Vaccine associated myocarditis revisited with COVID-19 mRNA vaccines
When I had reviewed the topic of vaccine associated myocarditis for an editorial in the BMH Medical Journal in 2017, most of the cases were associated with small pox vaccination [1]. There were also reports of streptococcal pneumonia vaccine and influenza vaccine associated myocarditis. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) used in the vaccine were also implicated in some cases [2,3].
While the large scale vaccination for small pox in an attempt to prepare for potential bioterrorism was the association in 2003 [4], COVID-19 mRNA vaccines are currently in the limelight for vaccine induced myocarditis...
Source: Cardiophile MD - July 22, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
Covid-19: preparing for the future - looking ahead to winter 2021/22 and beyond
This report warns that a mix of Covid-19, influenza, and the respiratory virus Respiratory Syncytial Virus, could push the NHS to breaking point this winter unless action is taken. The report urges policy makers and the NHS to prepare by expanding Covid-19 testing, increasing the speed and uptake of the Covid-19 vaccination, and strenthgened financial and staffing support.ReportThe Academy of Medical Sciences - news (Source: Health Management Specialist Library)
Source: Health Management Specialist Library - July 15, 2021 Category: UK Health Authors: The King ' s Fund Library Tags: Covid-19 NHS performance and productivity Source Type: blogs
AI-Powered App Interprets HIV Test Results
This study is a really strong partnership with AHRI that demonstrates the power of using deep learning to successfully classify ‘real-world’ field-acquired rapid test images, and reduce the number of errors that may happen when reading test results by eye,” said Rachel McKendry, a researcher involved in the study, in a UCL announcement. “This research shows the positive impact the mobile health tools can have in low- and middle-income countries, and paves the way for a larger study in the future.”
Study in Nature Medicine: Deep learning of HIV field-based rapid tests
Via: UCL (Source: Medgadget)
Source: Medgadget - June 22, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Informatics Medicine Public Health Source Type: blogs
Fight Aging! Newsletter, June 21st 2021
This study showed that the leakage of this mitochondrial nucleic material may occur as a result of mitochondrial dysfunction, which may involve genetic mutations in genes encoding mitochondrial proteins or incomplete degradation of mitochondrial dsDNA in the lysosome - which is a 'degradation factory' of the cell. Upon the leakage into the cytoplasm, this undegraded dsDNA is detected by a 'foreign' DNA sensor of the cytoplasm (IFI16) which then triggers the upregulation of mRNAs encoding for inflammatory proteins."
Using a PD zebrafish model (gba mutant), the researchers demonstrated that a combination of PD-like ph...
Source: Fight Aging! - June 20, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Yet Again We See A Technologically Ignorant Government Breaking Basic Information Management Rules!
This appeared last week: Clarity on COVID immunisation status on My Health Record The ADHA has issued new guidance to ensure patient records are correctly linking with up-to-date immunisation data. Morgan Liotta 10 Jun 2021 Recent upgrades to My Health Record(MHR) include a new consolidated view of immunisation details from the Australian Immunisation Register (AIR) and the individual ’s record, making it easier for healthcare providers to view their patients’ information.
To support the Australian Government ’s COVID-19 vaccination rollout, data from all states and territories is now flowing into MHR. Healthc...
Source: Australian Health Information Technology - June 18, 2021 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Details on the Failed Phase 3 Trial of the resTORbio mTORC1 Inhibitor
The short version of the story regarding the failure of resTORbio's phase 3 trial of an mTORC1 inhibitor targeting immune function and influenza infection in old people is that the FDA forced a last minute change of the phase 3 endpoint from the phase 2 endpoint of a reduction in clinically confirmed infections to a more nebulous outcome of whether or not people reported feeling better. Which is far from the worst offense that FDA staff have committed in the course of hindering the adoption of new medical technologies, but it is illustrative of the obstacle that regulators pose. We can all speculate as to what was going on...
