Towards a Cure for Aging
Work on treating aging as a medical condition, targeting the mechanisms that cause aging in order to slow or reverse its progression, has advanced to the point at which the popular science and medical resources of the world are writing overviews on the topic, seeking to better inform the public at large. We have come a long way in the past decade. The compelling animal data for approaches such as the targeted removal of senescent cells, showing rejuvenation in mice, is melting some of the skepticism that previously characterized attitudes towards the treatment of aging.
Heart disease. Cancer. Diabetes. Dementia. R...
Source: Fight Aging! - February 22, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 15th 2021
This study assessed cancer risk associations for 3 recently developed methylation-based biomarkers of aging: PhenoAge, GrimAge, and predicted telomere length.
We observed relatively strong associations of age-adjusted PhenoAge with risk of colorectal, kidney, lung, mature B-cell, and urothelial cancers. Similar findings were obtained for age-adjusted GrimAge, but the association with lung cancer risk was much larger, after adjustment for smoking status, pack-years, starting age, time since quitting, and other cancer risk factors. Most associations appeared linear, larger than for the first-generation measures, and w...
Source: Fight Aging! - February 14, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Gut Macrobiome in Chronic Inflammation and Aging
In recent years, a great deal of attention has been devoted to the role of the gut microbiome in aging, as populations shift to include fewer helpful and more harmful microbes. In particular, the ability of the gut microbiome to influence the state of chronic inflammation in aging may be at least as important as lifestyle choices such as degree of exercise. Expanding this line of thinking, researchers here look at the macrobiome, small parasitic animals that dwell in the gut, and their role in age-related inflammation.
A new review looks at the growing evidence to suggest that losing our 'old friend' helminth para...
Source: Fight Aging! - February 9, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Harvard Health Ad Watch: Can an arthritis drug help you become a morning person?
Perhaps this is obvious, but drug ads are not intended to inform you about the best way to treat a condition you may have. Their primary purpose is to sell a product, as explained in an earlier blog on direct-to-consumer drug ads. And the newest drugs tend to be the most expensive, even though some aren’t much better than older drugs.
So the ads you see for medications are usually not promoting the latest and greatest as much as they are promoting the newest and most expensive. And these ads vary widely in how much accurate, useful information is included and what information is left out. A recent ad for Xeljanz (tofacit...
Source: Harvard Health Blog - February 2, 2021 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Arthritis Health Healthy Aging Source Type: blogs
Innovation in treatment for people with rarer or less well-recognised long-term conditions
The King's Fund - This paper, commissioned by UCB, investigates how five leading specialist hospital services in the UK are innovating in care for people with severe psoriasis, inflammatory bowel disease (IBD), axial spondyloarthritis, osteoporosis and combinations of inflammatory conditions.ReportMore detail (Source: Health Management Specialist Library)
Source: Health Management Specialist Library - February 1, 2021 Category: UK Health Authors: The King ' s Fund Library Tags: Quality of care and clinical outcomes Source Type: blogs
How a woman with ulcerative colitis helped launch the Wheat Belly movement
The post How a woman with ulcerative colitis helped launch the Wheat Belly movement appeared first on Dr. William Davis. (Source: Wheat Belly Blog)
Source: Wheat Belly Blog - November 30, 2020 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle Inflammation Weight Loss Source Type: blogs
Fight Aging! Newsletter, October 26th 2020
In conclusion, all NAFLD histological stages were associated with significantly increased overall mortality, and this risk increased progressively with worsening NAFLD histology. Most of this excess mortality was from extrahepatic cancer and cirrhosis, while in contrast, the contributions of cardiovascular disease and HCC were modest.
BMP6 as a Target for Pro-Angiogenic Therapies
https://www.fightaging.org/archives/2020/10/bmp6-as-a-target-for-pro-angiogenic-therapies/
Today's research materials are focused on the fine details of angiogenesis, the formation of new blood vessels, and point to BMP6 as a p...
Source: Fight Aging! - October 25, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Interventions Targeting the Aging of the Gut Microbiome
Age-related changes to the microbial populations of the gut, the gut microbiome, appear important in the progression of aging. The effects on long-term health and risk of age-related conditions might be on a par with those of physical activity, and certainly overlap with those of diet. With ageing, beneficial microbes that produce metabolites (such as butyrate) that lead to better tissue function diminish in number, while harmful microbes that spur chronic inflammation grow in number. This may be due to loss of immune system competency, as the immune system gardens the gut microbiome, or it may be due to diminished intesti...
