FARS2 Deficiency Causes Cardiomyopathy by Disrupting Mitochondrial Homeostasis and the Mitochondrial Quality Control System

CONCLUSIONS: Our findings unveil the previously unrecognized role of FARS2 in heart and mitochondrial homeostasis. This study may provide new insights into the molecular diagnosis and prevention of heritable cardiomyopathy as well as therapeutic options for FARS2-associated cardiomyopathy.PMID:38362779 | DOI:10.1161/CIRCULATIONAHA.123.064489

Source: Circulation - February 16, 2024 Category: Cardiology Authors: Bowen Li Fangfang Liu Xihui Chen Tangdong Chen Juan Zhang Yifeng Liu Yan Yao Weihong Hu Mengjie Zhang Bo Wang Liwen Liu Kun Chen Yuanming Wu Source Type: research