Fight Aging! Newsletter, September 28th 2020
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results.
Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - September 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Will the CDC ever rise again?
I hate to say this, but I fear it is over. For our entire relationship, I have looked to the CDC to guide and educate me. I have put my faith in their recommendations. I have defended their stances on everything from obesity to Lyme disease to influenza across decades. I have done so because […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - September 25, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/christine-meyer" rel="tag" > Christine Meyer, MD < /a > < /span > Tags: Policy Public Health & Source Type: blogs
miR-192 in Extracellular Vesicles as a Negative Regulator of Inflammation in Old Tissues
This study found that the microRNA-192 (miR-192) is an aging-associated immune regulatory microRNA whose concentration was significantly increased in aged EVs due to the hyperinflammatory state of aged mice. Interestingly, EV miR-192 exhibited anti-inflammatory effects on macrophages. In our aged mouse model, aging was associated with prolonged inflammation in the lung upon stimulation with inactivated influenza whole virus particles (WVP), whereas EV miR-192 alleviated the prolonged inflammation associated with aging. The hyperinflammatory state of aged mice resulted in reduced production of specific antibodies and effica...
Source: Fight Aging! - September 23, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Remove Barriers that Prevent Nurses from Addressing Public and Private Health Crises
Michael F. CannonNurses have been on the front line of the COVID-19 pandemic as they have been for every public health crisis from the Spanish influenza to the AIDS epidemic. Yet state governments have made it harder for nurses to help victims of this and other diseases.In 2004, California enacted a law that restricts the ability of hospitals to assign nurses to where patients need them, which increases the cost of care. In that year, California became the first state to mandate inpatient facilities adhere to predeterminednurse ‐to‐patient ratios. The law restricts the number of patients each nurse can ...
Source: Cato-at-liberty - September 22, 2020 Category: American Health Authors: Michael F. Cannon Source Type: blogs
Discrimination, high blood pressure, and health disparities in African Americans
Over the past few months, we have all seen the results of significant disruption to daily life due to the COVID-19 pandemic, high levels of unemployment, and civil unrest driven by chronic racial injustice. These overlapping waves of societal insult have begun to bring necessary attention to the importance of health care disparities in the United States.
Direct links between stress, discrimination, racial injustice, and health outcomes occurring over one’s lifespan have not been well studied. But a recently published article in the journal Hypertension has looked at the connection between discrimination and increased ris...
Source: Harvard Health Blog - September 21, 2020 Category: Consumer Health News Authors: Chester Hedgepeth, III, MD, PhD Tags: Health care disparities Hypertension and Stroke Source Type: blogs
Time for flu shots — getting one is more important than ever!
Wondering when to get your flu shot? The best time is before influenza (flu) starts circulating widely. For most people, September or October is ideal for protection through the whole flu season, as the immune response from the vaccine wanes over time. And while changes and restrictions due to COVID-19 may make getting a flu vaccine less convenient for some this year, the pandemic makes it more important than ever.
Why do I need to get a flu vaccine yearly?
Influenza A and Influenza B cause most cases of flu in humans. Both have many strains that constantly change, accumulating genetic mutations that disguise them from the...
Source: Harvard Health Blog - September 17, 2020 Category: Consumer Health News Authors: Elise Merchant, MD Tags: Cold and Flu Coronavirus and COVID-19 Vaccines Source Type: blogs
Fight Aging! Newsletter, September 14th 2020
This study is the first to provide a direct link between this inflammation and plaque development - by way of IFITM3.
Scientists know that the production of IFITM3 starts in response to activation of the immune system by invading viruses and bacteria. These observations, combined with the new findings that IFITM3 directly contributes to plaque formation, suggest that viral and bacterial infections could increase the risk of Alzheimer's disease development. Indeed, researchers found that the level of IFITM3 in human brain samples correlated with levels of certain viral infections as well as with gamma-secretase activ...
