Cytomegalovirus Harmfully Alters Immune Cell Populations in the Aging Immune System

The aging of the immune system isn't just a matter of becoming vulnerable to commonplace infectious diseases, such as influenza. The immune system also removes senescent cells and cancerous cells, both of which present sizable risks to health in later life. Additionally, immune cells participate in normal tissue maintenance in a variety of ways. Further, the chronic inflammation characteristic of an aged immune system disrupts the normal function of many types of cell and tissue, contributing to a diverse range of age-related conditions. For most people, cytomegalovirus (CMV) is an apparently innocuous persistent herpesvirus infection, one that presents no obvious symptoms. A good deal of evidence supports a sizable role for CMV in the age-related decline of the immune system into inflammatory overactivation (inflammaging) and incapacity (immunosenescence), however. Most people are exposed to CMV at some point during their lives, and the immune system is incapable of clearing this persistent virus. Over time, ever more T cells of the adaptive immune system become devoted to targeting CMV rather than taking on other threats, and may even become harmful themselves as result of too much replication in response to the presence of CMV In effect, CMV actively corrodes the ability of the adaptive immune system to defend the body from other threats. In today's open access paper, researchers provide more supporting evidence for potentially detrimental changes in T cell p...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs

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Purpose of review To summarize the currently available definitive therapies for patients with inborn errors of immunity (IEIs) with a strong focus on recent advances in allogeneic hematopoietic cell transplantation (HCT) and gene therapy, including the use of alternative donors, graft manipulation techniques, less toxic approaches for pretransplant conditioning and gene transfer using autologous hematopoietic stem cells. Recent findings In the absence of a matched sibling or a matched related donor, therapeutic alternatives for patients with IEIs include alternative donor transplantation or autologous gene thera...
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In conclusion, there is a good amount of pre-clinical and clinical data showing a strong positive correlation between reduction of senescent cells frequencies and functional improvement of skin. Whether senescence of skin cells makes a significant causal contribution to skin ageing can still not be conclusively decided, however. Nonetheless, there is strong evidence existing today to assume that better understanding of cell senescence in skin may lead to a breakthrough in interventions into skin ageing. Isomerization of Tau May be Involved in Alzheimer's Disease https://www.fightaging.org/archives/2021/12/isome...
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