category: American Health Source Type: blogs
Fight Aging! Newsletter, January 3rd 2022
In this study, we showed that the iPaD (inducing Plagl2 and anti-Dyrk1a) lentivirus substantially rejuvenated the proliferative and neurogenic potential of NSCs in the aged brain. Clonal analysis by a sparse labeling approach as well as transcriptome analysis indicated that iPaD can rejuvenate aged NSCs (19-21 mo of age) to a level comparable with those at 1 or 2 months of age and successfully improved cognition of aged mice.
Once rejuvenated and activated by iPaD, aged dormant NSCs can generate, on average, 4.9 neurons but very few astrocytes in 3-week tracing. Furthermore, these activated NSCs were maintained for ...
Source: Fight Aging! - January 2, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards More Broadly Effective Influenza Vaccines
Might it be possible to develop a vaccine that works on every strain of influenza, rather than going through a seasonal exercise of vaccination every year? Or at least many strains, rather than just a few? In today's research materials, scientists discuss a possible approach, identifying a novel part of the influenza virus to target, a part of the viral structure that may mutate less readily than the usual vaccine targets. Viruses mutate aggressively when they infect large population, a challenge to both vaccination and natural immunity. The immune system recognizes small parts of a virus, epitopes, and the epitopes most r...
Source: Fight Aging! - December 30, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Flu Virus-Inspired Nanoparticles for mRNA Delivery
Researchers at the University of California San Diego developed a new delivery technique for mRNA. The method involves flu virus-inspired nanoparticles that can escape endosomes, the acidic vesicles that engulf and destroy materials that attempt to enter cells. The nanoparticles contain a protein receptor that allows them to unlock the endosomes and release the mRNA into the interior of cells. The technology could allow for more efficient and effective mRNA therapies.
With the COVID-19 vaccine program, mRNA is enjoying a moment in the limelight, as it acts as the powerhouse behind some of the most effective COVID-19 vac...
Source: Medgadget - December 13, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Medicine Nanomedicine Public Health flu mRNA vaccine UCSD Source Type: blogs
Fight Aging! Newsletter, December 13th 2021
In conclusion, there is a good amount of pre-clinical and clinical data showing a strong positive correlation between reduction of senescent cells frequencies and functional improvement of skin. Whether senescence of skin cells makes a significant causal contribution to skin ageing can still not be conclusively decided, however. Nonetheless, there is strong evidence existing today to assume that better understanding of cell senescence in skin may lead to a breakthrough in interventions into skin ageing.
Isomerization of Tau May be Involved in Alzheimer's Disease
https://www.fightaging.org/archives/2021/12/isom...
Source: Fight Aging! - December 12, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Innovation, mRNA, and Public Policy
Chris EdwardsThe main weapons against COVID-19 are the vaccines developed by Moderna and BioNTech after a decade of their research into mRNA technologies. That research was supported by more than $3 billion of private angel investment and venture capital.Democrats and Republicans both support medical research funding, and Republicans tout the Trump administration ’s Operation Warp Speed. But governments were not the key to mRNA development. Instead, we can thank the leaders and scientists at Moderna and BioNTech and the suppliers of private capital to them, as I discusshere andhere.TheWall Street Journal ’s A...
Source: Cato-at-liberty - December 6, 2021 Category: American Health Authors: Chris Edwards Source Type: blogs
Cytomegalovirus Harmfully Alters Immune Cell Populations in the Aging Immune System
The aging of the immune system isn't just a matter of becoming vulnerable to commonplace infectious diseases, such as influenza. The immune system also removes senescent cells and cancerous cells, both of which present sizable risks to health in later life. Additionally, immune cells participate in normal tissue maintenance in a variety of ways. Further, the chronic inflammation characteristic of an aged immune system disrupts the normal function of many types of cell and tissue, contributing to a diverse range of age-related conditions.
For most people, cytomegalovirus (CMV) is an apparently innocuous persistent he...
Source: Fight Aging! - December 6, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, December 6th 2021
In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated.
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity
Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2...
Source: Fight Aging! - December 5, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Oral Bacteria and Age-Related Airway Inflammation
Researchers have in the past proposed links between oral bacteria and chronic inflammation, particularly in the heart and brain, proposing that bacterial toxins and bacteria themselves enter the bloodstream via damaged gums. This undoubtedly happens, but supporting data is mixed when it comes to the question of whether or not this has a meaningful effect size in comparison to other inflammatory mechanisms and contributions to age-related disease. Here, a different route for bacteria is proposed: passage into the airways and lungs, a possibly explanation as why gum disease and respiratory mortality are correlated in older p...
Source: Fight Aging! - November 29, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Omicron (B.1.1529 COVID variant )
Last updated 1430 UK time 24th December 2021. Items added that day flagged NEW.Research literature and scientific informationPubMedLess sensitive strategy (finds 100 items as of 21st December - found 28 on 13th)More sensitive strategy - same as strategy above but have added Omicron lineages, BA.1 and BA.2(finds 140 items as of 21st December - found 67 on 13th. Note: results include work on any aspect of COVID from UK postcodes BA1 and BA2).PubMed COVID-19 Clinical Query Select aspect (diagnosis, treatment, etc.) from the drop down boxPreprintsCOVID preprints from medRxiv and bioRxiv (sorted...
Source: Browsing - November 27, 2021 Category: Databases & Libraries Tags: coronavirus COVID-19 Source Type: blogs
TWiV 832: Heavy metal flu fighters
TWiV reviews the vials labeled smallpox that were not, re-emergence of enterovirus D68 in Europe, efficacy of inactivated SARS-CoV-2 vaccine, and cellular correlates of protection for an oral influenza virus vaccine. Click arrow to playDownload TWiV 832 (77 MB .mp3, 128 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - November 21, 2021 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology adenovirus vector adjuvant correlate of protection Covaxin COVID-19 inactivated vaccine influenza influenza oral vaccine mass cytometry pandemic SARS-CoV-2 smallpox vaccine efficacy vaccinia virus viral Source Type: blogs
Medgadget Reviews the Sleep Number i10 360 Smart Bed
Conclusion
In the conclusion for our review ten years ago, we posed the question about whether such an expensive bed was worth it. Let’s be real: Sleep Number beds are not cheap. Our bed configuration for just the mattress alone was $4599. Even with the inclusion of Sleep IQ, you still may first want to consider other solutions to help monitor and improve your sleep. But we felt that the beds have improved much: the materials and appearance are more modern and advanced, and the added electronics make it as close as you can get to a smart bed. We just wish it could integrate with smart home systems; with so many li...
Source: Medgadget - November 10, 2021 Category: Medical Devices Authors: Scott Jung Tags: etc. Exclusive Orthopedic Surgery Pain Management bam labs sleep number sleepnumber Source Type: blogs
