Hypertrophic Obstructive Cardiomyopathy Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Effect Of Mavacamten On Echocardiographic Parameters In Patients With Obstructive Hypertrophic Cardiomyopathy: A Real World Cohort
In this study, we sought to evaluate the early effect of mavacamten on cardiac structure and function by echocardiography in a real-world cohort of patients. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Eman Rashed, Mili Mehta, Alejandro E. De Feria, Nosheen Reza, Nicole Hornsby, Amy Marzolf, Anjali Owens Tags: 343 Source Type: research

Left Ventricular Outflow Tract Obstruction In Cardiac Amyloidosis
In hypertrophic cardiomyopathy (HCM), systolic anterior motion of the mitral valve may result in left ventricular outflow tract (LVOT) obstruction (LVOTO) which, when present, is associated with increased mortality. LVOTO has been described in cardiac amyloidosis (CA), mimicking hypertrophic obstructive cardiomyopathy (HOCM), and represents a unique phenotype. Less is known regarding the characteristics of those with CA and LVOTO. We sought to describe the clinical characteristics and outcomes in this unique subset of patients. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Joshua Longinow, Michel Chedid El Helou, J. Emanuel Finet, Rohit Moudgil, Wael Jaber, Maran Thamilarsan, Patrick Collier, Treejeve Martyn, Andres Carmona Rubio, Deborah Kwon, Nicholas Smedira, Milind Desai, Wai Hong Tang, Mazen Hanna Tags: 269 Source Type: research

Exploring The Alarming Surge Of Life Threatening Events Linked To Mavacamten- Analysis Of FDA Adverse Event Reporting System Database
Mavacamten is a novel cardiac myosin ATPase inhibitor targeted for treatment of hypertrophic obstructive cardiomyopathy (HOCM). It acts by formation of actin-myosin cross-bridge thus reducing contractility and improving myocardial energetics. Since its approval in April 2022 by the U.S. Food and Drug Administration (FDA), it has been popular for treatment of patients with symptomatic New York Heart Association (NYHA) class II-III HOCM. During review by FDA, mavacamten exhibited a side effect profile of heart failure (HF) that was deemed significant enough to warrant as a boxed warning. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Resha Khanal, Kripa Rajak, Rajendra Shah, Anupam Halder, Kriti Kalra, Saman Razzaq, Binita Bhandari, Sristee Niraula, Shital Oli, Sharad Oli Tags: 236 Source Type: research

The Outcome Of Acute Heart Failure In Patients With Hypertrophic Obstructive Cardiomyopathy
Patients with hypertrophic obstructive cardiomyopathy (HOCM) have abnormal diastolic function, which impairs ventricular filling and increase filling pressure, despise a normal or small ventricular cavity. This work aimed to study the clinical outcome of acute heart failure in patients with HOCM. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Joseph Amoah, Sara Noureldin, Brittany Smith, Samir Dekowski, Michael Fatuyi, Francisco Somoza-Cano, Alero Arueyingho, Catherine Illah, Henry Egbuchiem Tags: 160 Source Type: research

A Young Pregnant Person With Old Myocardial Infarction
This case report presents the electrocardiogram findings of a pregnant patient in their 30s with a family history of hypertrophic obstructive cardiomyopathy. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - December 26, 2023 Category: Internal Medicine Source Type: research

Real ‐world candidacy to mavacamten in a contemporary hypertrophic obstructive cardiomyopathy population
ConclusionsRW HOCM patients differ from the EXPLORER-HCM population for their older age, lower LVEF and larger atrial volume, potentially reflecting a more advanced stage of the disease. About half of RW HOCM patients were found eligible to mavacamten.This article is protected by copyright. All rights reserved. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - December 23, 2023 Category: Cardiology Authors: Edoardo Bertero, Chiara Chiti, Maria Alessandra Schiavo, Giacomo Tini, Paolo Costa, Giancarlo Todiere, Barbara Mabritto, Lorenzo ‐Lupo Dei, Alessia Giannattasio, Davide Mariani, Carla Lofiego, Caterina Santolamazza, Emanuele Monda, Giovanni Tags: Short Report Source Type: research

