The Impact of CFTR Modulating Therapy on Chronic Lung Infection in Patients with Cystic Fibrosis
Acta Med Port. 2023 Sep 23. doi: 10.20344/amp.20106. Online ahead of print.ABSTRACTCystic fibrosis is the most common lethal genetic disease in the white population, affecting approximately 80 000 people worldwide. It is an autosomal recessive, monogenic, and multisystemic disease, with over 2000 mutations described in the CFTR protein gene. The dysfunction of this protein leads to a decrease in the secretion of chlorine and bicarbonate, sodium hyperabsorption, and consequent water absorption, resulting in the thickening of secretions and accumulation of pathogens. These changes culminate in inflammation, chronic pulmonary...
Source: Acta Medica Portuguesa - September 27, 2023 Category: General Medicine Authors: Joana Rodrigues Rita Boaventura Gabriela Fernandes Adelina Amorim Source Type: research

Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated with < em > Haemophilus influenzae < /em > Meningitis in a Newborn
This report highlights the possible involvement of B19 in the occurrence of acute neurological manifestations and emphasizes that its possible involvement might be better revealed by the use of metagenomic technology to detect viral agents in clinical situations of unknown or uncertain etiology.PMID:37754223 | DOI:10.3390/cimb45090439 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Noely Evangelista Ferreira Antonio C da Costa Esper G Kallas Cassia G T Silveira Ana Carolina S de Oliveira Layla Honorato Heuder G O Pai ão Silvia H Lima Dewton de M Vasconcelos Marina F C ôrtes Silvia F Costa Tania R T Mendoza H élio R Gomes Steven S Source Type: research

The Impact of CFTR Modulating Therapy on Chronic Lung Infection in Patients with Cystic Fibrosis
Acta Med Port. 2023 Sep 23. doi: 10.20344/amp.20106. Online ahead of print.ABSTRACTCystic fibrosis is the most common lethal genetic disease in the white population, affecting approximately 80 000 people worldwide. It is an autosomal recessive, monogenic, and multisystemic disease, with over 2000 mutations described in the CFTR protein gene. The dysfunction of this protein leads to a decrease in the secretion of chlorine and bicarbonate, sodium hyperabsorption, and consequent water absorption, resulting in the thickening of secretions and accumulation of pathogens. These changes culminate in inflammation, chronic pulmonary...
Source: Acta Medica Portuguesa - September 27, 2023 Category: General Medicine Authors: Joana Rodrigues Rita Boaventura Gabriela Fernandes Adelina Amorim Source Type: research

Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated with < em > Haemophilus influenzae < /em > Meningitis in a Newborn
This report highlights the possible involvement of B19 in the occurrence of acute neurological manifestations and emphasizes that its possible involvement might be better revealed by the use of metagenomic technology to detect viral agents in clinical situations of unknown or uncertain etiology.PMID:37754223 | PMC:PMC10529629 | DOI:10.3390/cimb45090439 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Noely Evangelista Ferreira Antonio C da Costa Esper G Kallas Cassia G T Silveira Ana Carolina S de Oliveira Layla Honorato Heuder G O Pai ão Silvia H Lima Dewton de M Vasconcelos Marina F C ôrtes Silvia F Costa Tania R T Mendoza H élio R Gomes Steven S Source Type: research

The Impact of CFTR Modulating Therapy on Chronic Lung Infection in Patients with Cystic Fibrosis
Acta Med Port. 2023 Sep 23. doi: 10.20344/amp.20106. Online ahead of print.ABSTRACTCystic fibrosis is the most common lethal genetic disease in the white population, affecting approximately 80 000 people worldwide. It is an autosomal recessive, monogenic, and multisystemic disease, with over 2000 mutations described in the CFTR protein gene. The dysfunction of this protein leads to a decrease in the secretion of chlorine and bicarbonate, sodium hyperabsorption, and consequent water absorption, resulting in the thickening of secretions and accumulation of pathogens. These changes culminate in inflammation, chronic pulmonary...
Source: Acta Medica Portuguesa - September 27, 2023 Category: General Medicine Authors: Joana Rodrigues Rita Boaventura Gabriela Fernandes Adelina Amorim Source Type: research

Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated with < em > Haemophilus influenzae < /em > Meningitis in a Newborn
This report highlights the possible involvement of B19 in the occurrence of acute neurological manifestations and emphasizes that its possible involvement might be better revealed by the use of metagenomic technology to detect viral agents in clinical situations of unknown or uncertain etiology.PMID:37754223 | PMC:PMC10529629 | DOI:10.3390/cimb45090439 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Noely Evangelista Ferreira Antonio C da Costa Esper G Kallas Cassia G T Silveira Ana Carolina S de Oliveira Layla Honorato Heuder G O Pai ão Silvia H Lima Dewton de M Vasconcelos Marina F C ôrtes Silvia F Costa Tania R T Mendoza H élio R Gomes Steven S Source Type: research

The Impact of CFTR Modulating Therapy on Chronic Lung Infection in Patients with Cystic Fibrosis
Acta Med Port. 2023 Sep 23. doi: 10.20344/amp.20106. Online ahead of print.ABSTRACTCystic fibrosis is the most common lethal genetic disease in the white population, affecting approximately 80 000 people worldwide. It is an autosomal recessive, monogenic, and multisystemic disease, with over 2000 mutations described in the CFTR protein gene. The dysfunction of this protein leads to a decrease in the secretion of chlorine and bicarbonate, sodium hyperabsorption, and consequent water absorption, resulting in the thickening of secretions and accumulation of pathogens. These changes culminate in inflammation, chronic pulmonary...
Source: Acta Medica Portuguesa - September 27, 2023 Category: General Medicine Authors: Joana Rodrigues Rita Boaventura Gabriela Fernandes Adelina Amorim Source Type: research

Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated with < em > Haemophilus influenzae < /em > Meningitis in a Newborn
This report highlights the possible involvement of B19 in the occurrence of acute neurological manifestations and emphasizes that its possible involvement might be better revealed by the use of metagenomic technology to detect viral agents in clinical situations of unknown or uncertain etiology.PMID:37754223 | PMC:PMC10529629 | DOI:10.3390/cimb45090439 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Noely Evangelista Ferreira Antonio C da Costa Esper G Kallas Cassia G T Silveira Ana Carolina S de Oliveira Layla Honorato Heuder G O Pai ão Silvia H Lima Dewton de M Vasconcelos Marina F C ôrtes Silvia F Costa Tania R T Mendoza H élio R Gomes Steven S Source Type: research

The Impact of CFTR Modulating Therapy on Chronic Lung Infection in Patients with Cystic Fibrosis
Acta Med Port. 2023 Sep 23. doi: 10.20344/amp.20106. Online ahead of print.ABSTRACTCystic fibrosis is the most common lethal genetic disease in the white population, affecting approximately 80 000 people worldwide. It is an autosomal recessive, monogenic, and multisystemic disease, with over 2000 mutations described in the CFTR protein gene. The dysfunction of this protein leads to a decrease in the secretion of chlorine and bicarbonate, sodium hyperabsorption, and consequent water absorption, resulting in the thickening of secretions and accumulation of pathogens. These changes culminate in inflammation, chronic pulmonary...
Source: Acta Medica Portuguesa - September 27, 2023 Category: General Medicine Authors: Joana Rodrigues Rita Boaventura Gabriela Fernandes Adelina Amorim Source Type: research

Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated with < em > Haemophilus influenzae < /em > Meningitis in a Newborn
This report highlights the possible involvement of B19 in the occurrence of acute neurological manifestations and emphasizes that its possible involvement might be better revealed by the use of metagenomic technology to detect viral agents in clinical situations of unknown or uncertain etiology.PMID:37754223 | PMC:PMC10529629 | DOI:10.3390/cimb45090439 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Noely Evangelista Ferreira Antonio C da Costa Esper G Kallas Cassia G T Silveira Ana Carolina S de Oliveira Layla Honorato Heuder G O Pai ão Silvia H Lima Dewton de M Vasconcelos Marina F C ôrtes Silvia F Costa Tania R T Mendoza H élio R Gomes Steven S Source Type: research

The Impact of CFTR Modulating Therapy on Chronic Lung Infection in Patients with Cystic Fibrosis
Acta Med Port. 2023 Sep 23. doi: 10.20344/amp.20106. Online ahead of print.ABSTRACTCystic fibrosis is the most common lethal genetic disease in the white population, affecting approximately 80 000 people worldwide. It is an autosomal recessive, monogenic, and multisystemic disease, with over 2000 mutations described in the CFTR protein gene. The dysfunction of this protein leads to a decrease in the secretion of chlorine and bicarbonate, sodium hyperabsorption, and consequent water absorption, resulting in the thickening of secretions and accumulation of pathogens. These changes culminate in inflammation, chronic pulmonary...
Source: Acta Medica Portuguesa - September 27, 2023 Category: General Medicine Authors: Joana Rodrigues Rita Boaventura Gabriela Fernandes Adelina Amorim Source Type: research

Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated with < em > Haemophilus influenzae < /em > Meningitis in a Newborn
This report highlights the possible involvement of B19 in the occurrence of acute neurological manifestations and emphasizes that its possible involvement might be better revealed by the use of metagenomic technology to detect viral agents in clinical situations of unknown or uncertain etiology.PMID:37754223 | PMC:PMC10529629 | DOI:10.3390/cimb45090439 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Noely Evangelista Ferreira Antonio C da Costa Esper G Kallas Cassia G T Silveira Ana Carolina S de Oliveira Layla Honorato Heuder G O Pai ão Silvia H Lima Dewton de M Vasconcelos Marina F C ôrtes Silvia F Costa Tania R T Mendoza H élio R Gomes Steven S Source Type: research

Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated with < em > Haemophilus influenzae < /em > Meningitis in a Newborn
This report highlights the possible involvement of B19 in the occurrence of acute neurological manifestations and emphasizes that its possible involvement might be better revealed by the use of metagenomic technology to detect viral agents in clinical situations of unknown or uncertain etiology.PMID:37754223 | PMC:PMC10529629 | DOI:10.3390/cimb45090439 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Noely Evangelista Ferreira Antonio C da Costa Esper G Kallas Cassia G T Silveira Ana Carolina S de Oliveira Layla Honorato Heuder G O Pai ão Silvia H Lima Dewton de M Vasconcelos Marina F C ôrtes Silvia F Costa Tania R T Mendoza H élio R Gomes Steven S Source Type: research

Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated with < em > Haemophilus influenzae < /em > Meningitis in a Newborn
This report highlights the possible involvement of B19 in the occurrence of acute neurological manifestations and emphasizes that its possible involvement might be better revealed by the use of metagenomic technology to detect viral agents in clinical situations of unknown or uncertain etiology.PMID:37754223 | PMC:PMC10529629 | DOI:10.3390/cimb45090439 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Noely Evangelista Ferreira Antonio C da Costa Esper G Kallas Cassia G T Silveira Ana Carolina S de Oliveira Layla Honorato Heuder G O Pai ão Silvia H Lima Dewton de M Vasconcelos Marina F C ôrtes Silvia F Costa Tania R T Mendoza H élio R Gomes Steven S Source Type: research