Fight Aging! Newsletter, January 4th 2021
The objective of this study is to quantify the overall and cancer type-specific risks of subsequent primary cancers (SPCs) among adult-onset cancer survivors by first primary cancer (FPC) types and sex. Among 1,537,101 survivors (mean age, 60.4 years; 48.8% women), 156,442 SPC cases and 88,818 SPC deaths occurred during 11,197,890 person-years of follow-up (mean, 7.3 years). Among men, the overall risk of developing any SPCs was statistically significantly higher for 18 of the 30 FPC types, and risk of dying from any SPCs was statistically significantly higher for 27 of 30 FPC types as compared with risks in the general po...
Source: Fight Aging! - January 3, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2020: Progress Towards the Treatment of Aging as a Medical Condition
While I suspect that COVID-19 will feature prominently in most retrospectives on 2020, I'll say only a little on it. The data on mortality by year end, if taken at face value, continues to suggest that the outcome will fall at the higher end of the early estimates of a pandemic three to six times worse than a bad influenza year, ten times worse than a normal influenza year. The people who die are near entirely the old, the co-morbid, and the immunocompromised. They die because they are suffering the damage and dysfunction of aging. Yet the societal conversation and the actions of policy makers ignore this.
There is ...
Source: Fight Aging! - December 31, 2020 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Last Christmas – a short story
Last Christmas by David Bradley (PDF/Kindle version here)
Funnily enough, it was four years to the day since the fourth variant had emerged. So, it was Christmas Day. Four years since the death toll passed 200 million. What a gift. Four years since the last dying embers of the theory of herd immunity had burned out and even the rich and the beyond-rich were suffering.
Four years. It’s hard to believe. What started as a very localised outbreak, with a mere handful of hospitalisations had quickly thrown the global community into panic and ultimately pandemic. The present that keeps on giving. Each genetic mutation unwrappi...
Source: David Bradley Sciencebase - Songs, Snaps, Science - December 29, 2020 Category: Science Authors: David Bradley Tags: Sciencebase Source Type: blogs
Last Christmas – a Xmas Gothic
Last Christmas by David Bradley (PDF/Kindle version here)
Funnily enough, it was four years to the day since the fourth variant had emerged. So, it was Christmas Day. Four years since the death toll passed 200 million. What a gift. Four years since the last dying embers of the theory of herd immunity had burned out and even the rich and the beyond-rich were suffering.
Four years. It’s hard to believe. What started as a very localised outbreak, with a mere handful of hospitalisations had quickly thrown the global community into panic and ultimately pandemic. The present that keeps on giving. Each genetic mutation unwrappi...
Source: David Bradley Sciencebase - Songs, Snaps, Science - December 29, 2020 Category: Science Authors: David Bradley Tags: Sciencebase Source Type: blogs
Fight Aging! Newsletter, December 28th 2020
In conclusion, our study demonstrated that the molecular processes of aging are relatively subtle in their progress, and the aging process of every tissue depends on the tissue's specialized function and environment. Hence, individual gene or process alone cannot be described as the key of aging in the whole organism.
Mouse Age Matters: How Age Affects the Murine Plasma Metabolome
A large part of metabolomics research relies on experiments involving mouse models, which are usually 6 to 20 weeks of age. However, in this age range mice undergo dramatic developmental changes. Even small age differences may l...
Source: Fight Aging! - December 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
ECMO – Extracorporeal membrane oxygenation
ECMO – extracorporeal membrane oxygenation
ECMO – Extracorporeal membrane oxygenation – has been in use for the past four decades to support persons who are unlikely to survive with mechanical ventilation. ECMO is used in both adult and pediatric practice, though in the initial years, use of ECMO was restricted to pediatric intensive care. The enthusiasm for use of ECMO in adults have been triggered by the beneficial effect noted during the last H1N1 influenza pandemic [1]. In contrast from cardiopulmonary bypass which is used for a short period during cardiac surgery, ECMO is used to support for a ...
Source: Cardiophile MD - December 26, 2020 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiac Surgery Source Type: blogs
Data for COVID-19 Mortality in Older People in the US
The general consensus on mortality due to COVID-19 is that it falls most heavily on people who are more impacted by aging: poor immune function when it comes to defense against pathogens; high levels of chronic inflammation that create a greater susceptibility to the way in which SARS-CoV-2 kills people; existing chronic disease; and a mortality rate that is already high even setting aside the pandemic. When younger people die due to the virus, in much smaller numbers, it is where they share these characteristics of inflammation, deficient immune systems, and chronic disease. This level of morbidity is unusual in younger i...