Favorable Long-Term Outcomes After Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy in Japan
Circ J. 2023 Dec 5. doi: 10.1253/circj.CJ-23-0846. Online ahead of print.NO ABSTRACTPMID:38057102 | DOI:10.1253/circj.CJ-23-0846 (Source: Circulation Journal)
Source: Circulation Journal - December 6, 2023 Category: Cardiology Authors: Yukichi Tokita Junya Matsuda Yoichi Imori Source Type: research

Early reverse remodeling of left heart morphology and function evaluated by cardiac magnetic resonance in hypertrophic obstructive cardiomyopathy after transapical beating-heart septal myectomy
This study aimed to evaluate the early morphology and function of the left heart in hypertrophic obstructive cardiomyopathy (HOCM) after transapical beating-heart septal myectomy (TA-BSM) using cardiovascular ... (Source: Journal of Cardiovascular Magnetic Resonance)
Source: Journal of Cardiovascular Magnetic Resonance - November 27, 2023 Category: Radiology Authors: Yun Zhao, Chenhe Li, Dazhong Tang, Yi Luo, Chunlin Xiang, Lu Huang, Xiaoyue Zhou, Jing Fang, Xiang Wei and Liming Xia Tags: Research Source Type: research

Hypertrophic cardiomyopathy is characterized by alterations of the mitochondrial calcium uniporter complex proteins: insights from patients with aortic valve stenosis versus hypertrophic obstructive cardiomyopathy
Introduction: Hypertrophies of the cardiac septum are caused either by aortic valve stenosis (AVS) or by congenital hypertrophic obstructive cardiomyopathy (HOCM). As they induce cardiac remodeling, these cardiac pathologies may promote an arrhythmogenic substrate with associated malignant ventricular arrhythmias and may lead to heart failure. While altered calcium (Ca2+) handling seems to be a key player in the pathogenesis, the role of mitochondrial calcium handling was not investigated in these patients to date.Methods: To investigate this issue, cardiac septal samples were collected from patients undergoing myectomy du...
Source: Frontiers in Pharmacology - November 22, 2023 Category: Drugs & Pharmacology Source Type: research

Perioperative outcomes of hypertrophic cardiomyopathy: An insight from the National Readmission Database
Data regarding hypertrophic obstructive cardiomyopathy (HOCM) patients undergoing noncardiac surgery is lacking. We sought to examine the perioperative outcomes of HOCM patients undergoing noncardiac surgery using a national database. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - November 16, 2023 Category: Cardiology Authors: Kirolos Barssoum, Abd Elrahman Abo Moad, Medhat Chowdhury, Ankit Agrawal, Ramy AbdelMassih, Sarathlal Renjithlal, Ahmed H. Mohamed, Majd Alhuarrat, Claudine Abdou, Mohamed Saleh, Rama Ellauzi, Wissam Khalife, Devesh Rai, Khaled Chatila, Hani Jneid Source Type: research

Alcohol septal ablation in patients aged 75 years or older with hypertrophic obstructive cardiomyopathy
Conclusion ASA had similar efficacy and intrahospital mortality in patients ≥75 years compared with younger patients. Higher rates of AV block with need for permanent pacemaker implantation were observed in patients ≥75 years of age. (Source: Heart)
Source: Heart - November 10, 2023 Category: Cardiology Authors: Lawin, D., Stellbrink, C., Stellbrink, E., Buck, B., Poudel, M. R., Tego, A., Marx, K., Lawrenz, T. Tags: Heart failure and cardiomyopathies Source Type: research

Long-Term Clinical Outcome After Alcohol Septal Ablation and Its Periprocedural Predictive Factors in Japan 　- A Retrospective Observational Study
CONCLUSIONS: This study presents long-term clinical outcomes after ASA in Japan. Moderate or severe MR after ASA was significantly associated with the composite of cardiovascular death or hospitalization for heart failure.PMID:37899174 | DOI:10.1253/circj.CJ-23-0529 (Source: Circulation Journal)
Source: Circulation Journal - October 29, 2023 Category: Cardiology Authors: Yuichi Sawayama Shunsuke Kubo Masanobu Ohya Sachiyo Ono Hiroyuki Tanaka Takeshi Maruo Yoshihisa Nakagawa Kazushige Kadota Source Type: research