Hypertrophic Cardiomyopathy Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Post-hoc standardisation of parametric T1 maps in cardiovascular magnetic resonance imaging: a proof-of-concept
This study was supported by the BMBF / DZHK.PMID:38490103 | DOI:10.1016/j.ebiom.2024.105055 (Source: Nuklearmedizin)
Source: Nuklearmedizin - March 15, 2024 Category: Radiology Authors: Darian Viezzer Thomas Hadler Jan Gr öschel Clemens Ammann Edyta Blaszczyk Christoph Kolbitsch Simone Hufnagel Riccardo Kranzusch-Gro ß Steffen Lange Jeanette Schulz-Menger Source Type: research

Post-hoc standardisation of parametric T1 maps in cardiovascular magnetic resonance imaging: a proof-of-concept
This study was supported by the BMBF / DZHK.PMID:38490103 | PMC:PMC10951905 | DOI:10.1016/j.ebiom.2024.105055 (Source: Nuklearmedizin)
Source: Nuklearmedizin - March 15, 2024 Category: Radiology Authors: Darian Viezzer Thomas Hadler Jan Gr öschel Clemens Ammann Edyta Blaszczyk Christoph Kolbitsch Simone Hufnagel Riccardo Kranzusch-Gro ß Steffen Lange Jeanette Schulz-Menger Source Type: research

Hypertrophic Cardiomyopathy
AbstractPurpose of ReviewHypertrophic cardiomyopathy (HCM) is a common inherited cardiac condition with potential for severe complications including sudden cardiac death. Early diagnosis allows appropriate risk stratification and prompt intervention to minimise the potential for adverse outcomes. The implications of poorly coordinated screening are significant, either missing relatives at high-risk or burdening low-risk individuals with a diagnosis associated with reduced life expectancy. We aim to guide clinicians through the diagnostic pathway through to novel treatment options. Several conditions mimic the condition, an...
Source: Current Heart Failure Reports - March 15, 2024 Category: Cardiology Source Type: research

Diagnostic yield from cardiac gene testing for inherited cardiac conditions and re-evaluation of pre-ACMG variants of uncertain significance
ConclusionOur study highlights the importance of collation and review of pre-ACMG genetic variants to increase diagnostic utility of genetic testing for inherited heart disease. Almost half of patients with pre-ACMG VUS reviewed had their variant re-classified to likely pathogenic/likely benign which resulted in a positive clinical impact for patients and their families. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 15, 2024 Category: General Medicine Source Type: research

Efficacy and Safety of aficamten in Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy: Results From the REDWOOD-HCM Trial, Cohort 4
Treatment of hypertrophic cardiomyopathy (HCM) is generally focused on improving heart failure (HF) symptoms in patients with obstructive HCM (oHCM), with repurposed medicines, invasive septal reduction, and more recently targeted drug therapy with cardiac myosin inhibitors.1-4 However, among the one-third of patients with HCM who do not have left ventricular outflow tract (LVOT) obstruction, a substantial proportion develop symptoms that impact daily life and, in some cases, progress to end-stage HF requiring heart transplant. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 14, 2024 Category: Cardiology Authors: Ahmad Masri, Mark V. Sherrid, Theodore P. Abraham, Lubna Choudhury, Pablo Garcia-Pavia, Christopher M. Kramer, Roberto Barriales-Villa, Anjali T. Owens, Florian Rader, Sherif F. Nagueh, Iacopo Olivotto, Sara Saberi, Albree Tower-Rader, Timothy C. Wong, Ca Source Type: research

Efficacy and Safety of Aficamten in Symptomatic Nonobstructive Hypertrophic Cardiomyopathy: Results From the REDWOOD-HCM Trial, Cohort 4
Treatment of hypertrophic cardiomyopathy (HCM) is generally focused on improving heart failure (HF) symptoms in patients with obstructive HCM (oHCM), with repurposed medicines, invasive septal reduction and, more recently, targeted drug therapy with cardiac myosin inhibitors.1 –4 However, among the one-third of patients with HCM who do not have left ventricular outflow tract (LVOT) obstruction, a substantial proportion develop symptoms that impact daily life and, in some cases, progress to end-stage HF requiring heart transplantation. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 14, 2024 Category: Cardiology Authors: AHMAD MASRI, MARK V. SHERRID, THEODORE P. ABRAHAM, LUBNA CHOUDHURY, PABLO GARCIA-PAVIA, CHRISTOPHER M. KRAMER, ROBERTO BARRIALES-VILLA, ANJALI T. OWENS, FLORIAN RADER, SHERIF F. NAGUEH, IACOPO OLIVOTTO, SARA SABERI, ALBREE TOWER-RADER, TIMOTHY C. WONG, CA Source Type: research

Alternative approaches for alcohol septal ablation in hypertrophic cardiomyopathy: the call for a personalized treatment
Hypertrophic cardiomyopathy (HCM) is a relatively common genetic condition characterized by increased thickness of the left ventricular wall1,2. The presence of left ventricular outflow tract (LVOT) obstruction is a defining feature of HCM and constitutes a key element in both the diagnosis and the management of the disease3. LVOT obstruction in HCM is primarily attributed to the systolic anterior movement (SAM) of elongated mitral valve leaflets, which come into contact with the septum at the subaortic level. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - March 13, 2024 Category: Cardiology Authors: Francesco Pelliccia, Elisabetta Moscarella, Paolo Calabr ò, Giuseppe Andò Tags: Editorial Source Type: research

How investigative reporting and the “fourth estate” saved hypertrophic cardiomyopathy…twice
Hypertrophic cardiomyopathy is a complex, often inherited, and heterogeneous cardiac disease once characterized by grim prognosis with limited treatment options1. However, contemporary management has dramatically altered clinical course resulting in greatly reduced hypertrophic cardiomyopathy-related mortality1. It is notable that these important clinical advances were aided on 2 occasions by aggressive involvement of the U.S. press and print media (sometimes referred to as the “Fourth Estate”)12,3. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 13, 2024 Category: General Medicine Authors: Barry J. Maron Tags: Commentary Source Type: research

Transcriptomics data integration and analysis to uncover hallmark genes in hypertrophic cardiomyopathy
CONCLUSION: In summary, the identification of key hub genes and their enrichment analysis in the current study may shed light on the mechanisms behind the occurrence and development of HCM.PMID:38463581 | PMC:PMC10918138 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Peng Chen Warda Yawar Ayesha Rida Farooqui Saqib Ali Nida Lathiya Zeeshan Ghous Rizwana Sultan Majid Alhomrani Saleh A Alghamdi Abdulraheem Ali Almalki Ahmad A Alghamdi Naif ALSuhaymi Muhammad Razi Ul Islam Hashmi Yasir Hameed Source Type: research