Source: Fight Aging! - December 23, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Encouraging clinical data for universal flu vaccine candidate
by Helen Stillwell The results from a phase I clinical trial to test the safety and immunogenicity of a universal flu vaccine candidate reported encouraging results – strong titers of broad and functional antibodies persisted for over a year in healthy adults following vaccination. Influenza viruses contain segmented RNA genomes. The viral envelope contains two types glycoproteins […] (Source: virology blog)
Source: virology blog - December 17, 2020 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Helen Stilwell antibody HA stem influenza phase I clinical trial universal flu vaccine viral virus viruses Source Type: blogs
The Year When Everything Changed: Covid, Self Care and High Tech Innovation In Medicine
By HANS DUVEFELT
Life as we knew it and medicine as we had viewed it shapeshifted so dramatically in the past year that it is still hard to believe.
Medicine has started to move from an in-person only profession to one that finally recognizes that clinical assessment and treatment have fewer boundaries than people assumed. A patient of mine with newly diagnosed mastocytosis had a productive first consultation with an immunologist hundreds of miles away right from her own living room.
Efficiency increased when we could handle straightforward clinical issues electronically, even over the telephone, and still get...
Source: The Health Care Blog - December 14, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Medical Practice Hans Duvefelt Source Type: blogs
Why are mRNA vaccines so exciting?
The very first vaccines for COVID-19 to complete Phase 3 testing are an entirely new type: mRNA vaccines. Vaccines of this type have never before been approved for use in any disease. How do they differ from traditional vaccines, and what makes them so exciting?
How traditional vaccines work
The main goal of a vaccine for a particular infectious agent, such as the virus that causes COVID-19, is to teach the immune system what that virus looks like. Once educated, the immune system will vigorously attack the actual virus, if it ever enters the body.
Viruses contain a core of genes made of DNA or RNA wrapped in a coat of pro...
Source: Harvard Health Blog - December 10, 2020 Category: Consumer Health News Authors: Anthony Komaroff, MD Tags: Coronavirus and COVID-19 Health Vaccines Source Type: blogs
Common cold, flu, or coronavirus?
In the early days of the outbreak, the novel coronavirus (COVID-19) was repeatedly compared to the flu (influenza) and even to the common cold (rhinoviruses, et al). This was due to an initial impression of shared symptoms.
The differences between these conditions are particularly important as we kick off National Influenza Vaccination Week (NIVW) and the ‘flu season’. So, how can we tell which of these diseases we are dealing with in a given patient?
Common cold
Let’s start with the common cold, a condition that can be caused by over 200 different strains of viruses. On average, an adult wil...
Source: GIDEON blog - December 8, 2020 Category: Databases & Libraries Authors: Kristina Symes Tags: Diagnosis Identify News Source Type: blogs
Avian influenza (H5N8)
There are reminders in the news that other infectious diseases carry on, with reports of outbreaks of H5N8 avian influenza in wild birds and on farms.A few resources (more may follow):UK government advice on avian influenza, with updates on the latest situation.NHSA flu diary - blog kept by Michael Coston. There is a post from yesterday describing an outbreak in North Yorkshire, and one from the 11th November about other cases, so scan the posts. (Source: Browsing)
Source: Browsing - November 30, 2020 Category: Databases & Libraries Tags: avian influenza H5N8 Source Type: blogs
Fight Aging! Newsletter, November 23rd 2020
In conclusion, the study indicates that HBOT may induce significant senolytic effects that include significantly increasing telomere length and clearance of senescent cells in the aging populations.
Data on the Prevalence of Liver Fibrosis in Middle Age
https://www.fightaging.org/archives/2020/11/data-on-the-prevalence-of-liver-fibrosis-in-middle-age/
Fibrosis is a consequence of age-related disarray in tissue maintenance processes, leading to the deposition of scar-like collagen that disrupts tissue structure and function. It is an ultimately fatal issue for which there are only poor treatment options ...
Source: Fight Aging! - November 22, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Why spiritual health is so important [PODCAST]
“Around the time of the coronavirus outbreak, 2019 also marked a full century since the death of Sir William Osler, who revolutionized medical training. Despite some lingering debate over whether Dr. Osler ’s pneumonia-related death should be counted among the 50 million lost to the 1918 influenza pandemic, his notes suggest that he believed the flu […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 22, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/elizabeth-j-berger" rel="tag" > Elizabeth J. Berger, APBCC < /a > < /span > Tags: Podcast Medical school Source Type: blogs
Overhyping the Effects of Hyperbaric Oxygen Treatment on Aging
In conclusion, the study indicates that HBOT may induce significant senolytic effects including significantly increasing telomere length and clearance of senescent cells in the aging populations. (Source: Fight Aging!)
Source: Fight Aging! - November 20, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
