Hypertrophic Cardiomyopathy Research 
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.GSE239872 Base editing effectively prevents the early-onset hypertrophic cardiomyopathy in Mybpc3 mutant mice
Contributors : Shuo Wu ; Ping Yang ; Zilong Geng ; Yige Li ; Zhizhao Guo ; Yingmei Lou ; Shasha Zhang ; Junhao Xiong ; Huan Hu ; William T Pu ; Dan Zhu ; Yan Zhang ; Bing ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPathogenic variants in MYBPC3 (myosin-binding protein C3) are the leading cause of genetic hypertrophic cardiomyopathy (HCM). Currently, there is no specific and effective treatment for this disease. Base editing is an emerging modality for treating monogenic diseases; however, its effect on MYBPC3 cardiomyopathy remains unexplored. Mybpc3-R946X/R946X m...
Source: GEO: Gene Expression Omnibus - April 4, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
An < em > In Silico < /em > Cardiomyocyte Reveals the Impact of Changes in CaMKII Signalling on Cardiomyocyte Contraction Kinetics in Hypertrophic Cardiomyopathy
In conclusion, our model reveals that impaired crossbridge kinetics is accompanied by a negative mismatch between the ATP supply and demand ratio. This suggests that improving this ratio may reduce the incidence of sudden death in HCM.PMID:38567164 | PMC:PMC10985279 | DOI:10.1155/2024/6160554 (Source: Cell Research)
Source: Cell Research - April 3, 2024 Category: Cytology Authors: Ismail Adeniran Hafsa Wadee Hans Degens Source Type: research
An < em > In Silico < /em > Cardiomyocyte Reveals the Impact of Changes in CaMKII Signalling on Cardiomyocyte Contraction Kinetics in Hypertrophic Cardiomyopathy
In conclusion, our model reveals that impaired crossbridge kinetics is accompanied by a negative mismatch between the ATP supply and demand ratio. This suggests that improving this ratio may reduce the incidence of sudden death in HCM.PMID:38567164 | PMC:PMC10985279 | DOI:10.1155/2024/6160554 (Source: Biomed Res)
Source: Biomed Res - April 3, 2024 Category: Research Authors: Ismail Adeniran Hafsa Wadee Hans Degens Source Type: research
Neuronal nitric oxide synthase required for erythropoietin modulation of heart function in mice
Discussion: Endogenous EPO has a protective effect on heart function. With EPO administration, in contrast to the protective effect to the cardiac injury of acute EPO treatment, extended EPO treatment to increase hematocrit in WT mice adversely affected the heart function with a corresponding increase in expression of heart failure-associated genes. This EPO activity was independent of EPO-stimulated erythropoiesis and required EPOR in non-erythroid tissue and nNOS activity, while nNOS−/− mice were protected from the EPO-associated adverse effect on heart function. These data provide evidence that nNOS contributes to t...
Source: Frontiers in Physiology - April 2, 2024 Category: Physiology Source Type: research
Heart Transplant Outcomes in Adults with Hypertrophic Cardiomyopathy: A Contemporary Analysis
Purpose: Heart transplant (HT) is the definitive therapy for adults with end stage symptomatic hypertrophic cardiomyopathy (HCM). Post-transplant outcomes are uncertain with few reports of inferior findings compared with other heart failure (HF) etiologies. Using adult HT listings and transplants, we compared outcomes between those with HCM, ischemic cardiomyopathies (ICM) or other HF etiologies in the contemporary era in the United States. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , I. Konstantinidis, N. Patel, K. Singh, A. Pillai, W. Baker, A. Jaiswal Source Type: research