Source: Fight Aging! - October 19, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Early, tight control of Crohn ’s disease may have lasting benefits
The gastrointestinal (GI) tract is a remarkable organ: it resides on the inside of our bodies, but is regularly in contact with the outside world by virtue of what we ingest. It is quite incredible that the immune cells of the GI tract are not activated more regularly by the many foreign products it encounters every day. Only when the GI tract encounters an intruder that risks causing disease do the immune cells of the GI tract spring into action.
That is, of course, under normal circumstances. In people with Crohn’s disease, the normally tolerant immune cells of the GI tract are activated without provocation, and this a...
Source: Harvard Health Blog - October 16, 2020 Category: Consumer Health News Authors: Sarah Flier, MD Tags: Digestive Disorders Source Type: blogs
Health in 2 Point 00, Episode 148 | A colonoscopy story ( & other health tech news)
Today on Health in 2 Point 00, Jess might be a little wary of my colonoscopy story, but it reveals just how well insurance companies communicate. In this episode, Jess and I cover GoodRx filing an S1 to go public, Trellus Health raising $5 million in seed funding for its platform for inflammatory bowel disease (IBD) and other chronic conditions, Klara Health raising $15 million for patient engagement, and Castor raising $12 million for its clinical trial platform. —Matthew Holt (Source: The Health Care Blog)
Source: The Health Care Blog - September 1, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Health in 2 Point 00 Health Tech Jessica DaMassa Matthew Holt Castor Clara Health GoodRX Trellus Health Source Type: blogs
Case of the Week 604
This week ' s case was generously donated by Dr. Peter Gilligan, and features a histopathology section of an appendix from a patient with Crohn ' s disease. The pathologist was concerned when they saw the following object in the lumen of the appendix. Identification? (Source: Creepy Dreadful Wonderful Parasites)
Source: Creepy Dreadful Wonderful Parasites - August 31, 2020 Category: Parasitology Source Type: blogs
Fight Aging! Newsletter, August 31st 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - August 30, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Two Part Interview with Greg Bailey of Juvenescence
Juvenescence and Life Biosciences are presently the two large business development companies in the growing longevity industry. They act much like venture funds, in that they create or take controlling positions in biotech startups, but are organized as companies in structure, with the ability to later go public. The resulting entity looks much like a Big Pharma company with many subsidiaries. It is quite possible to do this at a smaller scale and bootstrap towards much the same end goal - see Ichor Therapeutics and its portfolio companies, for example.
Greg Bailey is one of the cofounders of Juvenescence, alongside...
Source: Fight Aging! - August 25, 2020 Category: Research Authors: Reason Tags: Investment Source Type: blogs
Fight Aging! Newsletter, August 3rd 2020
In this study, we examined the effects of oxytocin on the Aβ-induced impairment of synaptic plasticity in mice.
To investigate the effect of oxytocin on synaptic plasticity, we prepared acute hippocampal slices for extracellular recording and assessed long-term potentiation (LTP) with perfusion of the Aβ active fragment (Aβ25-35) in the absence and presence of oxytocin. We found that oxytocin reversed the impairment of LTP induced by Aβ25-35 perfusion in the mouse hippocampus. These effects were blocked by pretreatment with the selective oxytocin receptor antagonist L-368,899. Furthermore, the treatment with the...
Source: Fight Aging! - August 2, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Organoids Used to Identify NRG1 as a Regulator of Tissue Repair in the Intestine
The intestinal lining is an important tissue. Among its other functions, it protects the body from inflammation that can be generated by the actions of gut microbes. This barrier declines with age, and this is thought to be influential in the increased chronic inflammation observed in older people. Ways to spur greater maintenance and repair on the part of cell populations making up intestinal tissue would likely be of great benefit, given the importance of chronic inflammation as a driver of age-related disease.
A strong cellular lining is essential for a healthy gut as it provides a barrier to the billions of mi...
Source: Fight Aging! - July 27, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
