Dismantling Barriers to Hepatitis B and Delta Screening, Prevention, and Linkage to Care among the PWUD Community in Philadelphia
This study found high rates of current and past HBV infection, and a 10% HBV/HDV co-infection rate. Despite availability of vaccine, one quarter of participants remained vulnerable to infection. Findings demonstrate the need to improve low-threshold HBV/HDV screening, vaccination, and linkage to care among PWUD. The study also identified gaps in the HBV/HDV care cascade, including lack of point-of-care diagnostics and lack of support for HROs to provide HBV services.PMID:38675969 | DOI:10.3390/v16040628 (Source: Cancer Control)
Source: Cancer Control - April 27, 2024 Category: Cancer & Oncology Authors: Beatrice Zovich Catherine Freeland Holly Moore Kara Sapp Anousha Qureshi Rachel Holbert Jason Zambrano Daljinder Bhangoo Chari Cohen Richard W Hass Amy Jessop Source Type: research
Changing etiological spectrum of acute liver failure
ConclusionsThe most common cause for ALF was hepatitis A virus, followed by hepatitis B virus, while in ALF mimics it was malaria followed by dengue fever, in our study. Patients of ALF mimics can have similar presentation, but a high index of suspicion and awareness is required to identify the common infectious ALF mimics for early diagnosis.Graphical Abstract (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - April 27, 2024 Category: Gastroenterology Source Type: research
Barriers to access to hepatitis C treatment with direct-acting antivirals in people who inject drugs in the community setting
. Qualitative study with prison population. Hepatitis C (HCV) treatments with direct... (Source: Harm Reduction Journal)
Source: Harm Reduction Journal - April 27, 2024 Category: Drugs & Pharmacology Authors: Elena Yela, Neus Sol é, Lidia Puig, Darío López Gallegos and Rafael Clua-García Tags: Research Source Type: research
Changing etiological spectrum of acute liver failure
ConclusionsThe most common cause for ALF was hepatitis A virus, followed by hepatitis B virus, while in ALF mimics it was malaria followed by dengue fever, in our study. Patients of ALF mimics can have similar presentation, but a high index of suspicion and awareness is required to identify the common infectious ALF mimics for early diagnosis.Graphical Abstract (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - April 27, 2024 Category: Gastroenterology Source Type: research
In Vitro Hepatotoxicity of Routinely Used Opioids and Sedative Drugs
Curr Issues Mol Biol. 2024 Mar 30;46(4):3022-3038. doi: 10.3390/cimb46040189.ABSTRACTA hepatocyte cell line was used to determine the hepatotoxicity of sedatives and opioids, as the hepatotoxicity of these drugs has not yet been well characterized. This might pose a threat, especially to critically ill patients, as they often receive high cumulative doses for daily analgosedation and often already have impaired liver function due to an underlying disease or complications during treatment. A well-established biosensor based on HepG2/C3A cells was used for the determination of the hepatotoxicity of commonly used sedatives an...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Katharina Haller Sandra Do ß Martin Sauer Source Type: research
Exploration of Germline Correlates and Risk of Immune-Related Adverse Events in Advanced Cancer Patients Treated with Immune Checkpoint Inhibitors
Curr Oncol. 2024 Mar 30;31(4):1865-1875. doi: 10.3390/curroncol31040140.ABSTRACTImmune checkpoint inhibitors (ICIs) are increasingly used in the treatment of many tumor types, and durable responses can be observed in select populations. However, patients may exhibit significant immune-related adverse events (irAEs) that may lead to morbidity. There is limited information on whether the presence of specific germline mutations may highlight those at elevated risk of irAEs. We evaluated 117 patients with metastatic solid tumors or hematologic malignancies who underwent genomic analysis through the ongoing Personalized OncoGen...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Emma Titmuss Irene S Yu Erin D Pleasance Laura M Williamson Karen Mungall Andrew J Mungall Daniel J Renouf Richard Moore Steven J M Jones Marco A Marra Janessa J Laskin Kerry J Savage Source Type: research
