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Therapeutic Strategy for Patients with Concomitant Pulmonary Artery Hypertension and Hypertrophic Obstructive Cardiomyopathy: A Rare Case Report
Medicina (Kaunas). 2023 Feb 18;59(2):401. doi: 10.3390/medicina59020401.ABSTRACTCombined cases of hypertrophic obstructive cardiomyopathy (HOCM) and pulmonary arterial hypertension (PAH) are rare and have a management dilemma. Although preload is crucial in the management of HOCM, anti-PAH agents dramatically change the preload, leading to improving or worsening heart failure in patients with HOCM. We had a 74-year-old woman with Sjogren-syndrome-associated PAH. Her heart failure worsened following the initiation of anti-PAH agents due to an incremental preload on the left ventricle, whereas HOCM clinically developed follo...
Source: Medicina (Kaunas) - February 25, 2023 Category: Universities & Medical Training Authors: Toshihide Izumida Teruhiko Imamura Shuhei Tanaka Shuji Joho Koichiro Kinugawa Source Type: research

Therapeutic Strategy for Patients with Concomitant Pulmonary Artery Hypertension and Hypertrophic Obstructive Cardiomyopathy: A Rare Case Report
Medicina (Kaunas). 2023 Feb 18;59(2):401. doi: 10.3390/medicina59020401.ABSTRACTCombined cases of hypertrophic obstructive cardiomyopathy (HOCM) and pulmonary arterial hypertension (PAH) are rare and have a management dilemma. Although preload is crucial in the management of HOCM, anti-PAH agents dramatically change the preload, leading to improving or worsening heart failure in patients with HOCM. We had a 74-year-old woman with Sjogren-syndrome-associated PAH. Her heart failure worsened following the initiation of anti-PAH agents due to an incremental preload on the left ventricle, whereas HOCM clinically developed follo...
Source: Medicina (Kaunas) - February 25, 2023 Category: Universities & Medical Training Authors: Toshihide Izumida Teruhiko Imamura Shuhei Tanaka Shuji Joho Koichiro Kinugawa Source Type: research

Therapeutic Strategy for Patients with Concomitant Pulmonary Artery Hypertension and Hypertrophic Obstructive Cardiomyopathy: A Rare Case Report
Medicina (Kaunas). 2023 Feb 18;59(2):401. doi: 10.3390/medicina59020401.ABSTRACTCombined cases of hypertrophic obstructive cardiomyopathy (HOCM) and pulmonary arterial hypertension (PAH) are rare and have a management dilemma. Although preload is crucial in the management of HOCM, anti-PAH agents dramatically change the preload, leading to improving or worsening heart failure in patients with HOCM. We had a 74-year-old woman with Sjogren-syndrome-associated PAH. Her heart failure worsened following the initiation of anti-PAH agents due to an incremental preload on the left ventricle, whereas HOCM clinically developed follo...
Source: Medicina (Kaunas) - February 25, 2023 Category: Universities & Medical Training Authors: Toshihide Izumida Teruhiko Imamura Shuhei Tanaka Shuji Joho Koichiro Kinugawa Source Type: research

Therapeutic Strategy for Patients with Concomitant Pulmonary Artery Hypertension and Hypertrophic Obstructive Cardiomyopathy: A Rare Case Report
Medicina (Kaunas). 2023 Feb 18;59(2):401. doi: 10.3390/medicina59020401.ABSTRACTCombined cases of hypertrophic obstructive cardiomyopathy (HOCM) and pulmonary arterial hypertension (PAH) are rare and have a management dilemma. Although preload is crucial in the management of HOCM, anti-PAH agents dramatically change the preload, leading to improving or worsening heart failure in patients with HOCM. We had a 74-year-old woman with Sjogren-syndrome-associated PAH. Her heart failure worsened following the initiation of anti-PAH agents due to an incremental preload on the left ventricle, whereas HOCM clinically developed follo...
Source: Medicina (Kaunas) - February 25, 2023 Category: Universities & Medical Training Authors: Toshihide Izumida Teruhiko Imamura Shuhei Tanaka Shuji Joho Koichiro Kinugawa Source Type: research

