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First-degree atrioventricular block in hypertrophic cardiomyopathy patients: an easy and worthy prognostic marker?
Monaldi Arch Chest Dis. 2024 Mar 6. doi: 10.4081/monaldi.2024.2860. Online ahead of print.ABSTRACTHypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease. Recently, a connection has been observed between the presence of first-degree atrioventricular block (FDAVB) and cardiovascular outcomes, although the pathophysiology of this association remains poorly understood. Considering the period 2000-2023, we retrospectively included HCM patients at sinus rhythm at the first appointment and sought possible interactions of FDAVB (defined as PR interval >200 ms) with different clinical and imaging variable...
Source: Monaldi Archives for Chest Disease - March 7, 2024 Category: Respiratory Medicine Authors: Ana Filipa Amador Catarina Martins da Costa Jo ão Da Silva Santos Cl áudia Camila Dias Elisabete Martins Source Type: research

Evaluation the relationship between myocardial fibrosis and left ventricular torsion measured by cardiac magnetic resonance feature-tracking in hypertrophic cardiomyopathy patients with preserved ejection fraction
This study sought to assess the impact of HCM on myocardial function as assessed by LV torsion and its relationship with MF. HCM (n = 79) and healthy controls (n = 40) underwent CMR. According to whether there was late gadolinium enhancement (LGE), patients were divided into LGE+ group and LGE− group. LV torsion and torsion rate were measured by CMR feature-tracking (CMR-FT). MF was quantitatively evaluated through LGE imaging. LGE was present in 44 patients (56%). Compared with healthy controls, torsion increased in the LGE− group (P < 0.001). Compared with LGE+ group, torsion was higher in the LGE− ...
Source: The International Journal of Cardiovascular Imaging - March 7, 2024 Category: Radiology Source Type: research

Autologous transplantation of green tea epigallocatechin-3-gallate pretreated adipose-derived stem cells increases cardiac regenerative capability through C-X-C motif chemokine receptor 4 expression in the treatment of rats with diabetic cardiomyopathy
This study investigates whether adipose-derived stem cells (ADSC) pretreated with EGCG show better protective effect on diabetic cardiomyopathy than ADSC without EGCG pretreatment. A cell model indicated that ADSC pretreated with EGCG increased cell functions including colony formation, migration and survival markers. All of these functions are blocked by small interfering C-X-C motif chemokine receptor 4 (siCXCR4) administration. These findings suggest that ADSC pretreatment with EGCG increases cell functions through CXCR4 expression. A diabetic animal model was designed to verify the above findings, including Sham, DM (d...
Source: Experimental Animals - March 6, 2024 Category: Research Authors: Tung-Sheng Chen Wei-Wen Kuo Chih-Yang Huang Source Type: research