In Vitro Hepatotoxicity of Routinely Used Opioids and Sedative Drugs
Curr Issues Mol Biol. 2024 Mar 30;46(4):3022-3038. doi: 10.3390/cimb46040189.ABSTRACTA hepatocyte cell line was used to determine the hepatotoxicity of sedatives and opioids, as the hepatotoxicity of these drugs has not yet been well characterized. This might pose a threat, especially to critically ill patients, as they often receive high cumulative doses for daily analgosedation and often already have impaired liver function due to an underlying disease or complications during treatment. A well-established biosensor based on HepG2/C3A cells was used for the determination of the hepatotoxicity of commonly used sedatives an...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Katharina Haller Sandra Do ß Martin Sauer Source Type: research
Exploration of Germline Correlates and Risk of Immune-Related Adverse Events in Advanced Cancer Patients Treated with Immune Checkpoint Inhibitors
Curr Oncol. 2024 Mar 30;31(4):1865-1875. doi: 10.3390/curroncol31040140.ABSTRACTImmune checkpoint inhibitors (ICIs) are increasingly used in the treatment of many tumor types, and durable responses can be observed in select populations. However, patients may exhibit significant immune-related adverse events (irAEs) that may lead to morbidity. There is limited information on whether the presence of specific germline mutations may highlight those at elevated risk of irAEs. We evaluated 117 patients with metastatic solid tumors or hematologic malignancies who underwent genomic analysis through the ongoing Personalized OncoGen...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Emma Titmuss Irene S Yu Erin D Pleasance Laura M Williamson Karen Mungall Andrew J Mungall Daniel J Renouf Richard Moore Steven J M Jones Marco A Marra Janessa J Laskin Kerry J Savage Source Type: research
The Great Imitator Masquerading as Autoimmune Hepatitis and Demystifying as Fulminant Syphilitic Retinitis
CONCLUSION: Acquired syphilitic hepatitis is rarely reported. Administering steroids potentially aggravated the infection. The characteristic features of placoid chorioretinitis and punctate inner retinitis connected the pieces of the puzzle together to the diagnosis of ocular and neurosyphilis. Intrahepatic cholestasis with negative serological panel of hepatotropic pathogens should raise the suspicion of non-hepatotropic pathogens especially syphilis.PMID:38669600 | DOI:10.1080/09273948.2024.2345290 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 26, 2024 Category: Allergy & Immunology Authors: Ron Kaufman Juan Martin Sanchez Radgonde Amer Source Type: research
In Vitro Hepatotoxicity of Routinely Used Opioids and Sedative Drugs
Curr Issues Mol Biol. 2024 Mar 30;46(4):3022-3038. doi: 10.3390/cimb46040189.ABSTRACTA hepatocyte cell line was used to determine the hepatotoxicity of sedatives and opioids, as the hepatotoxicity of these drugs has not yet been well characterized. This might pose a threat, especially to critically ill patients, as they often receive high cumulative doses for daily analgosedation and often already have impaired liver function due to an underlying disease or complications during treatment. A well-established biosensor based on HepG2/C3A cells was used for the determination of the hepatotoxicity of commonly used sedatives an...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Katharina Haller Sandra Do ß Martin Sauer Source Type: research
Exploration of Germline Correlates and Risk of Immune-Related Adverse Events in Advanced Cancer Patients Treated with Immune Checkpoint Inhibitors