Source: Fight Aging! - June 16, 2021 Category: Research Authors: Reason Tags: Politics and Legislation Source Type: blogs
In pursuit of health equity and the state of U.S. healthcare
Between 2014 and 2015, death rates increased for eight of the 10 leading causes; only death rates caused by cancer fell, and mortality rates for influenza and pneumonia stayed flat. (Source: Healthcare IT News Blog)
Source: Healthcare IT News Blog - June 15, 2021 Category: Information Technology Source Type: blogs
Fight Aging! Newsletter, June 14th 2021
In conclusion, a number of high-income countries, changes in health expectancies over time have not kept pace with the growth in life expectancy. That is, people are living longer but disability and poor health are occupying an increasing proportion of later life. Our findings suggest that countries still need to make significant progress to achieve the WHO's Decade of Healthy Ageing goal of healthier, longer lives for all.
Progress on Understanding Why Human Growth Hormone Receptor Variants are Associated with Greater Longevity
https://www.fightaging.org/archives/2021/06/progress-on-understanding-why-human-gr...
Source: Fight Aging! - June 13, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Inflammaging and Disruption of Coagulation as Contributions to High COVID-19 Mortality in the Old
The burden of infectious disease falls most heavily upon the old. The attention given to COVID-19 has highlighted that point, though much of the media seems determined to avoid talking about the fact that near all mortality due to the condition occurs in the old and the cormorbid. It is nothing new, of course. Influenza kills tens of thousands of old people every year in the US alone, without much attention given to it. That the elderly suffer and die is old news. It is, however, old news that we should revisit in this era of revolutionary progress in medical biotechnology. The causes of aging and age-related mortality are...
Source: Fight Aging! - June 9, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Acute Hemorrhagic Necrotizing Encephalopathy associated with COVID19
Sharing some keypoints about encephalopathy with COVID19 to help fellow Radiologists in the pandemic storm to identify the possibility. Reference article has been shared for further reading.Acute necrotizing encephalopathy is a rare complication of influenza and other viral infections and has been related to intracranial cytokine storms, which result in blood-brain barrier breakdown but without direct viral invasion or parainfectious demyelination. Although predominantly described in the pediatric population, acute necrotizing encephalopathy is known to occur in adults as well. The most characte...
Source: Sumer's Radiology Site - June 9, 2021 Category: Radiology Authors: Sumer Sethi Source Type: blogs
Do A & P Textbooks Have Too Much Content? | TAPP 94
Oh, thathuge A&P textbook I teach from! Do I really need tocover all of it? Host Kevin Patton discusses his take on this age-old problem. Does thecolor of my marking pen send a signal that I don't want to send to my students? A breakthrough in understandinghow teeth sense cold. And what in the world is atunneling nanotube—and can I get one at my local hardware store?Greek names for SARS-CoV-2 variants simplifies conversation and avoids stigma.00:00 | Introduction00:43 | How Do Teeth Sense Cold?07:04 | Sponsored by AAA08:32 | Red& Green for Student Feedback18:03 | What's a TNT?23:52 | Sponsored by HAPI25...
Source: The A and P Professor - June 7, 2021 Category: Physiology Authors: Kevin Patton Source Type: blogs
Do A & P Textbooks Have Too Much Content? | TAPP 94
Oh, thathuge A&P textbook I teach from! Do I really need tocover all of it? Host Kevin Patton discusses his take on this age-old problem. Does thecolor of my marking pen send a signal that I don't want to send to my students? A breakthrough in understandinghow teeth sense cold. And what in the world is atunneling nanotube—and can I get one at my local hardware store?Greek names for SARS-CoV-2 variants simplifies conversation and avoids stigma.00:00 | Introduction00:43 | How Do Teeth Sense Cold?07:04 | Sponsored by AAA08:32 | Red& Green for Student Feedback18:03 | What's a TNT?23:52 | Sponsored by HAPI25...
Source: The A and P Professor - June 7, 2021 Category: Physiology Authors: Kevin Patton Source Type: blogs
Fight Aging! Newsletter, June 7th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - June 6, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
CD4 / CD8 T Cell Ratio as a Measure of Immune Aging
The state of the aged adaptive immune system can be assessed in a practical way in animal studies, such as via exposure to influenza or other well-calibrated infectious disease. This assessment is also carried out on the human population as a whole in every influenza season, but for individual humans one wants a metric that is a little less do or die. The adaptive immune system is made up of many different subtypes of B cell and T cell, each serving a different purpose. While the overall population of T cells remains fairly consistent with age, the size of different T cell subtype populations changes in characteristic ways...
Source: Fight Aging! - June 4, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