Therapeutic Strategy for Patients with Concomitant Pulmonary Artery Hypertension and Hypertrophic Obstructive Cardiomyopathy: A Rare Case Report
Medicina (Kaunas). 2023 Feb 18;59(2):401. doi: 10.3390/medicina59020401.ABSTRACTCombined cases of hypertrophic obstructive cardiomyopathy (HOCM) and pulmonary arterial hypertension (PAH) are rare and have a management dilemma. Although preload is crucial in the management of HOCM, anti-PAH agents dramatically change the preload, leading to improving or worsening heart failure in patients with HOCM. We had a 74-year-old woman with Sjogren-syndrome-associated PAH. Her heart failure worsened following the initiation of anti-PAH agents due to an incremental preload on the left ventricle, whereas HOCM clinically developed follo...
Source: Medicina (Kaunas) - February 25, 2023 Category: Universities & Medical Training Authors: Toshihide Izumida Teruhiko Imamura Shuhei Tanaka Shuji Joho Koichiro Kinugawa Source Type: research

Radial artery pulse to ponder on
Clinical introduction A man in his 60s, hypertensive for the past 20 years, now presented with a history of angina and dyspnoea on exertion New York Heart Association class II for 6 months, which was persistent despite optimal medical therapy. He underwent a coronary angiography via radial route, and his arterial trace from the radial artery sheath is provided in figure 1. Figure 1Arterial waveform obtained from the radial sheath. Question What is the most likely explanation for this arterial tracing? Spike and dome pattern of hypertrophic obstructive cardiomyopathy. Waveform in hypertension and increased arterial stiffne...
Source: Heart - February 23, 2023 Category: Cardiology Authors: Velayutham, R., Ahmed, A. S. Tags: Image challenges Source Type: research

Sensors, Vol. 23, Pages 2438: The Development of a Novel Headspace O2 Concentration Measurement Sensor for Vials
Su Yang In the process of manufacture and transportation, vials are prone to breakage and cracks. Oxygen (O2) in the air entering vials can lead to the deterioration of medicine and a reduction in pesticide effects, threatening the life of patients. Therefore, accurate measurement of the headspace O2 concentration for vials is crucial to ensure pharmaceutical quality. In this invited paper, a novel headspace oxygen concentration measurement (HOCM) sensor for vials was developed based on tunable diode laser absorption spectroscopy (TDLAS). First, a long−optical−path multi−p...
Source: Sensors - February 22, 2023 Category: Biotechnology Authors: Chen Sun Huang Jin Su Yang Tags: Article Source Type: research

Getting to the Heart of the Issue: Demographics of Hypertrophic Cardiomyopathy
We have read with great interest your thought-provoking article by Maron et al,1 which discussed the changing demographics observed in hypertrophic cardiomyopathy (HOCM) in recent years. The study concluded that patients are significantly older at presentation, with thinner septae than in previous studies, often with milder symptomatology. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - February 15, 2023 Category: General Medicine Authors: Niharika Baviriseaty, Gerry Samantha Eichelberger, Jonathan D. Marks, Claire E. Stowers, Candice F. Mateja Tags: Letter Source Type: research

Reverse remodeling of left atrium assessed by cardiovascular magnetic resonance feature tracking in hypertrophic obstructive cardiomyopathy after septal myectomy
Assessing the structure and function of left atrium (LA) is crucial in hypertrophic obstructive cardiomyopathy (HOCM) because LA remodeling correlates with atrial fibrillation. However, few studies have invest... (Source: Journal of Cardiovascular Magnetic Resonance)
Source: Journal of Cardiovascular Magnetic Resonance - February 13, 2023 Category: Radiology Authors: Shujuan Yang, Xiuyu Chen, Kankan Zhao, Shiqin Yu, Wenhao Dong, Jiaxin Wang, Kai Yang, Qiulan Yang, Xuan Ma, Zhixiang Dong, Lele Liu, Yanyan Song, Minjie Lu, Shuiyun Wang and Shihua Zhao Tags: Research Source Type: research

Mavacamten: A First-in-class Oral Modulator of Cardiac Myosin for the Treatment of Symptomatic Hypertrophic Obstructive Cardiomyopathy
Heart Int. 2022 Oct 5;16(2):91-98. doi: 10.17925/HI.2022.16.2.91. eCollection 2022.ABSTRACTHypertrophic cardiomyopathy is the most common monogenic cardiovascular disease that is caused by sarcomeric protein gene mutations. A hallmark of the most common form of the disease is outflow obstruction secondary to systolic narrowing of the left ventricular outflow tract from septal hypertrophy, mitral valve abnormalities and, most importantly, hyperdynamic contractility. Recent mechanistic studies have identified excessive myosin adenosine triphosphatase activation and actin-myosin cross-bridging as major underlying causes. Thes...
Source: Heart International - February 6, 2023 Category: Cardiology Authors: Klevin Roger L Reyes Gizem Bilgili Florian Rader Source Type: research