Curr Oncol. 2024 Mar 30;31(4):1865-1875. doi: 10.3390/curroncol31040140.ABSTRACTImmune checkpoint inhibitors (ICIs) are increasingly used in the treatment of many tumor types, and durable responses can be observed in select populations. However, patients may exhibit significant immune-related adverse events (irAEs) that may lead to morbidity. There is limited information on whether the presence of specific germline mutations may highlight those at elevated risk of irAEs. We evaluated 117 patients with metastatic solid tumors or hematologic malignancies who underwent genomic analysis through the ongoing Personalized OncoGen...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Emma Titmuss Irene S Yu Erin D Pleasance Laura M Williamson Karen Mungall Andrew J Mungall Daniel J Renouf Richard Moore Steven J M Jones Marco A Marra Janessa J Laskin Kerry J Savage Source Type: research
The Great Imitator Masquerading as Autoimmune Hepatitis and Demystifying as Fulminant Syphilitic Retinitis
CONCLUSION: Acquired syphilitic hepatitis is rarely reported. Administering steroids potentially aggravated the infection. The characteristic features of placoid chorioretinitis and punctate inner retinitis connected the pieces of the puzzle together to the diagnosis of ocular and neurosyphilis. Intrahepatic cholestasis with negative serological panel of hepatotropic pathogens should raise the suspicion of non-hepatotropic pathogens especially syphilis.PMID:38669600 | DOI:10.1080/09273948.2024.2345290 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 26, 2024 Category: Allergy & Immunology Authors: Ron Kaufman Juan Martin Sanchez Radgonde Amer Source Type: research
In Vitro Hepatotoxicity of Routinely Used Opioids and Sedative Drugs
Curr Issues Mol Biol. 2024 Mar 30;46(4):3022-3038. doi: 10.3390/cimb46040189.ABSTRACTA hepatocyte cell line was used to determine the hepatotoxicity of sedatives and opioids, as the hepatotoxicity of these drugs has not yet been well characterized. This might pose a threat, especially to critically ill patients, as they often receive high cumulative doses for daily analgosedation and often already have impaired liver function due to an underlying disease or complications during treatment. A well-established biosensor based on HepG2/C3A cells was used for the determination of the hepatotoxicity of commonly used sedatives an...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Katharina Haller Sandra Do ß Martin Sauer Source Type: research
Seroprevalence of anti-SARS-CoV-2 in patients with hepatitis B and C: a pre-vaccination study
This study aims to assess the prevalence of anti-SARS-CoV-2 in hepatitis B and C patients in a pre-vaccination of COVID-19 period. Between March 2020 and January 2021, 199 serum samples from individuals with HBsAg/HBV DNA or anti-HCV/HCV RNA positivity were tested for antibodies (IgM and IgG) against SARS-CoV-2 using Electrochemiluminescent Immunoassay (ECLIA). Among these, 50.3 % (100/199) tested positive for hepatitis C virus infection and 49.7 % (99/199) for hepatitis B virus, confirmed through molecular and serological diagnosis. The anti-SARS-CoV-2 seroprevalence was 24.1 % (48/199) in this population, with 23.23 % (2...
Source: Braz J Infect Dis - April 26, 2024 Category: Infectious Diseases Authors: Lucas Lima da Silva Lia Laura Lewis-Ximenez Monica Magalhaes Figueiredo Vanessa Salete de Paula Livia Melo Villar Source Type: research
Kinetics of Hepatitis E Virus Infections in Asymptomatic Persons
Emerg Infect Dis. 2024 May;30(5):934-940. doi: 10.3201/eid3005.231764.ABSTRACTTo determine the kinetics of hepatitis E virus (HEV) in asymptomatic persons and to evaluate viral load doubling time and half-life, we retrospectively tested samples retained from 32 HEV RNA-positive asymptomatic blood donors in Germany. Close-meshed monitoring of viral load and seroconversion in intervals of ≈4 days provided more information about the kinetics of asymptomatic HEV infections. We determined that a typical median infection began with PCR-detectable viremia at 36 days and a maximum viral load of 2.0 × 104 IU/mL. Viremia doubled ...
Source: Emerging Infectious Diseases - April 26, 2024 Category: Infectious Diseases Authors: Ricarda Pl ümers Jens Dreier Cornelius Knabbe Eike Steinmann Daniel Todt Tanja Vollmer Source Type: research
