Hypertrophic Cardiomyopathy Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Resection of hypertrophic papillary muscles and mitral valve replacement in a patient with midventricular hypertrophic obstructive cardiomyopathy – a new approach
Midventricular hypertrophic obstructive cardiomyopathy (HOCM) is characterized by hypertrophy of the interventricular septum (IVS) and - in rare cases - of the papillary muscles (PM), which subsequently can ca... (Source: Journal of Cardiothoracic Surgery)
Source: Journal of Cardiothoracic Surgery - February 22, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Julian J. Berg, Jan Eckstein, Marcus-Andr é Deutsch, Jan F. Gummert and Masatoshi Hata Tags: Case Report Source Type: research

Comparative Evaluation of Alcohol Septal Ablation: Left Anterior Descending Versus Nonleft Anterior Descending Artery Approaches
This study aimed to compare the effectiveness and safety between ASA performed using a septal branch arising from a non-LAD artery and a branch arising from the LAD artery. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 22, 2024 Category: Cardiology Authors: Yoshihiro Harano, Yuki Sahashi, Yoshiaki Kawase, Hitoshi Matsuo Source Type: research

Comparative Evaluation of Alcohol Septal Ablation: Left Anterior Descending Versus Non-left Anterior Descending Artery Approaches
This study aimed to compare the effectiveness and safety between ASA performed using a septal branch arising from a non-LAD artery and a branch arising from the LAD artery. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 22, 2024 Category: Cardiology Authors: Yoshihiro Harano, Yuki Sahashi, Yoshiaki Kawase, Hitoshi Matsuo Source Type: research

Targeted Sequencing of Circular RNAs for Illumina-Based Counting and Nanopore Structure Determination
Methods Mol Biol. 2024;2765:127-142. doi: 10.1007/978-1-0716-3678-7_7.ABSTRACTIn the past years, circular RNAs (circRNAs) became a major focus of many studies in animals and plants. circRNAs are generated by backsplicing from the same linear transcripts that are canonically spliced to produce, for example, mature mRNAs. They exhibit tissue-specific expression pattern and are potentially involved in many diseases, among them cardiovascular diseases. However, despite the tremendous efforts to establish circRNA catalogues, much less is known about the biological function of the vast majority of circRNAs. We have previously in...
Source: Mol Biol Cell - February 21, 2024 Category: Molecular Biology Authors: Isabel S Naarmann-de Vries Christoph Dieterich Source Type: research

Evening but not morning aerobic training improves sympathetic activity and baroreflex sensitivity in elderly patients with treated hypertension
J Physiol. 2024 Feb 20. doi: 10.1113/JP285966. Online ahead of print.ABSTRACTThe blood pressure-lowering effect of aerobic training is preceded by improving cardiovascular autonomic control. We previously demonstrated that aerobic training conducted in the evening (ET) induces a greater decrease in blood pressure than morning training (MT). To study whether the greater blood pressure decrease after ET occurs through better cardiovascular autonomic regulation, this study aimed to compare MT versus ET on muscle sympathetic nerve activity (MSNA) and baroreflex sensitivity (BRS) in treated patients with hypertension. Elderly p...
Source: The Journal of Physiology - February 20, 2024 Category: Physiology Authors: Leandro C Brito Luan M Azev êdo Graziela Amaro-Vicente Luis R Costa Natan D da Silva Junior John R Halliwill Maria U P B Rondon Cl áudia L M Forjaz Source Type: research

Regard to assessing agreement between two raters with kappa statistics
Paratz et al.'s [1] investigation of 380 hypertrophic cardiomyopathy (HCM) patients unveiled that cardiac arrest primarily affected younger individuals exhibiting unexplained syncope, non-sustained ventricular tachycardia, increased septal thickness, and sarcomeric gene mutations. Risk-sudden cardiac death (SCD) and American Heart Association/American College of Cardiology (AHA/ACC) scores demonstrated poor agreement (Cohen's kappa coefficient 0.38). The Risk-SCD score exhibited low sensitivity but high specificity, while the AHA/ACC risk score lacked discriminatory power. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 20, 2024 Category: Cardiology Authors: Tianfei Yu, Bingrui Ren, Ming Li Source Type: research