Source: Fight Aging! - September 13, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Longevity of SARS-CoV-2 memory B cells
Immunity conferred by influenza virus vaccine is short-lived. After immunization with inactivated influenza virus vaccine, serum antibody levels peak within a few months and then decline rapidly. This decline was recently shown to be caused by loss of bone marrow plasma cells, a major source of serum antibodies. Results of a recent study partially address […] (Source: virology blog)
Source: virology blog - September 11, 2020 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information antibody B cell bone marrow plasma cell COVID-19 influenza vaccine memory B cell pandemic plasmablast SARS-CoV-2 viral virus viruses Source Type: blogs
TWiV 660: In case of emergency finish the trial
Daniel Griffin provides a clinical report on COVID-19, then we discuss decline of virus-specific bone marrow B cells within a year after influenza vaccination, the push to release SARS-CoV-2 vaccines before completion of phase 3 trials, and absence of evidence for infectious virus in aerosols. Click arrow to playDownload TWiV 660 (95 MB .mp3, 159 min)Subscribe […] (Source: virology blog)
Source: virology blog - September 10, 2020 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology aerosol transmission bone marrow B cells clinical trial coronavirus COVID-19 diagnostic tests influenza vaccine pandemic SARS-CoV-2 viral viruses Source Type: blogs
We Should Actually Try to Treat Aging for a Change
I am generally in favor of the sentiment offered in this commentary on recent clinical trial failures for the first attempts to guide anti-aging technologies through the FDA gauntlet, which is that researchers and developers should be aiming to treat aging, not specific age-related diseases. There is likely to be a greater incidence of failure on the way to the clinic, and for entirely avoidable reasons, if everyone is attempting to force a more or less square peg into a more or less round hole.
Longevity trials: time to change the approach?
Following the recent clinical trial failures by Unity Biotechnolog...
Source: Fight Aging! - September 8, 2020 Category: Research Authors: Reason Tags: Politics and Legislation Source Type: blogs
Federal Aid Creates Central ‐Planning Power
This study argues that Congress should repeal all federal aid-to-state programs for many reasons, including that aid comes with costly strings attached that destroy local democracy.Richard Epstein and Mario Loyolanoted about aid programs: “When Americans vote in state and local elections, they think they are voting on state and local policies. But often they are just deciding which local officials get to implement the dictates of distant and insulated federal bureaucrats, whom even Congress can’t control.”I came across a table (p. 82) in New Jersey ’s budget that lists the $15 billion the state received in 2020 fro...
Source: Cato-at-liberty - September 4, 2020 Category: American Health Authors: Chris Edwards Source Type: blogs
Announcing The COVID-19 Symptom Data Challenge
By FARZAD MOSTASHARI
In Partnership with Resolve to Save Lives, Carnegie Mellon University, and University of Maryland, Catalyst @ Health 2.0 is excited to announce the launch of The COVID-19 Symptom Data Challenge. The COVID-19 Symptom Data Challenge is looking for novel analytic approaches that use COVID-19 Symptom Survey data to enable earlier detection and improved situational awareness of the outbreak by public health and the public.
How the Challenge Works:
In Phase I, innovators submit a white paper (“digital poster”) summarizing the approach, methods, analysis, findings, relevant figures and graphs ...
Source: The Health Care Blog - September 1, 2020 Category: Consumer Health News Authors: matthew holt Tags: COVID-19 Data Health Policy challenge Facebook Source Type: blogs
FDA Determined Convalescent Plasma Is Safe, Leaves Decisions on Efficacy up to Clinicians/ Patients. That’s the Way It Should Always Be
Jeffrey A. SingerYesterday the Food and Drug Administration released a clinical memorandum giving Emergency Use Authorization for COVID-19 Convalescent Plasma (CCP) therapy, a previously unapproved biological product. Forseveral months clinicians treating severely ill COVID-19 patients have transfused plasma donated by convalescing COVID-19 patients, rich with the antibodies to the virus produced by their immune system, hoping that these same antibodies can help patients suffering from active infection. Early results have been promising but, as somecritics of the FDA decision have stated, more data is needed befo...
Source: Cato-at-liberty - August 24, 2020 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs
Fight Aging! Newsletter, August 24th 2020
We report that electrical stimulation (ES) stimulation of post-stroke aged rats led to an improved functional recovery of spatial long-term memory (T-maze), but not on the rotating pole or the inclined plane, both tests requiring complex sensorimotor skills. Surprisingly, ES had a detrimental effect on the asymmetric sensorimotor deficit.
Histologically, there was a robust increase in the number of doublecortin-positive cells in the dentate gyrus and SVZ of the infarcted hemisphere and the presence of a considerable number of neurons expressing tubulin beta III in the infarcted area. Among the genes that were unique...
Source: Fight Aging! - August 23, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards Better Vaccines and a Lower Burden of Infectious Disease in Old People
Over a lifetime, the burden of infectious disease - and particularly persistent infections such as cytomegalovirus - influences the pace of aging via its detrimental impact on immune function in later life. The slow upward trend in life expectancy over the past two centuries is due in no small part to reductions in infectious disease that accompanied improvements in sanitation and then medicine. In addition, in old age, once the immune system declines into ineffectieness, infectious disease becomes a much more serious concern. Infections that a young person defeats with ease become life-threatening. The primary strategy to...
Source: Fight Aging! - August 17, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