Tropomyosin-troponin complex in inherited cardiomyopathies
The tropomyosin-troponin complex (TTC) regulates cardiac contractility by controlling cross-bridge attachments to actin filaments based on intracellular Ca2+ levels. TTC consists of tropomyosin (TPM), cardiac troponin-T (cTnT), cardiac troponin-I (cTnI), and cardiac troponin-C (cTnC). Pathogenic variants (mutations) in genes encoding these proteins (TPM1 [TPM], TNNT2 [cTnT], TNNI3 [cTnI], and TNNC1 [cTnC]) cause different cardiomyopathy types, including hypertrophic (HCM), dilated (DCM), or restrictive cardiomyopathy (RCM). (Source: Heart Rhythm)
Source: Heart Rhythm - February 19, 2024 Category: Cardiology Authors: Christian Krijger Ju árez, Vasco Sequeira, Malou van den Boogaard, Christiaan C. Veerman, Nicola J. Hoetjes, Edwin Poel, Michael W.T. Tanck, Ronald H. Lekanne Deprez, Alexa M.C. Vermeer, Jolanda van der Velden, Ahmad S. Amin Source Type: research

Tropomyosin –troponin complex in inherited cardiomyopathies
The tropomyosin –troponin complex (TTC) regulates cardiac contractility by controlling cross-bridge attachments to actin filaments based on intracellular Ca2+ levels. TTC consists of tropomyosin (TPM), cardiac troponin-T (cTnT), cardiac troponin-I (cTnI), and cardiac troponin-C (cTnC). Pathogenic variants (mutati ons) in genes encoding these proteins (TPM1 [TPM], TNNT2 [cTnT], TNNI3 [cTnI], and TNNC1 [cTnC]) cause different cardiomyopathy types, including hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and restrictive cardiomyopathy (RCM). (Source: Heart Rhythm)
Source: Heart Rhythm - February 19, 2024 Category: Cardiology Authors: Christian Krijger Ju árez, Vasco Sequeira, Malou van den Boogaard, Christiaan C. Veerman, Nicola J. Hoetjes, Edwin Poel, Michael W.T. Tanck, Ronald H. Lekanne Deprez, Alexa M.C. Vermeer, Jolanda van der Velden, Ahmad S. Amin Tags: Research Letter Source Type: research

FARS2 Deficiency Causes Cardiomyopathy by Disrupting Mitochondrial Homeostasis and the Mitochondrial Quality Control System
CONCLUSIONS: Our findings unveil the previously unrecognized role of FARS2 in heart and mitochondrial homeostasis. This study may provide new insights into the molecular diagnosis and prevention of heritable cardiomyopathy as well as therapeutic options for FARS2-associated cardiomyopathy.PMID:38362779 | DOI:10.1161/CIRCULATIONAHA.123.064489 (Source: Circulation)
Source: Circulation - February 16, 2024 Category: Cardiology Authors: Bowen Li Fangfang Liu Xihui Chen Tangdong Chen Juan Zhang Yifeng Liu Yan Yao Weihong Hu Mengjie Zhang Bo Wang Liwen Liu Kun Chen Yuanming Wu Source Type: research

Pregnancy and cardiac maternal outcomes in women with inherited cardiomyopathy: interest of the CARPREG II risk score
ConclusionsPregnancy in women with inherited cardiomyopathy carries a high risk of maternal cardiovascular complications. CARPREG II is the most efficient predictor of cardiovascular complications in this population. (Source: ESC Heart Failure)
Source: ESC Heart Failure - February 16, 2024 Category: Cardiology Authors: Thomas Wallet, Lise Legrand, Richard Isnard, Estelle Gandjbakhch, Fran çoise Pousset, Julie Proukhnitzky, Marc Dommergues, Jacky Nizard, Philippe Charron Tags: Original Article Source Type: research

Prevalence and phenotypes associated with ALPK3 null variants in a large French multicentric cohort: Confirming its involvement in hypertrophic cardiomyopathy
Clin Genet. 2024 Feb 14. doi: 10.1111/cge.14505. Online ahead of print.ABSTRACTBiallelic disease-causing variants in the ALPK3 gene were first identified in children presenting with a severe cardiomyopathy. More recently, it was shown that carriers of heterozygous ALPK3 null variants are at risk of developing hypertrophic cardiomyopathy (HCM) with an adult onset. Since the number of reported ALPK3 patients is small, the mutational spectrum and clinical data are not fully described. In this multi-centric study, we described the molecular and clinical spectrum of a large cohort of ALPK3 patients. Genetic testing using target...
Source: Clinical Genetics - February 15, 2024 Category: Genetics & Stem Cells Authors: Flavie Ader Guillaume Jedraszak Alexandre Janin Clarisse Billon Nathalie Roux Buisson Adrien Bloch Meriem Bensalah Anachiara De Sandre-Giovannoli Adeline Goudal Luisa Marsili C écile Cazeneuve Philippe Charron Gilles Millat Pascale Richard Cardiogen Fren Source Type: research